| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumon Roy, Dongjoon Kim, Cristina Hernández, Rafael Simó, Sayon Ro. Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy. Experimental eye research. vol 140. 2016-02-19. PMID:26297615. |
beneficial effects of fenofibric acid on overexpression of extracellular matrix components, cox-2, and impairment of endothelial permeability associated with diabetic retinopathy. |
2016-02-19 |
2023-08-13 |
rat |
| Won-Jung Bae, Mee-Ran Shin, Soo-Kyung Kang, Zhang-Jun, Jun-Yeol Kim, Sang-Cheon Lee, Eun-Cheol Ki. HIF-2 Inhibition Supresses Inflammatory Responses and Osteoclastic Differentiation in Human Periodontal Ligament Cells. Journal of cellular biochemistry. vol 116. issue 7. 2016-01-29. PMID:25565665. |
hif-2α inhibitor and hif-2α sirna attenuated the nicotine- and lps- induced production of no and pge2 , upregulation of inos, cox-2, pro-inflammatory cytokines (il-1β, tnf-α, il-1β, il-6, il-8, il-10, il-11, and il-17), and matrix metalloproteinases (mmps; mmp-1, -8, -13, -2 and -9), and reversed the effect on timps (timp-1 and -2) in pdlcs. |
2016-01-29 |
2023-08-13 |
human |
| Ying-Yu Kuo, Wai-Tim Jim, Liang-Cheng Su, Chi-Jung Chung, Ching-Yu Lin, Chieh Huo, Jen-Chih Tseng, Shih-Han Huang, Chih-Jen Lai, Bo-Chih Chen, Bi-Juan Wang, Tzu-Min Chan, Hui-Ping Lin, Wun-Shaing Wayne Chang, Chuang-Rung Chang, Chih-Pin Chu. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. International journal of molecular sciences. vol 16. issue 5. 2016-01-18. PMID:25984601. |
cape treatment inhibits akt signaling, cell cycle regulatory proteins, nf-κb function, as well as activity of matrix metalloproteinase (mmps), epidermal growth factor receptor (egfr), and cyclooxygenase-2 (cox-2). |
2016-01-18 |
2023-08-13 |
Not clear |
| Xiao-Hong Zhang, Xian-Xiang Xu, Tao X. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908625. |
il-1β-induced inflammation and matrix degration were also alleviated by ro with down-regulating the expression of mmp 3, mmp 9 and cox-2. |
2016-01-12 |
2023-08-13 |
rat |
| Young Il Kim, Seung-Won Park, Yeo-Kwang Yoon, Kyung-Wook Lee, Jang-Hoon Lee, Hong-Jung Woo, Youngchul Ki. Orostachys japonicus inhibits the expression of MMP-2 and MMP-9 mRNA and modulates the expression of iNOS and COX-2 genes in human PMA-differentiated THP-1 cells via inhibition of NF-κB and MAPK activation. Molecular medicine reports. vol 12. issue 1. 2016-01-11. PMID:25760396. |
the present study aimed to investigate the mechanism by which o. japonicus extract affects the expression of matrix metalloproteinase (mmp)-2 and mmp-9, its association with the expression of the inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) genes in phorbol myristate acetate-differentiated thp-1 human monocytic leukemia cells and how it mediates the nuclear factor (nf)-κb and mitogen-activated protein kinase (mapk) pathways. |
2016-01-11 |
2023-08-13 |
human |
| Ganjun Feng, Hongying Chen, Junjie Li, Qiang Huang, Melanie J Gupte, Hao Liu, Yueming Song, Zhishen G. Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas. Biomaterials. vol 52. 2015-12-14. PMID:25818409. |
high expression of heme oxygenase-1 (ho-1) in np cells transfected by mpms loading ho-1 pdna significantly decreased the expression activity of matrix metalloproteinases 3 (mmp-3) and cyclo-oxygenase-2 (cox-2) induced by interleukin-1β (il-1β), and simultaneously increased the np phenotype-associated genes such as aggrecan, type ii collagen, and sox-9. |
2015-12-14 |
2023-08-13 |
rat |
| Daniela Ribeiro, Marisa Freitas, Sara M Tomé, Artur M S Silva, Stefan Laufer, José L F C Lima, Eduarda Fernande. Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood. Inflammation. vol 38. issue 2. 2015-11-27. PMID:25139581. |
