| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
hla-dr, iba1 and cd68 are widely used microglia markers in human tissue. |
2017-08-21 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
here, we directly compared the expression of hla-dr, iba1 and cd68 in microglia with different phenotypes, ranging from ramified to amoeboid, to foamy phagocytizing macrophages, in adjacent sections immunocytochemically double stained for two of the markers. |
2017-08-21 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
these results indicate that microglia markers have different potential for neuropathological analysis, with hla-dr and cd68 reflecting immune activation and response to tissue damage, and iba1 providing a marker more suited for structural studies in the absence of pathology. |
2017-08-21 |
2023-08-13 |
human |
| Xiaoning Han, Xi Lan, Qiang Li, Yufeng Gao, Wei Zhu, Tian Cheng, Takayuki Maruyama, Jian Wan. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 36. issue 6. 2017-08-09. PMID:26661165. |
ep3 receptor inhibition reduced lesion volume, neurologic deficit, cell death, matrix metalloproteinase-9 activity, neutrophil infiltration, and the number of cd68(+) microglia, but increased the number of ym-1(+) m2 microglia. |
2017-08-09 |
2023-08-13 |
mouse |
| A Trost, D Bruckner, A Kaser-Eichberger, K Motloch, B Bogner, C Runge, C Strohmaier, S Couillard-Despres, H A Reitsamer, F Schroed. Lymphatic and vascular markers in an optic nerve crush model in rat. Experimental eye research. vol 159. 2017-08-09. PMID:28315338. |
lesioned ons and unlesioned contralateral controls were analyzed 7 days (n = 5) and 14 days (n = 5) after onc, with the following markers: pdgfrb (pericyte), iba1 (microglia), cd68 (macrophages), reca (endothelial cell), gfap (astrocyte) as well as lyve-1 and podoplanin (pdpn; lymphatic markers). |
2017-08-09 |
2023-08-13 |
rat |
| Per Kristian Eide, Vigdis Andersen Eidsvaag, Erlend A Nagelhus, Hans-Arne Hansso. Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension. Brain research. vol 1644. 2017-06-29. PMID:27188961. |
scattered cd68 immunoreactive cells (activated microglia and macrophages) were recognized, indicative of some inflammation. |
2017-06-29 |
2023-08-13 |
Not clear |
| Rachel A Rice, Jason Pham, Rafael J Lee, Allison R Najafi, Brian L West, Kim N Gree. Microglial repopulation resolves inflammation and promotes brain recovery after injury. Glia. vol 65. issue 6. 2017-05-02. PMID:28251674. |
neuronal loss leads to a prolonged neuroinflammatory response, characterized by the presence of swollen microglia expressing cd68 and cd45, as well as elevated levels of cytokines, chemokines, complement, and other inflammatory signals. |
2017-05-02 |
2023-08-13 |
mouse |
| Xin Yan, Liang Qiao, En-Hui Yang, Jun-Tang Li. [Activity of glial cells in the olfactory bulb of Niemann-Pick disease type C1 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108900. |
the results showed that npc1 gene mutation strongly increased the activation of astrocytes and microglia in olfactory bulb associated with increased protein levels of cd68 and gfap. |
2017-04-28 |
2023-08-13 |
mouse |
| Zacharias Kohl, Johannes C M Schlachetzki, Judith Feldewerth, Philipp Hornauer, Martina Münch, Anthony Adame, Markus J Riemenschneider, Jürgen Winkler, Eliezer Maslia. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural plasticity. vol 2017. 2017-04-28. PMID:28409032. |
the number of iba1 and cd68 positive microglia associated with enlarged amoeboid microglia was increased particularly in ad, to a lesser extent in ftld and pdd/dlb as well, while the proportion of proliferating microglia was not altered. |
2017-04-28 |
2023-08-13 |
Not clear |
| Terumasa Chiba, Yoshinori Otani, Yoshihide Yamaguchi, Tomoko Ishibashi, Akiko Hayashi, Kenji F Tanaka, Maya Yamazaki, Kenji Sakimura, Hiroko Bab. Microglial phospholipase D4 deficiency influences myelination during brain development. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 92. issue 7. 2017-03-27. PMID:27477458. |
wild type microglia showed strong immunoreactivity for microglial marker cd68 at p5, whereas cd68 signals were weak in pld4-deficient microglia, suggesting that loss of pld4 affects microglial activation. |
2017-03-27 |
2023-08-13 |
mouse |
| Fan Wang, Mi Xiao, Ru-Juan Chen, Xiao-Jie Lin, Muhammad Siddiq, Li Li. Adoptive transfer of T regulatory cells inhibits lipopolysaccharide-induced inflammation in fetal brain tissue in a late-pregnancy preterm birth mouse model. Cell biology international. vol 41. issue 2. 2017-01-31. PMID:27888557. |
to evaluate the effect of regulatory t cells (tregs) on the inflammation resulting from lipopolysaccharide (lps) challenge in prenatal brain tissue, tregs isolated from pregnant mice were transferred into model mice, and the expression levels of fork head family transcription factor (foxp3), interleukin-6 (il-6), cd68 (a marker of microglia), and toll-like receptor 4 (tlr-4) were assessed in the fetal brain tissue. |
2017-01-31 |
2023-08-13 |
mouse |
