| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica M Rosin, Nikol Tretiakov, Emily Hanniman, Kiana Hampton, Deborah M Kurrasc. Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups. Frontiers in neuroscience. vol 16. 2022-03-07. PMID:35250464. |
staining for microglial activation using cd68 showed no change between control and prenatal bpa-exposed microglia, regardless of sex. |
2022-03-07 |
2023-08-13 |
Not clear |
| Dalia A Mandour, Sally M Shalaby, M A Bendar. Spinal cord-wide structural disruption in type 2 diabetes rescued by Exenatide "a glucagon-like peptide-1 analogue" via down-regulating inflammatory, oxidative stress and apoptotic signaling pathways. Journal of chemical neuroanatomy. 2022-02-10. PMID:35143896. |
also, they exhibited histopathological changes and increased cd68 positive microglia and bax immunoreactivity in the spinal cord. |
2022-02-10 |
2023-08-13 |
rat |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
since microglia activation could precede neuronal death, we now investigated 2 microglia activation markers, ionized calcium-binding adapter molecule 1 (iba1), and the phagocytosis marker cd68. |
2022-01-29 |
2023-08-13 |
human |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
heavy attachment of microglia on th neurons and remarkable expression of cd68 were also observed indicating phagocytosis in this group. |
2022-01-29 |
2023-08-13 |
human |
| Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Li. Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation. Brain, behavior, and immunity. vol 100. 2021-12-11. PMID:34848340. |
hippocampal microglia in mice in the hfd group generally had a more activated phenotype evidenced by a smaller microglial territory area and increased cluster of differentiation 68 (cd68, a marker of phagocytic activity) immunoreactivity, while the microglial density in the dentate gyrus (dg) was decreased, indicating microglial decline. |
2021-12-11 |
2023-08-13 |
mouse |
| Ayumi E Pottenger, Mitchell J Bartlett, Scott J Sherman, Torsten Falk, Helena W Morriso. Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment. Neuroscience letters. vol 765. 2021-12-03. PMID:34536508. |
yet an increase of cd68 in the snpc of 6-ohda-lesioned hemispheres post-ketamine indicates increased microglia phagocytosis suggestive of a lingering microglial response to 6-ohda injury in the snpc pointing to possible anti-inflammatory action in the pd model in addition to anti-dyskinetic action. |
2021-12-03 |
2023-08-13 |
rat |
| Huan Du, Man Ying Wong, Tingting Zhang, Mariela Nunez Santos, Charlene Hsu, Junke Zhang, Haiyuan Yu, Wenjie Luo, Fenghua H. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life science alliance. vol 4. issue 7. 2021-11-30. PMID:34103390. |
pgrn-deficient microglia exhibit increased expression of markers associated with microglial activation, including cd68, galectin-3, trem2, and gpnmb, specifically near aβ plaques. |
2021-11-30 |
2023-08-13 |
mouse |
| Keigo Takahashi, Steven Q Le, Shih-Hsin Kan, Matthew J Jansen, Patricia I Dickson, Jonathan D Coope. Neuropathology of murine Sanfilippo D syndrome. Molecular genetics and metabolism. 2021-11-30. PMID:34844863. |
we found significantly increased immunostaining for glial fibrillary associated protein (gfap), cd68 (a marker of activated microglia), and lysosomal-associated membrane protein-1 (lamp-1) in sanfilippo d mice compared to controls at 12 weeks of age in all brain regions. |
2021-11-30 |
2023-08-13 |
mouse |
| Jae Woong Byeon, Young Rae Jo, Yoon Kyung Shin, Hwan Tae Park, Hyun-Seok Par. Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain. Biochemical and biophysical research communications. vol 567. 2021-11-18. PMID:34146905. |
although differences were not detected in the cytoplasmic area of iba1-labeled microglia between gab2(±) and gab2(-/-) mice, the analysis of cd68 and cathepsin d (indicators of microglial lysosomal activation) immunolabeling within iba1+ cells revealed significant underdevelopment of microglial lysosomes in gab2(-/-) mice at p60. |
2021-11-18 |
2023-08-13 |
mouse |
| Jing Wang, Quanguang Zhang, Yujiao Lu, Yan Dong, Krishnan M Dhandapani, Darrell W Brann, Robert K Y. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34133773. |
at 2 and 4 days following gci, the gd3s-ko microglia demonstrated decreased amoebic morphology, reduced neuronal material engulfment, and lower expression of the phagolysosome marker cd68, as compared to the wt microglia. |
2021-11-16 |
2023-08-13 |
mouse |
| Ping Li, Tingting Shen, Xue Luo, Ju Yang, Zhen Luo, Yulong Tan, Genlin He, Zeze Wang, Xueting Yu, Ying Wang, Xuesen Yan. Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34172807. |
we found that dex treatment reduced the expression of cd68, inos, tnf-α, and il-1β, and increased the expression of cd206, arg1, il-10 and tgf-β in microglia, ameliorating heatstroke induced neuroinflammation and brain injury in mice. |
2021-11-03 |
2023-08-13 |
mouse |
| Xinyan Wu, Hanhai Zeng, Chaoran Xu, Huaijun Chen, Linfeng Fan, Hang Zhou, Qian Yu, Xiongjie Fu, Yucong Peng, Feng Yan, Xiaobo Yu, Gao Che. TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Frontiers in immunology. vol 12. 2021-11-02. PMID:34721438. |
