| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Kjell Johansson, Camilla Mohli. Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614320. |
biomarkers for reactive microglia included p2ry12, cd63 and cd68 and the general microglial markers were cd11b, iba1 and isolectin b |
2023-01-08 |
2023-08-14 |
Not clear |
| Rachel Gilfarb, Zoe Tapp, Elise Lemanski, John Velasquez, Sydney Cornelius, Olga N Kokiko-Cochran, Benedetta Leune. Multiparity differentially affects specific aspects of the acute neuroinflammatory response to traumatic brain injury in female mice. Neuroscience. 2022-12-19. PMID:36535576. |
increased cortical iba1, gfap, and cd68 immunolabeling was observed following tbi independent of parity and microglia morphology did not differ between tbi groups. |
2022-12-19 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
furthermore, microglia in the ca1 sr region showed an increase in soma and a more extensive arborization, an increased prevalence of immature lysosomes accompanied by an elevation in mrna expression of phagocytic markers mertk and cd68 and a surge in the expression of microglial outward k |
2022-12-09 |
2023-08-14 |
mouse |
| Hala M F Mohammad, Amani A El-Baz, Omayma M Mahmoud, Sahar Khalil, Rasha Atta, Samar Imbab. Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism. Journal of chemical neuroanatomy. 2022-12-04. PMID:36464068. |
the mid-brain tissues were processed for light and electron microscopy examinations, and immunohistochemical staining for tyrosine hydroxylase [th], and microglia cells' markers: [cd68 and iba1]. |
2022-12-04 |
2023-08-14 |
rat |
| Kazuya Takahash. Microglial heterogeneity in amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology. 2022-11-28. PMID:36440536. |
expression of the microglial activation marker cd68 and endothelial activation were also observed in the tmem119+ microglia group, suggesting the presence of inflammatory processes in als lesions. |
2022-11-28 |
2023-08-14 |
mouse |
| Linda Rubinstein, Frederico Kiffer, Stephanie Puukila, Moniece G Lowe, Brie Goo, Amalia Luthens, Ann-Sofie Schreurs, Samantha M Torres, Sonette Steczina, Candice G T Tahimic, Antiño R Alle. Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus. Life (Basel, Switzerland). vol 12. issue 11. 2022-11-11. PMID:36362993. |
indeed, we saw an elevation of the activated microglia cd68 marker following hu in the hippocampus, and this pathology was mitigated in mcat mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Hideko Noguchi, Sachiko Koyama, Kaoru Yagita, Masahiro Shijo, Kosuke Matsuzono, Hideomi Hamasaki, Takaaki Kanemaru, Tsuyoshi Okamoto, Keita Kai, Shinichi Aishima, Koji Abe, Naokazu Sasagasako, Hiroyuki Hond. Silence of resident microglia in GPI anchorless prion disease and activation of microglia in Gerstmann-Sträussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease. Journal of neuropathology and experimental neurology. 2022-11-04. PMID:36331509. |
activated microglia/macrophages expressing hla-dr and cd68 were predominant in gss and scjd whereas in gpialp, homeostatic microglia were retained and activated microglia/macrophages were rarely observed. |
2022-11-04 |
2023-08-14 |
Not clear |
| Anzela Niraula, Rachael D Fasnacht, Kelly M Ness, Jeremy M Frey, Sophia A Cuschieri, Mauricio D Dorfman, Joshua P Thale. Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity. Diabetes. 2022-11-01. PMID:36318114. |
mechanistically, ep4-deficient microglia showed an attenuated phagocytic state marked by reduced cd68 expression and fewer contacts with pomc neuron processes. |
2022-11-01 |
2023-08-14 |
mouse |
| Manuel G Bruera, María M Benedetto, Mario E Guido, Alicia L Degano, María A Conti. Glial cell response to constant low light exposure in rat retina. Visual neuroscience. vol 39. 2022-09-27. PMID:36164752. |
retinal cells presented an increased expression of the macroglia marker gfap, as well as increased mrna levels of microglia markers iba1 and cd68 after 6 days. |
2022-09-27 |
2023-08-14 |
rat |
| Hayley F North, Christin Weissleder, Janice M Fullerton, Maree J Webster, Cynthia Shannon Weicker. Increased immune cell and altered microglia and neurogenesis transcripts in an Australian schizophrenia subgroup with elevated inflammation. Schizophrenia research. vol 248. 2022-09-15. PMID:36108465. |
