| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefanie Obst, Meray Serdar, Josephine Herz, Karina Kempe, Meriem Assili, Mandana Rizazad, Dharmesh Hirani, Miguel A Alejandre Alcazar, Stefanie Endesfelder, Marius A Möbius, Mario Rüdiger, Ursula Felderhoff-Müser, Ivo Bendi. A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal Rats. Cells. vol 14. issue 6. 2025-03-26. PMID:40136692. |
in the brain, hyperoxia induced significant hypomyelination accompanied by a reduction in oligodendrocytes and cd68 expression on microglia cells. |
2025-03-26 |
2025-03-28 |
rat |
| Zhengxia Liu, Xiang Lin, Youquan Tu, Yun Zhou, Minghai Huang, Chunyan Fan. MALAT1 promotes microglia activation and neuronal apoptosis through via the miR-124-3p/ SGK1 axis mediating experimental autoimmune encephalomyelitis disease progression in mice. International immunopharmacology. vol 152. 2025-03-16. PMID:40090080. |
western blotting was used to detect changes in cd68 and iκbα/nfκb phosphorylation, key indicators of microglia activation. |
2025-03-16 |
2025-03-19 |
mouse |
| Áurea Maria Alves Nunes Almeida, Cleonice Creusa Dos Santos, Daniele Takahashi, Larissa Pereira da Silva, Verônica Moreira de Sousa, Monique Reis de Santana, Ana Elisa Del Arco, Balbino Lino Dos Santos, Jorge Mauricio David, Victor Diogenes Amaral da Silva, Suzana Braga-de-Souza, Silvia Lima Cost. The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor. Molecules (Basel, Switzerland). vol 30. issue 5. 2025-03-13. PMID:40076239. |
the microglia morphology and reactivity were evaluated by immunofluorescence against calcium-binding ionized adapter (iba-1) and cd68. |
2025-03-13 |
2025-03-15 |
Not clear |
| Austin N Smith, Samantha Nagrabski, Lisa Baker, Adam H Kramer, David J Sharp, Kimberly R Byrne. Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury. Journal of neuroinflammation. vol 22. issue 1. 2025-03-11. PMID:40065364. |
fl2 downregulation resulted in a marked accumulation of microglia at the lesion site, accompanied by increased inflammatory markers (il-1β, tgf-β1, and cd68). |
2025-03-11 |
2025-03-13 |
rat |
| Emily R Moran, Mark L Gabriel. Microglial Engulfment of Multisensory Terminals in the Midbrain Inferior Colliculus During an Early Critical Period. The Journal of comparative neurology. vol 533. issue 3. 2025-03-02. PMID:40023818. |
we also provide evidence that individual lcic microglia engulf both auditory and somatosensory terminals that co-localize with the lysosomal marker, cd68. |
2025-03-02 |
2025-03-05 |
mouse |
| Wissam B Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A Matsubar. 3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer's disease via machine learning. Acta neuropathologica communications. vol 12. issue 1. 2024-12-24. PMID:39719599. |
we also labelled retinal microglia for cluster of differentiation 68 (cd68), a transmembrane glycoprotein expressed by cells in the monocyte lineage and a marker of phagocytic activity and activated microglia. |
2024-12-24 |
2024-12-27 |
Not clear |
| Wissam B Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A Matsubar. 3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer's disease via machine learning. Acta neuropathologica communications. vol 12. issue 1. 2024-12-24. PMID:39719599. |
there was also significantly increased cd68 immunoreactivity in individual microglia within the ad group. |
2024-12-24 |
2024-12-27 |
Not clear |
| Pelin Saglam-Metiner, Sena Yanasik, Yusuf Caglar Odabasi, Jennifer Modamio, Moritz Negwer, Cigir Biray-Avci, Ayse Guler, Ali Erturk, Ender Yildirim, Ozlem Yesil-Celikta. ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation. Communications biology. vol 7. issue 1. 2024-12-05. PMID:39639082. |
subsequent to propofol administration, gene expressions of cd40 and tnf-α in mast cells, aif1 in microglia and gfap/s100b/olig2/mbp in macroglia were elevated, as well as nos2, cd80, cd40, cd68, il6 and tnf-α mediated proinflammation is noted in cerebral organoids, which resulted in higher expressions of gjb1, gaba-a and nmdar1 in the tissue construct of the platform. |
2024-12-05 |
2024-12-08 |
human |
| Maosha Dai, Shujun Sun, Yan Dai, Xiaoke Dou, Juexi Yang, Xiangdong Chen, Dong Yang, Yun Li. Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway. Neurochemical research. vol 50. issue 1. 2024-11-20. PMID:39565476. |
expression of microglial cell markers (iba1, cd11b, cd68, cd86 and cd206) and pro-inflammatory markers (inos and cox2) was assessed. |
2024-11-20 |
2024-11-23 |
mouse |
| Joanna Dunacka, Grzegorz Świątek, Danuta Wron. High Behavioral Reactivity to Novelty as a Susceptibility Factor for Memory and Anxiety Disorders in Streptozotocin-Induced Neuroinflammation as a Rat Model of Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519114. |
behavioral depression in hrs was associated with higher expression of β-amyloid deposits, particularly in the nacs, and activation of microglia (cd68 |