| Hao Wu, Eric V Brown, Nimish K Acharya, Denah M Appelt, Alexander Marks, Robert G Nagele, Venkat Venkatarama. Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice. Brain research. vol 1637. 2017-01-24. PMID:26907191. |
these events were concurrent with compromise of neurons, increase of activated microglia and lack of astrocytic activation as evidenced by decreased expression of microtubule-associated protein type 2 (map2), elevated number of cd68 positive cells and unaltered expression of glial fibrillary acidic protein (gfap) respectively. |
2017-01-24 |
2023-08-13 |
mouse |
| Abhishek Umashankar, Mandi J Corenblum, Sneha Ray, Michel Valdez, Eriko S Yoshimaru, Theodore P Trouard, Lalitha Madhava. Effects of the iron oxide nanoparticle Molday ION Rhodamine B on the viability and regenerative function of neural stem cells: relevance to clinical translation. International journal of nanomedicine. vol 11. 2016-12-13. PMID:27175074. |
in particular, in animals receiving the 50 μg/ml mirb-labeled nscs, this immune response consisted of an increased number of cd68(+)-activated microglia, which appeared to have phagocytosed mirb particles and cells contributing to an exaggerated mri signal dropout in the animals. |
2016-12-13 |
2023-08-13 |
rat |
| Jun-ichi Satoh, Yoshihiro Kino, Naohiro Asahina, Mika Takitani, Junko Miyoshi, Tsuyoshi Ishida, Yuko Sait. TMEM119 marks a subset of microglia in the human brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 1. 2016-10-19. PMID:26250788. |
notably, tmem119 immunoreactivity was expressed exclusively on a subset of iba1(+) cd68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases, such as alzheimer's disease (ad), whereas iba1(+) cd68(+) infiltrating macrophages do not express tmem119 in demyelinating lesions of multiple sclerosis and necrotic lesions of cerebral infarction. |
2016-10-19 |
2023-08-13 |
human |
| Lihong Huang, Gang Li, Xiaofang Feng, Luojun Wan. 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. BioMed research international. vol 2015. 2016-10-17. PMID:26844229. |
interestingly, reduced neurological deficits, decreased tnf-α and il-1 expression, less apoptotic cells and cd68 positive staining, and alleviated infarct and cerebral edema volume were observed when 15d-pgj2 was intraperitoneally injected after reperfusion in diabetic ischemia group, suggesting its neuroprotective role in regulating microglia activation, which may have a therapeutic application in the future. |
2016-10-17 |
2023-08-13 |
rat |
| b' Savina Apolloni, Paola Fabbrizio, Chiara Parisi, Susanna Amadio, Cinzia Volont\\xc3\\xa. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25482048.' |
moreover, in vitro, clemastine is able to modify several activation parameters of sod1(g93a) microglia, and particularly cd68 and arginase-1 expression, as well as phospho-erk1/2 and nadph oxidase 2 levels. |
2016-10-07 |
2023-08-13 |
mouse |
| Imran Noorani, Gareth Petty, Paul L Grundy, Geoff Sharpe, Sandrine Willaime-Morawek, Scott Harris, Gareth J Thomas, James Ar Nicoll, Delphine Boch. Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation? The journal of pathology. Clinical research. vol 1. issue 2. 2016-08-08. PMID:27499894. |
we quantified immunostaining of human astrocytic tumour tissue microarrays (86 patients; world health organisation grade ii-iv) for microglia ionized calcium binding adaptor molecule 1 (iba1) and cd68, and stem cell nestin, sox2 and cd133. |
2016-08-08 |
2023-08-13 |
human |
| Sumit Sarkar, James Raymick, Balmiki Ray, Debomoy K Lahiri, Merle G Paule, Larry Schmue. Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice. Current Alzheimer research. vol 12. issue 9. 2016-08-04. PMID:26510980. |
similarly, cd68 labeling, which detects activated microglia, along with amylo-glo labeling, suggests that microglial activation is significantly less in tht-treated mice. |
2016-08-04 |
2023-08-13 |
mouse |
| Awilda M Rosario, Pedro E Cruz, Carolina Ceballos-Diaz, Michael R Strickland, Zoe Siemienski, Meghan Pardo, Keri-Lyn Schob, Andrew Li, George V Aslanidi, Arun Srivastava, Todd E Golde, Paramita Chakrabart. Microglia-specific targeting by novel capsid-modified AAV6 vectors. Molecular therapy. Methods & clinical development. vol 3. 2016-06-16. PMID:27308302. |
indeed, these newly characterized raav6 capsid variants, specially a triply mutated y731f/y705f/t492v form, carrying a self-complementary genome and microglia-specific promoters (f4/80 or cd68) could efficiently and selectively transduce microglia in vitro. |
2016-06-16 |
2023-08-13 |
mouse |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
we performed an unbiased plaque-centered quantification of smi312(+) dystrophic neurites, gfap(+) reactive astrocytes, and iba1(+) and cd68(+) activated microglia in randomly selected dense-core (thioflavin-s(+)) plaques from the temporal neocortex of 40 ad subjects with a symptom duration ranging from 4 to 20 years, and nine nondemented control subjects with dense-core plaques. |
2016-06-14 |
2023-08-13 |
human |