| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabián Bernal, Francesc Graus, Alex Pifarré, Albert Saiz, Baya Benyahia, Teresa Ribalt. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta neuropathologica. vol 103. issue 5. 2002-06-21. PMID:11935268. |
to analyze inflammatory infiltrates, antibodies against lymphocyte subpopulations (cd3, cd20, cd4, cd8), macrophage and activated microglia (cd68), major histocompatibility complex (mhc) classes i and ii (hla-abc and hla-dr), and the intercellular adhesion molecules (icam) -1 and -3 were used. |
2002-06-21 |
2023-08-12 |
Not clear |
| C Fillebeen, M M Ruchoux, V Mitchell, S Vincent, M Benaïssa, A Pierc. Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731015. |
these cells were identified using immunocytochemistry as activated microglia since they exhibited macrophage markers such as the cd68 and the cr1 antigens. |
2002-02-14 |
2023-08-12 |
human |
| M C Zink, G D Coleman, J L Mankowski, R J Adams, P M Tarwater, K Fox, J E Clement. Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. The Journal of infectious diseases. vol 184. issue 8. 2001-12-07. PMID:11574916. |
macaques with increased mcp-1 in csf had significantly greater expression of markers of macrophage and microglia activation and infiltration (cd68; p= .003) and astrocyte activation (glial fibrillary acidic protein; p= .019 and p= .031 in white and gray matter, respectively). |
2001-12-07 |
2023-08-12 |
human |
| R Klein, W Roggendor. Increased microglia proliferation separates pilocytic astrocytomas from diffuse astrocytomas: a double labeling study. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307624. |
we investigated the proliferative activity of microglia in an immunohistochemical double-labeling study of pilocytic astrocytomas and astrocytomas who grade ii-iv using the antibodies mib-1 (ki67) as proliferation-marker and ki-m1p (cd68) as microglia marker. |
2001-08-30 |
2023-08-12 |
Not clear |
| M Mittelbronn, K Dietz, H J Schluesener, R Meyerman. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307625. |
cd68, mhc-ii and aif-1 showed the highest densities with significant regional differences ranging from 0.5% to 16.6% of all cells in the brain parenchyma with significantly more microglia in white than in gray matter. |
2001-08-30 |
2023-08-12 |
human |
| M Mittelbronn, K Dietz, H J Schluesener, R Meyerman. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta neuropathologica. vol 101. issue 3. 2001-08-30. PMID:11307625. |
we conclude that cd68, mhc-ii and aif-1 define the main microglial cell population, whereas lcf and lca are expressed by a subpopulation of microglial cells. |
2001-08-30 |
2023-08-12 |
human |
| L Yuan, A H Neufel. Activated microglia in the human glaucomatous optic nerve head. Journal of neuroscience research. vol 64. issue 5. 2001-07-26. PMID:11391707. |
in normal onhs, there are rarely microglia containing tgf-beta1, nos-2, tsp, timp-2, and cd68, but, in glaucomatous tissue, a few microglia are positive from the prelaminar to the postlaminar regions. |
2001-07-26 |
2023-08-12 |
human |
| A B Schmitt, A Buss, S Breuer, G A Brook, K Pech, D Martin, J Schoenen, J Noth, S Love, J M Schröder, G W Kreutzberg, W Nacimient. Major histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response. Acta neuropathologica. vol 100. issue 5. 2001-02-01. PMID:11045675. |
it is likely that the subsequent expression of cd68 on mhc ii-positive microglia reflects the conversion to a macrophage phenotype, when cells are phagocytosing degenerating presynaptic terminals in grey matter target regions at early survival times and removing axonal and myelin debris in descending tracts at later survival times. |
2001-02-01 |
2023-08-12 |
human |
| M Oehmichen, I Theuerkauf, C Meissne. Is traumatic axonal injury (AI) associated with an early microglial activation? Application of a double-labeling technique for simultaneous detection of microglia and AI. Acta neuropathologica. vol 97. issue 5. 2000-02-01. PMID:10334486. |
in 40 selected cases of confirmed ai, the topographical relation of ai and microglial reaction was assessed using an immunohistochemical double-labeling technique for simultaneous demonstration of ai using beta-amyloid precursor protein (beta-app) antibody and of microglia using cd68 antibody. |
2000-02-01 |
2023-08-12 |
Not clear |
| P Rezaie, K Patel, D K Mal. Microglia in the human fetal spinal cord--patterns of distribution, morphology and phenotype. Brain research. Developmental brain research. vol 115. issue 1. 1999-08-03. PMID:10366704. |
