| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhishek Umashankar, Mandi J Corenblum, Sneha Ray, Michel Valdez, Eriko S Yoshimaru, Theodore P Trouard, Lalitha Madhava. Effects of the iron oxide nanoparticle Molday ION Rhodamine B on the viability and regenerative function of neural stem cells: relevance to clinical translation. International journal of nanomedicine. vol 11. 2016-12-13. PMID:27175074. |
in particular, in animals receiving the 50 μg/ml mirb-labeled nscs, this immune response consisted of an increased number of cd68(+)-activated microglia, which appeared to have phagocytosed mirb particles and cells contributing to an exaggerated mri signal dropout in the animals. |
2016-12-13 |
2023-08-13 |
rat |
| Jun-ichi Satoh, Yoshihiro Kino, Naohiro Asahina, Mika Takitani, Junko Miyoshi, Tsuyoshi Ishida, Yuko Sait. TMEM119 marks a subset of microglia in the human brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 1. 2016-10-19. PMID:26250788. |
notably, tmem119 immunoreactivity was expressed exclusively on a subset of iba1(+) cd68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases, such as alzheimer's disease (ad), whereas iba1(+) cd68(+) infiltrating macrophages do not express tmem119 in demyelinating lesions of multiple sclerosis and necrotic lesions of cerebral infarction. |
2016-10-19 |
2023-08-13 |
human |
| Lihong Huang, Gang Li, Xiaofang Feng, Luojun Wan. 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. BioMed research international. vol 2015. 2016-10-17. PMID:26844229. |
interestingly, reduced neurological deficits, decreased tnf-α and il-1 expression, less apoptotic cells and cd68 positive staining, and alleviated infarct and cerebral edema volume were observed when 15d-pgj2 was intraperitoneally injected after reperfusion in diabetic ischemia group, suggesting its neuroprotective role in regulating microglia activation, which may have a therapeutic application in the future. |
2016-10-17 |
2023-08-13 |
rat |
| b' Savina Apolloni, Paola Fabbrizio, Chiara Parisi, Susanna Amadio, Cinzia Volont\\xc3\\xa. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25482048.' |
moreover, in vitro, clemastine is able to modify several activation parameters of sod1(g93a) microglia, and particularly cd68 and arginase-1 expression, as well as phospho-erk1/2 and nadph oxidase 2 levels. |
2016-10-07 |
2023-08-13 |
mouse |
| Imran Noorani, Gareth Petty, Paul L Grundy, Geoff Sharpe, Sandrine Willaime-Morawek, Scott Harris, Gareth J Thomas, James Ar Nicoll, Delphine Boch. Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation? The journal of pathology. Clinical research. vol 1. issue 2. 2016-08-08. PMID:27499894. |
we quantified immunostaining of human astrocytic tumour tissue microarrays (86 patients; world health organisation grade ii-iv) for microglia ionized calcium binding adaptor molecule 1 (iba1) and cd68, and stem cell nestin, sox2 and cd133. |
2016-08-08 |
2023-08-13 |
human |
| Sumit Sarkar, James Raymick, Balmiki Ray, Debomoy K Lahiri, Merle G Paule, Larry Schmue. Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice. Current Alzheimer research. vol 12. issue 9. 2016-08-04. PMID:26510980. |
similarly, cd68 labeling, which detects activated microglia, along with amylo-glo labeling, suggests that microglial activation is significantly less in tht-treated mice. |
2016-08-04 |
2023-08-13 |
mouse |
| Awilda M Rosario, Pedro E Cruz, Carolina Ceballos-Diaz, Michael R Strickland, Zoe Siemienski, Meghan Pardo, Keri-Lyn Schob, Andrew Li, George V Aslanidi, Arun Srivastava, Todd E Golde, Paramita Chakrabart. Microglia-specific targeting by novel capsid-modified AAV6 vectors. Molecular therapy. Methods & clinical development. vol 3. 2016-06-16. PMID:27308302. |
indeed, these newly characterized raav6 capsid variants, specially a triply mutated y731f/y705f/t492v form, carrying a self-complementary genome and microglia-specific promoters (f4/80 or cd68) could efficiently and selectively transduce microglia in vitro. |
2016-06-16 |
2023-08-13 |
mouse |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
we performed an unbiased plaque-centered quantification of smi312(+) dystrophic neurites, gfap(+) reactive astrocytes, and iba1(+) and cd68(+) activated microglia in randomly selected dense-core (thioflavin-s(+)) plaques from the temporal neocortex of 40 ad subjects with a symptom duration ranging from 4 to 20 years, and nine nondemented control subjects with dense-core plaques. |
2016-06-14 |
2023-08-13 |
human |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
dystrophic neurites (kendall τ = 0.34, p = 0.001), reactive astrocytes (kendall τ = 0.30, p = 0.003), and cd68(+) (kendall τ = 0.48, p < 0.0001), but not iba1 microglia (kendall τ = 0.045, p = 0.655), exhibited a significant positive correlation with symptom duration. |
2016-06-14 |
2023-08-13 |
human |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
