| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhan. Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization. Molecular pain. vol 17. 2021-10-14. PMID:33626986. |
the levels of microglia markers including ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation 11b (cd11b), pro-inflammatory phenotype markers including cd68, interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and anti-inflammatory phenotype markers including cd206, il-4 in the hippocampus and spinal cord were determined on day 21 after cci. |
2021-10-14 |
2023-08-13 |
mouse |
| Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhan. Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization. Molecular pain. vol 17. 2021-10-14. PMID:33626986. |
the results showed that cci produced mechanical allodynia and thermal hyperalgesia, and also increased the expressions of microglia markers (iba1, cd11b) and pro-inflammatory phenotype markers (cd68, il-1β, and tnf-α), but not anti-inflammatory phenotype marker (cd206, il-4) in the hippocampus and spinal cord, accompanied by increased scfas in the gut. |
2021-10-14 |
2023-08-13 |
mouse |
| Shotaro Hayashida, Katsuhisa Masaki, Satoshi O Suzuki, Ryo Yamasaki, Mitsuru Watanabe, Sachiko Koyama, Noriko Isobe, Takuya Matsushita, Kazuya Takahashi, Takeshi Tabira, Toru Iwaki, Jun-Ichi Kir. Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32902014. |
therefore, we investigated the distribution patterns of microglia and macrophages in 10 concentric lesions from four autopsied baló's disease cases and one neuromyelitis optica spectrum disorder (nmosd) case, using quantitative immunohistochemistry for the markers tmem119, p2ry12, cd68, cd163 and glut5. |
2021-10-06 |
2023-08-13 |
Not clear |
| Livia J De Picker, Gerardo Mendez Victoriano, Rhys Richards, Alexander J Gorvett, Simeon Lyons, George R Buckland, Tommaso Tofani, Jeanette L Norman, David S Chatelet, James A R Nicoll, Delphine Boch. Immune environment of the brain in schizophrenia and during the psychotic episode: A human post-mortem study. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34339805. |
dorsal prefrontal cortex of 40 controls (22f:18m) and 37 (10f:27m) schizophrenia cases, of whom 16 had active psychotic symptoms at the time of death, was immunostained for seven markers of microglia (cd16, cd32a, cd64, cd68, hla-dr, iba1 and p2ry12), two markers for perivascular macrophages (cd163 and cd206) and t-lymphocytes (cd3). |
2021-09-22 |
2023-08-13 |
human |
| Marcia G Honig, Conor C Dorian, John D Worthen, Anthony C Micetich, Isabelle A Mulder, Katelyn B Sanchez, William F Pierce, Nobel A Del Mar, Anton Reine. Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32090401. |
hierarchical cluster analysis of dorsal hippocampal microglia across the three groups based on morphology and expression of mhcii, cx3cr1, cd68 and iba1 revealed five distinct phenotypes. |
2021-09-17 |
2023-08-13 |
mouse |
| Yahan Zhang, Anna Lena Erhard, Tanja Plagemann, Nicole Eter, Peter Heiduschk. A modified protocol for isolation of retinal microglia from the pig. Experimental eye research. vol 207. 2021-09-17. PMID:33910034. |
identity of isolated cells as microglia was assessed by immunostaining against the microglia/macrophage markers iba1, cd11b, cd68, cd45 and tmem119. |
2021-09-17 |
2023-08-13 |
human |
| Tino Emanuele Poloni, Valentina Medici, Matteo Moretti, Silvia Damiana Visonà, Alice Cirrincione, Arenn Faye Carlos, Annalisa Davin, Stella Gagliardi, Orietta Pansarasa, Cristina Cereda, Livio Tronconi, Antonio Guaita, Mauro Ceron. COVID-19-related neuropathology and microglial activation in elderly with and without dementia. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-09-07. PMID:34145669. |
the neuroinflammatory picture was dominated by ameboid cd68 positive microglia, while only scant lymphocytic presence and very few traces of sars-cov-2 were detected. |
2021-09-07 |
2023-08-13 |
Not clear |
| Lynn van Olst, Carla Rodriguez-Mogeda, Carmen Picon, Svenja Kiljan, Rachel E James, Alwin Kamermans, Susanne M A van der Pol, Lydian Knoop, Iliana Michailidou, Evelien Drost, Marc Franssen, Geert J Schenk, Jeroen J G Geurts, Sandra Amor, Nicholas D Mazarakis, Jack van Horssen, Helga E de Vries, Richard Reynolds, Maarten E Witt. Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration. Acta neuropathologica. vol 141. issue 6. 2021-07-30. PMID:33779783. |
the microglial population in ms1 cortex was characterized by a higher density and increased expression of the activation markers hla class ii and cd68, whereas microglia in ms2 cortex showed increased morphological complexity and loss of p2y12 and tmem119 expression. |
2021-07-30 |
2023-08-13 |
rat |
| Ana I Ramírez, José A Fernández-Albarral, Rosa de Hoz, Inés López-Cuenca, Elena Salobrar-García, Pilar Rojas, Francisco Javier Valiente-Soriano, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Manuel Vidal-Sanz, Alberto Triviño, Juan J Salazar, José M Ramíre. Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. Progress in brain research. vol 256. issue 1. 2021-07-05. PMID:32958210. |
