| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariela Nunez Santos, Daniel H Paushter, Tingting Zhang, Xiaochun Wu, Tuancheng Feng, Jiaoying Lou, Huan Du, Stephanie M Becker, Robert Fragoza, Haiyuan Yu, Fenghua H. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. The Journal of biological chemistry. 2022-08-06. PMID:35933009. |
here, we identify cd68, a lysosome membrane protein highly expressed in microglia, as a binding partner of pgrn and pgrn-derived granulin e. deletion analysis of cd68 showed that this interaction is mediated by the mucin-proline-rich domain of cd68. |
2022-08-06 |
2023-08-14 |
Not clear |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
here we report that mice exposed to adolescent intermittent access to ethanol (aie) exhibit increased pain sensitivity and depressive-like behaviors that persist for several weeks after alcohol cessation and are accompanied by elevated cd68 expression in microglia and reduced numbers of serotonin (5-ht)-expressing neurons in the dorsal raphe nucleus (drn). |
2022-07-30 |
2023-08-14 |
mouse |
| Elsa Gonzalez De La Cruz, Quan Vo, Katie Moon, Karen N McFarland, Mary Weinrich, Tristan Williams, Benoit I Giasson, Paramita Chakrabart. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897751. |
we focused on microglia next, finding that while microglial burden was significantly upregulated in pff-seeded, mhcii-deficient mice relative to controls, the microglial activation marker cd68 was reduced in these mice, suggesting that these microglia were not responsive. |
2022-07-28 |
2023-08-14 |
mouse |
| Yoshiki Hase, Kamar E Ameen-Ali, Rachel Waller, Julie E Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B Wharton, Raj N Kalari. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain pathology (Zurich, Switzerland). 2022-06-24. PMID:35748290. |
we primarily used cd68 as a marker of phagocytic microglia, as well as other markers of microglia including iba-1 and tmem119, and the myeloid cell marker trem2 to assess dementia-specific changes. |
2022-06-24 |
2023-08-14 |
human |
| Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping G. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology. vol 109. 2022-06-16. PMID:35709590. |
in addition, prolonged isoflurane inhalation switched microglia into a proinflammatory m1 phenotype characterized by elevated cd68 and inos as well as decreased arginase-1 and il-10. |
2022-06-16 |
2023-08-14 |
mouse |
| Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Pen. Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628400. |
the expression levels of iba-1 and cd68 demonstrated, by western blot analysis, the inflammatory cytokine tnf-α content measured with enzyme-linked immunosorbent assay, and the number of microglia demonstrated by immunohistochemistry (ihc) were significantly increased at age of 7 months, all of which indicate microglia activation at an age of seizure onset. |
2022-05-28 |
2023-08-13 |
mouse |
| Han Rae Kim, Colin N Youn. Inhibition of Forebrain Microglia Ameliorates Non-alcoholic Fatty Liver Disease During Obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557243. |
hfd or normal chow male mice underwent sfo stereotaxic delivery of a designer receptors exclusively activated by designer drugs inhibitory construct targeted to microglia via the cd68 promoter (paav-cd68-hm4gi-mcherry). |
2022-05-13 |
2023-08-13 |
mouse |
| Hui-Ming Yang, Yong-Ling Wang, Chong-Yue Liu, Yu-Ting Zhou, Xiao-Feng Zhan. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-17. PMID:35430334. |
activated microglia and increased cd68 expression appeared two weeks after pq exposure in time-dependent manners. |
2022-04-17 |
2023-08-13 |
mouse |
| Jessica M Rosin, Nikol Tretiakov, Emily Hanniman, Kiana Hampton, Deborah M Kurrasc. Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups. Frontiers in neuroscience. vol 16. 2022-03-07. PMID:35250464. |
staining for microglial activation using cd68 showed no change between control and prenatal bpa-exposed microglia, regardless of sex. |
2022-03-07 |
2023-08-13 |
Not clear |
| Dalia A Mandour, Sally M Shalaby, M A Bendar. Spinal cord-wide structural disruption in type 2 diabetes rescued by Exenatide "a glucagon-like peptide-1 analogue" via down-regulating inflammatory, oxidative stress and apoptotic signaling pathways. Journal of chemical neuroanatomy. 2022-02-10. PMID:35143896. |
also, they exhibited histopathological changes and increased cd68 positive microglia and bax immunoreactivity in the spinal cord. |
2022-02-10 |
2023-08-13 |
rat |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
