| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuji Kurihara, Masashi Hatori, Yuriko Ando, Daisuke Ito, Takahiko Toyoshima, Makoto Tanaka, Satoru Shintan. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. Clinical & experimental metastasis. vol 26. issue 5. 2009-06-11. PMID:19241124. |
in the present study, to explore the effects of cox-2 inhibition on the interaction between cancer cells and fibroblasts, we examined the effects of these anti-cox-2 reagents on the expression of matrix metalloproteinases (mmps) in fibroblast cell lines wi-38 and mrc-5. |
2009-06-11 |
2023-08-12 |
human |
| Yuji Kurihara, Masashi Hatori, Yuriko Ando, Daisuke Ito, Takahiko Toyoshima, Makoto Tanaka, Satoru Shintan. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. Clinical & experimental metastasis. vol 26. issue 5. 2009-06-11. PMID:19241124. |
western blotting and enzyme-linked immunosorbent assay revealed that ns-398 and cox-2 as down-regulated the expression and secretion of mmp-2 and the tissue inhibitor of matrix metalloproteinase-2 (timp-2) in human fibroblast cell lines. |
2009-06-11 |
2023-08-12 |
human |
| Kushagra Bansal, Nisha Kapoor, Yeddula Narayana, Germain Puzo, Martine Gilleron, Kithiganahalli Narayanaswamy Balaj. PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling. PloS one. vol 4. issue 3. 2009-05-28. PMID:19290049. |
in these complex processes, cyclooxygenase-2 (cox-2) plays a major role in chronic inflammation and matrix metalloproteinase-9 (mmp-9) significantly in tissue remodeling. |
2009-05-28 |
2023-08-12 |
Not clear |
| Hyun Woo Jeong, Kuan Chi Hsu, Joo-Won Lee, Mira Ham, Jin Young Huh, Hyun Jung Shin, Woo Sik Kim, Jae Bum Ki. Berberine suppresses proinflammatory responses through AMPK activation in macrophages. American journal of physiology. Endocrinology and metabolism. vol 296. issue 4. 2009-05-21. PMID:19208854. |
consistently, bbr inhibited lps-induced expression of proinflammatory genes including il-1beta, il-6, inos, mcp-1, cox-2, and matrix metalloprotease-9 in peritoneal macrophages and raw 264.7 cells. |
2009-05-21 |
2023-08-12 |
mouse |
| BoMi Ryu, Yong Li, Zhong-Ji Qian, Moon-Moo Kim, Se-Kwon Ki. Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease. Chemico-biological interactions. vol 179. issue 2-3. 2009-05-06. PMID:19330880. |
furthermore, these phlorotannin derivatives (1, 2) inhibited mrna gene and protein levels of matrix metalloproteinase (mmp-1, mmp-3, and mmp-13), inos and cox-2 in casein zymography, western blot and reverse transcriptase-polymerase chain reaction (rt-pcr) assays. |
2009-05-06 |
2023-08-12 |
human |
| Nermin Karahan, Sirin Baspinar, Murat Yariktas, Nilgun Kapucuogl. Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. Journal of voice : official journal of the Voice Foundation. vol 23. issue 1. 2009-04-29. PMID:17624726. |
matrix metalloproteinases (mmp-2 and mmp-9) and cyclooxygenase-2 (cox-2) expressions in vocal fold polyps. |
2009-04-29 |
2023-08-12 |
human |
| Nermin Karahan, Sirin Baspinar, Murat Yariktas, Nilgun Kapucuogl. Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. Journal of voice : official journal of the Voice Foundation. vol 23. issue 1. 2009-04-29. PMID:17624726. |
the objective of this study was to investigate the roles of matrix metalloproteinases (mmp-2, mmp-9) and cyclooxygenase-2 (cox-2) in the pathogenesis of vocal fold polyps (vfps). |
2009-04-29 |
2023-08-12 |
human |
| Jean-Yves Jouzeau, David Moulin, Meriem Koufany, Sylvie Sebillaud, Arnaud Bianchi, Patrick Nette. [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]. Journal de la Societe de biologie. vol 202. issue 4. 2009-04-27. PMID:19094928. |
all ppar subtypes have been identified in joint or inflammatory cells and their activation resulted in a transcriptional repression of pro-inflammatory cytokines (il-1, tnfalpha), early inflammatory genes (nos(2), cox-2, mpges-1) or matrix metalloproteases (mmp-1, mmp-13), at least for the gamma subtype. |
2009-04-27 |
2023-08-12 |
Not clear |
| Adnan A Bekhit, Hayam M A Ashour, Alaa El-Din A Bekhit, Hamdy M Abdel-Rahman, Salma A Bekhi. Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 1. 2009-03-23. PMID:18951238. |
therefore, these compounds would represent a fruitful matrix for the development of dual anti-inflammatory antimicrobial candidates with remarkable cox-2 selectivity. |
2009-03-23 |
2023-08-12 |
human |
| G-M Kim, K-S Jin, C-S Chun. Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine. Cephalalgia : an international journal of headache. vol 28. issue 11. 2009-02-20. PMID:18727644. |
we evaluated no-mediated up-regulation of cyclooxygenase-2 (cox-2), tumour necrosis factor-alpha (tnf-alpha) and matrix metalloproteinase-9 (mmp-9), and the effect of glucocorticoid administration in an experimental animal model of migraine. |
