| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ponnuraj Nagendraprabhu, Ganapasam Sudhandira. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:19876598. |
astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of erk-2, nfkb and cox-2. |
2011-05-27 |
2023-08-12 |
rat |
| Dong Zhang, Qing-Yong Ma, Heng-Tong Hu, Min Zhan. β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFκB and AP-1. Cancer biology & therapy. vol 10. issue 1. 2011-04-19. PMID:20424515. |
β2-adrenoceptor antagonists also significantly altered vascular endothelial growth factor (vegf), cyclooxygenase-2 (cox-2), matrix metalloproteinase 2 (mmp-2) and mmp-9 expression. |
2011-04-19 |
2023-08-12 |
Not clear |
| Tung-Ming Leung, Man-Lung Fung, Emily C Liong, Thomas Y H Lau, Amin A Nanji, George L Tipo. Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice. Histology and histopathology. vol 26. issue 2. 2011-03-22. PMID:21154234. |
the expression of matrix metalloptroteinases (mmps), tissue inhibitors of metalloproteinases (timps), α-smooth muscle actin (α-sma), tumor necrosis factor-α (tnf-α) and cyclooxygenase-2 (cox-2) were investigated by rt-pcr. |
2011-03-22 |
2023-08-12 |
mouse |
| Hsi-Lung Hsieh, Hui-Hsin Wang, Cheng-Ying Wu, Chuen-Mao Yan. Reactive Oxygen Species-Dependent c-Fos/Activator Protein 1 Induction Upregulates Heme Oxygenase-1 Expression by Bradykinin in Brain Astrocytes. Antioxidants & redox signaling. vol 13. issue 12. 2011-03-15. PMID:20486760. |
our previous studies have demonstrated that bradykinin (bk) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and cox-2, via mitogen-activated protein kinases and nuclear factor-κb (nf-κb) in rat brain astrocytes (rba-1). |
2011-03-15 |
2023-08-12 |
rat |
| T P Hamsa, Girija Kutta. Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20858484. |
production of other factors by tumour cells which are involved in angiogenesis like cyclooxygenase (cox-2), inducible nitric oxide synthase (inos) and matrix metalloproteases (mmps) were also decrease by the treatment with harmine. |
2011-03-03 |
2023-08-12 |
mouse |
| Sattu Kamaraj, Pandi Anandakumar, Sundaram Jagan, Gopalakrishnan Ramakrishnan, Thiruvengadam Devak. Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20883688. |
the purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (cox-2), mast cells (mcs) and matrix metalloproteinases (mmps) during benzo(a)pyrene (b(a)p) induced lung carcinogenesis in mice. |
2011-03-03 |
2023-08-12 |
mouse |
| Xinhua Liao, Xiangming Che, Wei Zhao, Danjie Zhang, Tieqiang Bi, Guanghui Wan. The β-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor κB signaling. Oncology reports. vol 24. issue 6. 2011-02-24. PMID:21042766. |
in this study, we evaluated whether β-adrenoceptors (β-ars), nuclear factor κb (nf-κb), vascular endothelial growth factor (vegf), cyclooxygenase-2 (cox-2), matrix metalloproteinase-2 (mmp-2) and matrix metalloproteinase-9 (mmp-9) were involved in modulating cell apoptosis and cell cycle arrest by propranolol in human gastric adenocarcinoma cell lines (sgc-7901 and bgc-823) in vitro. |
2011-02-24 |
2023-08-12 |
human |
| Ajaikumar B Kunnumakkara, Bokyung Sung, Jayaraj Ravindran, Parmeswaran Diagaradjane, Amit Deorukhkar, Sanjit Dey, Cemile Koca, Vivek R Yadav, Zhimin Tong, Juri G Gelovani, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwa. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20864511. |
immunohistochemical analysis indicated a correlation between tumor growth inhibition and reduced expression of ki-67, cox-2, matrix metalloproteinase-9 (mmp-9), nf-κb p65, and vegf in the tissue. |
2010-12-21 |
2023-08-12 |
mouse |
| Rama Malaviya, Vasanthi R Sunil, Jessica Cervelli, Dana R Anderson, Wesley W Holmes, Michele L Conti, Ronald E Gordon, Jeffrey D Laskin, Debra L Laski. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicology and applied pharmacology. vol 248. issue 2. 2010-10-20. PMID:20659490. |
sm exposure also resulted in increased expression of markers of inflammation including cyclooxygenase-2 (cox-2), tumor necrosis factor-α (tnfα), inducible nitric oxide synthase (inos), and matrix metalloproteinase-9 (mmp-9), each of which has been implicated in pulmonary toxicity. |
2010-10-20 |
2023-08-12 |
rat |
| Fei Liu, Justin D Mih, Barry S Shea, Alvin T Kho, Asma S Sharif, Andrew M Tager, Daniel J Tschumperli. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. The Journal of cell biology. vol 190. issue 4. 2010-09-27. PMID:20733059. |
feedback amplification of fibrosis through matrix stiffening and cox-2 suppression. |
2010-09-27 |
2023-08-12 |
Not clear |
| Fei Liu, Justin D Mih, Barry S Shea, Alvin T Kho, Asma S Sharif, Andrew M Tager, Daniel J Tschumperli. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. The Journal of cell biology. vol 190. issue 4. 2010-09-27. PMID:20733059. |
increasing matrix stiffness strongly suppresses fibroblast expression of cox-2 (cyclooxygenase-2) and synthesis of prostaglandin e(2) (pge(2)), an autocrine inhibitor of fibrogenesis. |
