| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H S Cha, K S Ahn, C H Jeon, J Kim, E M Ko. Inhibitory effect of cyclo-oxygenase-2 inhibitor on the production of matrix metalloproteinases in rheumatoid fibroblast-like synoviocytes. Rheumatology international. vol 24. issue 4. 2004-12-23. PMID:12898179. |
in this study, we investigated the effect on cultured rheumatoid fibroblast-like synoviocytes (fls) of the selective cox-2 inhibitor celecoxib on the expression of matrix metalloproteinases (mmps), which play an important role in tissue degradation and angiogenesis in rheumatoid synovium. |
2004-12-23 |
2023-08-12 |
Not clear |
| H S Cha, K S Ahn, C H Jeon, J Kim, E M Ko. Inhibitory effect of cyclo-oxygenase-2 inhibitor on the production of matrix metalloproteinases in rheumatoid fibroblast-like synoviocytes. Rheumatology international. vol 24. issue 4. 2004-12-23. PMID:12898179. |
these results suggest that cox-2 inhibitors might influence matrix degradation or angiogenesis in ra by downregulating the expression of various mmps in rheumatoid fls. |
2004-12-23 |
2023-08-12 |
Not clear |
| Hiromichi Ito, Mark Duxbury, Eric Benoit, Thomas E Clancy, Michael J Zinner, Stanley W Ashley, Edward E Whan. Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Cancer research. vol 64. issue 20. 2004-12-03. PMID:15492268. |
here we tested the hypothesis that the cox-2 product prostaglandin e(2) (pge(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (mmp-2) expression and activity through an extracellular signal-regulated kinase (erk)/ets-1-dependent mechanism in pancreatic cancer. |
2004-12-03 |
2023-08-12 |
Not clear |
| P Siironen, A Ristimäki, S Nordling, J Louhimo, R Haapiainen, C Haglun. Expression of COX-2 is increased with age in papillary thyroid cancer. Histopathology. vol 44. issue 5. 2004-12-02. PMID:15139997. |
to study cyclooxygenase-2 (cox-2) and matrix metalloproteinase-2 (mmp-2) expression in papillary thyroid cancer (ptc). |
2004-12-02 |
2023-08-12 |
human |
| O Núñez, A Fernández-Martínez, P L Majano, A Apolinario, M Gómez-Gonzalo, I Benedicto, M López-Cabrera, L Boscá, G Clemente, C García-Monzón, P Martín-San. Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. Gut. vol 53. issue 11. 2004-12-02. PMID:15479690. |
cyclooxygenase 2 (cox-2) and matrix metalloproteinases (mmps) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis c virus (hcv) related liver disease in humans. |
2004-12-02 |
2023-08-12 |
Not clear |
| R S Fife, B Stott, R E Car. Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726667. |
we now report on the effects of a selective cox-2 inhibitor, celecoxib, on cell proliferation, matrix metalloproteinase (mmp) concentration, angiogenesis using an in vitro assay, and apoptosis in several human cancer cell lines. |
2004-11-19 |
2023-08-12 |
human |
| Wei-Chien Huang, Shu-Ting Chan, Tzu-Lin Yang, Cherng-Chyi Tzeng, Ching-Chow Che. Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. Carcinogenesis. vol 25. issue 10. 2004-11-09. PMID:15217903. |
in addition to icam-1 expression, cyl-19 s and cyl-26z also suppressed other nf-kappab-mediated gene expressions such as matrix metalloproteinase-9 (mmp-9) mrna and cyclooxygnease-2 (cox-2) protein. |
2004-11-09 |
2023-08-12 |
human |
| Sung Yoon Jeon, Kwang-Hyun Baek, Yong-Soo Kim, Chung-Gyu Park, Hyuk Sang Kwon, Seung Hyun Ko, Ki-Ho Song, Soon Jib Yoo, Hyun Shik Son, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang, Kun-Ho Yoo. Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor. Journal of cellular biochemistry. vol 91. issue 2. 2004-10-19. PMID:14743394. |
finally, we found increased mrna expression of five unknown and five known genes, including cytochrome c oxidase subunit i (coi), cyclooxygenase-2 (cox-2), matrix metalloproteinase-13 (mmp-13), wiskott-aldrich syndrome protein interacting protein (waspip), and hyaluronan synthase-2 (has-2). |
2004-10-19 |
2023-08-12 |
Not clear |
| Kenneth J O'Byrne, John G Edwards, David A Walle. Clinico-pathological and biological prognostic factors in pleural malignant mesothelioma. Lung cancer (Amsterdam, Netherlands). vol 45 Suppl 1. 2004-10-19. PMID:15261433. |
angiogenesis, tumour necrosis (tn), epidermal growth factor receptor (egfr) expression, cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps) have been linked with poor prognosis in some types of solid tumour and their relevance as prognostic factors in malignant mesothelioma is examined in this paper. |
2004-10-19 |
2023-08-12 |
Not clear |
| Masayasu Nishikawa, Philip P Stapleton, Tracy A Freeman, John P Gaughan, Takeaki Matsuda, John M Dal. NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. Journal of the American College of Surgeons. vol 199. issue 3. 2004-10-07. PMID:15325613. |
