| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung Eun Kim, Jae Yong Lee, Kyu-Sik Shim, Sunghee Lee, Kyoengwoo Min, Ji-Hoon Bae, Hak-Jun Kim, Kyeongsoon Park, Hae-Ryong Son. Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. International journal of biological macromolecules. vol 114. 2018-09-26. PMID:29548914. |
in vitro studies performed using real-time polymerase chain reaction (pcr) assay revealed that the sasp/ha was able to effectively and dose-dependently inhibit the mrna expression levels of pro-inflammatory cytokines such as matrix metalloproteinases-3 (mmp-3), cyclooxygenase-2 (cox-2), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α) in lps-stimulated synoviocytes. |
2018-09-26 |
2023-08-13 |
rat |
| Esra Aycan Ustyol, Fatih Karaarslan, Seldag Bekpinar, Kagan Ozkuk, Nergis Erdoga. Effects of Balneotherapy on Serum Levels of Shingosine-1-Phosphate in Patients With Osteoarthritis. Alternative therapies in health and medicine. vol 23. issue 6. 2018-08-20. PMID:28646803. |
baseline serum levels of s1p, cyclooxygenase 2 (cox-2), matrix metalloproteinase 3 (mmp-3), and heat shock protein 70 (hsp-70) were measured using enzyme-linked immunosorbent assays and high-sensitivity c-reactive protein, with an immunoturbidimetric assay. |
2018-08-20 |
2023-08-13 |
human |
| Ching Huang, Yi-Yuan Lin, Ai-Lun Yang, Tang-Wei Kuo, Chia-Hua Kuo, Shin-Da Le. Anti-Renal Fibrotic Effect of Exercise Training in Hypertension. International journal of molecular sciences. vol 19. issue 2. 2018-08-17. PMID:29461477. |
the inflammatory-related protein levels of interleukin-6 (il-6) and cyclooxygenase-2 (cox-2), as well as the fibrotic-related protein levels of transforming growth factor-beta (tgf-β), phospho-smad2/3 (p-smad2/3), connective tissue growth factor (ctgf), matrix metalloproteinase-9 (mmp-9), and matrix metalloproteinase-2 (mmp-2) were decreased in the shr-ex group when compared with the shr group. |
2018-08-17 |
2023-08-13 |
rat |
| Ming Wang, Hong-xia Cui, Chao Sun, Gang Li, Hong-lan Wang, Chun-hui Xia, Yu-chun Wang, Ji-cheng Li. [Effect of lupeol on migration and invasion of human breast cancer MDA-MB-231 cells and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 4. 2018-08-13. PMID:29859524. |
the expression of cyclooxygenase-2 (cox-2), matrix metalloproteinase-2 (mmp-2), -9 (mmp-9) and nuclear transcription factor-kappa b (nf-κb) p65 in breast cancer following treatment with different concentrations of lupeol was analyzed with western blot. |
2018-08-13 |
2023-08-13 |
human |
| Su Jeong Ha, Joon Park, Jangho Lee, Kyung-Mo Song, Min Young Um, Suengmok Cho, Sung Keun Jun. Rice bran supplement prevents UVB-induced skin photoaging in vivo. Bioscience, biotechnology, and biochemistry. vol 82. issue 2. 2018-07-10. PMID:29307270. |
western blot and immunohistochemical analyses revealed that repeated exposure to uvb upregulated matrix metalloproteinase-13 (mmp-13) and cyclooxygenase-2 (cox-2) expression, while consumption of rbs suppressed mmp-13 and cox-2 expression, as well as mitogen-activated protein kinase (mapk) signaling pathways. |
2018-07-10 |
2023-08-13 |
mouse |
| Y Zhang, S Dang, Y Wan, F Yang, T L. Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer. European journal of gynaecological oncology. vol 38. issue 1. 2018-06-21. PMID:29767863. |
to investigate the correlation of the expression of vascular endothelial growth factor (vegf), cyclooxygenase-2 (cox-2), and matrix metalloprotease-9 (mmp-9) in breast cancer tissues with molybdenum-targeted x-ray images. |
2018-06-21 |
2023-08-13 |
Not clear |
| Nunzia Caporarello, Gabriella Lupo, Melania Olivieri, Martina Cristaldi, Maria Teresa Cambria, Mario Salmeri, Carmelina Daniela Anfus. Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions (Review). Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28791360. |
