| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bianca Brawek, Bernd Schwendele, Karin Riester, Shinichi Kohsaka, Chommanad Lerdkrai, Yajie Liang, Olga Garaschu. Impairment of in vivo calcium signaling in amyloid plaque-associated microglia. Acta neuropathologica. vol 127. issue 4. 2014-11-04. PMID:24407428. |
in both strains plaque-associated microglia had hypertrophic/amoeboid morphology and were strongly positive for markers of activation such as cd11b and cd68. |
2014-11-04 |
2023-08-12 |
mouse |
| Kana Sugimoto, Ryutaro Nishioka, Airi Ikeda, Ayano Mise, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanak. Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1. Glia. vol 62. issue 2. 2014-09-26. PMID:24311432. |
ng2(+) microglia but not ng2(-) microglia expressed both cd68 and a triggering receptor expressed on myeloid cells 2 (trem-2), suggesting that ng2(+) microglia eliminated apoptotic neurons. |
2014-09-26 |
2023-08-12 |
rat |
| Karlien Van den Eynde, Stephan Missault, Erik Fransen, Leen Raeymaekers, Roland Willems, Wilhelmus Drinkenburg, Jean-Pierre Timmermans, Samir Kumar-Singh, Stefanie Dedeurwaerder. Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia. Behavioural brain research. vol 258. 2014-07-31. PMID:24129217. |
finally, the presence of activated microglia in brain regions associated with schizophrenia was evaluated using post-mortem immunohistochemistry against ox-42 (cd11b) and ed-1 (cd68). |
2014-07-31 |
2023-08-12 |
rat |
| Takeshi Kanaumi, Ivan Milenkovic, Homa Adle-Biassette, Eleonora Aronica, Gabor G Kovac. Non-neuronal cell responses differ between normal and Down syndrome developing brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 8. 2014-07-23. PMID:24113258. |
we evaluated immunoreactivity for cd68 (macrophage), hla-dr (microglia), olig2 and tppp/p25 (oligodendroglia), and gfap (astroglia) in the germinal matrix (gm), temporal lobe white matter (tewm) and hippocampus from 14 weeks of gestations to newborn in 28 ds patients and 30 age-matched controls. |
2014-07-23 |
2023-08-12 |
Not clear |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
western blots of microglia-specific markers iba1 and cd68, immunohistochemical and immunofluorescent assays demonstrated obviously activation of microglia in almost whole brain regions in the infected animals. |
2014-06-23 |
2023-08-12 |
rat |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
under the dynamic analysis on hallmarks of activation of microglia, a time-dependent increase of iba1 and cd68 was detected, accompanied by accumulation of prp(sc) and progression of neurodegenerative symptoms. |
2014-06-23 |
2023-08-12 |
rat |
| H Matsui, T Ohgomori, T Natori, K Miyamoto, S Kusunoki, K Sakamoto, N Ishiguro, S Imagama, K Kadomats. Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Cell death & disease. vol 4. 2014-06-12. PMID:24309933. |
in ean, microglia increased in number and expressed the activation marker cd68, but ks expression was abolished. |
2014-06-12 |
2023-08-12 |
rat |
| Mariela Chertoff, Kalpana Shrivastava, Berta Gonzalez, Laia Acarin, Lydia Giménez-Llor. Differential modulation of TREM2 protein during postnatal brain development in mice. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977213. |
additionally, the phenotypes of the trem2+ microglia also differ; expressing cd16/32, mhcii and cd86 (antigen presentation markers) and cd68 (phagocytic marker) in different regions as well as with different intensity till p7. |
2014-04-08 |
2023-08-12 |
mouse |
| Isabelle Arnoux, Maki Hoshiko, Léo Mandavy, Elena Avignone, Nobuhiko Yamamoto, Etienne Audina. Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex. Glia. vol 61. issue 10. 2014-03-27. PMID:23893820. |
we show that between p5 and p7 microglial cells acquire a more ramified morphology with a smaller soma, they express classical markers of microglia (iba1, cd11b, and cd68) but never markers of activation (mac-2 and mhcii) and rarely the proliferation marker ki67. |
2014-03-27 |
2023-08-12 |
mouse |
| G D'Alessandro, M Catalano, M Sciaccaluga, G Chece, R Cipriani, M Rosito, A Grimaldi, C Lauro, G Cantore, A Santoro, B Fioretti, F Franciolini, H Wulff, C Limatol. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell death & disease. vol 4. 2014-03-12. PMID:23949222. |
as kca3.1 channels are also expressed on microglia, we investigated the effects of tram-34 on microglia activation in gl-15 transplanted mice and found a reduction of cd68 staining in treated mice. |
2014-03-12 |
2023-08-12 |
mouse |
| David J Loane, Alok Kumar, Bogdan A Stoica, Rainier Cabatbat, Alan I Fade. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. Journal of neuropathology and experimental neurology. vol 73. issue 1. 2014-02-24. PMID:24335533. |
