| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuel Rodriguez, Lydia Alvarez-Erviti, Francisco J Blesa, Maria C Rodríguez-Oroz, Ainhoa Arina, Ignacio Melero, Luís Isaac Ramos, Jose A Obes. Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease. Neurobiology of disease. vol 28. issue 3. 2008-02-29. PMID:17897835. |
under these conditions, most bmdcs differentiated into microglia (cd68 expression was observed in 50% of gfp cells 60 days after mptp administration). |
2008-02-29 |
2023-08-12 |
mouse |
| Karma V Moser, Christian Humpe. Primary rat monocytes migrate through a BCEC-monolayer and express microglia-markers at the basolateral side. Brain research bulletin. vol 74. issue 5. 2008-01-09. PMID:17845908. |
monocytes and as a control primary microglia were immunohistochemically stained with markers for cd68 (clone ed-1), cd11b (clone ox-42) or cd11c (clone 8a2). |
2008-01-09 |
2023-08-12 |
rat |
| Hiroaki Matsumoto, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Masachika Shudou, Chisato Ii, Hisaaki Takahashi, Yoshinori Imai, Junya Tanak. Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265469. |
antibodies to cd11b, cd68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. |
2007-07-18 |
2023-08-12 |
rat |
| Hiroaki Matsumoto, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Masachika Shudou, Chisato Ii, Hisaaki Takahashi, Yoshinori Imai, Junya Tanak. Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265469. |
note that the traditional microglial markers isolectin b4, cd11b, and cd68 are not specific for microglia, particularly in a pathologic brain. |
2007-07-18 |
2023-08-12 |
rat |
| Milena Damjanac, Agnès Rioux Bilan, Laurence Barrier, Raymond Pontcharraud, Cantereau Anne, Jacques Hugon, Guylène Pag. Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17125750. |
in this study, we analyzed the staining of fluoro-jade b alone or combined with specific markers for detection of glial fibrillary acidic protein (gfap) or activated cd68 microglia in the double app(sl)/ps1 ki transgenic mice of alzheimer's disease (ad), which display a massive neuronal loss in the ca1 region of the hippocampus. |
2007-03-27 |
2023-08-12 |
mouse |
| Derrick F MacFabe, Donald P Cain, Karina Rodriguez-Capote, Andrew E Franklin, Jennifer E Hoffman, Francis Boon, A Roy Taylor, Martin Kavaliers, Klaus-Peter Ossenkop. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:16950524. |
neurohistological examinations of hippocampus and adjacent white matter (external capsule) of ppa treated rats revealed increased reactive astrogliosis (gfap immunoreactivity) and activated microglia (cd68 immunoreactivity) suggestive of a neuroinflammatory process. |
2007-03-01 |
2023-08-12 |
human |
| Ching-Liang Hsieh, Chin-Yi Cheng, Tung-Hu Tsai, I-hsin Lin, Chung-Hsiang Liu, Su-Yin Chiang, Jaung-Geng Lin, Chih-Jui Lao, Nou-Ying Tan. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. Journal of ethnopharmacology. vol 106. issue 2. 2006-11-29. PMID:16458462. |
ed1 (mouse anti rat cd68) and interleukin-1beta (il-1beta) immunostaining in the cerebral infarction region were also investigated for activation of microglia. |
2006-11-29 |
2023-08-12 |
mouse |
| Zun-Ji Ke, William M Bowen, Gary E Gibso. Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16781017. |
in wild type mice, td caused hypertrophy of cd68 positive microglia without increasing the number of microglia. |
2006-10-18 |
2023-08-12 |
mouse |
| Saraid S Billiards, Robin L Haynes, Rebecca D Folkerth, Felicia L Trachtenberg, Lena G Liu, Joseph J Volpe, Hannah C Kinne. Development of microglia in the cerebral white matter of the human fetus and infant. The Journal of comparative neurology. vol 497. issue 2. 2006-09-14. PMID:16705680. |
quantitative analysis with cd68 showed increased density of activated microglia in the cerebral white matter of the fetus (<37 pc weeks) relative to the neonate/infant (> or =37 pc weeks) and to the overlying cortex of either age group (p = 0.01). |
2006-09-14 |
2023-08-12 |
human |
| William L Maxwell, Mary Anne MacKinnon, Douglas H Smith, Tracy K McIntosh, David I Graha. Thalamic nuclei after human blunt head injury. Journal of neuropathology and experimental neurology. vol 65. issue 5. 2006-07-26. PMID:16772871. |
neurons, astrocytes, macrophages, and activated microglia were differentiated by luxol fast blue/cresyl violet, gfap, cd68, and cr3/43 staining and stereological techniques used to estimate cell number in a 28-microm-thick coronal section. |
2006-07-26 |
2023-08-12 |
human |
