| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J Loane, Bogdan A Stoica, Flaubert Tchantchou, Alok Kumar, James P Barrett, Titilola Akintola, Fengtian Xue, P Jeffrey Conn, Alan I Fade. Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 4. 2015-07-06. PMID:25096154. |
vu0360172 significantly reduced cd68 and nox2 expression in activated microglia in the cortex at 28 days post-injury, and also suppressed pro-inflammatory signaling pathways in bv2 and primary microglia. |
2015-07-06 |
2023-08-13 |
mouse |
| Claire Paquet, Jay Amin, François Mouton-Liger, Mariam Nasser, Seth Love, Françoise Gray, Ruth M Pickering, James A R Nicoll, Clive Holmes, Jacques Hugon, Delphine Boch. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of pathology. vol 235. issue 5. 2015-05-07. PMID:25430817. |
in ad, associations of spongiosis status, curvature ratio and ppkr load with microglial markers iba1, cd68 and cd32 suggest a role for microglia in neurodegeneration. |
2015-05-07 |
2023-08-13 |
human |
| Claire Paquet, Jay Amin, François Mouton-Liger, Mariam Nasser, Seth Love, Françoise Gray, Ruth M Pickering, James A R Nicoll, Clive Holmes, Jacques Hugon, Delphine Boch. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of pathology. vol 235. issue 5. 2015-05-07. PMID:25430817. |
after immunization, correlations were detected between the number of neun-positive neurons and ppkr with iba1, cd68 and cd64, suggesting that microglia are involved in the neuronal loss. |
2015-05-07 |
2023-08-13 |
human |
| Hanan Dawood Yass. Age-related changes in the optic nerve of Sprague-Dawley rats: an ultrastructural and immunohistochemical study. Acta histochemica. vol 116. issue 6. 2015-04-20. PMID:24958340. |
cd68 immunohistochemical staining revealed age-related changes in the morphology, location and number of cd68 positive microglia cells. |
2015-04-20 |
2023-08-13 |
rat |
| Olena Y Glushakova, Danny Johnson, Ronald L Haye. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. Journal of neurotrauma. vol 31. issue 13. 2015-02-23. PMID:24564198. |
ihc revealed tbi-induced focal abnormalities including blood-brain barrier (bbb) damage (igg), endothelial damage (intercellular adhesion molecule 1 [icam-1]), activation of reactive microglia (ionized calcium binding adaptor molecule 1 [iba1]), gliosis (glial fibrillary acidic protein [gfap]) and macrophage-mediated inflammation (cluster of differentiation 68 [cd68]), all showing different temporal profiles. |
2015-02-23 |
2023-08-12 |
rat |
| Egle Cekanaviciute, Nancy Fathali, Kristian P Doyle, Aaron M Williams, Jullet Han, Marion S Buckwalte. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. vol 62. issue 8. 2015-02-04. PMID:24733756. |
the peri-infarct cortex of ast-tbr2dn mice contained over 60% more activated cd11b(+) monocytic cells and twice as much immunostaining for the activated microglia and macrophage marker cd68 than controls. |
2015-02-04 |
2023-08-13 |
mouse |
| Vikas Singh, Sumonto Mitra, Anuj Kumar Sharma, Ruchi Gera, Debabrata Ghos. Isolation and characterization of microglia from adult mouse brain: selected applications for ex vivo evaluation of immunotoxicological alterations following in vivo xenobiotic exposure. Chemical research in toxicology. vol 27. issue 5. 2015-01-05. PMID:24754514. |
purity of the isolated microglia was checked by immunostaining of microglial (cd11b and cd68) and nonmicroglial (gfap) markers. |
2015-01-05 |
2023-08-13 |
mouse |
| Marcus Boehme, Madlen Guenther, Anna Stahr, Marie Liebmann, Nadine Jaenisch, Otto W Witte, Christiane Frah. Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24796813. |
during hippocampal aging, the transcript expression of pro-inflammatory cytokines (tnfα, il-1α, il-1β), the chemokine mip-1α, and markers for activated astrocytes (gfap, lcn2, but not vim and serpina3n) and microglia (iba1, f4/80, cd68, cd86) significantly increased. |
2014-12-23 |
2023-08-13 |
mouse |
| Bianca Brawek, Bernd Schwendele, Karin Riester, Shinichi Kohsaka, Chommanad Lerdkrai, Yajie Liang, Olga Garaschu. Impairment of in vivo calcium signaling in amyloid plaque-associated microglia. Acta neuropathologica. vol 127. issue 4. 2014-11-04. PMID:24407428. |
in both strains plaque-associated microglia had hypertrophic/amoeboid morphology and were strongly positive for markers of activation such as cd11b and cd68. |
2014-11-04 |
2023-08-12 |
mouse |
| Kana Sugimoto, Ryutaro Nishioka, Airi Ikeda, Ayano Mise, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanak. Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1. Glia. vol 62. issue 2. 2014-09-26. PMID:24311432. |
ng2(+) microglia but not ng2(-) microglia expressed both cd68 and a triggering receptor expressed on myeloid cells 2 (trem-2), suggesting that ng2(+) microglia eliminated apoptotic neurons. |