2009-02-20 |
2023-08-12 |
Not clear |
| Y A Ivanenkov, K V Balakin, S E Tkachenk. New approaches to the treatment of inflammatory disease : focus on small-molecule inhibitors of signal transduction pathways. Drugs in R&D. vol 9. issue 6. 2009-02-19. PMID:18989991. |
the accumulated scientific knowledge has already revealed key biological targets, such as cox-2, and related pro-inflammatory mediators (cytokines and chemokines, interleukins [ils], tumour necrosis factor [tnf]-alpha, migration inhibition factor [mif], interferon [ifn]-gamma and matrix metalloproteinases [mmps]) implicated in uncontrolled, destructive inflammatory reaction. |
2009-02-19 |
2023-08-12 |
Not clear |
| X Z W. New strategy of antiangiogenic therapy for hepatocellular carcinoma. Neoplasma. vol 55. issue 6. 2009-02-11. PMID:18999874. |
some ingredients of extracellular matrix such as endostatin and sulfated polysaccharide, some immunomodulatory agents and cox-2 inhibitor suppress the angiogenesis of hcc. |
2009-02-11 |
2023-08-12 |
Not clear |
| Kotha Subbaramaiah, Robert Benezra, Clifford Hudis, Andrew J Dannenber. Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18842581. |
silencing of cox-2 or pharmacological inhibition of cox-2 led to reduced pge(2) production, decreased id-1 expression, and reduced migration of cells through extracellular matrix. |
2009-02-04 |
2023-08-12 |
human |
| Saynur Vardar-Sengul, Eralp Buduneli, Oya Turkoglu, Nurcan Buduneli, Gül Atilla, Jaana Wahlgren, Timo Sorsa, Haluk Bayla. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. Journal of periodontology. vol 79. issue 10. 2009-01-13. PMID:18834249. |
the effects of selective cox-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, timp-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. |
2009-01-13 |
2023-08-12 |
rat |
| R I Viji, V B Sameer Kumar, M S Kiran, P R Sudhakara. Modulation of cyclooxygenase in endothelial cells by fibronectin: relevance to angiogenesis. Journal of cellular biochemistry. vol 105. issue 1. 2008-10-27. PMID:18459145. |
adhesion of endothelial cells (ecs) to extracellular matrix (ecm) induces the expression of cox-2 and pg production. |
2008-10-27 |
2023-08-12 |
human |
| Oscar Vidal, Antonio Soriano-Izquierdo, Manuel Pera, José I Elizalde, Antonio Palacín, Antoni Castells, Josep M Piqué, Alain Volant, Jean P Metge. Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: results of a study assessing a panel of angiogenic markers. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 12. issue 6. 2008-09-11. PMID:17972143. |
expression of vegf, ang-2, cyclooxygenase-2 (cox-2), urokinase-type plasminogen activator (upa) and its inhibitor pai-1, matrix metalloproteinases (mmp)-1 and -9 were assayed by immunohistochemistry. |
2008-09-11 |
2023-08-12 |
Not clear |
| I-C Wang, L Meliton, M Tretiakova, R H Costa, V V Kalinichenko, T V Kali. Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. Oncogene. vol 27. issue 30. 2008-08-12. PMID:18345025. |
elevated tumor formation in rosa26-foxm1 transgenic lungs was associated with persistent pulmonary inflammation, macrophage infiltration and increased expression of cyclooxygenase-2 (cox-2), cdc25c phosphatase, cyclin e2, chemokine ligands cxcl5, cxcl1 and ccl3, cathepsins and matrix metalloprotease-12. |
2008-08-12 |
2023-08-12 |
mouse |
| Evrim Erdemoglu, Mehmet Güney, Nermin Karahan, Tamer Munga. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. Maturitas. vol 59. issue 3. 2008-07-31. PMID:18378414. |
cyclooxygenase-2 (cox-2) and matrix metalloproteinase-2 and -9 (mmp-2 and mmp-9) are influenced by relative levels of estrogen and are involved in promoting cell proliferation and angiogenesis. |
2008-07-31 |
2023-08-12 |
Not clear |
| Rebecca K Studer, Lars G Gilbertson, Helga Georgescu, Gwendolyn Sowa, Nam Vo, James D Kan. p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 7. 2008-07-08. PMID:18302237. |
il-1 upregulation of mrna for cycloxygenase-2 (cox-2), matrix metalloproteinase-3 (mmp-3), il-1, and il-6, was blunted by p38 inhibition while downregulation of matrix proteins (collagen i, collagen ii, aggrecan) and insulin-like-growth-factor i (ifg-1) was also reversed. |
2008-07-08 |
2023-08-12 |
rabbit |
| Rebecca K Studer, Lars G Gilbertson, Helga Georgescu, Gwendolyn Sowa, Nam Vo, James D Kan. p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 7. 2008-07-08. PMID:18302237. |
p38 mapk inhibition in control cells increased mrna for matrix proteins (aggrecan, collagen ii, versican, collagen i) and anabolic factors (igf-1, tgf, and sox-9) from 50% to 120%, decreased basal pge-2 accumulation, but had no effect on message for timp-1, mmp-3, or cox-2. |
2008-07-08 |
2023-08-12 |
rabbit |