human fetal microglia display heterogeneity in phenotype and are more readily identified by cd68 in the spinal cord. |
1999-08-03 |
2023-08-12 |
human |
| W F Reynolds, J Rhees, D Maciejewski, T Paladino, H Sieburg, R A Maki, E Maslia. Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease. Experimental neurology. vol 155. issue 1. 1999-03-18. PMID:9918702. |
microglia costaining for mpo and cd68 are closely associated with plaques, suggesting that plaque components induce mpo expression in microglia. |
1999-03-18 |
2023-08-12 |
Not clear |
| A V Andjelkovic, B Nikolic, J S Pachter, N Zecevi. Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838024. |
), using lectins, ricinus communis agglutinin-1 [rca-1], and lycopersicon esculentum, tomato lectin (tl), which recognize macrophages and microglia, and antibodies for the macrophage antigen cd68. |
1999-03-16 |
2023-08-12 |
human |
| A V Andjelkovic, B Nikolic, J S Pachter, N Zecevi. Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838024. |
our finding that one class of cells can be labeled early only with lectins, while another can be labeled with both lectins and cd68 macrophage antibody, may reflect a different origin of microglia in the early embryonic cns compared to the fetal stages. |
1999-03-16 |
2023-08-12 |
human |
| M L Zhao, J S Liu, D He, D W Dickson, S C Le. Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain. Brain research. vol 813. issue 2. 1999-01-05. PMID:9838203. |
cell types were determined by morphology as well as immunocytochemistry for gfap (astrocytes) and cd68 (microglia). |
1999-01-05 |
2023-08-12 |
human |
| A B Schmitt, G A Brook, A Buss, W Nacimiento, J Noth, G W Kreutzber. Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen. Neuropathology and applied neurobiology. vol 24. issue 3. 1998-11-06. PMID:9717181. |
in the white matter, the removal of degenerating axons by phagocytosing microglia expressing hla-dr and cd68 antigens is a slower process which occurs over a period of months. |
1998-11-06 |
2023-08-12 |
Not clear |
| L F Lue, L Brachova, D G Walker, J Roger. Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients. Neurobiology of aging. vol 17. issue 3. 1996-12-03. PMID:8725904. |
cultured microglia phagocytosed latex beads, were reactive for dil-acetylated low density lipoprotein, were immunoreactive for cd68 and major histocompatibility complex ii markers, and were not immunoreactive for fibroblast, astrocyte, or oligodendrocyte markers. |
1996-12-03 |
2023-08-12 |
human |
| M Oehmichen, C Meissner, A Reiter, M Birkhol. Neuropathology in non-human immunodeficiency virus-infected drug addicts: hypoxic brain damage after chronic intravenous drug abuse. Acta neuropathologica. vol 91. issue 6. 1996-12-03. PMID:8781664. |
by contrast, in nearly 80% of these cases, the hippocampus showed enhanced expression of glial fibrillary acid protein by astrocytes and/or a proliferation of microglia, demonstrated by cd68 expression. |
1996-12-03 |
2023-08-12 |
human |
| H Mühleisen, J Gehrmann, R Meyerman. Reactive microglia in Creutzfeldt-Jakob disease. Neuropathology and applied neurobiology. vol 21. issue 6. 1996-10-09. PMID:8745240. |
we have, therefore, examined six brains from cases of sporadic cjd by immunohistochemical labelling of grey and white matter microglia from frontal, parietal, temporal, and occipital lobes, striatum, thalamus, cerebellum and brain stem with rca-1, lca, cd68, hla-dr, and ham56. |
1996-10-09 |
2023-08-12 |
Not clear |
| S C Dollard, H J James, L R Sharer, L G Epstein, H A Gelbard, S Dewhurs. Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis. Neuropathology and applied neurobiology. vol 21. issue 6. 1996-10-09. PMID:8745241. |
double-labelling studies using antibodies to cd68, or rca-1 lectin, markers for cells of monocyte/macrophage lineage, revealed an increase in the number of microglia and macrophages with nuclear immunoreactivity for nf kappa b in association with hiv-1 encephalitis. |
1996-10-09 |
2023-08-12 |
human |
| C M Hulett. Microglioma, a histiocytic neoplasm of the central nervous system. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 9. issue 3. 1996-08-22. PMID:8685234. |
the neoplastic cells stained intensely with cd68 (kp1) and ricinus communis agglutinin-120 markers for microglia and also with ham-56, a marker for macrophages. |
1996-08-22 |
2023-08-12 |
Not clear |