| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
dystrophic neurites (kendall τ = 0.34, p = 0.001), reactive astrocytes (kendall τ = 0.30, p = 0.003), and cd68(+) (kendall τ = 0.48, p < 0.0001), but not iba1 microglia (kendall τ = 0.045, p = 0.655), exhibited a significant positive correlation with symptom duration. |
2016-06-14 |
2023-08-13 |
human |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
when excluding control subjects, only the positive association between cd68(+) microglia and symptom duration remained significant (kendall τ = 0.39, p = 0.0003). |
2016-06-14 |
2023-08-13 |
human |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
second, we found a significant increase in cd68 immunostaining, which serve to identify activated microglia and also infiltrated peripheral macrophages, in these brain structures in response to lps insult, which was much more intense in cb2 receptor-deficient mice in the case of the substantia nigra. |
2016-05-31 |
2023-08-13 |
mouse |
| Ismini E Papageorgiou, Andrea Lewen, Lukas V Galow, Tiziana Cesetti, Jörg Scheffel, Tommy Regen, Uwe-Karsten Hanisch, Oliver Kan. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 1. 2016-05-13. PMID:26699475. |
we show that chronic activation with either bacterial lipopolysaccharide through toll-like receptor 4 (tlr4) or leukocyte cytokine ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, cd11b and cd68 up-regulation, and proinflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2016-05-13 |
2023-08-13 |
Not clear |
| Douglas G Walker, Lih-Fen Lu. Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimer's research & therapy. vol 7. issue 1. 2016-05-03. PMID:26286145. |
two other widely used markers to identify microglia in human brains are ionized calcium binding adaptor molecule-1 and cd68. |
2016-05-03 |
2023-08-13 |
human |
| Asif Manzoor Khan, Alicia A Babcock, Hamid Saeed, Christa Løth Myhre, Moustapha Kassem, Bente Finse. Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype. Neurobiology of aging. vol 36. issue 6. 2016-03-17. PMID:25892207. |
microglia in terc ko mice maintained a homogenous distribution and normal expression of cd45 and cd68 and the aging marker, ferritin, but were morphologically distinct from microglia in both adult and old wild-type mice. |
2016-03-17 |
2023-08-13 |
mouse |
| Alexandra Kaser-Eichberger, Falk Schroedl, Lara Bieler, Andrea Trost, Barbara Bogner, Christian Runge, Herbert Tempfer, Pia Zaunmair, Christina Kreutzer, Andreas Traweger, Herbert A Reitsamer, Sebastien Couillard-Despre. Expression of Lymphatic Markers in the Adult Rat Spinal Cord. Frontiers in cellular neuroscience. vol 10. 2016-02-23. PMID:26903808. |
further, double labeling experiments using cd68, another marker found in microglia and macrophages, also displayed co-localization in the iba1+ cells located at the spinal cord surface and those apposed to blood vessels. |
2016-02-23 |
2023-08-13 |
rat |
| Bo Zhang, Bing Wang, Shuhua Cao, Yongqiang Wan. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 6. 2015-11-11. PMID:26557015. |
importantly, cd68 mrna expression decreasing in the brain suggested that egcg inhibited microglia activation. |
2015-11-11 |
2023-08-13 |
rat |
| Seoyeon Bok, Taejun Wang, Chan-Ju Lee, Seong-Uk Jeon, Young-Eun Kim, Jeongwoo Kim, Beom-Ju Hong, Calvin Jinse Yoon, Sungjee Kim, Seung-Hoon Lee, Hak Jae Kim, Il Han Kim, Ki Hean Kim, G-One Ah. In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy. Biomedical optics express. vol 6. issue 9. 2015-09-29. PMID:26417502. |
intravenous injection of fluorescent antibodies allowed us to detect significantly elevated levels of iba-1 and cd68 positive activated microglia in the ipsilateral compared to the contralateral side of the infarct. |
2015-09-29 |
2023-08-13 |
mouse |
| Akihiro Matsumura, Syuuichirou Suzuki, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Hiromi Suzuki, Ayano Yamauchi, Kazuyuki Takata, Yoshihisa Kitamura, Shun Shimoham. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. Journal of Alzheimer's disease : JAD. vol 44. issue 2. 2015-09-21. PMID:25352454. |
temporal changes of cd68 and α7 nicotinic acetylcholine receptor expression in microglia in alzheimer's disease-like mouse models. |
2015-09-21 |
2023-08-13 |
mouse |
| Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Lin. P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts. Stem cells (Dayton, Ohio). vol 33. issue 2. 2015-09-16. PMID:25336287. |
while it is understood that cd68(+) microglia and astrocytes mediate phagocytosis during target-dependent pcd, little is known of the cell identity or the scavenger molecules used to remove apoptotic corpses during the earliest stages of human neurogenesis. |