since microglia activation could precede neuronal death, we now investigated 2 microglia activation markers, ionized calcium-binding adapter molecule 1 (iba1), and the phagocytosis marker cd68. |
2022-01-29 |
2023-08-13 |
human |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
heavy attachment of microglia on th neurons and remarkable expression of cd68 were also observed indicating phagocytosis in this group. |
2022-01-29 |
2023-08-13 |
human |
| Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Li. Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation. Brain, behavior, and immunity. vol 100. 2021-12-11. PMID:34848340. |
hippocampal microglia in mice in the hfd group generally had a more activated phenotype evidenced by a smaller microglial territory area and increased cluster of differentiation 68 (cd68, a marker of phagocytic activity) immunoreactivity, while the microglial density in the dentate gyrus (dg) was decreased, indicating microglial decline. |
2021-12-11 |
2023-08-13 |
mouse |
| Ayumi E Pottenger, Mitchell J Bartlett, Scott J Sherman, Torsten Falk, Helena W Morriso. Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment. Neuroscience letters. vol 765. 2021-12-03. PMID:34536508. |
yet an increase of cd68 in the snpc of 6-ohda-lesioned hemispheres post-ketamine indicates increased microglia phagocytosis suggestive of a lingering microglial response to 6-ohda injury in the snpc pointing to possible anti-inflammatory action in the pd model in addition to anti-dyskinetic action. |
2021-12-03 |
2023-08-13 |
rat |
| Huan Du, Man Ying Wong, Tingting Zhang, Mariela Nunez Santos, Charlene Hsu, Junke Zhang, Haiyuan Yu, Wenjie Luo, Fenghua H. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life science alliance. vol 4. issue 7. 2021-11-30. PMID:34103390. |
pgrn-deficient microglia exhibit increased expression of markers associated with microglial activation, including cd68, galectin-3, trem2, and gpnmb, specifically near aβ plaques. |
2021-11-30 |
2023-08-13 |
mouse |
| Keigo Takahashi, Steven Q Le, Shih-Hsin Kan, Matthew J Jansen, Patricia I Dickson, Jonathan D Coope. Neuropathology of murine Sanfilippo D syndrome. Molecular genetics and metabolism. 2021-11-30. PMID:34844863. |
we found significantly increased immunostaining for glial fibrillary associated protein (gfap), cd68 (a marker of activated microglia), and lysosomal-associated membrane protein-1 (lamp-1) in sanfilippo d mice compared to controls at 12 weeks of age in all brain regions. |
2021-11-30 |
2023-08-13 |
mouse |
| Jae Woong Byeon, Young Rae Jo, Yoon Kyung Shin, Hwan Tae Park, Hyun-Seok Par. Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain. Biochemical and biophysical research communications. vol 567. 2021-11-18. PMID:34146905. |
although differences were not detected in the cytoplasmic area of iba1-labeled microglia between gab2(±) and gab2(-/-) mice, the analysis of cd68 and cathepsin d (indicators of microglial lysosomal activation) immunolabeling within iba1+ cells revealed significant underdevelopment of microglial lysosomes in gab2(-/-) mice at p60. |
2021-11-18 |
2023-08-13 |
mouse |
| Jing Wang, Quanguang Zhang, Yujiao Lu, Yan Dong, Krishnan M Dhandapani, Darrell W Brann, Robert K Y. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34133773. |
at 2 and 4 days following gci, the gd3s-ko microglia demonstrated decreased amoebic morphology, reduced neuronal material engulfment, and lower expression of the phagolysosome marker cd68, as compared to the wt microglia. |
2021-11-16 |
2023-08-13 |
mouse |
| Ping Li, Tingting Shen, Xue Luo, Ju Yang, Zhen Luo, Yulong Tan, Genlin He, Zeze Wang, Xueting Yu, Ying Wang, Xuesen Yan. Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34172807. |
we found that dex treatment reduced the expression of cd68, inos, tnf-α, and il-1β, and increased the expression of cd206, arg1, il-10 and tgf-β in microglia, ameliorating heatstroke induced neuroinflammation and brain injury in mice. |
2021-11-03 |
2023-08-13 |
mouse |
| Xinyan Wu, Hanhai Zeng, Chaoran Xu, Huaijun Chen, Linfeng Fan, Hang Zhou, Qian Yu, Xiongjie Fu, Yucong Peng, Feng Yan, Xiaobo Yu, Gao Che. TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Frontiers in immunology. vol 12. 2021-11-02. PMID:34721438. |
meanwhile, trem1 inhibitory peptide decreased neuroinflammation (evidenced by the decreased levels of markers including il-6, il-1β, tnf-α) by attenuating proinflammatory subtype transition of microglia (evidenced by the decreased levels of markers including cd68, cd16, cd86) and decreasing the formation of neutrophil extracellular traps (evidenced by the decreased levels of markers including cith3, mpo, and ne). |
2021-11-02 |
2023-08-13 |
Not clear |