| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min-Chul Seo, Sangseop Kim, Sang-Hyun Kim, Long Tai Zheng, Eui Kyun Park, Won-Ha Lee, Kyoungho Su. Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:17969104. |
using bv-2 mouse microglial cells and mouse primary microglial cultures, we have demonstrated that (1) collagen induces inflammatory activation of microglia as evidenced by production of nitric oxide, expression of inducible nitric oxide synthase, cox-2, cd40, and matrix metalloproteinase-9; (2) ddr1 is expressed in microglia and is phosphorylated by collagen treatment; and (3) collagen-induced microglial activation is abrogated by ddr1 blockade but not by integrin neutralization. |
2008-04-23 |
2023-08-12 |
mouse |
| S K Banu, J Lee, V O Speights, A Starzinski-Powitz, J A Aros. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. Endocrinology. vol 149. issue 3. 2008-04-22. PMID:18039779. |
cell motility and invasion inhibitory effects of cox-2 inhibition/silencing are mediated through matrix metalloproteinase-2 and -9 activities. |
2008-04-22 |
2023-08-12 |
human |
| Sei-Jung Lee, Kye-Taek Li. UDN glycoprotein inhibits activator protein-1 and matrix metalloproteinase-9 via blocking of oxygen radicals in HT-29 cells. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17453155. |
we also evaluated the anti-inflammatory potential of udn glycoprotein based on the activity of the pro-inflammatory signal mediators [inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and matrix metalloproteinases-9 (mmp-9)]. |
2008-02-05 |
2023-08-12 |
human |
| Eun Jeong Lee, Eun Mi Choi, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, Jong-Il Kim, Jeong A Ha. Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. Experimental & molecular medicine. vol 39. issue 4. 2007-12-14. PMID:17934334. |
in addition, cox-2 overexpression enhanced mobility and invasiveness of u2os cells, which was accompanied by increases of matrix metalloproteinase-2 and -9 (mmp-2 and -9) activities. |
2007-12-14 |
2023-08-12 |
human |
| Maiko Noriyuki, Toshiyuki Sumi, Xu Zhi, Fumiko Misugi, Hiroyuki Nobeyama, Hiroyuki Yoshida, Yoshinari Matsumoto, Tomoyo Yasui, Ken-Ichi Honda, Osamu Ishik. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. International journal of oncology. vol 31. issue 3. 2007-11-30. PMID:17671679. |
we investigated the clinicopathological characteristics of uterine cervical cancer in young women, and examined the expression of vascular endothelial growth factor (vegf), matrix metalloproteinases (mmps) and cyclooxygenase-2 (cox-2). |
2007-11-30 |
2023-08-12 |
Not clear |
| Kwang Seok Ahn, Gautam Sethi, Ta-Hsiang Chao, Saskia T C Neuteboom, Madan M Chaturvedi, Michael A Palladino, Anas Younes, Bharat B Aggarwa. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood. vol 110. issue 7. 2007-11-06. PMID:17609425. |
here we demonstrate that salinosporamide a potentiated the apoptosis induced by tumor necrosis factor alpha (tnf), bortezomib, and thalidomide, and this correlated with down-regulation of gene products that mediate cell proliferation (cyclin d1, cyclooxygenase-2 [cox-2], and c-myc), cell survival (bcl-2, bcl-xl, cflip, traf1, iap1, iap2, and survivin), invasion (matrix metallopro-teinase-9 [mmp-9] and icam-1), and angiogenesis (vascular endothelial growth factor [vegf]). |
2007-11-06 |
2023-08-12 |
Not clear |
| Yuji Kuge, Nozomi Takai, Seigo Ishino, Takashi Temma, Masashi Shiomi, Hideo Saj. Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. Biological & pharmaceutical bulletin. vol 30. issue 9. 2007-10-12. PMID:17827712. |
distribution profiles of membrane type-1 matrix metalloproteinase (mt1-mmp), matrix metalloproteinase-2 (mmp-2) and cyclooxygenase-2 (cox-2) in rabbit atherosclerosis: comparison with plaque instability analysis. |
2007-10-12 |
2023-08-12 |
rabbit |
| Yuji Kuge, Nozomi Takai, Seigo Ishino, Takashi Temma, Masashi Shiomi, Hideo Saj. Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. Biological & pharmaceutical bulletin. vol 30. issue 9. 2007-10-12. PMID:17827712. |
despite increasing evidence that membrane type 1 matrix metalloproteinase (mt1-mmp), matrix metalloproteinase-2 (mmp-2), and cyclooxygenase-2 (cox-2) are involved in the pathogenesis of atherosclerosis, the possible links among these enzymes remain unclear. |
2007-10-12 |
2023-08-12 |
rabbit |
| Sei-Jung Lee, Kye-Taek Li. UDN glycoprotein regulates activities of manganese-superoxide dismutase, activator protein-1, and nuclear factor-kappaB stimulated by reactive oxygen radicals in lipopolysaccharide-stimulated HCT-116 cells. Cancer letters. vol 254. issue 2. 2007-10-04. PMID:17459574. |
to further verify the anti-inflammatory effect of udn glycoprotein, we investigated the activity of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and matrix metalloproteinases-9 (mmp-9) in lps-treated hct-116 cells, using western blot analysis and gelatin zymographic assay. |
2007-10-04 |
2023-08-12 |
human |
| N Karahan, M Güney, S Baspinar, B Oral, N Kapucuoglu, T Munga. Expression of gelatinase (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) in endometrial carcinoma. European journal of gynaecological oncology. vol 28. issue 3. 2007-08-30. PMID:17624083. |
in this study the immunohistochemical expression of both cox-2 and matrix metalloproteinases has been shown for the first time in endometrium carcinoma. |
2007-08-30 |
2023-08-12 |
