| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
to resolve these issues we directly observed microglia behaviors with two-photon microscopy in ex vivo spinal cord slices from cx3cr1-gfp mice complemented with confocal analyses of cd68 protein. |
2020-12-11 |
2023-08-13 |
mouse |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
confocal 3d analyses revealed increased microglia coverage of the motoneuron cell body surface with time after injury and the presence of cd68 granules in microglia surfaces opposed to motoneurons. |
2020-12-11 |
2023-08-13 |
mouse |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
microglia in these clusters display the highest cd68 expression and associate with cytotoxic t-cells. |
2020-12-11 |
2023-08-13 |
mouse |
| Douglas G Walker, Tiffany M Tang, Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E Serrano, Lucia I Sue, Thomas G Beach, Lih-Fen Lu. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. International journal of molecular sciences. vol 21. issue 2. 2020-11-02. PMID:31968618. |
based on these results, p2ry12 expression by microglia should not be considered solely a marker of resting microglia as p2ry12 immunoreactivity was identifying microglia positive for cd68, progranulin and to a limited extent hla-dr, markers of activation. |
2020-11-02 |
2023-08-13 |
Not clear |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the levels of microglia markers including ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation 11b (cd11b), m1 markers including cd68, inducible nitric oxide synthase (inos), interleukin-1β (il-1β), il-6, tumor necrosis factor-a (tnf-α), 8-hydroxy-2-deoxyguanosine (8-oh-dg), and m2 markers including cd206, arginase 1 (arg1), il-4 in the prefrontal cortex were determined on day 14 after sni. |
2020-10-01 |
2023-08-13 |
rat |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the results showed that sni produced mechanical allodynia and depressive-like behaviors, and also increased the expressions of microglia markers (iba1, cd11b) and m1 markers (cd68, inos, il-1β, tnf-α, and 8-oh-dg) in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
rat |
| Hayato Asai, Koichi Inoue, Eisuke Sakuma, Yoshiaki Shinohara, Takatoshi Uek. Potential implication of SGK1-dependent activity change in BV-2 microglial cells. International journal of physiology, pathophysiology and pharmacology. vol 10. issue 2. 2020-10-01. PMID:29755644. |
in the present report, we prepared sgk1-lacked microglial cell line (bv-2) and demonstrated that deficiency of sgk1 in microglia induced its toxic conversion, in which it took amoeboid morphology characteristic of reactive microglia, increased cd68 expression, quickened its proliferation, and showed higher susceptibility to atp and subsequent cell death. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dong Hwan Ho, A Reum Je, Haejin Lee, Ilhong Son, Hee-Seok Kweon, Hyung-Gun Kim, Wongi Seo. LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation. Experimental neurobiology. vol 27. issue 3. 2020-10-01. PMID:30022868. |
finally, the protein levels of cd68, an active microglia marker, drp1 and tnf-α were significantly higher in brain lysates of g2019s transgenic mice compared with the levels in their littermates. |
2020-10-01 |
2023-08-13 |
mouse |
| Barbara Klein, Heike Mrowetz, Conor Michael Barker, Simona Lange, Francisco J Rivera, Ludwig Aigne. Age Influences Microglial Activation After Cuprizone-Induced Demyelination. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30297998. |
for this purpose, several microglia markers (ionized calcium binding adaptor molecule 1 (iba-1), p2ry12, f4/80, cd68, major histocompatibility complex ii (mhcii), macrophage receptor with collagenous structure (marco), translocator protein 18 kd (tspo), cd206, and cd163) were analyzed in the acute cuprizone demyelination model in young (2-month-old) and middle-aged (10-month-old) mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Barbara Klein, Heike Mrowetz, Conor Michael Barker, Simona Lange, Francisco J Rivera, Ludwig Aigne. Age Influences Microglial Activation After Cuprizone-Induced Demyelination. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30297998. |
age-related changes in microglia of healthy controls were more pronounced in the analyzed gray matter region (higher levels of f4/80 and marco as well as lower expression of cd68 in middle-aged mice). |
2020-10-01 |
2023-08-13 |
mouse |
| Una Avdic, Matilda Ahl, Maria Öberg, Christine T Ekdah. Immune Profile in Blood Following Non-convulsive Epileptic Seizures in Rats. Frontiers in neurology. vol 10. 2020-10-01. PMID:31333561. |