2014-09-26 |
2023-08-12 |
rat |
| Karlien Van den Eynde, Stephan Missault, Erik Fransen, Leen Raeymaekers, Roland Willems, Wilhelmus Drinkenburg, Jean-Pierre Timmermans, Samir Kumar-Singh, Stefanie Dedeurwaerder. Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia. Behavioural brain research. vol 258. 2014-07-31. PMID:24129217. |
finally, the presence of activated microglia in brain regions associated with schizophrenia was evaluated using post-mortem immunohistochemistry against ox-42 (cd11b) and ed-1 (cd68). |
2014-07-31 |
2023-08-12 |
rat |
| Takeshi Kanaumi, Ivan Milenkovic, Homa Adle-Biassette, Eleonora Aronica, Gabor G Kovac. Non-neuronal cell responses differ between normal and Down syndrome developing brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 8. 2014-07-23. PMID:24113258. |
we evaluated immunoreactivity for cd68 (macrophage), hla-dr (microglia), olig2 and tppp/p25 (oligodendroglia), and gfap (astroglia) in the germinal matrix (gm), temporal lobe white matter (tewm) and hippocampus from 14 weeks of gestations to newborn in 28 ds patients and 30 age-matched controls. |
2014-07-23 |
2023-08-12 |
Not clear |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
western blots of microglia-specific markers iba1 and cd68, immunohistochemical and immunofluorescent assays demonstrated obviously activation of microglia in almost whole brain regions in the infected animals. |
2014-06-23 |
2023-08-12 |
rat |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
under the dynamic analysis on hallmarks of activation of microglia, a time-dependent increase of iba1 and cd68 was detected, accompanied by accumulation of prp(sc) and progression of neurodegenerative symptoms. |
2014-06-23 |
2023-08-12 |
rat |
| H Matsui, T Ohgomori, T Natori, K Miyamoto, S Kusunoki, K Sakamoto, N Ishiguro, S Imagama, K Kadomats. Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Cell death & disease. vol 4. 2014-06-12. PMID:24309933. |
in ean, microglia increased in number and expressed the activation marker cd68, but ks expression was abolished. |
2014-06-12 |
2023-08-12 |
rat |
| Mariela Chertoff, Kalpana Shrivastava, Berta Gonzalez, Laia Acarin, Lydia Giménez-Llor. Differential modulation of TREM2 protein during postnatal brain development in mice. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977213. |
additionally, the phenotypes of the trem2+ microglia also differ; expressing cd16/32, mhcii and cd86 (antigen presentation markers) and cd68 (phagocytic marker) in different regions as well as with different intensity till p7. |
2014-04-08 |
2023-08-12 |
mouse |
| Isabelle Arnoux, Maki Hoshiko, Léo Mandavy, Elena Avignone, Nobuhiko Yamamoto, Etienne Audina. Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex. Glia. vol 61. issue 10. 2014-03-27. PMID:23893820. |
we show that between p5 and p7 microglial cells acquire a more ramified morphology with a smaller soma, they express classical markers of microglia (iba1, cd11b, and cd68) but never markers of activation (mac-2 and mhcii) and rarely the proliferation marker ki67. |
2014-03-27 |
2023-08-12 |
mouse |
| G D'Alessandro, M Catalano, M Sciaccaluga, G Chece, R Cipriani, M Rosito, A Grimaldi, C Lauro, G Cantore, A Santoro, B Fioretti, F Franciolini, H Wulff, C Limatol. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell death & disease. vol 4. 2014-03-12. PMID:23949222. |
as kca3.1 channels are also expressed on microglia, we investigated the effects of tram-34 on microglia activation in gl-15 transplanted mice and found a reduction of cd68 staining in treated mice. |
2014-03-12 |
2023-08-12 |
mouse |
| David J Loane, Alok Kumar, Bogdan A Stoica, Rainier Cabatbat, Alan I Fade. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. Journal of neuropathology and experimental neurology. vol 73. issue 1. 2014-02-24. PMID:24335533. |
notably, highly activated microglia that expressed major histocompatibility complex class ii (cr3/43), cd68, and nadph oxidase (nox2) were detected at the margins of the expanding lesion at 1 year after injury; biochemical markers of neuroinflammation and oxidative stress were significantly elevated at this time point. |
2014-02-24 |
2023-08-12 |
mouse |
| Emiliano Trias, Pablo Díaz-Amarilla, Silvia Olivera-Bravo, Eugenia Isasi, Derek A Drechsel, Nathan Lopez, C Samuel Bradford, Kyle E Ireton, Joseph S Beckman, Luis Barbeit. Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS. Frontiers in cellular neuroscience. vol 7. 2014-01-08. PMID:24399933. |
cultures of spinal cord prepared from symptomatic sod1 (g93a) rats yielded large numbers of microglia expressing iba1, cd11b, and cd68. |
2014-01-08 |
2023-08-12 |
rat |