2015-09-16 |
2023-08-13 |
human |
| Peter Filipcik, Martin Cente, Norbert Zilka, Tomas Smolek, Jozef Hanes, Juraj Kucerak, Alena Opattova, Branislav Kovacech, Michal Nova. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25772164. |
the topological dissociation of neuronally expressed pathological tau and the induction of astrocytic hsp27, gfap, and vimentin along with up-regulation of microglia specific markers such as cd18, cd68 and c3 point to cooperation of astrocytes, microglia and neurons in response to intra-neuronal accumulation of insoluble tau. |
2015-08-27 |
2023-08-13 |
rat |
| David J Loane, Bogdan A Stoica, Flaubert Tchantchou, Alok Kumar, James P Barrett, Titilola Akintola, Fengtian Xue, P Jeffrey Conn, Alan I Fade. Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 4. 2015-07-06. PMID:25096154. |
vu0360172 significantly reduced cd68 and nox2 expression in activated microglia in the cortex at 28 days post-injury, and also suppressed pro-inflammatory signaling pathways in bv2 and primary microglia. |
2015-07-06 |
2023-08-13 |
mouse |
| Claire Paquet, Jay Amin, François Mouton-Liger, Mariam Nasser, Seth Love, Françoise Gray, Ruth M Pickering, James A R Nicoll, Clive Holmes, Jacques Hugon, Delphine Boch. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of pathology. vol 235. issue 5. 2015-05-07. PMID:25430817. |
in ad, associations of spongiosis status, curvature ratio and ppkr load with microglial markers iba1, cd68 and cd32 suggest a role for microglia in neurodegeneration. |
2015-05-07 |
2023-08-13 |
human |
| Claire Paquet, Jay Amin, François Mouton-Liger, Mariam Nasser, Seth Love, Françoise Gray, Ruth M Pickering, James A R Nicoll, Clive Holmes, Jacques Hugon, Delphine Boch. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of pathology. vol 235. issue 5. 2015-05-07. PMID:25430817. |
after immunization, correlations were detected between the number of neun-positive neurons and ppkr with iba1, cd68 and cd64, suggesting that microglia are involved in the neuronal loss. |
2015-05-07 |
2023-08-13 |
human |
| Hanan Dawood Yass. Age-related changes in the optic nerve of Sprague-Dawley rats: an ultrastructural and immunohistochemical study. Acta histochemica. vol 116. issue 6. 2015-04-20. PMID:24958340. |
cd68 immunohistochemical staining revealed age-related changes in the morphology, location and number of cd68 positive microglia cells. |
2015-04-20 |
2023-08-13 |
rat |
| Olena Y Glushakova, Danny Johnson, Ronald L Haye. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. Journal of neurotrauma. vol 31. issue 13. 2015-02-23. PMID:24564198. |
ihc revealed tbi-induced focal abnormalities including blood-brain barrier (bbb) damage (igg), endothelial damage (intercellular adhesion molecule 1 [icam-1]), activation of reactive microglia (ionized calcium binding adaptor molecule 1 [iba1]), gliosis (glial fibrillary acidic protein [gfap]) and macrophage-mediated inflammation (cluster of differentiation 68 [cd68]), all showing different temporal profiles. |
2015-02-23 |
2023-08-12 |
rat |
| Egle Cekanaviciute, Nancy Fathali, Kristian P Doyle, Aaron M Williams, Jullet Han, Marion S Buckwalte. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. vol 62. issue 8. 2015-02-04. PMID:24733756. |
the peri-infarct cortex of ast-tbr2dn mice contained over 60% more activated cd11b(+) monocytic cells and twice as much immunostaining for the activated microglia and macrophage marker cd68 than controls. |
2015-02-04 |
2023-08-13 |
mouse |
| Vikas Singh, Sumonto Mitra, Anuj Kumar Sharma, Ruchi Gera, Debabrata Ghos. Isolation and characterization of microglia from adult mouse brain: selected applications for ex vivo evaluation of immunotoxicological alterations following in vivo xenobiotic exposure. Chemical research in toxicology. vol 27. issue 5. 2015-01-05. PMID:24754514. |
purity of the isolated microglia was checked by immunostaining of microglial (cd11b and cd68) and nonmicroglial (gfap) markers. |
2015-01-05 |
2023-08-13 |
mouse |
| Marcus Boehme, Madlen Guenther, Anna Stahr, Marie Liebmann, Nadine Jaenisch, Otto W Witte, Christiane Frah. Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24796813. |
during hippocampal aging, the transcript expression of pro-inflammatory cytokines (tnfα, il-1α, il-1β), the chemokine mip-1α, and markers for activated astrocytes (gfap, lcn2, but not vim and serpina3n) and microglia (iba1, f4/80, cd68, cd86) significantly increased. |
2014-12-23 |
2023-08-13 |
mouse |