| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah C Hellewell, Edwin B Yan, Doreen A Agyapomaa, Nicole Bye, M Cristina Morganti-Kossman. Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822466. |
extensive microglia/macrophage accumulation detected with the cd68 antibody was maximal at 14 days post-injury in the corpus callosum (macrophages 157.5 ± 55.48; microglia 72.71 ± 20.75), and coincided with regions of axonal damage. |
2011-03-03 |
2023-08-12 |
rat |
| Dominik Michalski, Jens Grosche, Johann Pelz, Dietmar Schneider, Christopher Weise, Ute Bauer, Johannes Kacza, Ulrich Gärtner, Carsten Hobohm, Wolfgang Härti. A novel quantification of blood-brain barrier damage and histochemical typing after embolic stroke in rats. Brain research. vol 1359. 2011-01-25. PMID:20732314. |
the following markers were identified for sufficient detection of nvu components: rat endothelial cell antigen-1 (reca) and laminin for vessels, lycopersicon esculentum and griffonia simplicifolia agglutinin for vessels and microglial subpopulations, ionized calcium binding adaptor molecule 1 (iba1), cd68 and cd11b for macrophages, activated microglia, monocytes and neutrophils, s100β for astroglia, as well as neun and huc/d for neurons. |
2011-01-25 |
2023-08-12 |
human |
| Mélanie Lalancette-Hébert, Alexandre Moquin, Angela O Choi, Jasna Kriz, Dusica Maysinge. Lipopolysaccharide-QD micelles induce marked induction of TLR2 and lipid droplet accumulation in olfactory bulb microglia. Molecular pharmaceutics. vol 7. issue 4. 2010-11-24. PMID:20459083. |
the increased tlr2 expression was complemented with enhanced cd68 expression in activated microglia in the same regions. |
2010-11-24 |
2023-08-12 |
mouse |
| Vanesa Sanchez-Guajardo, Fabia Febbraro, Deniz Kirik, Marina Romero-Ramo. Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098715. |
microglia activation was assessed by stereological quantification of mac1+ cells, as well as the expression patterns of cd68 and mch ii. |
2010-05-20 |
2023-08-12 |
human |
| Vanesa Sanchez-Guajardo, Fabia Febbraro, Deniz Kirik, Marina Romero-Ramo. Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098715. |
on the other hand, when alpha-syn induced both neuronal pathology and cell death, there was a delayed increase in microglia cell numbers, which correlated with long-lasting cd68 expression and a morphology reminiscent of peripheral macrophages. |
2010-05-20 |
2023-08-12 |
human |
| Bin Li, Karen Bedard, Silvia Sorce, Boris Hinz, Michel Dubois-Dauphin, Karl-Heinz Kraus. NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression. Journal of innate immunity. vol 1. issue 6. 2010-05-11. PMID:20375612. |
hmc3 cells are typical microglia, as suggested by the constitutive expression of iba-1 and cd14, and ifn-gamma-induced expression of cd11b, cd68 and mhcii. |
2010-05-11 |
2023-08-12 |
human |
| Derek A Wainwright, Junping Xin, Nichole A Mesnard, Virginia M Sanders, Kathryn J Jone. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neuroscience letters. vol 471. issue 1. 2010-04-05. PMID:20056129. |
after facial nerve axotomy, tlr2 mrna was significantly upregulated in the facial motor nucleus and co-immunofluorescence localized tlr2 to cd68(+) microglia, but not gfap(+) astrocytes. |
2010-04-05 |
2023-08-12 |
mouse |
| Ana Clara Cristóvão, Ana Saavedra, Carla Pais Fonseca, Filipa Campos, Emília Pedrosa Duarte, Graça Baltaza. Microglia of rat ventral midbrain recovers its resting state over time in vitro: let microglia rest before work. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19739250. |
after 13 div, this tendency was reversed, with cultures showing higher number of ramified cells and fewer cd68(+) cells along with lower phagocytic and ros production capability, suggesting that microglia must be kept in vitro for at least 13 days to recover its resting state. |
2010-03-30 |
2023-08-12 |
rat |
| Ana M Santos, David Martín-Oliva, Rosa M Ferrer-Martín, Mohamed Tassi, Ruth Calvente, Ana Sierra, Maria-Carmen Carrasco, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial response to light-induced photoreceptor degeneration in the mouse retina. The Journal of comparative neurology. vol 518. issue 4. 2010-03-23. PMID:20020538. |
differences were also observed at 10 days after light exposure: cd11b, cd45, and f4/80 continued to be strongly expressed in retinal microglia, whereas the expression of cd68 and sra had decreased to near-normal values. |
2010-03-23 |
2023-08-12 |
mouse |
| Swati B Naphade, Kristina A Kigerl, Lyn B Jakeman, Sandra K Kostyk, Phillip G Popovich, Jeff Kure. Progranulin expression is upregulated after spinal contusion in mice. Acta neuropathologica. vol 119. issue 1. 2010-03-15. PMID:19946692. |
progranulin immunoreactivity colocalized with myeloid cell markers cd11b and cd68, indicating that expression increased primarily in activated microglia and macrophages. |
2010-03-15 |
2023-08-12 |
mouse |
| I Szaingurten-Solodkin, N Hadad, R Lev. Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia. Glia. vol 57. issue 16. 2010-01-05. PMID:19455582. |
