| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsushi Nagai, Seiji Mishima, Yuri Ishida, Hiroto Ishikura, Takayuki Harada, Shotai Kobayashi, Seung U Ki. Immortalized human microglial cell line: phenotypic expression. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15957187. |
this immortalized microglia hmo6 cell line exhibits cell-type-specific antigens for microglia, including cd11b (mac-1), cd68, cd86 (b7-2), hla-abc, hla-dr, and rca-1 lectin, and actively phagocytoses latex beads. |
2005-11-07 |
2023-08-12 |
human |
| Tracy L Hagemann, Stephen A Gaeta, Mark A Smith, Delinda A Johnson, Jeffrey A Johnson, Albee Messin. Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. Human molecular genetics. vol 14. issue 16. 2005-10-20. PMID:16014634. |
these transcripts are further elevated with age, with additional induction of macrophage-specific markers such as mac1 and cd68, suggesting activation of microglia. |
2005-10-20 |
2023-08-12 |
mouse |
| Payam Rezaie, Vanessa Corbisiero, David Mal. Transient expression of MIDC-8 in the normal mouse brain. Neuroscience letters. vol 377. issue 3. 2005-05-04. PMID:15755524. |
in this study, we have immunohistochemically characterized the expression of mononuclear phagocyte markers cd14, cd36, cd68, cd204 and marco by parenchymal microglia in the developing and adult mouse brain. |
2005-05-04 |
2023-08-12 |
mouse |
| Ian Galea, Karine Palin, Tracey A Newman, Nico Van Rooijen, V Hugh Perry, Delphine Boch. Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia. vol 49. issue 3. 2005-03-01. PMID:15538754. |
in particular, activated microglia and invading hematogenous leukocytes were mannose receptor negative while expressing the f4/80 antigen, macrosialin (cd68), fcrii (cd32), scavenger receptor (cd204), and cr3 (cd11b/cd18). |
2005-03-01 |
2023-08-12 |
mouse |
| David J Rademacher, Christopher S Kearn, Erica J Carrier, Sachin Patel, Maria A Delgado, Andrew Barkmeier, David E Klick, Nicole M Breese, Sandra L Pfister, Kasem Nithipatikom, William B Campbell, Cecilia J Hillar. Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. Journal of neuroimmunology. vol 149. issue 1-2. 2004-05-10. PMID:15020073. |
like primary neonatal microglia, these cells (named rtmgl1) exhibit a ramified morphology, bind isolectin b4, express cd68 and are weakly positive for cd11b and mhc class ii. |
2004-05-10 |
2023-08-12 |
rat |
| Payam Rezaie, Jürgen Bohl, Norbert Ulfi. Anomalous alterations affecting microglia in the central nervous system of a fetus at 12 weeks of gestation: case report. Acta neuropathologica. vol 107. issue 2. 2004-04-05. PMID:14634758. |
by contrast, sections stained immunohistochemically to detect mhc class ii (cr3/43) and cd68 (pg-m1) antigens revealed a marked pathological change in the morphology and density of microglia within the cns. |
2004-04-05 |
2023-08-12 |
human |
| Anton B Tonchev, Tetsumori Yamashima, Liang Zhao, Hideyuki Okan. Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys. Glia. vol 42. issue 3. 2003-06-10. PMID:12673828. |
the ischemic insult significantly increased the number of proliferating cells in the hippocampus and temporal neocortex, where the majority brdu-labeled cells expressed markers for microglia (iba1, cd68, and ham56) or astrocytes (s-100beta and glial fibrillary acidic protein [gfap]). |
2003-06-10 |
2023-08-12 |
monkey |
| G Trillo-Pazos, A Diamanturos, L Rislove, T Menza, W Chao, P Belem, S Sadiq, S Morgello, L Sharer, D J Volsk. Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744468. |
sections from frontal cortex and basal ganglia were stained by immunohistochemistry for cd68 (microglia), gfap (astrocytes), map2 (neurons), and p24 (hiv-1 positive cells) and different cell types were microdissected by lcm. |
2003-06-04 |
2023-08-12 |
Not clear |
| Manfred Oehmichen, Till Walter, Christoph Meissner, Hans-Jürgen Friedric. Time course of cortical hemorrhages after closed traumatic brain injury: statistical analysis of posttraumatic histomorphological alterations. Journal of neurotrauma. vol 20. issue 1. 2003-04-18. PMID:12614591. |
following routine staining and immunohistochemical staining of microglia (cd68), astrocytes (gfap) and injured axons (beta-app), paraffin sections were examined by light microscopy for the presence of the selected histomorphological features. |
2003-04-18 |
2023-08-12 |
Not clear |
| Teresa Wierzba-Bobrowicz, Elzbieta Gwiazda, Elzbieta Kosno-Kruszewska, Eliza Lewandowska, Waldemar Lechowicz, Ewa Bertrand, Grazyna M Szpak, Bogna Schmidt-Sido. Morphological analysis of active microglia--rod and ramified microglia in human brains affected by some neurological diseases (SSPE, Alzheimer's disease and Wilson's disease). Folia neuropathologica. vol 40. issue 3. 2003-03-07. PMID:12572918. |
