| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K Sandur, Shishir Shishodia, Bharat B Aggarwa. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Molecular pharmacology. vol 69. issue 1. 2006-02-07. PMID:16219905. |
such tnf-induced nf-kappab-regulated gene products involved in cellular proliferation [cyclooxygenase-2 (cox-2), cyclin d1, and c-myc], antiapoptosis [inhibitor of apoptosis protein (iap)1, iap2, x-chromosome-linked iap, bcl-2, bcl-x(l), bfl-1/a1, tnf receptor-associated factor 1, and cellular fas-associated death domain protein-like interleukin-1beta-converting enzyme inhibitory protein-like inhibitory protein], and metastasis (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1) were also down-regulated by curcumin. |
2006-02-07 |
2023-08-12 |
Not clear |
| Giovana R Thomas, Hari Nadiminti, Jacinto Regalad. Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. International journal of experimental pathology. vol 86. issue 6. 2006-01-13. PMID:16309541. |
several biomarkers studied to date such as the proteins p53, cyclin d1, p16, cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. |
2006-01-13 |
2023-08-12 |
Not clear |
| Vivian Y Shin, William K K Wu, Kent-Man Chu, Helen P S Wong, Emily K Y Lam, Emily K K Tai, Marcel W L Koo, Chi-Hin Ch. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Molecular cancer research : MCR. vol 3. issue 11. 2006-01-13. PMID:16317086. |
the activity of matrix metalloproteinases 2 and 9 and protein expressions of plasminogen activators (urokinase-type plasminogen activator and its receptor), which are the indicators of invasion and migration processes, were increased by nicotine but blocked by cox-2 and vegfr inhibitors. |
2006-01-13 |
2023-08-12 |
human |
| Naoyuki Kawao, Mami Nagataki, Keita Nagasawa, Satoko Kubo, Kelly Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley D Hollenberg, Wallace K MacNaughton, Hiroyuki Nishikawa, Atsufumi Kawabat. Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16120814. |
the par(2)-triggered pge(2) formation was attenuated by inhibition of the following signal pathway enzymes: cyclooxygenases 1 and 2 (cox-1 and cox-2, respectively), cytosolic ca(2+)-dependent phospholipase a(2) (cpla(2)), the mitogen-activated protein kinases (mapks), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (mek)-extracellular signal-regulated kinase (erk) and p38 mapk, src family tyrosine kinase, epidermal growth factor (egf) receptor tyrosine kinase (egfrk), and protein kinase c (pkc), but not by inhibition of matrix metalloproteinases. |
2006-01-12 |
2023-08-12 |
human |
| Angela Ferrario, Anita M Fisher, Natalie Rucker, Charles J Gome. Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors. Cancer research. vol 65. issue 20. 2005-12-19. PMID:16230411. |
pdt also induces expression of angiogenic and survival molecules including vascular endothelial growth factor, cyclooxygenase-2 (cox-2), and matrix metalloproteinases. |
2005-12-19 |
2023-08-12 |
mouse |
| Yunbiao Lu, Larry M Wah. Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-kappa B activity in lipopolysaccharide-activated human primary monocytes. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 8. 2005-12-13. PMID:16210649. |
cyclooxygenase-2 (cox-2), pge(2), and matrix metalloproteinases (mmps) are important mediators during the process of inflammation. |
2005-12-13 |
2023-08-12 |
human |
| Mario Ferretti, Abiraman Srinivasan, James Deschner, Robert Gassner, Frank Baliko, Nicholas Piesco, Robert Salter, Sudha Agarwa. Anti-inflammatory effects of continuous passive motion on meniscal fibrocartilage. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 23. issue 5. 2005-10-27. PMID:16140197. |
the menisci were harvested and glycosaminoglycans (gag), interleukin-1beta (il-1beta), matrix metalloproteinase-1 (mmp-1), cyclooxygenase-2 (cox-2), and interleukin-10 (il-10) were determined by histochemical analysis. |
2005-10-27 |
2023-08-12 |
rabbit |
| Kotaro Sena, Robert M Leven, Khurram Mazhar, Dale R Sumner, Amarjit S Vird. Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells. Ultrasound in medicine & biology. vol 31. issue 5. 2005-10-13. PMID:15866420. |
compared with the controls, lipus treatment resulted in elevated transient expression of early response genes (c-jun, c-myc, cox-2, egr-1, tsc-22) as well as the bone differentiation marker genes, osteonectin and osteopontin, at 3 h. this induction of early response genes as well as extracellular matrix genes associated with cell proliferation and differentiation may represent the effect of lipus to cells of osteoblastic lineage. |
2005-10-13 |
2023-08-12 |
rat |
| Yasunari Takada, Michael Andreeff, Bharat B Aggarwa. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood. vol 106. issue 2. 2005-08-18. PMID:15811958. |
the nf-kappab-regulated gene products cyclin d1, cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9), survivin, inhibitor-of-apoptosis protein-1 (iap1), iap2, x chromosome-linked iap (xiap), bcl-2, bfl-1/a1, tnf receptor-associated factor-1 (traf1), and fas-associated death domain protein-like interleukin-1beta-converting enzyme inhibitory protein (flip) were all down-regulated by indole-3-carbinol. |
2005-08-18 |
2023-08-12 |
Not clear |
| Hui-Zhong Zhang, Zhi-Qiang Lu, De-Rong Xie, Hai-Gang Li, Li-Hua Xiong, Hua Zhang, Xiao-Bing Che. [Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer]. Ai zheng = Aizheng = Chinese journal of cancer. vol 23. issue 10. 2005-08-15. PMID:15473933. |