2024-11-09 |
2024-11-17 |
rat |
| Xindi Li, Jiayi Liu, Andrew J Boreland, Sneha Kapadia, Siwei Zhang, Alessandro C Stillitano, Yara Abbo, Lorraine Clark, Dongbing Lai, Yunlong Liu, Peter B Barr, Jacquelyn L Meyers, Chella Kamarajan, Weipeng Kuang, Arpana Agrawal, Paul A Slesinger, Danielle Dick, Jessica Salvatore, Jay Tischfield, Jubao Duan, Howard J Edenberg, Anat Kreimer, Ronald P Hart, Zhiping P Pan. Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. Science advances. vol 10. issue 45. 2024-11-08. PMID:39514655. |
ethanol exposure induced elevated cd68 expression and morphological changes in microglia, with differential responses between high-prs and low-prs microglial cells. |
2024-11-08 |
2024-11-16 |
human |
| Maria Gotkiewicz, Janne Capra, Pasi O Miettinen, Teemu Natunen, Heikki Tanil. Three-dimensional view of microglia-amyloid plaque interactions. Glia. 2024-10-22. PMID:39435610. |
these end-feet were filled with the lysosomal marker cd68, while both non-fibrillar and fibrillar amyloid was found in perinuclear vesicles of some "snowplower" microglia. |
2024-10-22 |
2024-10-24 |
mouse |
| Gabriela C De Paula, Rui F Simões, Alba M Garcia-Serrano, João M N Duart. High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice. Neurochemical research. 2024-09-20. PMID:39302596. |
we determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers iba1, cd68, gfap and emr1 in the hypothalamus, and analyzed morphology of microglia (iba-1 |
2024-09-20 |
2024-09-22 |
mouse |
| Zixuan Lin, Liping Wang, Yaozong Niu, Zhaopeng Xie, Xiaohan Zha. Interaction between microglial cells and CD1C+ B dendritic cells leads to CD8+ T cells depletion during the early stages of renal clear cell carcinoma. Medicine. vol 103. issue 31. 2024-08-02. PMID:39093774. |
the microglia marker cd68 and cd1c+ b dendritic cells marker cd11c were detected using multiplex immunofluorescence staining. |
2024-08-02 |
2024-08-06 |
Not clear |
| Junqi Yao, Liming Zhang, Chunkui Zhang, Xing Chen, Ke Bao, Shaojun Hou, Yongyu Yin, Kun Liu, Qing Wen, Xin Huang, Lun Son. Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice. Brain, behavior, and immunity. 2024-07-23. PMID:39043349. |
rhythmic 40 hz lf exposure significantly decreased the number of iba1-positive microglia in the pfc and hippocampus, and the expression levels of the m1 markers of microglia inos and cd68 were reduced significantly in crs mice. |
2024-07-23 |
2024-07-26 |
mouse |
| Yanhui Cui, Zhaolan Hu, Laifa Wang, Bi Zhu, Ling Deng, Hui Zhang, Xueqin Wan. DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis. Neurochemical research. 2024-06-04. PMID:38834844. |
further experiments revealed that nbp inhibited the toll-like receptor 4/nuclear factor kappa b signaling pathway, decreased the level of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, and interleukin-6, and m1-type microglia markers (cd68, inducible nitric oxide synthase), and reduced the expression of panoptosis-related molecules including caspase-1, caspase-3, caspase-8, gasdermin d, and mixed lineage kinase domain-like protein in the hippocampus of the maco rats. |
2024-06-04 |
2024-06-07 |
rat |
| Koeul Choi, Joonhee Lee, Gukdo Kim, Younghyun Lim, Hyo Jung Kan. Recovery of synaptic loss and depressive-like behavior induced by GATA1 through blocking of the neuroinflammatory response. Frontiers in cellular neuroscience. vol 18. 2024-05-24. PMID:38784708. |
through flow cytometry and immunohistochemical analysis, we found that activated microglia showed pro-inflammatory phenotypes characterized by the expression of cd86 and cd68. |
2024-05-24 |
2024-05-27 |
Not clear |
| Mousumi Ghosh, Jinyoung Lee, Ashley N Burke, Thomas A Strong, Jacqueline Sagen, Damien D Pears. Sex Dependent Disparities in the Central Innate Immune Response after Moderate Spinal Cord Contusion in Rat. Cells. vol 13. issue 7. 2024-04-12. PMID:38607084. |
the altered expression of these markers is indicative of a disparate secretome between the microglia of males and females after sci and that the female microglia possesses higher phagocytic capabilities (increased cd68). |
2024-04-12 |
2024-04-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. |
2024-02-10 |
2024-02-12 |
rat |
| Sarah R Morris, Taylor Swift-LaPointe, Andrew Yung, Valentin H Prevost, Shana George, Andrew Bauman, Piotr Kozlowski, Zahra Samadi-Bahrami, Caron Fournier, Pushwant Mattu, Lisa Parker, Femke Streijger, Veronica Hirsch-Reinshagen, G R Wayne Moore, Brian K Kwon, Cornelia Laul. Advanced MRI biomarkers of the injured spinal cord - a comparative study of imaging and histology in human traumatic SCI. Journal of neurotrauma. 2024-02-06. PMID:38318802. |
the histologic features were analysed by staining with luxol fast blue (lfb) for myelin lipids, and class ii major histocompatibility complex (class ii mhc) and cd68 for microglia and macrophages. |
2024-02-06 |
2024-02-09 |
human |