the focus of the present review was some principal 'alternative' approaches to classic antiangiogenic therapies, including the cyclooxygenase-2 (cox-2) blockade, the use of oligonucleotide complementary to the mirna to compete with the mrna target (antimirs) and the inhibition of matrix metalloproteinases (mmps). |
2018-05-14 |
2023-08-13 |
Not clear |
| Kelly M DeMars, Changjun Yang, Carolina I Castro-Rivera, Eduardo Candelario-Jali. Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-22. PMID:29448097. |
degradation of brd2 and brd4 was associated with significantly reduced expression of several pro-inflammatory genes: inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), interleukin (il)-1β, tumor necrosis factor-a (tnf-α), il-6, chemokine (c-c motif) ligand 2 (ccl2), and matrix metalloproteinase-9 (mmp-9). |
2018-03-22 |
2023-08-13 |
Not clear |
| Hajer Taleb, R Keith Morris, Cathryn E Withycombe, Sarah E Maddocks, Ara D Kanekania. Date syrup-derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells. Nutrition research (New York, N.Y.). vol 36. issue 7. 2018-01-18. PMID:27333954. |
it was hypothesized that polyphenols in date syrup reduce angiogenic responses such as cell migration, tube formation, and matrix metalloproteinase activity in an inflammatory model by exhibiting anti-inflammatory activity mediated by vascular endothelial growth factor (vegf) and the prostaglandin enzyme cyclooxygenase-2 (cox-2) in endothelial cells. |
2018-01-18 |
2023-08-13 |
Not clear |
| Katrin Gutsche, Elisa B Randi, Volker Blank, Daniel Fink, Roland H Wenger, Cornelia Leo, Carsten C Schol. Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27717868. |
gene array analysis of ibc cells following chronic ih (45-60 days) demonstrated increased expression of pro-metastatic genes of the extracellular matrix, such as tenascin-c (tnc; an essential factor of the metastatic niche) and matrix metalloproteinase 9 (mmp9), and of pro-inflammatory processes, such as cyclooxygenase-2 (cox-2). |
2017-12-25 |
2023-08-13 |
Not clear |
| Balaji Krishnamachary, Ioannis Stasinopoulos, Samata Kakkad, Marie-France Penet, Desmond Jacob, Flonne Wildes, Yelena Mironchik, Arvind P Pathak, Meiyappan Solaiyappan, Zaver M Bhujwall. Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28152501. |
we investigated the role of cox-2 expressed by triple negative breast cancer cells in altering the structure and function of the extracellular matrix (ecm). |
2017-09-20 |
2023-08-13 |
Not clear |
| Renata M Martinez, Felipe A Pinho-Ribeiro, David L Vale, Vinicius S Steffen, Fabiana T M C Vicentini, Josiane A Vignoli, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrand. Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice. Journal of photochemistry and photobiology. B, Biology. vol 171. 2017-09-20. PMID:28501692. |
dorsal skin samples were collected after uvb exposure to evaluate: i) skin edema (weight) was measured by punch biopsy; ii) spectrophotometric assays were used to measure myeloperoxidase (mpo) and catalase activities, ferric (frap) and abts cation reducing antioxidant power, superoxide anion production and levels of reduced glutathione (gsh); iii) enzymography was used to measure matrix metalloproteinase-9 (mmp-9) activity; iv) chemiluminescence was used to measure the lipid peroxidation (lpo); v) enzyme-linked immunosorbent assay (elisa) was used to measure tumor necrosis factor alpha (tnf-α) levels; vi) reverse transcription quantitative pcr (rt-qpcr) was used to measure cyclooxygenase-2 (cox-2), gp91 |
2017-09-20 |
2023-08-13 |
mouse |
| Wendan Cheng, Juehua Jing, Zhen Wang, Dongying Wu, Yumin Huan. Chondroprotective Effects of Ginsenoside Rg1 in Human Osteoarthritis Chondrocytes and a Rat Model of Anterior Cruciate Ligament Transection. Nutrients. vol 9. issue 3. 2017-09-14. PMID:28287423. |
gene expression and protein levels of type ii collagen, aggrecan, matrix metalloproteinase (mmp)-13 and cyclooxygenase-2 (cox-2) were determined in vitro by quantitative real-time-polymerase chain reaction and western blotting. |
2017-09-14 |
2023-08-13 |
human |
