| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana I Ramírez, José A Fernández-Albarral, Rosa de Hoz, Inés López-Cuenca, Elena Salobrar-García, Pilar Rojas, Francisco Javier Valiente-Soriano, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Manuel Vidal-Sanz, Alberto Triviño, Juan J Salazar, José M Ramíre. Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. Progress in brain research. vol 256. issue 1. 2021-07-05. PMID:32958210. |
aged oht eyes and the eyes contralateral to them showed an up-regulation of the cd68 expression in the branched microglia and a down-regulation in the mhcii and p2ry12 expression with respect to the eyes of young oht mice. |
2021-07-05 |
2023-08-13 |
mouse |
| Chotima Böttcher, Camila Fernández-Zapata, Gijsje J L Snijders, Stephan Schlickeiser, Marjolein A M Sneeboer, Desiree Kunkel, Lot D De Witte, Josef Prille. Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32917850. |
we found no evidence for the induction of inflammation-associated molecules, such as cd11b, cd45, ccl2, il-1β, il-6, tnf, mip-1β (ccl4), il-10, and even decreased expression of hla-dr and cd68 in microglia from mdd cases. |
2021-06-18 |
2023-08-13 |
Not clear |
| Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W Dickso. Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32430064. |
in contrast, there was increased expression of cd68 and cd163 in microglia in affected white matter. |
2021-05-28 |
2023-08-13 |
Not clear |
| Eoin O'Neill, Éadaoin W Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningha. Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33307172. |
this did not significantly alter numbers of pu.1-positive microglia, iba1-positive microglial morphology or mrna expression of microglia-associated gene transcripts (tyrobp, sall1, cd68, sra2, clec7a) in the hippocampus or frontal cortex and produced modest reductions in cx3cr1 and p2ry12. |
2021-05-28 |
2023-08-13 |
mouse |
| Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M D Carneiro, Chang Y Chun. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33176182. |
we observed the increase in the number of activated microglia expressing cd68 after exposure to three weeks of chronic stress, whereas no changes in total microglia number were observed. |
2021-05-27 |
2023-08-13 |
mouse |
| Ning Zhang, Chunhong Liu, Ruiyan Zhang, Li Jin, Xiaohan Yin, Xuexing Zheng, Hans-Christian Siebert, Yubao Li, Zhengping Wang, Gabriele Loers, Athanasios K Petridi. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food & function. vol 11. issue 6. 2021-04-26. PMID:32539054. |
concomitant, the protein expressions of glial fibrillary acidic protein (gfap, an astrocyte marker), ionized calcium-binding adaptor molecule 1 (iba-1, a microglial marker), cd68 (an activated microglia marker) and cd16/32 (a m1 microglial marker) were down-regulated, while the expression of oligodendrocyte lineage transcription factor 2 (olig2, an oligodendrocyte precursor cells marker) was up-regulated by the kd treatment. |
2021-04-26 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
chronic activation with ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, mhc ii and cd68 up-regulation, and pro-inflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2021-04-06 |
2023-08-13 |
mouse |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
we report an increase in leukocyte common antigen (cd45) and cluster of differentiation 68 (cd68) expression in the brain of rtg4510 mice without altering the expression levels of a cell-surface protein transmembrane protein 119 (tmem119) and ionized calcium-binding adaptor molecule 1 (iba-1) in resident microglia. |
2021-03-29 |
2023-08-13 |
mouse |
| Zhang Yuan, Shi Yi-Yun, Yu Hai-Ya. Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460187. |
triad3a knockdown enhanced the infarction area, cell death, microglia activity, and the expression levels of pro-inflammatory markers including tumor necrosis factor-α (tnf-α), interleukin (il)-1β, il-6, inducible nitric oxide synthase (inos), cd32 and cd68 in mcao mice. |
2021-03-01 |
2023-08-13 |
mouse |
| Xiaokun Han, Xi Chen, Shuilian Chen, Qian Luo, Xuan Liu, Anqi He, Shengyu He, Jin Qiu, Pei Chen, Yihui Wu, Jiejie Zhuang, Meng Yang, Chuangran Wu, Nandan Wu, Ying Yang, Jian Ge, Jing Zhuang, Keming Y. Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460188. |