cox-2 also relates to degradation of the extracellular matrix, but the relationship between cox-2 and the plasminogen activator system is unclear. |
2004-10-07 |
2023-08-12 |
mouse |
| Shishir Shishodia, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. Cancer research. vol 64. issue 14. 2004-09-09. PMID:15256475. |
cyclooxygenase (cox)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (nf)-kappab by suppressing activation of ikappabalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin d1, cox-2, and matrix metalloproteinase-9. |
2004-09-09 |
2023-08-12 |
human |
| Shishir Shishodia, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. Cancer research. vol 64. issue 14. 2004-09-09. PMID:15256475. |
csc induced the expression of nf-kappab-regulated proteins, cox-2, cyclin d1, and matrix metalloproteinase-9, and celecoxib abolished the induction of all three. |
2004-09-09 |
2023-08-12 |
human |
| M Jakob, O Démarteau, R Suetterlin, M Heberer, I Marti. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. Rheumatology (Oxford, England). vol 43. issue 7. 2004-08-30. PMID:15113997. |
to investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins d(2) (pgd(2)), e(2) (pge(2)) and f(2)alpha (pgf(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes. |
2004-08-30 |
2023-08-12 |
human |
| Mario Scartozzi, Eva Galizia, Federica Freddari, Rossana Berardi, Riccardo Cellerino, Stefano Cascin. Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. Cancer treatment reviews. vol 30. issue 5. 2004-08-24. PMID:15245777. |
these biological factors are often derived from the genetic process, which is thought to represent a crucial step to gastric cancer (dna copy number changes, microsatellite instability, thymidilate synthase, e-cadherin, beta-catenin, mucin antigen, p53, c-erb b-2, cox-2, matrix metalloproteinases, vegfr and egfr). |
2004-08-24 |
2023-08-12 |
Not clear |
| Mario Scartozzi, Eva Galizia, Federica Freddari, Rossana Berardi, Riccardo Cellerino, Stefano Cascin. Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. Cancer treatment reviews. vol 30. issue 5. 2004-08-24. PMID:15245777. |
some of those putative prognostic indicators can also be considered predictive of response to therapy as they are a molecular target either to chemotherapeutics (i.e., thymidilate synthase that is targeted by 5fu) or to a new class of antineoplastic molecules (i.e., c-erb b-2 targeted by trastuzumab, cox-2 by nsaids, matrix metalloproteinases, egfr and vegfr by specific inhibitors). |
2004-08-24 |
2023-08-12 |
Not clear |
| Hiromichi Ito, Mark Duxbury, Eric Benoit, Robert S Farivar, James Gardner-Thorpe, Michael J Zinner, Stanley W Ashley, Edward E Whan. Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. Biochemical and biophysical research communications. vol 318. issue 2. 2004-06-25. PMID:15120641. |
in this study, we investigated the role of cox-2 in fibronectin-induced up-regulation of rhabdomyosarcoma matrix metalloproteinase (mmp)-2 activity and cellular invasiveness. |
2004-06-25 |
2023-08-12 |
human |
| David H Kinder, Amy L Aulthous. MCF-7 breast cancer cell line grown in agarose culture for study of COX-2 inhibitors in three-dimensional growth system. Cancer letters. vol 205. issue 1. 2004-04-28. PMID:15036660. |
herein we report a method for studying slow acting pharmaceutical cox-2 inhibitors in the mcf-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. |
2004-04-28 |
2023-08-12 |
Not clear |
| ShouWei Han, Jesse Roma. Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth. Biochemical and biophysical research communications. vol 314. issue 4. 2004-03-23. PMID:14751245. |
we have shown that the matrix glycoprotein fibronectin stimulates lung carcinoma cell proliferation via induction of cox-2 expression with subsequent pge(2) protein biosynthesis. |
2004-03-23 |
2023-08-12 |
human |
| Oscar Núñez Martínez, Gerardo Clemente Ricote, Carmelo García Monzó. [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases]. Medicina clinica. vol 121. issue 19. 2004-03-18. PMID:14678698. |
in the liver, cox-2 and prostaglandins production has been implicated in hepatic regeneration, liver matrix remodeling and portal hypertension. |
2004-03-18 |
2023-08-12 |
human |
| Scott A Ochsner, Anthony J Day, Marilyn S Rugg, Richard M Breyer, Richard H Gomer, Joanne S Richard. Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansion. Endocrinology. vol 144. issue 10. 2003-10-29. PMID:12959984. |
one matrix component, tnf-alpha-stimulated gene 6 (tsg-6), is a hyaluronan binding protein induced in cumulus cells of preovulatory follicles by the lh surge and is decreased in cumulus cells of cox-2 and prostaglandin e2 (pge2) receptor subtype ep2 null mice that exhibit impaired ovulation and cumulus expansion. |
2003-10-29 |
2023-08-12 |
mouse |