consistent with our previous report (north et al., 2021b), those with high-inflammation and schizophrenia had unchanged mrna expression of markers for steady-state and activated microglia (iba1, hexb, cd68), decreased expression of phagocytic microglia markers (p2ry12, p2ry13), but increased expression of markers for macrophages (cd163), monocytes (cd14), natural killer cells (fcgr3a), and the adhesion molecule icam1. |
2022-09-15 |
2023-08-14 |
Not clear |
| Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Yan Xu, Fudong Li. Regulation of microglial activation in stroke in aged mice: a translational study. Aging. vol 14. issue undefined. 2022-08-13. PMID:35963621. |
irf5 cko aged microglia had significantly lower levels of il-1β and cd68 than controls; whereas significantly higher levels of il-1β and tnf-α were seen in irf4 cko vs. control microglia. |
2022-08-13 |
2023-08-14 |
mouse |
| Mariela Nunez Santos, Daniel H Paushter, Tingting Zhang, Xiaochun Wu, Tuancheng Feng, Jiaoying Lou, Huan Du, Stephanie M Becker, Robert Fragoza, Haiyuan Yu, Fenghua H. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. The Journal of biological chemistry. 2022-08-06. PMID:35933009. |
here, we identify cd68, a lysosome membrane protein highly expressed in microglia, as a binding partner of pgrn and pgrn-derived granulin e. deletion analysis of cd68 showed that this interaction is mediated by the mucin-proline-rich domain of cd68. |
2022-08-06 |
2023-08-14 |
Not clear |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
here we report that mice exposed to adolescent intermittent access to ethanol (aie) exhibit increased pain sensitivity and depressive-like behaviors that persist for several weeks after alcohol cessation and are accompanied by elevated cd68 expression in microglia and reduced numbers of serotonin (5-ht)-expressing neurons in the dorsal raphe nucleus (drn). |
2022-07-30 |
2023-08-14 |
mouse |
| Elsa Gonzalez De La Cruz, Quan Vo, Katie Moon, Karen N McFarland, Mary Weinrich, Tristan Williams, Benoit I Giasson, Paramita Chakrabart. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897751. |
we focused on microglia next, finding that while microglial burden was significantly upregulated in pff-seeded, mhcii-deficient mice relative to controls, the microglial activation marker cd68 was reduced in these mice, suggesting that these microglia were not responsive. |
2022-07-28 |
2023-08-14 |
mouse |
| Yoshiki Hase, Kamar E Ameen-Ali, Rachel Waller, Julie E Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B Wharton, Raj N Kalari. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain pathology (Zurich, Switzerland). 2022-06-24. PMID:35748290. |
we primarily used cd68 as a marker of phagocytic microglia, as well as other markers of microglia including iba-1 and tmem119, and the myeloid cell marker trem2 to assess dementia-specific changes. |
2022-06-24 |
2023-08-14 |
human |
| Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping G. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology. vol 109. 2022-06-16. PMID:35709590. |
in addition, prolonged isoflurane inhalation switched microglia into a proinflammatory m1 phenotype characterized by elevated cd68 and inos as well as decreased arginase-1 and il-10. |
2022-06-16 |
2023-08-14 |
mouse |
| Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Pen. Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628400. |
the expression levels of iba-1 and cd68 demonstrated, by western blot analysis, the inflammatory cytokine tnf-α content measured with enzyme-linked immunosorbent assay, and the number of microglia demonstrated by immunohistochemistry (ihc) were significantly increased at age of 7 months, all of which indicate microglia activation at an age of seizure onset. |
2022-05-28 |
2023-08-13 |
mouse |
| Han Rae Kim, Colin N Youn. Inhibition of Forebrain Microglia Ameliorates Non-alcoholic Fatty Liver Disease During Obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557243. |
hfd or normal chow male mice underwent sfo stereotaxic delivery of a designer receptors exclusively activated by designer drugs inhibitory construct targeted to microglia via the cd68 promoter (paav-cd68-hm4gi-mcherry). |
2022-05-13 |
2023-08-13 |
mouse |
| Hui-Ming Yang, Yong-Ling Wang, Chong-Yue Liu, Yu-Ting Zhou, Xiao-Feng Zhan. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-17. PMID:35430334. |
activated microglia and increased cd68 expression appeared two weeks after pq exposure in time-dependent manners. |
2022-04-17 |
2023-08-13 |
mouse |