| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl, Kay Brun. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Molecular pharmacology. vol 66. issue 6. 2005-03-24. PMID:15361550. |
apoptosis and cell death by r(+)-ma were not affected by antagonists of cannabinoid receptors (cb1, cb2) and vanilloid receptor 1. |
2005-03-24 |
2023-08-12 |
human |
| Xiang-Qun Xie, Jian-Zhong Che. NMR structural comparison of the cytoplasmic juxtamembrane domains of G-protein-coupled CB1 and CB2 receptors in membrane mimetic dodecylphosphocholine micelles. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15550382. |
efforts have been devoted to studying the juxtamembrane segment in order to understand the biological importance of the segment in g-protein activation of the cannabinoid cb1 and cb2 receptors. |
2005-03-22 |
2023-08-12 |
Not clear |
| Seishi Kishimoto, Yuriko Kobayashi, Saori Oka, Maiko Gokoh, Keizo Waku, Takayuki Sugiur. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. Journal of biochemistry. vol 135. issue 4. 2005-03-21. PMID:15115777. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2005-03-21 |
2023-08-12 |
human |
| Seishi Kishimoto, Yuriko Kobayashi, Saori Oka, Maiko Gokoh, Keizo Waku, Takayuki Sugiur. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. Journal of biochemistry. vol 135. issue 4. 2005-03-21. PMID:15115777. |
the effect of 2-arachidonoylglycerol was blocked by treatment of the cells with sr144528, a cannabinoid cb2 receptor antagonist, indicating that the effect of 2-arachidonoylglycerol is mediated through the cb2 receptor. |
2005-03-21 |
2023-08-12 |
human |
| B Sawicki, R L Zbucki, A Hryniewicz, P Kosiorek, I Bialuk, M M Winnicka, J Dada. Influence of cannabinoids on immunoreactivity of regulatory peptides, produced in rat thyroid C cells; preliminary investigations. Roczniki Akademii Medycznej w Bialymstoku (1995). vol 49 Suppl 1. 2005-03-15. PMID:15638402. |
mammalian tissues contain two types of cannabinoid receptors cb1 and cb2. |
2005-03-15 |
2023-08-12 |
rat |
| Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525273. |
cannabinoid cb2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. |
2005-03-04 |
2023-08-12 |
rat |
| Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525273. |
peripheral cannabinoid 2 receptors (cb2 receptors) modulate immune responses and attenuate nociceptive behaviour in models of acute and persistent pain. |
2005-03-04 |
2023-08-12 |
rat |
| Wen S Sheng, Shuxian Hu, Xinan Min, Guy A Cabral, James R Lokensgard, Phillip K Peterso. Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia. vol 49. issue 2. 2005-03-02. PMID:15390091. |
expression of the cannabinoid receptors cb1 and cb2 was detected on human astrocytes. |
2005-03-02 |
2023-08-12 |
human |
| Susanne Andrea Golech, Richard M McCarron, Ye Chen, Joliet Bembry, Frederick Lenz, Raphael Mechoulam, Esther Shohami, Maria Spat. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain research. Molecular brain research. vol 132. issue 1. 2005-03-02. PMID:15548432. |
many of the 2-ag-induced cellular responses (i.e., neuromodulation, cytoprotection and vasodilation) are mediated by cannabinoid receptors cb1 and cb2. |
2005-03-02 |
2023-08-12 |
human |
| Basalingappa L Hungund, Balapal S Basavarajapp. Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542757. |
the cdna and genomic sequences encoding g-protein-coupled cannabinoid receptors (cb1 and cb2) from several species have now been cloned. |
2005-02-18 |
2023-08-12 |
mouse |
| T U C Järbe, N V DiPatrizio, D Lu, A Makriyanni. (-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats. Behavioural pharmacology. vol 15. issue 7. 2005-02-17. PMID:15472574. |
the compound is cannabinoid cb1 receptor subtype selective (cb1 ki=6.86 nmol/l, cb2 ki=52.0 nmol/l). |
2005-02-17 |
2023-08-12 |
rat |
| Matthew J McFarland, Eric L Barke. Anandamide transport. Pharmacology & therapeutics. vol 104. issue 2. 2005-02-17. PMID:15518883. |
n-arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid cb1 and cb2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-thc), the active component of marijuana. |
2005-02-17 |
2023-08-12 |
Not clear |
| Angelo A Izz. Cannabinoids and intestinal motility: welcome to CB2 receptors. British journal of pharmacology. vol 142. issue 8. 2005-01-26. PMID:15277313. |
cannabinoids and intestinal motility: welcome to cb2 receptors. |
2005-01-26 |
2023-08-12 |
rat |
| Eric Jüttler, Ioana Potrovita, Victoria Tarabin, Simone Prinz, Tuan Dong-Si, George Fink, Markus Schwaninge. The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B). Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380375. |
this suggests that neither the antioxidant properties of cannabinoids nor binding to cb1 or cb2 receptors are responsible for the inhibition of nf-kappab activity and apoptosis. |
2005-01-18 |
2023-08-12 |
Not clear |
| A G Nackley, A M Zvonok, A Makriyannis, A G Hohman. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15317842. |
activation of cannabinoid cb2 receptors suppresses c-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. |
2004-12-30 |
2023-08-12 |
rat |
| A G Nackley, A M Zvonok, A Makriyannis, A G Hohman. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15317842. |
these data demonstrate that activation of cannabinoid cb2 receptors is sufficient to suppress neuronal activity at central levels of processing in the spinal dorsal horn. |
2004-12-30 |
2023-08-12 |
rat |
| Saori Oka, Shinobu Ikeda, Seishi Kishimoto, Maiko Gokoh, Shin Yanagimoto, Keizo Waku, Takayuki Sugiur. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. Journal of leukocyte biology. vol 76. issue 5. 2004-12-14. PMID:15316028. |
to date, two types of cannabinoid receptors have been identified: the cb1 receptor, abundantly expressed in the brain, and the cb2 receptor, expressed in various lymphoid tissues such as the spleen. |
2004-12-14 |
2023-08-12 |
human |
| Benjamin F Cravatt, Aron H Lichtma. The endogenous cannabinoid system and its role in nociceptive behavior. Journal of neurobiology. vol 61. issue 1. 2004-12-13. PMID:15362158. |
the endocannabinoid system includes: (1) at least two families of lipid signaling molecules, the n-acyl ethanolamines (e.g., anandamide) and the monoacylglycerols (e.g., 2-arachidonoyl glycerol); (2) multiple enzymes involved in the biosynthesis and degradation of these lipids, including the integral membrane enzyme fatty acid amide hydrolase; and (3) two g-protein coupled receptors, cb1 and cb2, which are primarily localized to the nervous system and immune system, respectively. |
2004-12-13 |
2023-08-12 |
Not clear |
| Siriporn Chuchawankul, Mika Shima, Nancy E Buckley, Constance B Hartmann, Kathleen L McCo. Role of cannabinoid receptors in inhibiting macrophage costimulatory activity. International immunopharmacology. vol 4. issue 2. 2004-12-02. PMID:14996418. |
hence, cb2 and possibly another receptor subtype may be involved in mediating cannabinoid suppression of macrophage costimulation. |
2004-12-02 |
2023-08-12 |
mouse |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
a cannabinoid cb2 receptor antagonist, [n-[(1s)-endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide] (sr 144528), reduced the inhibitory effect of win 55212-2, but not a cannabinoid cb1 antagonist, [n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamidehydrochloride] (sr 141716a). |
2004-12-02 |
2023-08-12 |
Not clear |