the results of the present study show that activation of microglia by 5 microm aggregated abeta(1-42) (as evident by the amoeboid morphology and increased cd68 immunofluorescence reactivity) caused an immediate activation of cpla(2)alpha, measured by its phosphorylated form and its specific activity, followed by a gradual elevation of its expression and activity during 24 h. inhibition of cpla(2)alpha expression and activity by the presence of 1 microm specific antisense resulted in a significant decrease in nadph oxidase activity that releases superoxides, pge(2) formation, inos expression, and no production, indicating a major role for cpla(2)alpha in the regulation of these inflammatory processes. |
2010-01-05 |
2023-08-12 |
rat |
| Saurav Brahmachari, Arundhati Jana, Kalipada Paha. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 9. 2009-12-09. PMID:19812204. |
nab, but not sodium formate, was found to inhibit lps-induced expression of inducible no synthase (inos), proinflammatory cytokines (tnf-alpha and il-1beta) and surface markers (cd11b, cd11c, and cd68) in mouse microglia. |
2009-12-09 |
2023-08-12 |
mouse |
| Dariusz Adamek, Edyta Radwańska, Mariusz Gajd. Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. Folia neuropathologica. vol 47. issue 3. 2009-11-17. PMID:19813143. |
we found expression of rcas1 co-localizing with gfap+ cells of gliomas and with cd68 and cd74 in large macrophages infiltrating metastatic and primary tumours and sometimes in cells which had morphological characteristics of microglia. |
2009-11-17 |
2023-08-12 |
Not clear |
| P J Clark, W J Brzezinska, M W Thomas, N A Ryzhenko, S A Toshkov, J S Rhode. Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience. vol 155. issue 4. 2009-02-06. PMID:18664375. |
minimal changes in microglia associated with inflammation (using immunohistochemical detection of cd68) were detected at the time of behavioral testing. |
2009-02-06 |
2023-08-12 |
mouse |
| Jun-ichi Satoh, Shinya Obayashi, Tamako Misawa, Hiroko Tabunoki, Takashi Yamamura, Kunimasa Arima, Hidehiko Konn. Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 28. issue 6. 2009-01-28. PMID:18410276. |
pathologically, cd68(+) macrophages and microglia expressed intense immunoreactivities for ifi30 and cd163 in nmo lesions, consisting of inflammatory demyelination, axonal loss, necrosis, cavity formation, and vascular fibrosis. |
2009-01-28 |
2023-08-12 |
Not clear |
| Malabendu Jana, Carlos A Palencia, Kalipada Paha. Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 10. 2008-12-12. PMID:18981147. |
fibrillar abeta1-42 peptides induced the expression of inducible no synthase, proinflammatory cytokines (tnf-alpha, il-1beta, and il-6), and integrin markers (cd11b, cd11c, and cd68) in mouse primary microglia and bv-2 microglial cells. |
2008-12-12 |
2023-08-12 |
mouse |
| Rebecca D Folkerth, Felicia L Trachtenberg, Robin L Hayne. Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia. Journal of neuropathology and experimental neurology. vol 67. issue 7. 2008-09-19. PMID:18596545. |
glial fibrillary acidic protein and cd68 scores for reactive astrocytes and microglia, respectively, were not significantly increased, suggesting a minimal inflammatory response. |
2008-09-19 |
2023-08-12 |
Not clear |
| Z Zhang, Z-Y Zhang, U Fauser, H J Schluesene. Mechanical allodynia and spinal up-regulation of P2X4 receptor in experimental autoimmune neuritis rats. Neuroscience. vol 152. issue 2. 2008-07-10. PMID:18276080. |
double staining revealed that almost all p2x(4)r(+) cells co-expressed cd68, a marker for reactive microglia, but not the astrocyte marker, glial fibrillary acidic protein (gfap). |
2008-07-10 |
2023-08-12 |
rat |
| Marcel Maier, Ying Peng, Liying Jiang, Timothy J Seabrook, Michael C Carroll, Cynthia A Lemer. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 25. 2008-07-10. PMID:18562603. |
in contrast, at 17 months of age, app;c3(-/-) mice showed significant changes of up to twofold increased total abeta and fibrillar amyloid plaque burden in midfrontal cortex and hippocampus, which correlated with (1) significantly increased tris-buffered saline (tbs)-insoluble abeta(42) levels and reduced tbs-soluble abeta(42) and abeta(40) levels in brain homogenates, (2) a trend for increased abeta levels in the plasma, (3) a significant loss of neuronal-specific nuclear protein-positive neurons in the hippocampus, and (4) differential activation of microglia toward a more alternative phenotype (e.g., significantly increased cd45-positive microglia, increased brain levels of interleukins 4 and 10, and reduced levels of cd68, f4/80, inducible nitric oxide synthase, and tumor necrosis factor). |
2008-07-10 |
2023-08-12 |
mouse |
| Melissa Cosenza-Nashat, Meng-Liang Zhao, Heather D Marshall, Qiusheng Si, Susan Morgello, Sunhee C Le. Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation. Journal of neurovirology. vol 13. issue 6. 2008-03-28. PMID:18097885. |
furthermore, staining for cd45rb (as opposed to cd68) facilitated the identification of ki67+ microglia, indicating that cd68 could underestimate proliferating microglia. |
2008-03-28 |
2023-08-12 |
human |