| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Mayur Choudhary, Goldis Male. CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy. Advances in experimental medicine and biology. vol 1415. 2023-07-13. PMID:37440035. |
additionally, animal models of retinal degeneration have shown upregulation of cd68, in a protective population of retinal microglia. |
2023-07-13 |
2023-08-14 |
mouse |
| Madigan M Reid, Marie-Audrey I Kautzmann, Gethein Andrew, Andre Obenaus, Pranab K Mukherjee, Larissa Khoutorova, Jeff X Ji, Cassia R Roque, Reinaldo B Oria, Bola F Habeb, Ludmila Belayev, Nicolas G Baza. NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes. Cellular and molecular neurobiology. 2023-06-04. PMID:37270727. |
overall, we uncovered that protection after middle cerebral artery occlusion (mcao) by the lipid mediators elicits expression of microglia and astrocyte-specific genes (tmem119, fcrls, osmr, msr1, cd68, cd163, amigo2, thbs1, and tm4sf1) likely participating in enhancing homeostatic microglia, modulating neuroinflammation, promoting damp clearance, activating npc differentiation and maturation, synapse integrity and contributing to cell survival. |
2023-06-04 |
2023-08-14 |
Not clear |
| Gabrielle Angst, Xin Tang, Chenran Wan. Functional Analysis of a Novel Immortalized Murine Microglia Cell Line in 3D Spheroid Model. Neurochemical research. 2023-05-17. PMID:37195378. |
the img-1 cells kept their microglia morphology, and they expressed macrophage/microglia-specific proteins of cd11b, cd68, p2ry12, and iba1 in vitro. |
2023-05-17 |
2023-08-14 |
Not clear |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
higher synapse density in females was paralleled by higher activity of microglia, as indicated by morphological changes, cd68 expression, and proximity of microglia to synaptic sites. |
2023-05-12 |
2023-08-14 |
mouse |
| Dadi Li, Shuxian Zhao, Bin Zhu, Wanmin Zhao, Ya Ding, Xuejun Li, Donglin Fu, Haiyang Yu, Baogui Wang, Tan Pa. Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival. Drug development research. 2023-03-29. PMID:36988113. |
cd68 staining and western blot analysis were used to investigate the effect of cm on microglia activation. |
2023-03-29 |
2023-08-14 |
rat |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
males exhibited decreases in the phagocytic-lysosomal marker cd68 in microglia in these regions, whereas females showed an increase in cd68 in the hypothalamus suggesting sexually dimorphic and brain region specific change in microglia state in response to social isolation. |
2023-03-15 |
2023-08-14 |
mouse |
| María Vargas-Soria, Mónica García-Alloza, Miriam Corraliza-Góme. Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies. Journal of neuroinflammation. vol 20. issue 1. 2023-03-03. PMID:36869375. |
although a strict classification of microglia remains elusive given their capacity to adapt to the environment and their morphological, ultrastructural and molecular dynamism, diabetes modulates microglial phenotypic states, triggering specific responses that include upregulation of activity markers (such as iba1, cd11b, cd68, mhc-ii and f4/80), morphological shift to amoeboid shape, secretion of a wide variety of cytokines and chemokines, metabolic reprogramming and generalized increase of oxidative stress. |
2023-03-03 |
2023-08-14 |
Not clear |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Kjell Johansson, Camilla Mohli. Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614320. |
biomarkers for reactive microglia included p2ry12, cd63 and cd68 and the general microglial markers were cd11b, iba1 and isolectin b |
2023-01-08 |
2023-08-14 |
Not clear |
| Rachel Gilfarb, Zoe Tapp, Elise Lemanski, John Velasquez, Sydney Cornelius, Olga N Kokiko-Cochran, Benedetta Leune. Multiparity differentially affects specific aspects of the acute neuroinflammatory response to traumatic brain injury in female mice. Neuroscience. 2022-12-19. PMID:36535576. |
increased cortical iba1, gfap, and cd68 immunolabeling was observed following tbi independent of parity and microglia morphology did not differ between tbi groups. |
2022-12-19 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