meanwhile, trem1 inhibitory peptide decreased neuroinflammation (evidenced by the decreased levels of markers including il-6, il-1β, tnf-α) by attenuating proinflammatory subtype transition of microglia (evidenced by the decreased levels of markers including cd68, cd16, cd86) and decreasing the formation of neutrophil extracellular traps (evidenced by the decreased levels of markers including cith3, mpo, and ne). |
2021-11-02 |
2023-08-13 |
Not clear |
| Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhan. Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization. Molecular pain. vol 17. 2021-10-14. PMID:33626986. |
the levels of microglia markers including ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation 11b (cd11b), pro-inflammatory phenotype markers including cd68, interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and anti-inflammatory phenotype markers including cd206, il-4 in the hippocampus and spinal cord were determined on day 21 after cci. |
2021-10-14 |
2023-08-13 |
mouse |
| Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhan. Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization. Molecular pain. vol 17. 2021-10-14. PMID:33626986. |
the results showed that cci produced mechanical allodynia and thermal hyperalgesia, and also increased the expressions of microglia markers (iba1, cd11b) and pro-inflammatory phenotype markers (cd68, il-1β, and tnf-α), but not anti-inflammatory phenotype marker (cd206, il-4) in the hippocampus and spinal cord, accompanied by increased scfas in the gut. |
2021-10-14 |
2023-08-13 |
mouse |
| Shotaro Hayashida, Katsuhisa Masaki, Satoshi O Suzuki, Ryo Yamasaki, Mitsuru Watanabe, Sachiko Koyama, Noriko Isobe, Takuya Matsushita, Kazuya Takahashi, Takeshi Tabira, Toru Iwaki, Jun-Ichi Kir. Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32902014. |
therefore, we investigated the distribution patterns of microglia and macrophages in 10 concentric lesions from four autopsied baló's disease cases and one neuromyelitis optica spectrum disorder (nmosd) case, using quantitative immunohistochemistry for the markers tmem119, p2ry12, cd68, cd163 and glut5. |
2021-10-06 |
2023-08-13 |
Not clear |
| Livia J De Picker, Gerardo Mendez Victoriano, Rhys Richards, Alexander J Gorvett, Simeon Lyons, George R Buckland, Tommaso Tofani, Jeanette L Norman, David S Chatelet, James A R Nicoll, Delphine Boch. Immune environment of the brain in schizophrenia and during the psychotic episode: A human post-mortem study. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34339805. |
dorsal prefrontal cortex of 40 controls (22f:18m) and 37 (10f:27m) schizophrenia cases, of whom 16 had active psychotic symptoms at the time of death, was immunostained for seven markers of microglia (cd16, cd32a, cd64, cd68, hla-dr, iba1 and p2ry12), two markers for perivascular macrophages (cd163 and cd206) and t-lymphocytes (cd3). |
2021-09-22 |
2023-08-13 |
human |
| Marcia G Honig, Conor C Dorian, John D Worthen, Anthony C Micetich, Isabelle A Mulder, Katelyn B Sanchez, William F Pierce, Nobel A Del Mar, Anton Reine. Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32090401. |
hierarchical cluster analysis of dorsal hippocampal microglia across the three groups based on morphology and expression of mhcii, cx3cr1, cd68 and iba1 revealed five distinct phenotypes. |
2021-09-17 |
2023-08-13 |
mouse |
| Yahan Zhang, Anna Lena Erhard, Tanja Plagemann, Nicole Eter, Peter Heiduschk. A modified protocol for isolation of retinal microglia from the pig. Experimental eye research. vol 207. 2021-09-17. PMID:33910034. |
identity of isolated cells as microglia was assessed by immunostaining against the microglia/macrophage markers iba1, cd11b, cd68, cd45 and tmem119. |
2021-09-17 |
2023-08-13 |
human |
| Tino Emanuele Poloni, Valentina Medici, Matteo Moretti, Silvia Damiana Visonà, Alice Cirrincione, Arenn Faye Carlos, Annalisa Davin, Stella Gagliardi, Orietta Pansarasa, Cristina Cereda, Livio Tronconi, Antonio Guaita, Mauro Ceron. COVID-19-related neuropathology and microglial activation in elderly with and without dementia. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-09-07. PMID:34145669. |
the neuroinflammatory picture was dominated by ameboid cd68 positive microglia, while only scant lymphocytic presence and very few traces of sars-cov-2 were detected. |
2021-09-07 |
2023-08-13 |
Not clear |
| Lynn van Olst, Carla Rodriguez-Mogeda, Carmen Picon, Svenja Kiljan, Rachel E James, Alwin Kamermans, Susanne M A van der Pol, Lydian Knoop, Iliana Michailidou, Evelien Drost, Marc Franssen, Geert J Schenk, Jeroen J G Geurts, Sandra Amor, Nicholas D Mazarakis, Jack van Horssen, Helga E de Vries, Richard Reynolds, Maarten E Witt. Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration. Acta neuropathologica. vol 141. issue 6. 2021-07-30. PMID:33779783. |
the microglial population in ms1 cortex was characterized by a higher density and increased expression of the activation markers hla class ii and cd68, whereas microglia in ms2 cortex showed increased morphological complexity and loss of p2y12 and tmem119 expression. |
2021-07-30 |
2023-08-13 |
rat |