both morphological forms of activated microglia reacted to antibodies: hla ii, cd68, ham56 and lectin rca-1. |
2003-03-07 |
2023-08-12 |
human |
| Ling Chen, Peizeng Yang, Aize Kijlstr. Distribution, markers, and functions of retinal microglia. Ocular immunology and inflammation. vol 10. issue 1. 2003-02-04. PMID:12461701. |
in the human retina, microglia express mhc class i, mhc class ii, cd45, cd68, and s22 markers. |
2003-02-04 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Mikio Shoji, Yasuo Harigaya, Takeshi Kawarabayashi, Masaki Ikeda, Makoto Naito, Etsuro Matsubara, Koji Abe, Yoichi Nakazat. Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Archiv : an international journal of pathology. vol 441. issue 4. 2003-01-23. PMID:12404061. |
immunohistochemically, plaque-accompanied microglia showed a slight enlargement of the cytoplasm with consistent labeling of mac-1 and macrosialin (murine cd68), and with partial labeling of ia antigen and macrophage-colony stimulating factor receptor. |
2003-01-23 |
2023-08-12 |
mouse |
| Fabián Bernal, Francesc Graus, Alex Pifarré, Albert Saiz, Baya Benyahia, Teresa Ribalt. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta neuropathologica. vol 103. issue 5. 2002-06-21. PMID:11935268. |
to analyze inflammatory infiltrates, antibodies against lymphocyte subpopulations (cd3, cd20, cd4, cd8), macrophage and activated microglia (cd68), major histocompatibility complex (mhc) classes i and ii (hla-abc and hla-dr), and the intercellular adhesion molecules (icam) -1 and -3 were used. |
2002-06-21 |
2023-08-12 |
Not clear |
| C Fillebeen, M M Ruchoux, V Mitchell, S Vincent, M Benaïssa, A Pierc. Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731015. |
these cells were identified using immunocytochemistry as activated microglia since they exhibited macrophage markers such as the cd68 and the cr1 antigens. |
2002-02-14 |
2023-08-12 |
human |
| M C Zink, G D Coleman, J L Mankowski, R J Adams, P M Tarwater, K Fox, J E Clement. Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. The Journal of infectious diseases. vol 184. issue 8. 2001-12-07. PMID:11574916. |
macaques with increased mcp-1 in csf had significantly greater expression of markers of macrophage and microglia activation and infiltration (cd68; p= .003) and astrocyte activation (glial fibrillary acidic protein; p= .019 and p= .031 in white and gray matter, respectively). |
2001-12-07 |
2023-08-12 |
human |
| R Klein, W Roggendor. Increased microglia proliferation separates pilocytic astrocytomas from diffuse astrocytomas: a double labeling study. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307624. |
we investigated the proliferative activity of microglia in an immunohistochemical double-labeling study of pilocytic astrocytomas and astrocytomas who grade ii-iv using the antibodies mib-1 (ki67) as proliferation-marker and ki-m1p (cd68) as microglia marker. |
2001-08-30 |
2023-08-12 |
Not clear |
| M Mittelbronn, K Dietz, H J Schluesener, R Meyerman. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307625. |
cd68, mhc-ii and aif-1 showed the highest densities with significant regional differences ranging from 0.5% to 16.6% of all cells in the brain parenchyma with significantly more microglia in white than in gray matter. |
2001-08-30 |
2023-08-12 |
human |
| M Mittelbronn, K Dietz, H J Schluesener, R Meyerman. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307625. |
we conclude that cd68, mhc-ii and aif-1 define the main microglial cell population, whereas lcf and lca are expressed by a subpopulation of microglial cells. |
2001-08-30 |
2023-08-12 |
human |
| L Yuan, A H Neufel. Activated microglia in the human glaucomatous optic nerve head. Journal of neuroscience research. vol 64. issue 5. 2001-07-26. PMID:11391707. |
in normal onhs, there are rarely microglia containing tgf-beta1, nos-2, tsp, timp-2, and cd68, but, in glaucomatous tissue, a few microglia are positive from the prelaminar to the postlaminar regions. |
2001-07-26 |
2023-08-12 |
human |
| A B Schmitt, A Buss, S Breuer, G A Brook, K Pech, D Martin, J Schoenen, J Noth, S Love, J M Schröder, G W Kreutzberg, W Nacimient. Major histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response. Acta neuropathologica. vol 100. issue 5. 2001-02-01. PMID:11045675. |
it is likely that the subsequent expression of cd68 on mhc ii-positive microglia reflects the conversion to a macrophage phenotype, when cells are phagocytosing degenerating presynaptic terminals in grey matter target regions at early survival times and removing axonal and myelin debris in descending tracts at later survival times. |
2001-02-01 |
2023-08-12 |
human |