furthermore, microglia in the ca1 sr region showed an increase in soma and a more extensive arborization, an increased prevalence of immature lysosomes accompanied by an elevation in mrna expression of phagocytic markers mertk and cd68 and a surge in the expression of microglial outward k |
2022-12-09 |
2023-08-14 |
mouse |
| Hala M F Mohammad, Amani A El-Baz, Omayma M Mahmoud, Sahar Khalil, Rasha Atta, Samar Imbab. Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism. Journal of chemical neuroanatomy. 2022-12-04. PMID:36464068. |
the mid-brain tissues were processed for light and electron microscopy examinations, and immunohistochemical staining for tyrosine hydroxylase [th], and microglia cells' markers: [cd68 and iba1]. |
2022-12-04 |
2023-08-14 |
rat |
| Kazuya Takahash. Microglial heterogeneity in amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology. 2022-11-28. PMID:36440536. |
expression of the microglial activation marker cd68 and endothelial activation were also observed in the tmem119+ microglia group, suggesting the presence of inflammatory processes in als lesions. |
2022-11-28 |
2023-08-14 |
mouse |
| Linda Rubinstein, Frederico Kiffer, Stephanie Puukila, Moniece G Lowe, Brie Goo, Amalia Luthens, Ann-Sofie Schreurs, Samantha M Torres, Sonette Steczina, Candice G T Tahimic, Antiño R Alle. Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus. Life (Basel, Switzerland). vol 12. issue 11. 2022-11-11. PMID:36362993. |
indeed, we saw an elevation of the activated microglia cd68 marker following hu in the hippocampus, and this pathology was mitigated in mcat mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Hideko Noguchi, Sachiko Koyama, Kaoru Yagita, Masahiro Shijo, Kosuke Matsuzono, Hideomi Hamasaki, Takaaki Kanemaru, Tsuyoshi Okamoto, Keita Kai, Shinichi Aishima, Koji Abe, Naokazu Sasagasako, Hiroyuki Hond. Silence of resident microglia in GPI anchorless prion disease and activation of microglia in Gerstmann-Sträussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease. Journal of neuropathology and experimental neurology. 2022-11-04. PMID:36331509. |
activated microglia/macrophages expressing hla-dr and cd68 were predominant in gss and scjd whereas in gpialp, homeostatic microglia were retained and activated microglia/macrophages were rarely observed. |
2022-11-04 |
2023-08-14 |
Not clear |
| Anzela Niraula, Rachael D Fasnacht, Kelly M Ness, Jeremy M Frey, Sophia A Cuschieri, Mauricio D Dorfman, Joshua P Thale. Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity. Diabetes. 2022-11-01. PMID:36318114. |
mechanistically, ep4-deficient microglia showed an attenuated phagocytic state marked by reduced cd68 expression and fewer contacts with pomc neuron processes. |
2022-11-01 |
2023-08-14 |
mouse |
| Manuel G Bruera, María M Benedetto, Mario E Guido, Alicia L Degano, María A Conti. Glial cell response to constant low light exposure in rat retina. Visual neuroscience. vol 39. 2022-09-27. PMID:36164752. |
retinal cells presented an increased expression of the macroglia marker gfap, as well as increased mrna levels of microglia markers iba1 and cd68 after 6 days. |
2022-09-27 |
2023-08-14 |
rat |
| Hayley F North, Christin Weissleder, Janice M Fullerton, Maree J Webster, Cynthia Shannon Weicker. Increased immune cell and altered microglia and neurogenesis transcripts in an Australian schizophrenia subgroup with elevated inflammation. Schizophrenia research. vol 248. 2022-09-15. PMID:36108465. |
consistent with our previous report (north et al., 2021b), those with high-inflammation and schizophrenia had unchanged mrna expression of markers for steady-state and activated microglia (iba1, hexb, cd68), decreased expression of phagocytic microglia markers (p2ry12, p2ry13), but increased expression of markers for macrophages (cd163), monocytes (cd14), natural killer cells (fcgr3a), and the adhesion molecule icam1. |
2022-09-15 |
2023-08-14 |
Not clear |
| Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Yan Xu, Fudong Li. Regulation of microglial activation in stroke in aged mice: a translational study. Aging. vol 14. issue undefined. 2022-08-13. PMID:35963621. |
irf5 cko aged microglia had significantly lower levels of il-1β and cd68 than controls; whereas significantly higher levels of il-1β and tnf-α were seen in irf4 cko vs. control microglia. |
2022-08-13 |
2023-08-14 |
mouse |