| Sheila Ignacio, Dan H Moore, Andrew P Smith, Nancy M Le. Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179515. |
treatment of the animals with baicalein, an herbal extract with anti-inflammatory and numerous other effects, downregulated the microglia markers cd68, cd80, and cd86, all of which were upregulated in untreated mutant animals. |
2006-06-06 |
2023-08-12 |
mouse |
| Mariella Caffo, Gerardo Caruso, Antonino Germanò, Salvatore Galatioto, Francesco Meli, Francesco Tomasell. CD68 and CR3/43 immunohistochemical expression in secretory meningiomas. Neurosurgery. vol 57. issue 3. 2006-05-31. PMID:16145535. |
the objective of this study was to analyze the expression of cd68, a macrophage marker specific for resting microglia, and the expression of major histocompatibility complex class ii cr3/43 in sms. |
2006-05-31 |
2023-08-12 |
Not clear |
| Yasutaka Tajima, Kazumasa Sudoh, Akihisa Matsumot. [A case of adult onset subacute sclerosing panencephalitis; sequential clinico-radiological findings over two years]. Rinsho shinkeigaku = Clinical neurology. vol 45. issue 9. 2005-11-14. PMID:16248401. |
as for immunohistochemical findings, cd68 positive cells were frequently observed, and this result implied the activation of microglia. |
2005-11-14 |
2023-08-12 |
Not clear |
| Atsushi Nagai, Seiji Mishima, Yuri Ishida, Hiroto Ishikura, Takayuki Harada, Shotai Kobayashi, Seung U Ki. Immortalized human microglial cell line: phenotypic expression. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15957187. |
this immortalized microglia hmo6 cell line exhibits cell-type-specific antigens for microglia, including cd11b (mac-1), cd68, cd86 (b7-2), hla-abc, hla-dr, and rca-1 lectin, and actively phagocytoses latex beads. |
2005-11-07 |
2023-08-12 |
human |
| Tracy L Hagemann, Stephen A Gaeta, Mark A Smith, Delinda A Johnson, Jeffrey A Johnson, Albee Messin. Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. Human molecular genetics. vol 14. issue 16. 2005-10-20. PMID:16014634. |
these transcripts are further elevated with age, with additional induction of macrophage-specific markers such as mac1 and cd68, suggesting activation of microglia. |
2005-10-20 |
2023-08-12 |
mouse |
| Payam Rezaie, Vanessa Corbisiero, David Mal. Transient expression of MIDC-8 in the normal mouse brain. Neuroscience letters. vol 377. issue 3. 2005-05-04. PMID:15755524. |
in this study, we have immunohistochemically characterized the expression of mononuclear phagocyte markers cd14, cd36, cd68, cd204 and marco by parenchymal microglia in the developing and adult mouse brain. |
2005-05-04 |
2023-08-12 |
mouse |
| Ian Galea, Karine Palin, Tracey A Newman, Nico Van Rooijen, V Hugh Perry, Delphine Boch. Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia. vol 49. issue 3. 2005-03-01. PMID:15538754. |
in particular, activated microglia and invading hematogenous leukocytes were mannose receptor negative while expressing the f4/80 antigen, macrosialin (cd68), fcrii (cd32), scavenger receptor (cd204), and cr3 (cd11b/cd18). |
2005-03-01 |
2023-08-12 |
mouse |
| David J Rademacher, Christopher S Kearn, Erica J Carrier, Sachin Patel, Maria A Delgado, Andrew Barkmeier, David E Klick, Nicole M Breese, Sandra L Pfister, Kasem Nithipatikom, William B Campbell, Cecilia J Hillar. Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. Journal of neuroimmunology. vol 149. issue 1-2. 2004-05-10. PMID:15020073. |
like primary neonatal microglia, these cells (named rtmgl1) exhibit a ramified morphology, bind isolectin b4, express cd68 and are weakly positive for cd11b and mhc class ii. |
2004-05-10 |
2023-08-12 |
rat |
| Payam Rezaie, Jürgen Bohl, Norbert Ulfi. Anomalous alterations affecting microglia in the central nervous system of a fetus at 12 weeks of gestation: case report. Acta neuropathologica. vol 107. issue 2. 2004-04-05. PMID:14634758. |
by contrast, sections stained immunohistochemically to detect mhc class ii (cr3/43) and cd68 (pg-m1) antigens revealed a marked pathological change in the morphology and density of microglia within the cns. |
2004-04-05 |
2023-08-12 |
human |
| Anton B Tonchev, Tetsumori Yamashima, Liang Zhao, Hideyuki Okan. Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys. Glia. vol 42. issue 3. 2003-06-10. PMID:12673828. |
the ischemic insult significantly increased the number of proliferating cells in the hippocampus and temporal neocortex, where the majority brdu-labeled cells expressed markers for microglia (iba1, cd68, and ham56) or astrocytes (s-100beta and glial fibrillary acidic protein [gfap]). |
2003-06-10 |
2023-08-12 |
monkey |