when excluding control subjects, only the positive association between cd68(+) microglia and symptom duration remained significant (kendall τ = 0.39, p = 0.0003). |
2016-06-14 |
2023-08-13 |
human |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
second, we found a significant increase in cd68 immunostaining, which serve to identify activated microglia and also infiltrated peripheral macrophages, in these brain structures in response to lps insult, which was much more intense in cb2 receptor-deficient mice in the case of the substantia nigra. |
2016-05-31 |
2023-08-13 |
mouse |
| Ismini E Papageorgiou, Andrea Lewen, Lukas V Galow, Tiziana Cesetti, Jörg Scheffel, Tommy Regen, Uwe-Karsten Hanisch, Oliver Kan. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 1. 2016-05-13. PMID:26699475. |
we show that chronic activation with either bacterial lipopolysaccharide through toll-like receptor 4 (tlr4) or leukocyte cytokine ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, cd11b and cd68 up-regulation, and proinflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2016-05-13 |
2023-08-13 |
Not clear |
| Douglas G Walker, Lih-Fen Lu. Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimer's research & therapy. vol 7. issue 1. 2016-05-03. PMID:26286145. |
two other widely used markers to identify microglia in human brains are ionized calcium binding adaptor molecule-1 and cd68. |
2016-05-03 |
2023-08-13 |
human |
| Asif Manzoor Khan, Alicia A Babcock, Hamid Saeed, Christa Løth Myhre, Moustapha Kassem, Bente Finse. Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype. Neurobiology of aging. vol 36. issue 6. 2016-03-17. PMID:25892207. |
microglia in terc ko mice maintained a homogenous distribution and normal expression of cd45 and cd68 and the aging marker, ferritin, but were morphologically distinct from microglia in both adult and old wild-type mice. |
2016-03-17 |
2023-08-13 |
mouse |
| Alexandra Kaser-Eichberger, Falk Schroedl, Lara Bieler, Andrea Trost, Barbara Bogner, Christian Runge, Herbert Tempfer, Pia Zaunmair, Christina Kreutzer, Andreas Traweger, Herbert A Reitsamer, Sebastien Couillard-Despre. Expression of Lymphatic Markers in the Adult Rat Spinal Cord. Frontiers in cellular neuroscience. vol 10. 2016-02-23. PMID:26903808. |
further, double labeling experiments using cd68, another marker found in microglia and macrophages, also displayed co-localization in the iba1+ cells located at the spinal cord surface and those apposed to blood vessels. |
2016-02-23 |
2023-08-13 |
rat |
| Bo Zhang, Bing Wang, Shuhua Cao, Yongqiang Wan. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 6. 2015-11-11. PMID:26557015. |
importantly, cd68 mrna expression decreasing in the brain suggested that egcg inhibited microglia activation. |
2015-11-11 |
2023-08-13 |
rat |
| Seoyeon Bok, Taejun Wang, Chan-Ju Lee, Seong-Uk Jeon, Young-Eun Kim, Jeongwoo Kim, Beom-Ju Hong, Calvin Jinse Yoon, Sungjee Kim, Seung-Hoon Lee, Hak Jae Kim, Il Han Kim, Ki Hean Kim, G-One Ah. In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy. Biomedical optics express. vol 6. issue 9. 2015-09-29. PMID:26417502. |
intravenous injection of fluorescent antibodies allowed us to detect significantly elevated levels of iba-1 and cd68 positive activated microglia in the ipsilateral compared to the contralateral side of the infarct. |
2015-09-29 |
2023-08-13 |
mouse |
| Akihiro Matsumura, Syuuichirou Suzuki, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Hiromi Suzuki, Ayano Yamauchi, Kazuyuki Takata, Yoshihisa Kitamura, Shun Shimoham. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. Journal of Alzheimer's disease : JAD. vol 44. issue 2. 2015-09-21. PMID:25352454. |
temporal changes of cd68 and α7 nicotinic acetylcholine receptor expression in microglia in alzheimer's disease-like mouse models. |
2015-09-21 |
2023-08-13 |
mouse |
| Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Lin. P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts. Stem cells (Dayton, Ohio). vol 33. issue 2. 2015-09-16. PMID:25336287. |
while it is understood that cd68(+) microglia and astrocytes mediate phagocytosis during target-dependent pcd, little is known of the cell identity or the scavenger molecules used to remove apoptotic corpses during the earliest stages of human neurogenesis. |
2015-09-16 |
2023-08-13 |
human |
| Peter Filipcik, Martin Cente, Norbert Zilka, Tomas Smolek, Jozef Hanes, Juraj Kucerak, Alena Opattova, Branislav Kovacech, Michal Nova. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25772164. |
the topological dissociation of neuronally expressed pathological tau and the induction of astrocytic hsp27, gfap, and vimentin along with up-regulation of microglia specific markers such as cd18, cd68 and c3 point to cooperation of astrocytes, microglia and neurons in response to intra-neuronal accumulation of insoluble tau. |
2015-08-27 |
2023-08-13 |
rat |