| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariela Chertoff, Kalpana Shrivastava, Berta Gonzalez, Laia Acarin, Lydia Giménez-Llor. Differential modulation of TREM2 protein during postnatal brain development in mice. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977213. |
additionally, the phenotypes of the trem2+ microglia also differ; expressing cd16/32, mhcii and cd86 (antigen presentation markers) and cd68 (phagocytic marker) in different regions as well as with different intensity till p7. |
2014-04-08 |
2023-08-12 |
mouse |
| Isabelle Arnoux, Maki Hoshiko, Léo Mandavy, Elena Avignone, Nobuhiko Yamamoto, Etienne Audina. Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex. Glia. vol 61. issue 10. 2014-03-27. PMID:23893820. |
we show that between p5 and p7 microglial cells acquire a more ramified morphology with a smaller soma, they express classical markers of microglia (iba1, cd11b, and cd68) but never markers of activation (mac-2 and mhcii) and rarely the proliferation marker ki67. |
2014-03-27 |
2023-08-12 |
mouse |
| G D'Alessandro, M Catalano, M Sciaccaluga, G Chece, R Cipriani, M Rosito, A Grimaldi, C Lauro, G Cantore, A Santoro, B Fioretti, F Franciolini, H Wulff, C Limatol. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell death & disease. vol 4. 2014-03-12. PMID:23949222. |
as kca3.1 channels are also expressed on microglia, we investigated the effects of tram-34 on microglia activation in gl-15 transplanted mice and found a reduction of cd68 staining in treated mice. |
2014-03-12 |
2023-08-12 |
mouse |
| David J Loane, Alok Kumar, Bogdan A Stoica, Rainier Cabatbat, Alan I Fade. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. Journal of neuropathology and experimental neurology. vol 73. issue 1. 2014-02-24. PMID:24335533. |
notably, highly activated microglia that expressed major histocompatibility complex class ii (cr3/43), cd68, and nadph oxidase (nox2) were detected at the margins of the expanding lesion at 1 year after injury; biochemical markers of neuroinflammation and oxidative stress were significantly elevated at this time point. |
2014-02-24 |
2023-08-12 |
mouse |
| Emiliano Trias, Pablo Díaz-Amarilla, Silvia Olivera-Bravo, Eugenia Isasi, Derek A Drechsel, Nathan Lopez, C Samuel Bradford, Kyle E Ireton, Joseph S Beckman, Luis Barbeit. Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS. Frontiers in cellular neuroscience. vol 7. 2014-01-08. PMID:24399933. |
cultures of spinal cord prepared from symptomatic sod1 (g93a) rats yielded large numbers of microglia expressing iba1, cd11b, and cd68. |
2014-01-08 |
2023-08-12 |
rat |
| Johannes Elsas, Bernd Sellhaus, Marietta Herrmann, Anne Kinkeldey, Joachim Weis, Willi Jahnen-Dechent, Martin Häusle. Fetuin-a in the developing brain. Developmental neurobiology. vol 73. issue 5. 2013-10-21. PMID:23109215. |
double immunofluorescence studies revealed colocalization with neun (mature neurons), beta iii tubulin (immature neurons), gfap (astrocytes), and cd68 (activated microglia). |
2013-10-21 |
2023-08-12 |
mouse |
| Y Tanaka, T Matsuwaki, K Yamanouchi, M Nishihar. Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice. Neuroscience. vol 231. 2013-07-25. PMID:23201826. |
to investigate the role of pgrn in inflammatory responses related to activated microglia, we compared the immunoreactivity and expression of ionized calcium-binding adaptor molecule 1 (iba1), cd68, and cd11b as markers for activated microglia between wild-type (wt) and grn-deficient (ko) mice. |
2013-07-25 |
2023-08-12 |
mouse |
| Yuliya Borre, Volkan Sir, Sander de Kivit, Koen G Westphal, Berend Olivier, Ronald S Oostin. Minocycline restores spatial but not fear memory in olfactory bulbectomized rats. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23051675. |
here we show that the onset of these cognitive changes parallel in time with signs of microglia activation (increased mrna levels of il-1β and cd68) in hippocampus. |
2013-05-02 |
2023-08-12 |
rat |
| Jessica L Teeling, Roxana O Carare, Martin J Glennie, V Hugh Perr. Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction. Acta neuropathologica. vol 124. issue 4. 2013-04-15. PMID:22618994. |
we show that immune complexes formed in the brain parenchyma generate a robust and long-lasting inflammatory response, characterized by increased expression of the microglia markers cd11b, cd68 and fcrii/iii, but no neutrophil recruitment. |
2013-04-15 |
2023-08-12 |
mouse |
| Debbie A E Hendrickx, Nathalie Koning, Karianne G Schuurman, Miriam E van Strien, Corbert G van Eden, Jörg Hamann, Inge Huiting. Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis. Journal of neuropathology and experimental neurology. vol 72. issue 2. 2013-03-11. PMID:23334594. |
by immunohistochemistry, cd68, cxcl16, and sr-ai/ii were expressed by foamy macrophages in the rim and by ramified microglia around chronic active ms lesions. |
2013-03-11 |
2023-08-12 |
human |
