| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina Zoratti, Dijle Kipmen-Korgun, Karin Osibow, Roland Malli, Wolfgang F Graie. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. British journal of pharmacology. vol 140. issue 8. 2004-10-21. PMID:14645143. |
the endocannabinoid anandamide has been reported to affect neuronal cells, immune cells and smooth muscle cells via either cb1 or cb2 receptors. |
2004-10-21 |
2023-08-12 |
cattle |
| Emmanuel Contassot, Rick Wilmotte, Mirna Tenan, Marie-Claude Belkouch, Valérie Schnüriger, Nicolas de Tribolet, Karim Burkhardt, Pierre-Yves Dietrich, Karim Bourkhard. Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. Journal of neuropathology and experimental neurology. vol 63. issue 9. 2004-10-21. PMID:15453094. |
however, the clinical application of this drug is limited by possible undesirable side effects due to a broad expression of cannabinoid receptors (cb1 and cb2). |
2004-10-21 |
2023-08-12 |
human |
| Yoonkyung Do, Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294950. |
the precise role of cannabinoid receptors (cb)1 and cb2, as well as endogenous ligands for these receptors, on immune cells remains unclear. |
2004-09-28 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
cannabinoid antagonist sr-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving cb1 or cb2 receptors. |
2004-09-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
recent evidence indicates the existence of cannabinoid receptors distinct from cb1 or cb2 that are inhibited by sr-141716 but not by other cb1 antagonists such as am251. |
2004-09-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
we conclude that sr-141716 inhibits the acute hemodynamic effects of lps by interacting with a cardiac receptor distinct from cb1 or cb2 that mediates negative inotropy and may be activated by anandamide or a related endocannabinoid released during endotoxemia. |
2004-09-03 |
2023-08-12 |
mouse |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
dronabinol (delta 9-tetrahydocannabinol, thc), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the cb1 and the cb2 subtype of cannabinoid receptors. |
2004-08-03 |
2023-08-12 |
Not clear |
| Ester Frid. The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159678. |
endogenous cannabinoids (endocannabinoids) and their cannabinoid cb1 and cb2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. |
2004-08-03 |
2023-08-12 |
human |
| Marc Steffens, Thomas J Feuerstei. Receptor-independent depression of DA and 5-HT uptake by cannabinoids in rat neocortex--involvement of Na(+)/K(+)-ATPase. Neurochemistry international. vol 44. issue 7. 2004-07-28. PMID:15209421. |
the effect of win55212-2 was not mediated by cannabinoid receptors, since the cb1 receptor antagonist am251 failed to diminish uptake inhibition by win55212-2 and since the ki estimates of win55212-2 were outside the range of the dissociation constants of win55212-2 at both cb1 and cb2 receptors. |
2004-07-28 |
2023-08-12 |
rat |
| B Park, H M Gibbons, M D Mitchell, M Glas. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 10. 2004-07-15. PMID:14580383. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) plant and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2004-07-15 |
2023-08-12 |
human |
| Nazik Rayman, King H Lam, Jon D Laman, Peter J Simons, Bob Löwenberg, Pieter Sonneveld, Ruud Delwe. Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 4. 2004-06-15. PMID:14764676. |
using the human raji b cell line as a model, we demonstrate in a transwell assay that moderate migration occurs upon stimulation of the cb2 receptor with the endocannabinoid 2-arachidonoylglycerol, which is enhanced by cd40 costimulation. |
2004-06-15 |
2023-08-12 |
human |
| Sultan Ahmad, Andy Dra. Novel G protein-coupled receptors as pain targets. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 1. 2004-06-03. PMID:14983976. |
indeed, opioid and cannabinoid ligands are of established therapeutic value for pain management, and further exploitation of the specific gpcr subtypes (delta-opioid, cb1 and cb2) for these ligands may yield more selective, potent analgesics with favorable side effects. |
2004-06-03 |
2023-08-12 |
Not clear |
| Xiang Ni, Ellen B Geller, Michael J Eppihimer, Toby K Eisenstein, Martin W Adler, Ronald F Tum. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Multiple sclerosis (Houndmills, Basingstoke, England). vol 10. issue 2. 2004-06-03. PMID:15124761. |
furthermore, use of the selective antagonists for the cb1 receptor (sr 141716a) and the cb2 receptor (sr144528) in this study demonstrated that the cannabinoid's inhibitory effects on leukocyte/endothelial interactions can be mediated by activating cb2 receptor. |
2004-06-03 |
2023-08-12 |
mouse |
| Fong Ming Mo, László Offertáler, George Kuno. Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. European journal of pharmacology. vol 489. issue 1-2. 2004-05-26. PMID:15063151. |
atypical cannabinoid stimulates endothelial cell migration via a gi/go-coupled receptor distinct from cb1, cb2 or edg-1. |
2004-05-26 |
2023-08-12 |
human |
| Fong Ming Mo, László Offertáler, George Kuno. Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. European journal of pharmacology. vol 489. issue 1-2. 2004-05-26. PMID:15063151. |
this effect was antagonized by o-1918, by the pi3k inhibitor wortmannin, and by pertussis toxin, but not by the cannabinoid cb1 receptor antagonist am251 or the cannabinoid cb2 receptor antagonist sr144528. |
2004-05-26 |
2023-08-12 |
human |
| Fong Ming Mo, László Offertáler, George Kuno. Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. European journal of pharmacology. vol 489. issue 1-2. 2004-05-26. PMID:15063151. |
these results indicate that an abn-cbd-sensitive endothelial receptor distinct from cannabinoid cb1, cb2 or edg-1 receptors mediates not only vasorelaxation but also endothelial cell migration. |
2004-05-26 |
2023-08-12 |
human |
| Tiziano Croci, Marco Landi, Anne-Marie Galzin, Pietro Marin. Role of cannabinoid CB1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents. British journal of pharmacology. vol 140. issue 1. 2004-05-25. PMID:12967941. |
(1) we investigated the effect of the cannabinoid cb1 receptor antagonist, sr 141716, on indomethacin-induced small intestine inflammation and escherichia coli lipopolysaccharide (lps)-induced plasma tnf-alpha (tnf) release in comparison to the cannabinoid cb2 receptor antagonist, sr 144528, in rodents. |
2004-05-25 |
2023-08-12 |
mouse |
| C Robin Hiley, William R For. Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling. Biological reviews of the Cambridge Philosophical Society. vol 79. issue 1. 2004-05-19. PMID:15005177. |
cannabinoids act on specific, g-protein-coupled, receptors which are currently divided into two types, cb1 and cb2. |
2004-05-19 |
2023-08-12 |
human |
| Hema J Patel, Mark A Birrell, Natascia Crispino, David J Hele, Priya Venkatesan, Peter J Barnes, Magdi H Yacoub, Maria G Belvis. Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. British journal of pharmacology. vol 140. issue 2. 2004-05-07. PMID:12970104. |
inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (cb2) receptor activation. |
2004-05-07 |
2023-08-12 |
human |
| Hema J Patel, Mark A Birrell, Natascia Crispino, David J Hele, Priya Venkatesan, Peter J Barnes, Magdi H Yacoub, Maria G Belvis. Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. British journal of pharmacology. vol 140. issue 2. 2004-05-07. PMID:12970104. |
the non-selective cannabinoid (cb) receptor agonist, cp 55940, and the selective cb2 agonist, jwh 133 inhibited sensory nerve depolarisations of the guinea-pig vagus nerve induced by hypertonic saline, capsaicin and pge2. |
2004-05-07 |
2023-08-12 |
human |