| Mona Pourjafar, Massoud Saidijam, Kamran Mansouri, Sara Malih, Tayebeh Ranjbar Nejad, Nooshin Shabab, Rezvan Najaf. Cytoprotective effects of endothelin-1 on mesenchymal stem cells: an in vitro study. Clinical and experimental pharmacology & physiology. vol 43. issue 8. 2017-09-11. PMID:27161651. |
mscs were treated with various concentrations of et-1 and the expression of cyclooxygenase-2 (cox-2), hypoxia-inducible factor-1 (hif-1), c-x-c chemokine receptor type 4 (cxcr4), c-c chemokine receptor type 2 (ccr2), vascular endothelial growth factor (vegf), angiopoietin-2 (ang-2), angiopoietin-4 (ang-4) and matrix metalloproteinase-2 (mmp-2) were examined. |
2017-09-11 |
2023-08-13 |
Not clear |
| D Kim, G Lee, Y H Huh, S Y Lee, K H Park, S Kim, J Kim, J Koh, J Ry. NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation. Journal of dental research. vol 96. issue 6. 2017-08-08. PMID:28165872. |
when nampt was overexpressed with the nampt-synthesizing adenovirus vector (ad- nampt), the pdl cells exhibited an increased expression of cytokines (il6), chemokines (il8 and chemokine [c-c motif] ligand 5 [ccl5]), inflammatory mediators (cyclooxygenase 2 [cox-2]), and matrix-degrading enzymes (matrix metalloproteinase [mmp] 1 and mmp3). |
2017-08-08 |
2023-08-13 |
mouse |
| Liping Feng, Carla E Ransom, Matthew K Nazzal, Terrence K Allen, Yi-Ju Li, Tracy Truong, Lauren C Potts, Patrick C Seed, Amy P Murth. The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection. PloS one. vol 11. issue 12. 2017-07-03. PMID:27977732. |
interleukin-8 (il-8), matrix metalloproteinase 9 (mmp9) and cyclooxygenase (cox-2) mrna expression were quantified by qrt-pcr. |
2017-07-03 |
2023-08-13 |
Not clear |
| Sandra J Mena, Carolina Manosalva, Maria D Carretta, Stefanie Teuber, Iván Olmo, Rafael A Burgos, Maria A Hidalg. Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils. Innate immunity. vol 22. issue 6. 2017-06-29. PMID:27363707. |
in this study, we investigated the molecular mechanisms governing the up-regulation of cyclooxygenase-2 (cox-2) and il-8, as well as matrix metalloproteinase (mmp)-9 granule release in ffar1/gpr40 agonist-stimulated neutrophils. |
2017-06-29 |
2023-08-13 |
cattle |
| Wenbin Ye, Zhaoming Zhong, Siyuan Zhu, Shuai Zheng, Jun Xiao, Shaolian Song, Hui Yu, Qian Wu, Zhen Lin, Jianting Che. Advanced oxidation protein products induce catabolic effect through oxidant-dependent activation of NF-κ B pathway in human chondrocyte. International immunopharmacology. vol 39. 2017-04-07. PMID:27475664. |
exposure of chondrocyte to aopps significantly increased the production of catabolic factors, such as cyclooxygenase-2 (cox-2), matrix metalloproteinase 3 (mmps)-3 and mmp-13. |
2017-04-07 |
2023-08-13 |
human |
| Jeong-Hyeon Ko, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Seok-Geun Lee, Junhee Lee, Woong Mo Yang, Jae-Young Um, Kwang Seok Ah. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3. Immunopharmacology and immunotoxicology. vol 38. issue 5. 2017-03-21. PMID:27324722. |
3fc also downregulated the expression of stat3-regulated gene products such as bcl-2, bcl-xl, mcl-1, survivin, inhibitor of apoptosis protein-1 (iap-1), cyclin d1, cyclooxygenase-2 (cox-2), and matrix metalloproteinases-9 (mmp-9) in mm cells. |
2017-03-21 |
2023-08-13 |
Not clear |
| Chien-Liang Fang, Ling-Hung Huang, Hung-Yueh Tsai, Hsin-I Chan. Dermal Lipogenesis Inhibits Adiponectin Production in Human Dermal Fibroblasts while Exogenous Adiponectin Administration Prevents against UVA-Induced Dermal Matrix Degradation in Human Skin. International journal of molecular sciences. vol 17. issue 7. 2017-03-21. PMID:27428951. |
moreover, uva radiation could induce the mrna expressions of epidermal growth factor receptor (egfr), adiponectin receptor 1 (adipor1), matrix metalloproteinase-1 (mmp-1), mmp-3, and cyclooxygenase-2 (cox-2), but downregulate the mrna expressions of type i and type iii collagen. |
2017-03-21 |
2023-08-13 |
human |