| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa R Zanier, Federica Marchesi, Fabrizio Ortolano, Carlo Perego, Maedeh Arabian, Tommaso Zoerle, Eliana Sammali, Francesca Pischiutta, Maria-Grazia De Simon. Fractalkine Receptor Deficiency Is Associated with Early Protection but Late Worsening of Outcome following Brain Trauma in Mice. Journal of neurotrauma. vol 33. issue 11. 2018-01-04. PMID:26180940. |
microglia (m) and macrophage (μ) activation and polarization were assessed by quantitative immunohistochemistry for cd11b, cd68, ym1, and inducible nitric oxide synthase (inos)-markers of m/μ activation, phagocytosis, m2, and m1 phenotypes, respectively. |
2018-01-04 |
2023-08-13 |
mouse |
| Cheryl Reeves, Mohamed Tachrount, David Thomas, Zuzanna Michalak, Joan Liu, Matthew Ellis, Beate Diehl, Anna Miserocchi, Andrew W McEvoy, Sofia Eriksson, Tarek Yousry, Maria Tho. Combined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy. Brain pathology (Zurich, Switzerland). vol 26. issue 3. 2018-01-02. PMID:26268959. |
quantitative immunohistochemistry for myelination (myelin basic protein/smi94), neuronal populations [microtubule-associated protein 2 (map2), neurofilament (smi31, smi32), synaptophysin, neun, calbindin], reactive glia (gfap), microglia (cd68) and blood-brain barrier permeability (albumin) was carried out in 43 regions of interest (roi) from normal and abnormal white matter and cortex. |
2018-01-02 |
2023-08-13 |
Not clear |
| Hai-Yun Wu, Xue-Qi Tang, Xiao-Fang Mao, Yong-Xiang Wan. Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial β-Endorphin Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 48. 2017-12-07. PMID:29084866. |
treatment with exenatide in cultured primary spinal microglia concentration dependently stimulated the expression of the m2 microglial markers il-10, il-4, arg 1, and cd206, but not the m1 microglial markers tnf-α, il-1β, il-6, or cd68. |
2017-12-07 |
2023-08-13 |
rat |
| Jonathan D Cherry, Yorghos Tripodis, Victor E Alvarez, Bertrand Huber, Patrick T Kiernan, Daniel H Daneshvar, Jesse Mez, Philip H Montenigro, Todd M Solomon, Michael L Alosco, Robert A Stern, Ann C McKee, Thor D Stei. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27793189. |
duration of rhi exposure and the development and severity of cte were associated with reactive microglial morphology and increased numbers of cd68 immunoreactive microglia in the dlf. |
2017-10-25 |
2023-08-13 |
human |
| Camille Planty, Corey P Mallett, Kevin Yim, Jorge C G Blanco, Marina Boukhvalova, Thomas March, Robbert van der Most, Eric Destexh. Evaluation of the potential effects of AS03-adjuvanted A(H1N1)pdm09 vaccine administration on the central nervous system of non-primed and A(H1N1)pdm09-primed cotton rats. Human vaccines & immunotherapeutics. vol 13. issue 1. 2017-10-23. PMID:27629482. |
potential effects on the cns were investigated by histopathological evaluation of brain sections stained with hematoxylin-and-eosin, or by immunohistochemical staining of microglia, using iba1 and cd68 as markers for microglia identification/activation, albumin as indicator of vascular leakage, and hypocretin. |
2017-10-23 |
2023-08-13 |
rat |
| Diane M Brooks, Sarjubhai A Patel, Eric D Wohlgehagen, Erin O Semmens, Alan Pearce, Edmond A Sorich, Thomas F Ra. Multiple mild traumatic brain injury in the rat produces persistent pathological alterations in the brain. Experimental neurology. vol 297. 2017-10-05. PMID:28756201. |
cd68 positive microglia were significantly increased in the ipsilateral corpus callosum, cortex, and internal capsule of injured animals. |
2017-10-05 |
2023-08-13 |
rat |
| Giovanni Marfia, Stefania Elena Navone, Loubna Abdel Hadi, Moira Paroni, Valeria Berno, Matteo Beretta, Roberta Gualtierotti, Francesca Ingegnoli, Vincenzo Levi, Monica Miozzo, Jens Geginat, Lorenzo Fassina, Paolo Rampini, Carlo Tremolada, Laura Riboni, Rolando Campanell. The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. Stem cells and development. vol 25. issue 14. 2017-09-11. PMID:27217090. |
our results demonstrate that the conditioned medium (cm) of adscs isolated by two different processing methods (lipoaspirate and lipogems) significantly inhibited the lipopolysaccharide (lps)-induced effects on microglia activation, including microglial expression of cd68, cytokine secretion, proliferation, and migration. |
2017-09-11 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
staining of hla-dr, iba1 and cd68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. |
2017-08-21 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
hla-dr, iba1 and cd68 are widely used microglia markers in human tissue. |
2017-08-21 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
here, we directly compared the expression of hla-dr, iba1 and cd68 in microglia with different phenotypes, ranging from ramified to amoeboid, to foamy phagocytizing macrophages, in adjacent sections immunocytochemically double stained for two of the markers. |
2017-08-21 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