this study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit cox-1 and cox-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship. |
2015-11-27 |
2023-08-13 |
human |
| Jinn-Yuan Hsu, Kwang-Yu Chang, Shang-Hung Chen, Chung-Ta Lee, Sheng-Tsung Chang, Hung-Chi Cheng, Wen-Chang Chang, Ben-Kuen Che. Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. Oncotarget. vol 6. issue 3. 2015-11-25. PMID:25595899. |
cox-2 depletion inhibited egf-induced matrix metalloproteinase (mmp)-1, mmp-2, mmp-3, mmp-9, and fibronectin expression and rac1/cdc42 activation. |
2015-11-25 |
2023-08-13 |
Not clear |
| Andreea Iren Serban, Loredana Stanca, Cornelia Sima, Andrea Cristina Staicu, Otilia Zarnescu, Anca Dinischiot. Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress. Chemico-biological interactions. vol 239. 2015-11-24. PMID:26079203. |
the increased activity of cyclooxigenase-2 (cox-2) and matrix metalloproteinases (mmps) support the idea that si/sio2 qds have a potential to induce inflammatory response, a scenario also indicated by the profile of hsp60 and hsp90 heat shock proteins. |
2015-11-24 |
2023-08-13 |
Not clear |
| Shridhivya A Reddy, Sandeep B Shelar, Truong-Minh Dang, Baxter Neng-Cun Lee, Hong Yang, Siew-Min Ong, Hui-Li Ng, Wai-Keung Chui, Siew-Cheng Wong, Eng-Hui Che. Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner. International immunopharmacology. vol 24. issue 2. 2015-11-23. PMID:25585231. |
in raw 264.7 cells, the itcs at non-toxic concentrations caused an inhibition of no and prostaglandin e2 (pge2) release through suppressing expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2), as well as a reduction in matrix metalloproteinase-9 (mmp-9) expression, secretion and gelatinolytic activity. |
2015-11-23 |
2023-08-13 |
human |
| Sang Yoon Jung, Chulwon Kim, Wan-Seok Kim, Seok-Geun Lee, Jun-Hee Lee, Bum Sang Shim, Sung-Hoon Kim, Kyoo Seok Ahn, Kwang Seok Ah. Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells. Phytotherapy research : PTR. vol 29. issue 7. 2015-11-05. PMID:25857479. |
it also abrogated the expression of bcl-2 (b-cell lymphoma 2), bcl-xl (b-cell lymphoma-extra large), survivin, inhibitors of apoptosis protein 1/2, cox-2 (cyclooxygenase-2), cyclin d1, matrix metalloproteinase-9, and vegf (vascular endothelial growth factor), as well as upregulated the expression of pro-apoptotic gene products. |
2015-11-05 |
2023-08-13 |
human |
| Hsiu-Mei Chiang, Shih-Yun Chan, Yin Chu, Kuo-Ching We. Fisetin Ameliorated Photodamage by Suppressing the Mitogen-Activated Protein Kinase/Matrix Metalloproteinase Pathway and Nuclear Factor-κB Pathways. Journal of agricultural and food chemistry. vol 63. issue 18. 2015-11-03. PMID:25882230. |
the results revealed that 5-25 μm fisetin inhibits cyclooxygenase-2 (cox-2) and matrix metalloproteinase (mmp)-1, mmp-3, mmp-9 expression induced by ultraviolet b (uvb) irradiation in human skin fibroblasts. |
2015-11-03 |
2023-08-13 |
human |
| Yuma Maeda, Fumiko Sekiguchi, Rumi Yamanaka, Ryo Sugimoto, Daichi Yamasoba, Shiori Tomita, Hiroyuki Nishikawa, Atsufumi Kawabat. Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells. Biological chemistry. vol 396. issue 2. 2015-09-16. PMID:25205726. |
par1 stimulation caused pge2 release, an effect suppressed by inhibitors of cox-1, cox-2, ipla2, cpla2, map kinases (mapks), src, egf receptor (egfr) tyrosine kinase (egfr-tk) and matrix metalloproteinase (mmp), but not by an intracellular ca2+ chelator or inhibitors of pi3 kinase, protein kinase c (pkc) and nf-κb. |
2015-09-16 |
2023-08-13 |
mouse |
| Bin Guo, Xue-Chao Tian, Dang-Dang Li, Zhan-Qing Yang, Hang Cao, Qiao-Ling Zhang, Ju-Xiong Liu, Zhan-Peng Yu. Expression, regulation and function of Egr1 during implantation and decidualization in mice. Cell cycle (Georgetown, Tex.). vol 13. issue 16. 2015-08-19. PMID:25486203. |
