| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Clark, W J Brzezinska, M W Thomas, N A Ryzhenko, S A Toshkov, J S Rhode. Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience. vol 155. issue 4. 2009-02-06. PMID:18664375. |
minimal changes in microglia associated with inflammation (using immunohistochemical detection of cd68) were detected at the time of behavioral testing. |
2009-02-06 |
2023-08-12 |
mouse |
| Jun-ichi Satoh, Shinya Obayashi, Tamako Misawa, Hiroko Tabunoki, Takashi Yamamura, Kunimasa Arima, Hidehiko Konn. Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 28. issue 6. 2009-01-28. PMID:18410276. |
pathologically, cd68(+) macrophages and microglia expressed intense immunoreactivities for ifi30 and cd163 in nmo lesions, consisting of inflammatory demyelination, axonal loss, necrosis, cavity formation, and vascular fibrosis. |
2009-01-28 |
2023-08-12 |
Not clear |
| Malabendu Jana, Carlos A Palencia, Kalipada Paha. Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 10. 2008-12-12. PMID:18981147. |
fibrillar abeta1-42 peptides induced the expression of inducible no synthase, proinflammatory cytokines (tnf-alpha, il-1beta, and il-6), and integrin markers (cd11b, cd11c, and cd68) in mouse primary microglia and bv-2 microglial cells. |
2008-12-12 |
2023-08-12 |
mouse |
| Rebecca D Folkerth, Felicia L Trachtenberg, Robin L Hayne. Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia. Journal of neuropathology and experimental neurology. vol 67. issue 7. 2008-09-19. PMID:18596545. |
glial fibrillary acidic protein and cd68 scores for reactive astrocytes and microglia, respectively, were not significantly increased, suggesting a minimal inflammatory response. |
2008-09-19 |
2023-08-12 |
Not clear |
| Z Zhang, Z-Y Zhang, U Fauser, H J Schluesene. Mechanical allodynia and spinal up-regulation of P2X4 receptor in experimental autoimmune neuritis rats. Neuroscience. vol 152. issue 2. 2008-07-10. PMID:18276080. |
double staining revealed that almost all p2x(4)r(+) cells co-expressed cd68, a marker for reactive microglia, but not the astrocyte marker, glial fibrillary acidic protein (gfap). |
2008-07-10 |
2023-08-12 |
rat |
| Marcel Maier, Ying Peng, Liying Jiang, Timothy J Seabrook, Michael C Carroll, Cynthia A Lemer. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 25. 2008-07-10. PMID:18562603. |
in contrast, at 17 months of age, app;c3(-/-) mice showed significant changes of up to twofold increased total abeta and fibrillar amyloid plaque burden in midfrontal cortex and hippocampus, which correlated with (1) significantly increased tris-buffered saline (tbs)-insoluble abeta(42) levels and reduced tbs-soluble abeta(42) and abeta(40) levels in brain homogenates, (2) a trend for increased abeta levels in the plasma, (3) a significant loss of neuronal-specific nuclear protein-positive neurons in the hippocampus, and (4) differential activation of microglia toward a more alternative phenotype (e.g., significantly increased cd45-positive microglia, increased brain levels of interleukins 4 and 10, and reduced levels of cd68, f4/80, inducible nitric oxide synthase, and tumor necrosis factor). |
2008-07-10 |
2023-08-12 |
mouse |
| Melissa Cosenza-Nashat, Meng-Liang Zhao, Heather D Marshall, Qiusheng Si, Susan Morgello, Sunhee C Le. Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation. Journal of neurovirology. vol 13. issue 6. 2008-03-28. PMID:18097885. |
furthermore, staining for cd45rb (as opposed to cd68) facilitated the identification of ki67+ microglia, indicating that cd68 could underestimate proliferating microglia. |
2008-03-28 |
2023-08-12 |
human |
| Manuel Rodriguez, Lydia Alvarez-Erviti, Francisco J Blesa, Maria C Rodríguez-Oroz, Ainhoa Arina, Ignacio Melero, Luís Isaac Ramos, Jose A Obes. Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease. Neurobiology of disease. vol 28. issue 3. 2008-02-29. PMID:17897835. |
under these conditions, most bmdcs differentiated into microglia (cd68 expression was observed in 50% of gfp cells 60 days after mptp administration). |
2008-02-29 |
2023-08-12 |
mouse |
| Karma V Moser, Christian Humpe. Primary rat monocytes migrate through a BCEC-monolayer and express microglia-markers at the basolateral side. Brain research bulletin. vol 74. issue 5. 2008-01-09. PMID:17845908. |
monocytes and as a control primary microglia were immunohistochemically stained with markers for cd68 (clone ed-1), cd11b (clone ox-42) or cd11c (clone 8a2). |
2008-01-09 |
2023-08-12 |
rat |
| Hiroaki Matsumoto, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Masachika Shudou, Chisato Ii, Hisaaki Takahashi, Yoshinori Imai, Junya Tanak. Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265469. |
