| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takafumi Sakakibara, Sayuri Sukigara, Takashi Saito, Taisuke Otsuki, Akio Takahashi, Yuu Kaneko, Takanobu Kaido, Yuko Saito, Noriko Sato, Yukio Kimura, Eiji Nakagawa, Kenji Sugai, Masayuki Sasaki, Yu-Ichi Goto, Masayuki Ito. Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression. Journal of neuropathology and experimental neurology. vol 71. issue 8. 2012-10-03. PMID:22805777. |
all neuronal cells expressed the mature neuron marker map2/2b but not the microglia markers iba-1 and cd68. |
2012-10-03 |
2023-08-12 |
Not clear |
| Holly R Chinnery, Samuel McLenachan, Nicolette Binz, Yan Sun, John V Forrester, Mariapia A Degli-Esposti, Eric Pearlman, Paul G McMenami. TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation. The American journal of pathology. vol 180. issue 1. 2012-02-17. PMID:22085974. |
fluorescein isothiocyanate-cpg-odn rapidly penetrated the cornea and ocular media to reach the retina, where it was present within cd68(+) retinal macrophages and microglia. |
2012-02-17 |
2023-08-12 |
mouse |
| Rea Pihlaja, Jari Koistinaho, Riitta Kauppinen, Jouko Sandholm, Heikki Tanila, Milla Koistinah. Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes. Glia. vol 59. issue 11. 2012-01-06. PMID:21826742. |
concomitant to aβ reduction, both cd68 and cd45 immunoreactivities were significantly upregulated but phagocytic microglia were often surrounding and engulfing aβ burdened, tunel-positive astrocytes rather than co-localizing with aβ alone. |
2012-01-06 |
2023-08-12 |
mouse |
| Yoshihiro Seki, Satoshi O Suzuki, Kenta Masui, Shiori Harada, Seiji Nakamura, Shigenobu Kanba, Toru Iwak. A simple and high-yield method for preparation of rat microglial cultures utilizing Aclar plastic film. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21092060. |
the smk cells exhibited markers specific for the microglia lineage, including iba-1, cd11b, cd45, cd68, major histocompatibility complex (mhc) class i and mhc class ii, but not for the astrocyte-specific markers, gfap and glutamate aspartate transporter. |
2011-09-22 |
2023-08-12 |
rat |
| Cibelle Mariano, Sandra Leitão Silva, Pedro Pereira, Adelaide Fernandes, Dora Brites, Maria A Brit. Evidence of tricellulin expression by immune cells, particularly microglia. Biochemical and biophysical research communications. vol 409. issue 4. 2011-09-02. PMID:21624353. |
cultured rat microglia exhibited a notorious tricellulin staining, consistent with an extensive expression of the protein along the cell, which was not absolutely coincident with the lysosomal marker cd68. |
2011-09-02 |
2023-08-12 |
human |
| Jon Dang, Bhimashankar Mitkari, Markus Kipp, Cordian Beye. Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats. Brain, behavior, and immunity. vol 25. issue 4. 2011-08-29. PMID:21277368. |
iba1, cd68 and cd3, were significantly reduced in the penumbra after hormone treatment suggesting attenuation of microglia and lymphocyte attraction. |
2011-08-29 |
2023-08-12 |
rat |
| Emily C Brantley, Lixia Guo, Chenyu Zhang, Qingtang Lin, Kenji Yokoi, Robert R Langley, Ewa Kruzel, Marva Maya, Seung Wook Kim, Sun-Jin Kim, Dominic Fan, Isaiah J Fidle. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Translational oncology. vol 3. issue 6. 2011-07-14. PMID:21151477. |
experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (gfp(+)) and gfp(-) mice revealed that these microglia are derived from circulating monocytes (gfp(+), f4/80(+), and cd68(+)). |
2011-07-14 |
2023-08-12 |
mouse |
| Sarah C Hellewell, Edwin B Yan, Doreen A Agyapomaa, Nicole Bye, M Cristina Morganti-Kossman. Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822466. |
extensive microglia/macrophage accumulation detected with the cd68 antibody was maximal at 14 days post-injury in the corpus callosum (macrophages 157.5 ± 55.48; microglia 72.71 ± 20.75), and coincided with regions of axonal damage. |
2011-03-03 |
2023-08-12 |
rat |
| Dominik Michalski, Jens Grosche, Johann Pelz, Dietmar Schneider, Christopher Weise, Ute Bauer, Johannes Kacza, Ulrich Gärtner, Carsten Hobohm, Wolfgang Härti. A novel quantification of blood-brain barrier damage and histochemical typing after embolic stroke in rats. Brain research. vol 1359. 2011-01-25. PMID:20732314. |
the following markers were identified for sufficient detection of nvu components: rat endothelial cell antigen-1 (reca) and laminin for vessels, lycopersicon esculentum and griffonia simplicifolia agglutinin for vessels and microglial subpopulations, ionized calcium binding adaptor molecule 1 (iba1), cd68 and cd11b for macrophages, activated microglia, monocytes and neutrophils, s100β for astroglia, as well as neun and huc/d for neurons. |
2011-01-25 |
2023-08-12 |
human |
| Mélanie Lalancette-Hébert, Alexandre Moquin, Angela O Choi, Jasna Kriz, Dusica Maysinge. Lipopolysaccharide-QD micelles induce marked induction of TLR2 and lipid droplet accumulation in olfactory bulb microglia. Molecular pharmaceutics. vol 7. issue 4. 2010-11-24. PMID:20459083. |