expression of cyclooxygenase-2 (cox-2)and matrix metalloproteinase-2 (mmp-2)increased in most tumor tissues. |
2005-08-15 |
2023-08-12 |
Not clear |
| Marcus W Wiedmann, Karel Cac. Molecularly targeted therapy for gastrointestinal cancer. Current cancer drug targets. vol 5. issue 3. 2005-06-24. PMID:15892618. |
other promising new drugs currently under preclinical and clinical evaluation, are vegfr2 inhibitor ptk787/zk 222584, thalidomide, farnesyl transferase inhibitor r115777 (tipifarnib, zarnestra(tm)), matrix metalloproteinase inhibitors, proteasome inhibitor bortezomib (velcade(tm)), mammalian target of rapamycin (mtor) inhibitors, cyclooxygenase-2 (cox-2) inhibitors, platelet derived growth factor receptor (pdgf-r) inhibitors, protein kinase c (pkc) inhibitors, mitogen-activated protein kinase kinase (mek) 1/2 inhibitors, rous sarcoma virus transforming oncogene (src) kinase inhibitors, histondeacetylase (hdac) inhibitors, small hypoxia-inducible factor (hif) inhibitors, aurora kinase inhibitors, hedgehog inhibitors, and tgf-beta signalling inhibitors. |
2005-06-24 |
2023-08-12 |
Not clear |
| Katsuhiko Nosho, Mio Yoshida, Hiroyuki Yamamoto, Hiroaki Taniguchi, Yasushi Adachi, Masashi Mikami, Yuji Hinoda, Kohzoh Ima. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis. vol 26. issue 5. 2005-06-08. PMID:15695237. |
association of ets-related transcriptional factor e1af expression with overexpression of matrix metalloproteinases, cox-2 and inos in the early stage of colorectal carcinogenesis. |
2005-06-08 |
2023-08-12 |
human |
| Anna Sivula, Anne Talvensaari-Mattila, Johan Lundin, Heikki Joensuu, Caj Haglund, Ari Ristimäki, Taina Turpeenniemi-Hujane. Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. Breast cancer research and treatment. vol 89. issue 3. 2005-05-19. PMID:15754118. |
expression of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-2 (mmp-2) associates with reduced survival in human breast cancer. |
2005-05-19 |
2023-08-12 |
mouse |
| Rafael Mayoral, Amalia Fernández-Martínez, Lisardo Boscá, Paloma Martín-San. Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells. Carcinogenesis. vol 26. issue 4. 2005-05-03. PMID:15661807. |
the effect of the expression of cyclooxygenase-2 (cox-2) and prostaglandin e2 (pge2) synthesis on cell migration, the secretion of matrix metalloproteinases (mmps) and the adhesion of human hepatoma cell lines has been investigated. |
2005-05-03 |
2023-08-12 |
human |
| Jaime Symowicz, Brian P Adley, Michelle M M Woo, Nelly Auersperg, Laurie G Hudson, M Sharon Stac. Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer research. vol 65. issue 6. 2005-04-25. PMID:15781636. |
lpa contributes to the development, progression, and metastasis of ovarian cancer in part by inducing the expression of genes that contribute to proliferation, survival, or invasion, including cyclooxgenase-2 (cox-2) and matrix metalloproteinase-2 (mmp-2). |
2005-04-25 |
2023-08-12 |
Not clear |
| Katsuhiko Nosho, Hiroyuki Yamamoto, Hiroaki Taniguchi, Yasushi Adachi, Yukinari Yoshida, Yoshiaki Arimura, Takao Endo, Yuji Hinoda, Kohzoh Ima. Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 23. 2005-04-14. PMID:15585629. |
interplay of insulin-like growth factor-ii, insulin-like growth factor-i, insulin-like growth factor-i receptor, cox-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. |
2005-04-14 |
2023-08-12 |
Not clear |
| Katsuhiko Nosho, Hiroyuki Yamamoto, Hiroaki Taniguchi, Yasushi Adachi, Yukinari Yoshida, Yoshiaki Arimura, Takao Endo, Yuji Hinoda, Kohzoh Ima. Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 23. 2005-04-14. PMID:15585629. |
the aim of this study was to characterize the relationship of insulin-like growth factor (igf)-ii expression with igf-i, igf-i receptor (igf-ir), cyclooxygenase-2 (cox-2), and matrix metalloproteinase (mmp)-7 in early colorectal carcinogenesis. |
2005-04-14 |
2023-08-12 |
Not clear |
| Jelena Zaric, Curzio Rüeg. Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation. The Journal of biological chemistry. vol 280. issue 2. 2005-02-25. PMID:15525653. |
furthermore, the addition of matrix proteins in solution promoted cox-2 protein expression in suspended or poly-l-lysine-attached huvec. |
2005-02-25 |
2023-08-12 |
human |
| Alex Y Hui, Andrew J Dannenberg, Joseph J Y Sung, Kotha Subbaramaiah, Baoheng Du, Peter Olinga, Scott L Friedma. Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells. Journal of hepatology. vol 41. issue 2. 2005-02-09. PMID:15288474. |
we assessed the impact of cox-2 inhibition and pge(2) on the regulation of tgf-beta 1-stimulated matrix synthesis in an immortalized human hsc line, lx-1 and corroborated these findings in primary stellate cells. |
2005-02-09 |
2023-08-12 |
human |
| Min-Ah Choi, Seong Hwan Kim, Won-Yoon Chung, Jae-Kwan Hwang, Kwang-Kyun Par. Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model. Biochemical and biophysical research communications. vol 326. issue 1. 2005-02-03. PMID:15567173. |
higher expression levels of cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9), and phosphorylated extracellular signal-regulated kinase (erk) were observed in the metastatic group compared with control, but these were attenuated by the treatment of xanthorrhizol. |
2005-02-03 |
2023-08-12 |
mouse |