| Debbie A E Hendrickx, Nathalie Koning, Karianne G Schuurman, Miriam E van Strien, Corbert G van Eden, Jörg Hamann, Inge Huiting. Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis. Journal of neuropathology and experimental neurology. vol 72. issue 2. 2013-03-11. PMID:23334594. |
these data suggest that srs are involved in myelin uptake in ms, and that upregulation of cd68, cxcl16, and sr-ai/ii is one of the initial events in microglia as they initiate myelin phagocytosis. |
2013-03-11 |
2023-08-12 |
human |
| Minghuan Wang, Jeffrey J Iliff, Yonghong Liao, Michael J Chen, Matthew S Shinseki, Arun Venkataraman, Jessica Cheung, Wei Wang, Maiken Nedergaar. Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238711. |
microinfarcts were spread throughout the deep cortex, subcortical tissue, and hippocampus and were comprised of a core positive for cd68 (a marker for reactive microglia and macrophages), surrounded by large regions of glial fibrillary acidic protein-positive reactive astrogliosis. |
2013-02-27 |
2023-08-12 |
mouse |
| Adam D Hart, Andreas Wyttenbach, V Hugh Perry, Jessica L Teelin. Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences. Brain, behavior, and immunity. vol 26. issue 5. 2012-10-19. PMID:22155499. |
we detected significant regional, age dependent differences in microglial phenotypes, with the microglia of white matter and caudal areas of the cns exhibiting greater upregulation of cd11b, cd68, cd11c, f4/80 and fcγri than grey matter and rostral cns areas. |
2012-10-19 |
2023-08-12 |
mouse |
| Takafumi Sakakibara, Sayuri Sukigara, Takashi Saito, Taisuke Otsuki, Akio Takahashi, Yuu Kaneko, Takanobu Kaido, Yuko Saito, Noriko Sato, Yukio Kimura, Eiji Nakagawa, Kenji Sugai, Masayuki Sasaki, Yu-Ichi Goto, Masayuki Ito. Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression. Journal of neuropathology and experimental neurology. vol 71. issue 8. 2012-10-03. PMID:22805777. |
all neuronal cells expressed the mature neuron marker map2/2b but not the microglia markers iba-1 and cd68. |
2012-10-03 |
2023-08-12 |
Not clear |
| Holly R Chinnery, Samuel McLenachan, Nicolette Binz, Yan Sun, John V Forrester, Mariapia A Degli-Esposti, Eric Pearlman, Paul G McMenami. TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation. The American journal of pathology. vol 180. issue 1. 2012-02-17. PMID:22085974. |
fluorescein isothiocyanate-cpg-odn rapidly penetrated the cornea and ocular media to reach the retina, where it was present within cd68(+) retinal macrophages and microglia. |
2012-02-17 |
2023-08-12 |
mouse |
| Rea Pihlaja, Jari Koistinaho, Riitta Kauppinen, Jouko Sandholm, Heikki Tanila, Milla Koistinah. Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes. Glia. vol 59. issue 11. 2012-01-06. PMID:21826742. |
concomitant to aβ reduction, both cd68 and cd45 immunoreactivities were significantly upregulated but phagocytic microglia were often surrounding and engulfing aβ burdened, tunel-positive astrocytes rather than co-localizing with aβ alone. |
2012-01-06 |
2023-08-12 |
mouse |
| Yoshihiro Seki, Satoshi O Suzuki, Kenta Masui, Shiori Harada, Seiji Nakamura, Shigenobu Kanba, Toru Iwak. A simple and high-yield method for preparation of rat microglial cultures utilizing Aclar plastic film. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21092060. |
the smk cells exhibited markers specific for the microglia lineage, including iba-1, cd11b, cd45, cd68, major histocompatibility complex (mhc) class i and mhc class ii, but not for the astrocyte-specific markers, gfap and glutamate aspartate transporter. |
2011-09-22 |
2023-08-12 |
rat |
| Cibelle Mariano, Sandra Leitão Silva, Pedro Pereira, Adelaide Fernandes, Dora Brites, Maria A Brit. Evidence of tricellulin expression by immune cells, particularly microglia. Biochemical and biophysical research communications. vol 409. issue 4. 2011-09-02. PMID:21624353. |
cultured rat microglia exhibited a notorious tricellulin staining, consistent with an extensive expression of the protein along the cell, which was not absolutely coincident with the lysosomal marker cd68. |
2011-09-02 |
2023-08-12 |
human |
| Jon Dang, Bhimashankar Mitkari, Markus Kipp, Cordian Beye. Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats. Brain, behavior, and immunity. vol 25. issue 4. 2011-08-29. PMID:21277368. |
iba1, cd68 and cd3, were significantly reduced in the penumbra after hormone treatment suggesting attenuation of microglia and lymphocyte attraction. |
2011-08-29 |
2023-08-12 |
rat |
| Emily C Brantley, Lixia Guo, Chenyu Zhang, Qingtang Lin, Kenji Yokoi, Robert R Langley, Ewa Kruzel, Marva Maya, Seung Wook Kim, Sun-Jin Kim, Dominic Fan, Isaiah J Fidle. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Translational oncology. vol 3. issue 6. 2011-07-14. PMID:21151477. |
experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (gfp(+)) and gfp(-) mice revealed that these microglia are derived from circulating monocytes (gfp(+), f4/80(+), and cd68(+)). |
2011-07-14 |
2023-08-12 |
mouse |