Not clear |
| Suk Joo Choi, Soo young Oh, Jong Hwa Kim, Cheong Rae Ro. Changes of nuclear factor kappa B (NF-kappaB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. European journal of obstetrics, gynecology, and reproductive biology. vol 132. issue 2. 2007-08-28. PMID:17011110. |
changes of nuclear factor kappa b (nf-kappab), cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) in human myometrium before and during term labor. |
2007-08-28 |
2023-08-12 |
human |
| Suk Joo Choi, Soo young Oh, Jong Hwa Kim, Cheong Rae Ro. Changes of nuclear factor kappa B (NF-kappaB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. European journal of obstetrics, gynecology, and reproductive biology. vol 132. issue 2. 2007-08-28. PMID:17011110. |
to investigate the changes of nuclear factor kappa b (nf-kappab), cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) in human term myometrium before and during term labor. |
2007-08-28 |
2023-08-12 |
human |
| Ioannis Stasinopoulos, David R O'Brien, Flonne Wildes, Kristine Glunde, Zaver M Bhujwall. Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. Molecular cancer research : MCR. vol 5. issue 5. 2007-06-29. PMID:17510310. |
microarray analysis showed that cox-2 silencing resulted in the loss of mrna expression of several oncogenic markers, such as matrix metalloproteinase-1, chemokine (c-x-c motif) receptor 4, and interleukin-11, which have been correlated with poor disease outcome, and in the up-regulation of antimetastatic transcripts, such as thrombospondin-1 and epstein-barr-induced 3. |
2007-06-29 |
2023-08-12 |
mouse |
| Ioannis Stasinopoulos, David R O'Brien, Flonne Wildes, Kristine Glunde, Zaver M Bhujwall. Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. Molecular cancer research : MCR. vol 5. issue 5. 2007-06-29. PMID:17510310. |
cells lacking cox-2 were less able to invade reconstituted extracellular matrix than parental cells in vitro. |
2007-06-29 |
2023-08-12 |
mouse |
| Mehdi Shakibaei, Thilo John, Gundula Schulze-Tanzil, Ingo Lehmann, Ali Mobasher. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochemical pharmacology. vol 73. issue 9. 2007-05-17. PMID:17291458. |
expression of collagen type ii, integrin beta1, cyclo-oxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) was monitored by western blotting. |
2007-05-17 |
2023-08-12 |
human |
| Linda Connelly, Cheryl Robinson-Benion, Melissa Chont, Leshana Saint-Jean, Haijing Li, Vasiliy V Polosukhin, Timothy S Blackwell, Fiona E Yul. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. The Journal of biological chemistry. vol 282. issue 13. 2007-05-10. PMID:17261585. |
during pregnancy, p100/p52 expression resulted in delayed ductal development with impaired secondary branching and increased levels of cyclin d1, matrix metalloproteinase-2 (mmp-2), matrix metalloproteinase-9 (mmp-9), and cyclo-oxygenase-2 (cox-2) in the mammary gland. |
2007-05-10 |
2023-08-12 |
mouse |
| Min A Jeong, Ki Won Lee, Do-Young Yoon, Hyong Joo Le. Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404058. |
elevated levels of cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps) are frequently found in various types of cancerous and transformed cells, with recent studies implicating the upregulation of cox-2 and mmps in the development of breast cancer. |
2007-05-08 |
2023-08-12 |
human |
| T John, B Kohl, A Mobasheri, W Ertel, M Shakibae. Interleukin-18 induces apoptosis in human articular chondrocytes. Histology and histopathology. vol 22. issue 5. 2007-03-23. PMID:17330802. |
the effects of il-18 on the cartilage-specific matrix protein collagen type ii, the cytoskeletal protein vinculin, the cell matrix signal transduction receptor beta-integrin, key signalling proteins of the mapkinase pathway (such as shc (sarc homology collagen) and activated mapkinase [erk-1/-2]), the pro-inflammatory enzyme cyclo-oxygenase-2 (cox-2) and the apoptosis marker activated caspase-3 were evaluated by western blot analysis and immunofluorescence labelling. |
2007-03-23 |
2023-08-12 |
human |
| S H Song, J K Lee, J Y Hur, I Kim, H S Saw, Y K Par. The expression of epidermal growth factor receptor, vascular endothelial growth factor, matrix metalloproteinase-2, and cyclooxygenase-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16. issue 6. 2007-02-23. PMID:17177839. |
the aim of this study was to investigate the correlations between human papillomavirus (hpv) load and vascular endothelial growth factor (vegf), epidermal growth factor receptor (egfr), matrix metalloproteinase-2 (mmp-2), and cyclooxygenase-2 (cox-2), and to identify biomarkers that may predict high-risk hpv clearance or persistence after conization with negative margins. |
2007-02-23 |
2023-08-12 |
human |
| Fumiko Sekiguchi, Shino Saito, Kaori Takaoka, Hitomi Hayashi, Mami Nagataki, Keita Nagasawa, Hiroyuki Nishikawa, Hirofumi Matsui, Atsufumi Kawabat. Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells. Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:17069767. |
the par1-activating peptide (par1-ap) and thrombin increased pge(2) release from rgm1 cells for 18h, an effect being suppressed by inhibitors of cox-1, cox-2, mek, p38 map kinase (p38 mapk), protein kinase c (pkc), src and egf receptor-tyrosine kinase (egfr-tk), but not jnk and matrix metalloproteinase (mmp)/a disintegrin and metalloproteinases (adams). |
2007-02-22 |
2023-08-12 |
rat |