in particular, markers associated with microglia, macrophages and antigen presenting cells, such as cd68, mhcii, and galectin-3, were increased and the t-cell marker cd4 was decreased in serum compared to both non-stimulated controls and ncse rats without spontaneous seizures, without correlation to interictal epileptiform activity. |
2020-10-01 |
2023-08-13 |
rat |
| Yali Chen, Mengmei Yin, Xuejin Cao, Gang Hu, Ming Xia. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. Aging and disease. vol 9. issue 3. 2020-09-30. PMID:29896426. |
compared with young controls, aged mice fed normal diet showed mild activation of hippocampal microglia with increased expression of cd68, a marker of the microglial m1 phenotype, and decreased expression of cd206, a marker of the microglial m2 phenotype. |
2020-09-30 |
2023-08-13 |
mouse |
| Laura Annovazzi, Marta Mellai, Enrica Bovio, Samanta Mazzetti, Bianca Pollo, Davide Schiffe. Microglia immunophenotyping in gliomas. Oncology letters. vol 15. issue 1. 2020-09-29. PMID:29399160. |
normal resting microglia, reactive microglia, intermediate and bumpy forms and macrophage-like cells can be distinguished by iba1, cd68, cd16 and cd163 and further categorized by cd11b, cd45, c-maf and cd98. |
2020-09-29 |
2023-08-13 |
Not clear |
| Maria Martinez-Lage, Timothy M Lynch, Yingtao Bi, Carolina Cocito, Gregory P Way, Sharmistha Pal, Josephine Haller, Rachel E Yan, Amy Ziober, Aivi Nguyen, Manoj Kandpal, Donald M O'Rourke, Jeffrey P Greenfield, Casey S Greene, Ramana V Davuluri, Nadia Dahman. Immune landscapes associated with different glioblastoma molecular subtypes. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31815646. |
tissue micro arrays (tma) were stained for cd20 (b lymphocytes), cd5, cd3, cd4, cd8 (t lymphocytes), cd68 (microglia), and cd163 (bone marrow derived macrophages) antibodies. |
2020-09-25 |
2023-08-13 |
Not clear |
| Wenbin Ding, Hongyan Lin, Xin Hong, Dongliang Ji, Feng W. Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease. Toxicology. vol 436. 2020-08-31. PMID:32169474. |
consistently, p188 attenuated p + m-mediated increased mrna levels of microglia proliferation related csf1r and csf2ra, microglial engulfment associated cd68, icam1, and icam2, and pro-inflammatory il-6, il-1β, cd11b, and tnf-α in hippocampus. |
2020-08-31 |
2023-08-13 |
mouse |
| Daniela Talhada, Isabel Gonçalves, João Carlos Gomes, Maria João Saraiva, Cecília Reis Santos, Karsten Rusche. Transthyretin expression in the postischemic brain. PloS one. vol 14. issue 9. 2020-03-16. PMID:31479465. |
no ttr immunoreactivity was found when stainings were performed with markers for neurons (neuronal nuclei, neun), reactive astrocytes (glial fibrillary acidic protein, gfap) or microglia (cluster of differentiation 68, cd68). |
2020-03-16 |
2023-08-13 |
mouse |
| Yohanna Eriksson, Martina Boström, Åsa Sandelius, Kaj Blennow, Henrik Zetterberg, Georg Kuhn, Marie Kal. The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain. Cell death & disease. vol 9. issue 7. 2019-11-25. PMID:29991719. |
it also resulted in less microglia activation 6 h after cir, where montelukast lowered the levels of cd68 compared to the vehicle groups. |
2019-11-25 |
2023-08-13 |
mouse |
| Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Debbie R Boone, Emanuele Mocciaro, Harris Weisz, Margaret A Parsley, Stacy L Sell, Helen Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria-Adelaide Micc. Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma. Journal of neurotrauma. vol 35. issue 13. 2019-10-07. PMID:29562823. |
microglia activation and neuronal injury were assessed in brain sections by immunofluorescence using specific antibodies against cd68 and active caspase-3, respectively. |
2019-10-07 |
2023-08-13 |
rat |
| Yukari Yoshida, Yukihiko Sejimo, Masashi Kurachi, Yasuki Ishizaki, Takashi Nakano, Akihisa Takahash. X-ray irradiation induces disruption of the blood-brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain. Neurochemistry international. vol 119. 2019-09-30. PMID:29545059. |
in addition, the number of activated microglia (cd68 |
2019-09-30 |
2023-08-13 |
mouse |
| Hongsheng Miao, Runming Li, Cong Han, Xiuzhen Lu, Hang Zhan. Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats. Journal of neurophysiology. vol 120. issue 3. 2019-08-01. PMID:29790836. |
minocycline improved ich-induced neurological deficits and reduced m1 microglia marker protein (cd68, cd16) expression as well as m2 microglial polarization (cd206 and arginase 1 protein). |
2019-08-01 |
2023-08-13 |
rat |