| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
in contrast, jwh-015 ((2-methyl-1-propyl-1h-indol-3-yl)-napthalen-1-yl-methanone) was 3- to 10-fold selective at the human cannabinoid cb2 receptor. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
cannabinoid cb2 receptor antagonist, am-630 ((6-iodo-2-methyl-1-(2-morpholin-4-yl-ethyl)-1h-indol-3-yl)-(4-methoxy-phenyl)-methanone) was more potent at the rat receptor in radioligand binding and functional assays than that of the human receptor. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
the findings of the pharmacological differences between the human and rat cannabinoid cb2 receptors in this study provide critical information for characterizing cannabinoid ligands in in vivo rodent models for drug discovery purpose. |
2005-05-16 |
2023-08-12 |
human |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
delta9-tetrahydrocannabinol (delta9-thc) and (-)-cannabidiol are major constituents of the cannabis sativa plant with different pharmacological profiles: (-)-delta9-tetrahydrocannabinol, but not (-)-cannabidiol, activates cannabinoid cb1 and cb2 receptors and induces psychoactive and peripheral effects. |
2005-05-06 |
2023-08-12 |
mouse |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
although all (+)-cannabidiols bind to cannabinoid cb1 and cb2 receptors, only (+)-7-oh-cannabidiol-dmh was centrally active, while all (+)-cannabidiol analogues completely arrested defecation. |
2005-05-06 |
2023-08-12 |
mouse |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
the effects of (+)-cannabidiol-dmh and (+)-7-oh-cannabidiol-dmh were partially antagonized by the cannabinoid cb1 receptor antagonist n-(piperidiny-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide (sr141716), but not by the cannabinoid cb2 receptor antagonist n-[-(1s)-endo-1,3,3-trimethil bicyclo [2.2.1] heptan-2-yl-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528), and had no effect on cb1(-/-) receptor knockout mice. |
2005-05-06 |
2023-08-12 |
mouse |
| Takayuki Sugiura, Saori Oka, Maiko Gokoh, Seishi Kishimoto, Keizo Wak. New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation. Journal of pharmacological sciences. vol 96. issue 4. 2005-04-28. PMID:15599096. |
to date, two types of cannabinoid receptors (cb1 and cb2) have been identified. |
2005-04-28 |
2023-08-12 |
mouse |
| Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 6. 2005-04-28. PMID:15749859. |
we demonstrated that the human breast cancer cell lines mcf-7 and mda-mb-231 and the mouse mammary carcinoma 4t1 express low to undetectable levels of cannabinoid receptors, cb1 and cb2, and that these cells are resistant to delta9-thc-induced cytotoxicity. |
2005-04-28 |
2023-08-12 |
mouse |
| S Filppula, S Yaddanapudi, R Mercier, W Xu, S Pavlopoulos, A Makriyanni. Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system. The journal of peptide research : official journal of the American Peptide Society. vol 64. issue 6. 2005-04-22. PMID:15613086. |
expressed protein encoded by a carboxy (c)-terminal his-tagged cb2 construct displayed a b(max) value of 9.3 pmol/mg with a k(d) of 7.30 nm using [3(h)]cp-55(940), a standard cannabinoid radioligand, and was selected for subsequent purification experiments. |
2005-04-22 |
2023-08-12 |
human |
| Sabine Steffens, Niels R Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Meliha Karsak, Andreas Zimmer, Jean-Louis Frossard, François Mac. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. vol 434. issue 7034. 2005-04-21. PMID:15815632. |
thus, thc or cannabinoids with activity at the cb2 receptor may be valuable targets for treating atherosclerosis. |
2005-04-21 |
2023-08-12 |
mouse |
| Sami Sarfaraz, Farrukh Afaq, Vaqar M Adhami, Hasan Mukhta. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer research. vol 65. issue 5. 2005-04-19. PMID:15753356. |
