| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara Klein, Heike Mrowetz, Conor Michael Barker, Simona Lange, Francisco J Rivera, Ludwig Aigne. Age Influences Microglial Activation After Cuprizone-Induced Demyelination. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30297998. |
for this purpose, several microglia markers (ionized calcium binding adaptor molecule 1 (iba-1), p2ry12, f4/80, cd68, major histocompatibility complex ii (mhcii), macrophage receptor with collagenous structure (marco), translocator protein 18 kd (tspo), cd206, and cd163) were analyzed in the acute cuprizone demyelination model in young (2-month-old) and middle-aged (10-month-old) mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Barbara Klein, Heike Mrowetz, Conor Michael Barker, Simona Lange, Francisco J Rivera, Ludwig Aigne. Age Influences Microglial Activation After Cuprizone-Induced Demyelination. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30297998. |
age-related changes in microglia of healthy controls were more pronounced in the analyzed gray matter region (higher levels of f4/80 and marco as well as lower expression of cd68 in middle-aged mice). |
2020-10-01 |
2023-08-13 |
mouse |
| Una Avdic, Matilda Ahl, Maria Öberg, Christine T Ekdah. Immune Profile in Blood Following Non-convulsive Epileptic Seizures in Rats. Frontiers in neurology. vol 10. 2020-10-01. PMID:31333561. |
in particular, markers associated with microglia, macrophages and antigen presenting cells, such as cd68, mhcii, and galectin-3, were increased and the t-cell marker cd4 was decreased in serum compared to both non-stimulated controls and ncse rats without spontaneous seizures, without correlation to interictal epileptiform activity. |
2020-10-01 |
2023-08-13 |
rat |
| Yali Chen, Mengmei Yin, Xuejin Cao, Gang Hu, Ming Xia. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. Aging and disease. vol 9. issue 3. 2020-09-30. PMID:29896426. |
compared with young controls, aged mice fed normal diet showed mild activation of hippocampal microglia with increased expression of cd68, a marker of the microglial m1 phenotype, and decreased expression of cd206, a marker of the microglial m2 phenotype. |
2020-09-30 |
2023-08-13 |
mouse |
| Laura Annovazzi, Marta Mellai, Enrica Bovio, Samanta Mazzetti, Bianca Pollo, Davide Schiffe. Microglia immunophenotyping in gliomas. Oncology letters. vol 15. issue 1. 2020-09-29. PMID:29399160. |
normal resting microglia, reactive microglia, intermediate and bumpy forms and macrophage-like cells can be distinguished by iba1, cd68, cd16 and cd163 and further categorized by cd11b, cd45, c-maf and cd98. |
2020-09-29 |
2023-08-13 |
Not clear |
| Maria Martinez-Lage, Timothy M Lynch, Yingtao Bi, Carolina Cocito, Gregory P Way, Sharmistha Pal, Josephine Haller, Rachel E Yan, Amy Ziober, Aivi Nguyen, Manoj Kandpal, Donald M O'Rourke, Jeffrey P Greenfield, Casey S Greene, Ramana V Davuluri, Nadia Dahman. Immune landscapes associated with different glioblastoma molecular subtypes. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31815646. |
tissue micro arrays (tma) were stained for cd20 (b lymphocytes), cd5, cd3, cd4, cd8 (t lymphocytes), cd68 (microglia), and cd163 (bone marrow derived macrophages) antibodies. |
2020-09-25 |
2023-08-13 |
Not clear |
| Wenbin Ding, Hongyan Lin, Xin Hong, Dongliang Ji, Feng W. Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease. Toxicology. vol 436. 2020-08-31. PMID:32169474. |
consistently, p188 attenuated p + m-mediated increased mrna levels of microglia proliferation related csf1r and csf2ra, microglial engulfment associated cd68, icam1, and icam2, and pro-inflammatory il-6, il-1β, cd11b, and tnf-α in hippocampus. |
2020-08-31 |
2023-08-13 |
mouse |
| Daniela Talhada, Isabel Gonçalves, João Carlos Gomes, Maria João Saraiva, Cecília Reis Santos, Karsten Rusche. Transthyretin expression in the postischemic brain. PloS one. vol 14. issue 9. 2020-03-16. PMID:31479465. |
no ttr immunoreactivity was found when stainings were performed with markers for neurons (neuronal nuclei, neun), reactive astrocytes (glial fibrillary acidic protein, gfap) or microglia (cluster of differentiation 68, cd68). |
2020-03-16 |
2023-08-13 |
mouse |
| Yohanna Eriksson, Martina Boström, Åsa Sandelius, Kaj Blennow, Henrik Zetterberg, Georg Kuhn, Marie Kal. The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain. Cell death & disease. vol 9. issue 7. 2019-11-25. PMID:29991719. |
it also resulted in less microglia activation 6 h after cir, where montelukast lowered the levels of cd68 compared to the vehicle groups. |
2019-11-25 |
2023-08-13 |
mouse |
| Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Debbie R Boone, Emanuele Mocciaro, Harris Weisz, Margaret A Parsley, Stacy L Sell, Helen Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria-Adelaide Micc. Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma. Journal of neurotrauma. vol 35. issue 13. 2019-10-07. PMID:29562823. |
microglia activation and neuronal injury were assessed in brain sections by immunofluorescence using specific antibodies against cd68 and active caspase-3, respectively. |
2019-10-07 |
2023-08-13 |
rat |
| Yukari Yoshida, Yukihiko Sejimo, Masashi Kurachi, Yasuki Ishizaki, Takashi Nakano, Akihisa Takahash. X-ray irradiation induces disruption of the blood-brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain. Neurochemistry international. vol 119. 2019-09-30. PMID:29545059. |
in addition, the number of activated microglia (cd68 |
2019-09-30 |
2023-08-13 |
mouse |
| Hongsheng Miao, Runming Li, Cong Han, Xiuzhen Lu, Hang Zhan. Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats. Journal of neurophysiology. vol 120. issue 3. 2019-08-01. PMID:29790836. |
minocycline improved ich-induced neurological deficits and reduced m1 microglia marker protein (cd68, cd16) expression as well as m2 microglial polarization (cd206 and arginase 1 protein). |
2019-08-01 |
2023-08-13 |
rat |
| Vikas Singh, Shaivya Kushwaha, Ruchi Gera, Jamal Ahmad Ansari, Juhi Mishra, Jayant Dewangan, Satyakam Patnaik, Debabrata Ghos. Sneaky Entry of IFNγ Through Arsenic-Induced Leaky Blood-Brain Barrier Reduces CD200 Expression by Microglial pro-Inflammatory Cytokine. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29948949. |
finally, intracerebral injection of anti-ifnγ neutralizing antibody in arsenic-exposed brain reduced microglia activation (il-6 and tnf-α and cd68 expression) and subsequently rescued cd200 level. |
2019-07-11 |
2023-08-13 |
mouse |
| Olena Y Glushakova, Andriy O Glushakov, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28637381. |
we studied astrocytes (glial fibrillary acidic protein [gfap]), microglia (ionized calcium-binding adapter molecule 1 [iba1]), bbb (endothelial barrier antigen [eba]), and activated microglia/macrophages (cluster of differentiation 68 [cd68]). |
2019-07-08 |
2023-08-13 |
rat |
| Shane M O'Neil, Kristina G Witcher, Daniel B McKim, Jonathan P Godbou. Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30477578. |
indeed, we and others have reported microglia develop a pro-inflammatory or "primed" profile with age, characterized by increased expression of inflammatory mediators (e.g., mhc-ii, cd68, il-1β). |
2019-06-03 |
2023-08-13 |
mouse |
| Wolfgang J Streit, Heiko Braak, Kelly Del Tredici, Judith Leyh, Julia Lier, Habibeh Khoshbouei, Christian Eisenlöffel, Wolf Müller, Ingo Bechman. Microglial activation occurs late during preclinical Alzheimer's disease. Glia. vol 66. issue 12. 2019-04-15. PMID:30417428. |
amyloid-induced neuroinflammatory clusters of iba1, cd68, and ferritin-positive microglia were evident in the immediate vicinity of aggregated aβ. |
2019-04-15 |
2023-08-13 |
human |
| Naoki Abe, Mohammed E Choudhury, Minori Watanabe, Shun Kawasaki, Tasuku Nishihara, Hajime Yano, Shirabe Matsumoto, Takehiro Kunieda, Yoshiaki Kumon, Toshihiro Yorozuya, Junya Tanak. Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea. Glia. vol 66. issue 10. 2019-03-18. PMID:30194744. |
furthermore, macrophages expressed nadph oxidase 2, interleukin-1β (il-1β), and cd68 at higher levels than microglia. |
2019-03-18 |
2023-08-13 |
rat |
| Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreir. Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain. Neuroscience letters. vol 673. 2019-03-11. PMID:29518539. |
the role of ra-np on endothelial cells and organotypic slice cultures exposed to oxygen and glucose deprivation was assessed by evaluating markers pertaining to survival, proliferation, oxidative stress (no, ros), neuronal damage (enolase), vascular oxidation (p47phox) and microglia activation (cd68). |
2019-03-11 |
2023-08-13 |
mouse |
| Yasuhisa Ano, Yuta Takaichi, Kazuyuki Uchida, Keiji Kondo, Hiroyuki Nakayama, Akihiko Takashim. Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-03-11. PMID:30501069. |
flow cytometry analysis demonstrated that the expression of cells producing cd86, cd68, tspo, mip-1α, tnf-α, and il-1β in microglia was increased in rtg4510 mice compared with wild-type mice. |
2019-03-11 |
2023-08-13 |
mouse |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
as part of investigations of microglia using post-mortem resources provided by the medical research council cognitive function and ageing studies (mrc-cfas), we immunostained the cerebral cortex of 299 participants for trem2 using the sigma antibody hpa010917 and compared with the macrophage/microglial markers iba1 and cd68. |
2019-03-05 |
2023-08-13 |
human |