notably, highly activated microglia that expressed major histocompatibility complex class ii (cr3/43), cd68, and nadph oxidase (nox2) were detected at the margins of the expanding lesion at 1 year after injury; biochemical markers of neuroinflammation and oxidative stress were significantly elevated at this time point. |
2014-02-24 |
2023-08-12 |
mouse |
| Emiliano Trias, Pablo Díaz-Amarilla, Silvia Olivera-Bravo, Eugenia Isasi, Derek A Drechsel, Nathan Lopez, C Samuel Bradford, Kyle E Ireton, Joseph S Beckman, Luis Barbeit. Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS. Frontiers in cellular neuroscience. vol 7. 2014-01-08. PMID:24399933. |
cultures of spinal cord prepared from symptomatic sod1 (g93a) rats yielded large numbers of microglia expressing iba1, cd11b, and cd68. |
2014-01-08 |
2023-08-12 |
rat |
| Johannes Elsas, Bernd Sellhaus, Marietta Herrmann, Anne Kinkeldey, Joachim Weis, Willi Jahnen-Dechent, Martin Häusle. Fetuin-a in the developing brain. Developmental neurobiology. vol 73. issue 5. 2013-10-21. PMID:23109215. |
double immunofluorescence studies revealed colocalization with neun (mature neurons), beta iii tubulin (immature neurons), gfap (astrocytes), and cd68 (activated microglia). |
2013-10-21 |
2023-08-12 |
mouse |
| Y Tanaka, T Matsuwaki, K Yamanouchi, M Nishihar. Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice. Neuroscience. vol 231. 2013-07-25. PMID:23201826. |
to investigate the role of pgrn in inflammatory responses related to activated microglia, we compared the immunoreactivity and expression of ionized calcium-binding adaptor molecule 1 (iba1), cd68, and cd11b as markers for activated microglia between wild-type (wt) and grn-deficient (ko) mice. |
2013-07-25 |
2023-08-12 |
mouse |
| Yuliya Borre, Volkan Sir, Sander de Kivit, Koen G Westphal, Berend Olivier, Ronald S Oostin. Minocycline restores spatial but not fear memory in olfactory bulbectomized rats. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23051675. |
here we show that the onset of these cognitive changes parallel in time with signs of microglia activation (increased mrna levels of il-1β and cd68) in hippocampus. |
2013-05-02 |
2023-08-12 |
rat |
| Jessica L Teeling, Roxana O Carare, Martin J Glennie, V Hugh Perr. Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction. Acta neuropathologica. vol 124. issue 4. 2013-04-15. PMID:22618994. |
we show that immune complexes formed in the brain parenchyma generate a robust and long-lasting inflammatory response, characterized by increased expression of the microglia markers cd11b, cd68 and fcrii/iii, but no neutrophil recruitment. |
2013-04-15 |
2023-08-12 |
mouse |
| Debbie A E Hendrickx, Nathalie Koning, Karianne G Schuurman, Miriam E van Strien, Corbert G van Eden, Jörg Hamann, Inge Huiting. Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis. Journal of neuropathology and experimental neurology. vol 72. issue 2. 2013-03-11. PMID:23334594. |
by immunohistochemistry, cd68, cxcl16, and sr-ai/ii were expressed by foamy macrophages in the rim and by ramified microglia around chronic active ms lesions. |
2013-03-11 |
2023-08-12 |
human |
| Debbie A E Hendrickx, Nathalie Koning, Karianne G Schuurman, Miriam E van Strien, Corbert G van Eden, Jörg Hamann, Inge Huiting. Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis. Journal of neuropathology and experimental neurology. vol 72. issue 2. 2013-03-11. PMID:23334594. |
these data suggest that srs are involved in myelin uptake in ms, and that upregulation of cd68, cxcl16, and sr-ai/ii is one of the initial events in microglia as they initiate myelin phagocytosis. |
2013-03-11 |
2023-08-12 |
human |
| Minghuan Wang, Jeffrey J Iliff, Yonghong Liao, Michael J Chen, Matthew S Shinseki, Arun Venkataraman, Jessica Cheung, Wei Wang, Maiken Nedergaar. Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238711. |
microinfarcts were spread throughout the deep cortex, subcortical tissue, and hippocampus and were comprised of a core positive for cd68 (a marker for reactive microglia and macrophages), surrounded by large regions of glial fibrillary acidic protein-positive reactive astrogliosis. |
2013-02-27 |
2023-08-12 |
mouse |
| Adam D Hart, Andreas Wyttenbach, V Hugh Perry, Jessica L Teelin. Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences. Brain, behavior, and immunity. vol 26. issue 5. 2012-10-19. PMID:22155499. |
we detected significant regional, age dependent differences in microglial phenotypes, with the microglia of white matter and caudal areas of the cns exhibiting greater upregulation of cd11b, cd68, cd11c, f4/80 and fcγri than grey matter and rostral cns areas. |
2012-10-19 |
2023-08-12 |
mouse |