we found pretreatment with tmp significantly inhibited lps-induced upregulation of cd68, a marker of mononuclear microglia activation. |
2021-03-01 |
2023-08-13 |
Not clear |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
characterization of trem2+ microglia showed expression of cd16/32, cd68, and occasional galectin-3. |
2020-12-18 |
2023-08-13 |
Not clear |
| Ola A Hussein, Asmaa Fathi Abdel Mola, Amal Rate. Tramadol administration induced hippocampal cells apoptosis, astrogliosis, and microgliosis in juvenile and adult male mice, histological and immunohistochemical study. Ultrastructural pathology. vol 44. issue 1. 2020-12-14. PMID:31924115. |
astrogliosis and microgliosis were proved by the increased immunoreactivity of astrocytes to glial fibrillary acidic protein (gfap) and microglia to cd68. |
2020-12-14 |
2023-08-13 |
mouse |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
to resolve these issues we directly observed microglia behaviors with two-photon microscopy in ex vivo spinal cord slices from cx3cr1-gfp mice complemented with confocal analyses of cd68 protein. |
2020-12-11 |
2023-08-13 |
mouse |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
confocal 3d analyses revealed increased microglia coverage of the motoneuron cell body surface with time after injury and the presence of cd68 granules in microglia surfaces opposed to motoneurons. |
2020-12-11 |
2023-08-13 |
mouse |
| Travis M Rotterman, Francisco J Alvare. Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457369. |
microglia in these clusters display the highest cd68 expression and associate with cytotoxic t-cells. |
2020-12-11 |
2023-08-13 |
mouse |
| Douglas G Walker, Tiffany M Tang, Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E Serrano, Lucia I Sue, Thomas G Beach, Lih-Fen Lu. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. International journal of molecular sciences. vol 21. issue 2. 2020-11-02. PMID:31968618. |
based on these results, p2ry12 expression by microglia should not be considered solely a marker of resting microglia as p2ry12 immunoreactivity was identifying microglia positive for cd68, progranulin and to a limited extent hla-dr, markers of activation. |
2020-11-02 |
2023-08-13 |
Not clear |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the levels of microglia markers including ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation 11b (cd11b), m1 markers including cd68, inducible nitric oxide synthase (inos), interleukin-1β (il-1β), il-6, tumor necrosis factor-a (tnf-α), 8-hydroxy-2-deoxyguanosine (8-oh-dg), and m2 markers including cd206, arginase 1 (arg1), il-4 in the prefrontal cortex were determined on day 14 after sni. |
2020-10-01 |
2023-08-13 |
rat |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the results showed that sni produced mechanical allodynia and depressive-like behaviors, and also increased the expressions of microglia markers (iba1, cd11b) and m1 markers (cd68, inos, il-1β, tnf-α, and 8-oh-dg) in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
rat |
| Hayato Asai, Koichi Inoue, Eisuke Sakuma, Yoshiaki Shinohara, Takatoshi Uek. Potential implication of SGK1-dependent activity change in BV-2 microglial cells. International journal of physiology, pathophysiology and pharmacology. vol 10. issue 2. 2020-10-01. PMID:29755644. |
in the present report, we prepared sgk1-lacked microglial cell line (bv-2) and demonstrated that deficiency of sgk1 in microglia induced its toxic conversion, in which it took amoeboid morphology characteristic of reactive microglia, increased cd68 expression, quickened its proliferation, and showed higher susceptibility to atp and subsequent cell death. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dong Hwan Ho, A Reum Je, Haejin Lee, Ilhong Son, Hee-Seok Kweon, Hyung-Gun Kim, Wongi Seo. LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation. Experimental neurobiology. vol 27. issue 3. 2020-10-01. PMID:30022868. |
finally, the protein levels of cd68, an active microglia marker, drp1 and tnf-α were significantly higher in brain lysates of g2019s transgenic mice compared with the levels in their littermates. |
2020-10-01 |
2023-08-13 |
mouse |