antibodies to cd11b, cd68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. |
2007-07-18 |
2023-08-12 |
rat |
| Hiroaki Matsumoto, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Masachika Shudou, Chisato Ii, Hisaaki Takahashi, Yoshinori Imai, Junya Tanak. Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265469. |
note that the traditional microglial markers isolectin b4, cd11b, and cd68 are not specific for microglia, particularly in a pathologic brain. |
2007-07-18 |
2023-08-12 |
rat |
| Milena Damjanac, Agnès Rioux Bilan, Laurence Barrier, Raymond Pontcharraud, Cantereau Anne, Jacques Hugon, Guylène Pag. Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17125750. |
in this study, we analyzed the staining of fluoro-jade b alone or combined with specific markers for detection of glial fibrillary acidic protein (gfap) or activated cd68 microglia in the double app(sl)/ps1 ki transgenic mice of alzheimer's disease (ad), which display a massive neuronal loss in the ca1 region of the hippocampus. |
2007-03-27 |
2023-08-12 |
mouse |
| Derrick F MacFabe, Donald P Cain, Karina Rodriguez-Capote, Andrew E Franklin, Jennifer E Hoffman, Francis Boon, A Roy Taylor, Martin Kavaliers, Klaus-Peter Ossenkop. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:16950524. |
neurohistological examinations of hippocampus and adjacent white matter (external capsule) of ppa treated rats revealed increased reactive astrogliosis (gfap immunoreactivity) and activated microglia (cd68 immunoreactivity) suggestive of a neuroinflammatory process. |
2007-03-01 |
2023-08-12 |
human |
| Ching-Liang Hsieh, Chin-Yi Cheng, Tung-Hu Tsai, I-hsin Lin, Chung-Hsiang Liu, Su-Yin Chiang, Jaung-Geng Lin, Chih-Jui Lao, Nou-Ying Tan. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. Journal of ethnopharmacology. vol 106. issue 2. 2006-11-29. PMID:16458462. |
ed1 (mouse anti rat cd68) and interleukin-1beta (il-1beta) immunostaining in the cerebral infarction region were also investigated for activation of microglia. |
2006-11-29 |
2023-08-12 |
mouse |
| Zun-Ji Ke, William M Bowen, Gary E Gibso. Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16781017. |
in wild type mice, td caused hypertrophy of cd68 positive microglia without increasing the number of microglia. |
2006-10-18 |
2023-08-12 |
mouse |
| Saraid S Billiards, Robin L Haynes, Rebecca D Folkerth, Felicia L Trachtenberg, Lena G Liu, Joseph J Volpe, Hannah C Kinne. Development of microglia in the cerebral white matter of the human fetus and infant. The Journal of comparative neurology. vol 497. issue 2. 2006-09-14. PMID:16705680. |
quantitative analysis with cd68 showed increased density of activated microglia in the cerebral white matter of the fetus (<37 pc weeks) relative to the neonate/infant (> or =37 pc weeks) and to the overlying cortex of either age group (p = 0.01). |
2006-09-14 |
2023-08-12 |
human |
| William L Maxwell, Mary Anne MacKinnon, Douglas H Smith, Tracy K McIntosh, David I Graha. Thalamic nuclei after human blunt head injury. Journal of neuropathology and experimental neurology. vol 65. issue 5. 2006-07-26. PMID:16772871. |
neurons, astrocytes, macrophages, and activated microglia were differentiated by luxol fast blue/cresyl violet, gfap, cd68, and cr3/43 staining and stereological techniques used to estimate cell number in a 28-microm-thick coronal section. |
2006-07-26 |
2023-08-12 |
human |
| Sheila Ignacio, Dan H Moore, Andrew P Smith, Nancy M Le. Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179515. |
treatment of the animals with baicalein, an herbal extract with anti-inflammatory and numerous other effects, downregulated the microglia markers cd68, cd80, and cd86, all of which were upregulated in untreated mutant animals. |
2006-06-06 |
2023-08-12 |
mouse |
| Mariella Caffo, Gerardo Caruso, Antonino Germanò, Salvatore Galatioto, Francesco Meli, Francesco Tomasell. CD68 and CR3/43 immunohistochemical expression in secretory meningiomas. Neurosurgery. vol 57. issue 3. 2006-05-31. PMID:16145535. |
the objective of this study was to analyze the expression of cd68, a macrophage marker specific for resting microglia, and the expression of major histocompatibility complex class ii cr3/43 in sms. |
2006-05-31 |
2023-08-12 |
Not clear |
| Yasutaka Tajima, Kazumasa Sudoh, Akihisa Matsumot. [A case of adult onset subacute sclerosing panencephalitis; sequential clinico-radiological findings over two years]. Rinsho shinkeigaku = Clinical neurology. vol 45. issue 9. 2005-11-14. PMID:16248401. |
as for immunohistochemical findings, cd68 positive cells were frequently observed, and this result implied the activation of microglia. |
2005-11-14 |
2023-08-12 |
Not clear |