2010-09-27 |
2023-08-12 |
Not clear |
| Fei Liu, Justin D Mih, Barry S Shea, Alvin T Kho, Asma S Sharif, Andrew M Tager, Daniel J Tschumperli. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. The Journal of cell biology. vol 190. issue 4. 2010-09-27. PMID:20733059. |
together, these results demonstrate a dominant role for normal tissue compliance, acting in part through autocrine pge(2), in maintaining fibroblast quiescence and reveal a feedback relationship between matrix stiffening, cox-2 suppression, and fibroblast activation that promotes and amplifies progressive fibrosis. |
2010-09-27 |
2023-08-12 |
Not clear |
| Dong-Oh Moon, Mun-Ok Kim, Yung Hyun Choi, Yung-Min Park, Gi-Young Ki. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. International immunopharmacology. vol 10. issue 5. 2010-09-08. PMID:20188213. |
the expression levels of prostaglandin e(2) (pge(2)), cyclooxygenase-2 (cox-2), and matrix metalloproteinases (mmps) in human flss were also determined. |
2010-09-08 |
2023-08-12 |
mouse |
| Yan Chen, Ping Che. [Expressions of cyclooxygenase-2 and matrix metalloproteinase-2 and airflow obstruction in patients with chronic obstructive pulmonary disease]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 28. issue 5. 2010-09-02. PMID:15949313. |
to investigate the expression of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-2 (mmp-2) in induced sputum and airway obstruction in patients with stable chronic obstructive pulmonary disease (copd). |
2010-09-02 |
2023-08-12 |
Not clear |
| Robert Ramer, Burkhard Hin. Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells. Biochemical pharmacology. vol 80. issue 6. 2010-08-12. PMID:20488167. |
this study therefore investigates the impact of two cannabinoids, delta(9)-tetrahydrocannabinol (thc) and r(+)-methanandamide (ma), on the migration of human tm cells and the involvement of the pg-synthesizing enzyme cyclooxygenase-2 (cox-2) and one of its potential downstream targets, the tissue inhibitor of matrix metalloproteinases-1 (timp-1), to this response. |
2010-08-12 |
2023-08-12 |
human |
| Seth B Coffelt, Andrea O Tal, Alexander Scholz, Michele De Palma, Sunil Patel, Carmen Urbich, Subhra K Biswas, Craig Murdoch, Karl H Plate, Yvonne Reiss, Claire E Lewi. Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer research. vol 70. issue 13. 2010-08-09. PMID:20530679. |
here, we show that circulating human tems are already preprogrammed in the circulation to be more angiogenic and express higher levels of such proangiogenic genes as matrix metalloproteinase-9 (mmp-9), vegfa, cox-2, and wnt5a than tie2(-) monocytes. |
2010-08-09 |
2023-08-12 |
mouse |
| Brij Kishore Sharma, Prithvi Singh, Manju Shekhawat, Pradeep Pilani. A rationale for the activity profile of benzenesulfonamide derivatives as cyclooxygenase (COX) inhibitors. European journal of medicinal chemistry. vol 45. issue 6. 2010-07-27. PMID:20211512. |
the derived qsar models revealed that higher values of behm2 (the highest eigenvalue n.2 of burden matrix) and c-009 (fragment chrx2) and lower value of mats2m (atomic masses weighted moran autocorrelation of lag 2) are advantageous to the cox-2 inhibition activity. |
2010-07-27 |
2023-08-12 |
Not clear |
| Man-Tat Lau, Alice S T Wong, Peter C K Leun. Gonadotropins induce tumor cell migration and invasion by increasing cyclooxygenases expression and prostaglandin E(2) production in human ovarian cancer cells. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20392831. |
western blot and gelatin zymography showed that cox-1 and cox-2 were critical for gonadotropin-induced expression of metastasis-related proteinases, matrix metalloproteinase (mmp)-2 and mmp-9. |
2010-07-05 |
2023-08-12 |
human |
| Riina Nieminen, Riku Korhonen, Teemu Moilanen, Andrew R Clark, Eeva Moilane. Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs. Arthritis and rheumatism. vol 62. issue 6. 2010-06-28. PMID:20178133. |
the purpose of the present study was to investigate the effects of aurothiomalate on the activity of p38 mapk and on the expression of mapk phosphatase 1 (mkp-1), cyclooxygenase 2 (cox-2), matrix metalloproteinase 3 (mmp-3), and interleukin-6 (il-6) in immortalized murine h4 chondrocytes and in intact human and murine cartilage. |
2010-06-28 |
2023-08-12 |
human |
| Kyung Mi Lee, Ki Won Lee, Sanguine Byun, Sung Keun Jung, Sang Kwon Seo, Yong-Seok Heo, Ann M Bode, Hyong Joo Lee, Zigang Don. 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. Cancer prevention research (Philadelphia, Pa.). vol 3. issue 4. 2010-06-25. PMID:20233901. |
exposure to 5-dk significantly suppressed uvb-induced tumorigenesis in mouse skin in a dose-dependent manner, and it inhibited the uvb-induced expression of cox-2, proliferating cell nuclear antigen, vascular endothelial growth factor, and matrix metalloproteinase-9. |
2010-06-25 |
2023-08-12 |
mouse |