these results indicate that microglia markers have different potential for neuropathological analysis, with hla-dr and cd68 reflecting immune activation and response to tissue damage, and iba1 providing a marker more suited for structural studies in the absence of pathology. |
2017-08-21 |
2023-08-13 |
human |
| Xiaoning Han, Xi Lan, Qiang Li, Yufeng Gao, Wei Zhu, Tian Cheng, Takayuki Maruyama, Jian Wan. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 36. issue 6. 2017-08-09. PMID:26661165. |
ep3 receptor inhibition reduced lesion volume, neurologic deficit, cell death, matrix metalloproteinase-9 activity, neutrophil infiltration, and the number of cd68(+) microglia, but increased the number of ym-1(+) m2 microglia. |
2017-08-09 |
2023-08-13 |
mouse |
| A Trost, D Bruckner, A Kaser-Eichberger, K Motloch, B Bogner, C Runge, C Strohmaier, S Couillard-Despres, H A Reitsamer, F Schroed. Lymphatic and vascular markers in an optic nerve crush model in rat. Experimental eye research. vol 159. 2017-08-09. PMID:28315338. |
lesioned ons and unlesioned contralateral controls were analyzed 7 days (n = 5) and 14 days (n = 5) after onc, with the following markers: pdgfrb (pericyte), iba1 (microglia), cd68 (macrophages), reca (endothelial cell), gfap (astrocyte) as well as lyve-1 and podoplanin (pdpn; lymphatic markers). |
2017-08-09 |
2023-08-13 |
rat |
| Per Kristian Eide, Vigdis Andersen Eidsvaag, Erlend A Nagelhus, Hans-Arne Hansso. Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension. Brain research. vol 1644. 2017-06-29. PMID:27188961. |
scattered cd68 immunoreactive cells (activated microglia and macrophages) were recognized, indicative of some inflammation. |
2017-06-29 |
2023-08-13 |
Not clear |
| Rachel A Rice, Jason Pham, Rafael J Lee, Allison R Najafi, Brian L West, Kim N Gree. Microglial repopulation resolves inflammation and promotes brain recovery after injury. Glia. vol 65. issue 6. 2017-05-02. PMID:28251674. |
neuronal loss leads to a prolonged neuroinflammatory response, characterized by the presence of swollen microglia expressing cd68 and cd45, as well as elevated levels of cytokines, chemokines, complement, and other inflammatory signals. |
2017-05-02 |
2023-08-13 |
mouse |
| Xin Yan, Liang Qiao, En-Hui Yang, Jun-Tang Li. [Activity of glial cells in the olfactory bulb of Niemann-Pick disease type C1 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108900. |
the results showed that npc1 gene mutation strongly increased the activation of astrocytes and microglia in olfactory bulb associated with increased protein levels of cd68 and gfap. |
2017-04-28 |
2023-08-13 |
mouse |
| Zacharias Kohl, Johannes C M Schlachetzki, Judith Feldewerth, Philipp Hornauer, Martina Münch, Anthony Adame, Markus J Riemenschneider, Jürgen Winkler, Eliezer Maslia. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural plasticity. vol 2017. 2017-04-28. PMID:28409032. |
the number of iba1 and cd68 positive microglia associated with enlarged amoeboid microglia was increased particularly in ad, to a lesser extent in ftld and pdd/dlb as well, while the proportion of proliferating microglia was not altered. |
2017-04-28 |
2023-08-13 |
Not clear |
| Terumasa Chiba, Yoshinori Otani, Yoshihide Yamaguchi, Tomoko Ishibashi, Akiko Hayashi, Kenji F Tanaka, Maya Yamazaki, Kenji Sakimura, Hiroko Bab. Microglial phospholipase D4 deficiency influences myelination during brain development. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 92. issue 7. 2017-03-27. PMID:27477458. |
wild type microglia showed strong immunoreactivity for microglial marker cd68 at p5, whereas cd68 signals were weak in pld4-deficient microglia, suggesting that loss of pld4 affects microglial activation. |
2017-03-27 |
2023-08-13 |
mouse |
| Fan Wang, Mi Xiao, Ru-Juan Chen, Xiao-Jie Lin, Muhammad Siddiq, Li Li. Adoptive transfer of T regulatory cells inhibits lipopolysaccharide-induced inflammation in fetal brain tissue in a late-pregnancy preterm birth mouse model. Cell biology international. vol 41. issue 2. 2017-01-31. PMID:27888557. |
to evaluate the effect of regulatory t cells (tregs) on the inflammation resulting from lipopolysaccharide (lps) challenge in prenatal brain tissue, tregs isolated from pregnant mice were transferred into model mice, and the expression levels of fork head family transcription factor (foxp3), interleukin-6 (il-6), cd68 (a marker of microglia), and toll-like receptor 4 (tlr-4) were assessed in the fetal brain tissue. |
2017-01-31 |
2023-08-13 |
mouse |
| Hao Wu, Eric V Brown, Nimish K Acharya, Denah M Appelt, Alexander Marks, Robert G Nagele, Venkat Venkatarama. Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice. Brain research. vol 1637. 2017-01-24. PMID:26907191. |
these events were concurrent with compromise of neurons, increase of activated microglia and lack of astrocytic activation as evidenced by decreased expression of microtubule-associated protein type 2 (map2), elevated number of cd68 positive cells and unaltered expression of glial fibrillary acidic protein (gfap) respectively. |
2017-01-24 |
2023-08-13 |
mouse |