the increased tlr2 expression was complemented with enhanced cd68 expression in activated microglia in the same regions. |
2010-11-24 |
2023-08-12 |
mouse |
| Vanesa Sanchez-Guajardo, Fabia Febbraro, Deniz Kirik, Marina Romero-Ramo. Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098715. |
microglia activation was assessed by stereological quantification of mac1+ cells, as well as the expression patterns of cd68 and mch ii. |
2010-05-20 |
2023-08-12 |
human |
| Vanesa Sanchez-Guajardo, Fabia Febbraro, Deniz Kirik, Marina Romero-Ramo. Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098715. |
on the other hand, when alpha-syn induced both neuronal pathology and cell death, there was a delayed increase in microglia cell numbers, which correlated with long-lasting cd68 expression and a morphology reminiscent of peripheral macrophages. |
2010-05-20 |
2023-08-12 |
human |
| Bin Li, Karen Bedard, Silvia Sorce, Boris Hinz, Michel Dubois-Dauphin, Karl-Heinz Kraus. NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression. Journal of innate immunity. vol 1. issue 6. 2010-05-11. PMID:20375612. |
hmc3 cells are typical microglia, as suggested by the constitutive expression of iba-1 and cd14, and ifn-gamma-induced expression of cd11b, cd68 and mhcii. |
2010-05-11 |
2023-08-12 |
human |
| Derek A Wainwright, Junping Xin, Nichole A Mesnard, Virginia M Sanders, Kathryn J Jone. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neuroscience letters. vol 471. issue 1. 2010-04-05. PMID:20056129. |
after facial nerve axotomy, tlr2 mrna was significantly upregulated in the facial motor nucleus and co-immunofluorescence localized tlr2 to cd68(+) microglia, but not gfap(+) astrocytes. |
2010-04-05 |
2023-08-12 |
mouse |
| Ana Clara Cristóvão, Ana Saavedra, Carla Pais Fonseca, Filipa Campos, Emília Pedrosa Duarte, Graça Baltaza. Microglia of rat ventral midbrain recovers its resting state over time in vitro: let microglia rest before work. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19739250. |
after 13 div, this tendency was reversed, with cultures showing higher number of ramified cells and fewer cd68(+) cells along with lower phagocytic and ros production capability, suggesting that microglia must be kept in vitro for at least 13 days to recover its resting state. |
2010-03-30 |
2023-08-12 |
rat |
| Ana M Santos, David Martín-Oliva, Rosa M Ferrer-Martín, Mohamed Tassi, Ruth Calvente, Ana Sierra, Maria-Carmen Carrasco, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial response to light-induced photoreceptor degeneration in the mouse retina. The Journal of comparative neurology. vol 518. issue 4. 2010-03-23. PMID:20020538. |
differences were also observed at 10 days after light exposure: cd11b, cd45, and f4/80 continued to be strongly expressed in retinal microglia, whereas the expression of cd68 and sra had decreased to near-normal values. |
2010-03-23 |
2023-08-12 |
mouse |
| Swati B Naphade, Kristina A Kigerl, Lyn B Jakeman, Sandra K Kostyk, Phillip G Popovich, Jeff Kure. Progranulin expression is upregulated after spinal contusion in mice. Acta neuropathologica. vol 119. issue 1. 2010-03-15. PMID:19946692. |
progranulin immunoreactivity colocalized with myeloid cell markers cd11b and cd68, indicating that expression increased primarily in activated microglia and macrophages. |
2010-03-15 |
2023-08-12 |
mouse |
| I Szaingurten-Solodkin, N Hadad, R Lev. Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia. Glia. vol 57. issue 16. 2010-01-05. PMID:19455582. |
the results of the present study show that activation of microglia by 5 microm aggregated abeta(1-42) (as evident by the amoeboid morphology and increased cd68 immunofluorescence reactivity) caused an immediate activation of cpla(2)alpha, measured by its phosphorylated form and its specific activity, followed by a gradual elevation of its expression and activity during 24 h. inhibition of cpla(2)alpha expression and activity by the presence of 1 microm specific antisense resulted in a significant decrease in nadph oxidase activity that releases superoxides, pge(2) formation, inos expression, and no production, indicating a major role for cpla(2)alpha in the regulation of these inflammatory processes. |
2010-01-05 |
2023-08-12 |
rat |
| Saurav Brahmachari, Arundhati Jana, Kalipada Paha. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 9. 2009-12-09. PMID:19812204. |
nab, but not sodium formate, was found to inhibit lps-induced expression of inducible no synthase (inos), proinflammatory cytokines (tnf-alpha and il-1beta) and surface markers (cd11b, cd11c, and cd68) in mouse microglia. |
2009-12-09 |
2023-08-12 |
mouse |
| Dariusz Adamek, Edyta Radwańska, Mariusz Gajd. Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. Folia neuropathologica. vol 47. issue 3. 2009-11-17. PMID:19813143. |
we found expression of rcas1 co-localizing with gfap+ cells of gliomas and with cd68 and cd74 in large macrophages infiltrating metastatic and primary tumours and sometimes in cells which had morphological characteristics of microglia. |
2009-11-17 |
2023-08-12 |
Not clear |