here we show that expression levels of both cannabinoid receptors, cb1 and cb2, are significantly higher in ca-human papillomavirus-10 (virally transformed cells derived from adenocarcinoma of human prostate tissue), and other human prostate cells lncap, dui45, pc3, and cwr22rnu1 than in human prostate epithelial and pz-hpv-7 (virally transformed cells derived from normal human prostate tissue) cells. |
2005-04-19 |
2023-08-12 |
human |
| Boris Julien, Pascale Grenard, Fatima Teixeira-Clerc, Jeanne Tran Van Nhieu, Liying Li, Meliha Karsak, Andreas Zimmer, Ariane Mallat, Sophie Lotersztaj. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. vol 128. issue 3. 2005-04-06. PMID:15765409. |
cannabinoids are the active components of marijuana and act via 2 g-protein-coupled receptors, cb1 and cb2. |
2005-04-06 |
2023-08-12 |
Not clear |
| Heidi M B Lesscher, Emily Hoogveld, J Peter H Burbach, Jan M van Ree, Mirjam A F M Gerrit. Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 1. 2005-03-29. PMID:15572271. |
the endogenous cannabinoid system is a relatively novel discovered system consisting of cannabinoid cb1 receptors, which are expressed both in the periphery and in the central nervous system, peripheral cannabinoid cb2 receptors and endogenous cannabinoids, which are anandamide and 2-arachidonyl glycerol. |
2005-03-29 |
2023-08-12 |
Not clear |
| Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl, Kay Brun. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Molecular pharmacology. vol 66. issue 6. 2005-03-24. PMID:15361550. |
apoptosis and cell death by r(+)-ma were not affected by antagonists of cannabinoid receptors (cb1, cb2) and vanilloid receptor 1. |
2005-03-24 |
2023-08-12 |
human |
| Xiang-Qun Xie, Jian-Zhong Che. NMR structural comparison of the cytoplasmic juxtamembrane domains of G-protein-coupled CB1 and CB2 receptors in membrane mimetic dodecylphosphocholine micelles. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15550382. |
efforts have been devoted to studying the juxtamembrane segment in order to understand the biological importance of the segment in g-protein activation of the cannabinoid cb1 and cb2 receptors. |
2005-03-22 |
2023-08-12 |
Not clear |
| Seishi Kishimoto, Yuriko Kobayashi, Saori Oka, Maiko Gokoh, Keizo Waku, Takayuki Sugiur. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. Journal of biochemistry. vol 135. issue 4. 2005-03-21. PMID:15115777. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2005-03-21 |
2023-08-12 |
human |
| Seishi Kishimoto, Yuriko Kobayashi, Saori Oka, Maiko Gokoh, Keizo Waku, Takayuki Sugiur. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. Journal of biochemistry. vol 135. issue 4. 2005-03-21. PMID:15115777. |
the effect of 2-arachidonoylglycerol was blocked by treatment of the cells with sr144528, a cannabinoid cb2 receptor antagonist, indicating that the effect of 2-arachidonoylglycerol is mediated through the cb2 receptor. |
2005-03-21 |
2023-08-12 |
human |
| B Sawicki, R L Zbucki, A Hryniewicz, P Kosiorek, I Bialuk, M M Winnicka, J Dada. Influence of cannabinoids on immunoreactivity of regulatory peptides, produced in rat thyroid C cells; preliminary investigations. Roczniki Akademii Medycznej w Bialymstoku (1995). vol 49 Suppl 1. 2005-03-15. PMID:15638402. |
mammalian tissues contain two types of cannabinoid receptors cb1 and cb2. |
2005-03-15 |
2023-08-12 |
rat |
| Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525273. |
cannabinoid cb2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. |
2005-03-04 |
2023-08-12 |
rat |
| Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525273. |
peripheral cannabinoid 2 receptors (cb2 receptors) modulate immune responses and attenuate nociceptive behaviour in models of acute and persistent pain. |
2005-03-04 |
2023-08-12 |
rat |