further study found that egr1 played a role through influencing the expression of cyclooxygenase-2 (cox-2), microsomal prostaglandin e synthase 1 (mpges-1), vascular endothelial growth factor (vegf), transformation related protein 53 (trp53) and matrix metallopeptidase 9 (mmp9) genes in the process of mouse embryo implantation. |
2015-08-19 |
2023-08-13 |
mouse |
| T Chitranjali, P Anoop Chandran, G Muraleedhara Kuru. Omega-3 fatty acid concentrate from Dunaliella salina possesses anti-inflammatory properties including blockade of NF-κB nuclear translocation. Immunopharmacology and immunotoxicology. vol 37. issue 1. 2015-08-17. PMID:25391558. |
the concentrate was also found to be a potent blocker of cyclooxygenase (cox-2) and matrix metalloproteinase (mmp-2 and mmp-9) expression. |
2015-08-17 |
2023-08-13 |
Not clear |
| G L Shyni, G Sindhu, A Hele. Downregulation of inflammatory mediators and pro-inflammatory cytokines by alkaloids of Jeevaneeya rasayana in adjuvant-induced arthritis. Immunological investigations. vol 44. issue 1. 2015-08-06. PMID:25058430. |
paw swelling, inflammatory mediators such as cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9), level of prostaglandin e2 (pge2), expression of cytokines and serum nitric oxide (no) level were analyzed in experimental rats after an experimental period of 21 days. |
2015-08-06 |
2023-08-13 |
rat |
| Tzu-Chun Cheng, Ching-Shu Lai, Min-Ching Chung, Nagabhushanam Kalyanam, Muhammed Majeed, Chi-Tang Ho, Yuan-Soon Ho, Min-Hsiung Pa. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PloS one. vol 9. issue 11. 2015-07-20. PMID:25389774. |
these inhibitory effects were accompanied by mechanistic down-regulation of the protein levels of cyclooxygenase-2 (cox-2), matrix metallopeptidase-9 (mmp-9), vascular endothelial growth factor (vegf), and cyclin d1, as well as by the induction of apoptosis in colon tumors. |
2015-07-20 |
2023-08-13 |
mouse |
| Wei Wang, Liang Sun, Pengfei Zhang, Junfei Song, Wenguang Li. An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits. Acta biomaterialia. vol 10. issue 12. 2015-07-16. PMID:25169257. |
after implantation for 2, 4 and 6weeks, the samples were retrieved for quantitative real-time polymerase chain reaction, and the inflammatory related genes interleukin-1β, matrix metalloproteinases-13, cox-2 and bone and cartilage related genes sox-9, aggrecan, coll ii and coll i were determined. |
2015-07-16 |
2023-08-13 |
rabbit |
| Naiqing Liu, Jianguo Huang, Shuxiang Sun, Zhongjin Zhou, Jingyu Zhang, Fahui Gao, Qinli Su. Expression of matrix metalloproteinase-9, cyclooxygenase-2 and vascular endothelial growth factor are increased in gastrointestinal stromal tumors. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131278. |
this study is to investigate the expression of matrix metalloproteinase-9 (mmp-9), cyclooxygenase-2 (cox-2) and vascular endothelial growth factor (vegf) in gastrointestinal stromal tumor (gist). |
2015-07-01 |
2023-08-13 |
Not clear |
| Zora Vochyánová, Ladislava Bartošová, Veronika Bujdáková, Petr Fictum, Roman Husník, Pavel Suchý, Karel Šmejkal, Jan Hoše. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. vol 101. 2015-05-29. PMID:25623260. |
the effect of the treatment was assessed by monitoring the disease activity index (dai), histopathological examination, evaluation of the weight and length of the colon and by analysis of the levels and activities of cyclooxygenase-2 (cox-2), matrix metalloproteinase-2 (mmp2), superoxide dismutase-2 (sod2), and catalase (cat) in the inflamed tissue. |
2015-05-29 |
2023-08-13 |
rat |