aged oht eyes and the eyes contralateral to them showed an up-regulation of the cd68 expression in the branched microglia and a down-regulation in the mhcii and p2ry12 expression with respect to the eyes of young oht mice. |
2021-07-05 |
2023-08-13 |
mouse |
| Chotima Böttcher, Camila Fernández-Zapata, Gijsje J L Snijders, Stephan Schlickeiser, Marjolein A M Sneeboer, Desiree Kunkel, Lot D De Witte, Josef Prille. Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32917850. |
we found no evidence for the induction of inflammation-associated molecules, such as cd11b, cd45, ccl2, il-1β, il-6, tnf, mip-1β (ccl4), il-10, and even decreased expression of hla-dr and cd68 in microglia from mdd cases. |
2021-06-18 |
2023-08-13 |
Not clear |
| Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W Dickso. Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32430064. |
in contrast, there was increased expression of cd68 and cd163 in microglia in affected white matter. |
2021-05-28 |
2023-08-13 |
Not clear |
| Eoin O'Neill, Éadaoin W Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningha. Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33307172. |
this did not significantly alter numbers of pu.1-positive microglia, iba1-positive microglial morphology or mrna expression of microglia-associated gene transcripts (tyrobp, sall1, cd68, sra2, clec7a) in the hippocampus or frontal cortex and produced modest reductions in cx3cr1 and p2ry12. |
2021-05-28 |
2023-08-13 |
mouse |
| Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M D Carneiro, Chang Y Chun. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33176182. |
we observed the increase in the number of activated microglia expressing cd68 after exposure to three weeks of chronic stress, whereas no changes in total microglia number were observed. |
2021-05-27 |
2023-08-13 |
mouse |
| Ning Zhang, Chunhong Liu, Ruiyan Zhang, Li Jin, Xiaohan Yin, Xuexing Zheng, Hans-Christian Siebert, Yubao Li, Zhengping Wang, Gabriele Loers, Athanasios K Petridi. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food & function. vol 11. issue 6. 2021-04-26. PMID:32539054. |
concomitant, the protein expressions of glial fibrillary acidic protein (gfap, an astrocyte marker), ionized calcium-binding adaptor molecule 1 (iba-1, a microglial marker), cd68 (an activated microglia marker) and cd16/32 (a m1 microglial marker) were down-regulated, while the expression of oligodendrocyte lineage transcription factor 2 (olig2, an oligodendrocyte precursor cells marker) was up-regulated by the kd treatment. |
2021-04-26 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
chronic activation with ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, mhc ii and cd68 up-regulation, and pro-inflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2021-04-06 |
2023-08-13 |
mouse |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
we report an increase in leukocyte common antigen (cd45) and cluster of differentiation 68 (cd68) expression in the brain of rtg4510 mice without altering the expression levels of a cell-surface protein transmembrane protein 119 (tmem119) and ionized calcium-binding adaptor molecule 1 (iba-1) in resident microglia. |
2021-03-29 |
2023-08-13 |
mouse |
| Zhang Yuan, Shi Yi-Yun, Yu Hai-Ya. Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460187. |
triad3a knockdown enhanced the infarction area, cell death, microglia activity, and the expression levels of pro-inflammatory markers including tumor necrosis factor-α (tnf-α), interleukin (il)-1β, il-6, inducible nitric oxide synthase (inos), cd32 and cd68 in mcao mice. |
2021-03-01 |
2023-08-13 |
mouse |
| Xiaokun Han, Xi Chen, Shuilian Chen, Qian Luo, Xuan Liu, Anqi He, Shengyu He, Jin Qiu, Pei Chen, Yihui Wu, Jiejie Zhuang, Meng Yang, Chuangran Wu, Nandan Wu, Ying Yang, Jian Ge, Jing Zhuang, Keming Y. Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460188. |
we found pretreatment with tmp significantly inhibited lps-induced upregulation of cd68, a marker of mononuclear microglia activation. |
2021-03-01 |
2023-08-13 |
Not clear |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
characterization of trem2+ microglia showed expression of cd16/32, cd68, and occasional galectin-3. |
2020-12-18 |
2023-08-13 |
Not clear |
| Ola A Hussein, Asmaa Fathi Abdel Mola, Amal Rate. Tramadol administration induced hippocampal cells apoptosis, astrogliosis, and microgliosis in juvenile and adult male mice, histological and immunohistochemical study. Ultrastructural pathology. vol 44. issue 1. 2020-12-14. PMID:31924115. |
astrogliosis and microgliosis were proved by the increased immunoreactivity of astrocytes to glial fibrillary acidic protein (gfap) and microglia to cd68. |
2020-12-14 |
2023-08-13 |
mouse |