| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerie L Joers, Ila Bagheri, Jazmyn Coronado, Cecilia Hillard, Malu Gámez Tanse. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751274. |
cannabinoid type 2 receptors (cb2) are highly expressed in immune cells and upregulated in activated microglia under conditions of neurologic disease, such as ad. |
2025-01-03 |
2025-01-05 |
Not clear |
| Anderson Tadeu de Araújo-Ramos, Anderson Joel Martino-Andrad. Role of the Endocannabinoid System in Gonadal Development: Implications for Endocrine Disruption and Reproductive Toxicity. Reproductive toxicology (Elmsford, N.Y.). 2024-12-21. PMID:39709063. |
the ecs comprises lipid-derived ligands such as anandamide (aea) and 2-arachidonoylglycerol (2-ag), along with cannabinoid receptors cb1 and cb2, which are expressed in various gonadal cells. |
2024-12-21 |
2024-12-24 |
human |
| Bruno Musetti, Alejandra Kun, David Menchaca, Alejandra Rodríguez-Haralambides, Javier Varela, Leonor Thomson, Edward M Bahnso. Cannabis sativa extracts inhibit LDL oxidation and the formation of foam cells in vitro, acting as potential multi-step inhibitors of atherosclerosis development. PloS one. vol 19. issue 12. 2024-12-20. PMID:39705234. |
the effect of the cannabinoid extracts on the endocytic process was independent of the canonical cannabinoid receptors, cb1 and cb2, but related to the action of non-canonical receptors (trpv1, trpv4 and gpr55), involved in calcium signaling. |
2024-12-20 |
2024-12-23 |
Not clear |
| Dandan Liu, Mingyue Zhang, Xiaohai Xu, Xuelai Zhong, Chao Ma, Xiaoyu Zheng, Xiaohong Wu, Guonian Wan. Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain. European journal of medical research. vol 29. issue 1. 2024-12-19. PMID:39696656. |
while low-dose cannabinoid 2 (cb2) receptor agonists attenuate morphine tolerance in cancer pain models, chemokine ligand 12 (cxcl12)/chemokine receptor 4 (cxcr4) expression induces morphine tolerance. |
2024-12-19 |
2024-12-21 |
rat |
| Eun Ha Heo, Ravinder Abro. Thermodynamic role of receptor phosphorylation barcode in cannabinoid receptor desensitization. Biochemical and biophysical research communications. vol 743. 2024-12-18. PMID:39693934. |
the endocannabinoid signaling system is comprised of cb1 and cb2 g protein-coupled receptors (gpcrs). |
2024-12-18 |
2024-12-21 |
Not clear |
| Dinesh Thapa, Mohan Patil, Leon N Warne, Rodrigo Carlessi, Marco Falasc. Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations. Cells. vol 13. issue 23. 2024-12-17. PMID:39682761. |
specifically, cannabinoid 2 (cb2) receptors, which are upregulated during inflammation, have been distinctively linked to anti-inflammatory and analgesic effects. |
2024-12-17 |
2024-12-21 |
mouse |
| Dinesh Thapa, Mohan Patil, Leon N Warne, Rodrigo Carlessi, Marco Falasc. Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations. Cells. vol 13. issue 23. 2024-12-17. PMID:39682761. |
hu308, a synthetic cannabinoid developed to activate cb2 receptors selectively, aims to minimize unwanted off-target side effects. |
2024-12-17 |
2024-12-21 |
mouse |
| Artem M Kosenkov, Valentina N Mal'tseva, Sergei A Maiorov, Sergei G Gaidi. The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy. Reviews in the neurosciences. 2024-12-11. PMID:39660979. |
in recent years, gi-protein-coupled receptors, particularly cannabinoid receptors cb1 and cb2, have garnered increasing attention as promising targets for the treatment seizures and prevention of epilepsy. |
2024-12-11 |
2024-12-13 |
Not clear |
| M Wolyniak, M Wlodarczyk, F Piscitelli, R Verde, V Di Marzo, A Mokrowiecka, E Malecka-Wojciesko, A Fabisia. Modulation of CB1 and CB2 receptors and endocannabinoid activity in inflammatory bowel diseases. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 5. 2024-12-09. PMID:39652903. |
modulation of cb1 and cb2 receptors and endocannabinoid activity in inflammatory bowel diseases. |
2024-12-09 |
2024-12-12 |
human |
| Arsalan Rauf, Mudassar Nisar, Muhammad Shaeel, Ali Athar, Muhammad Mujtaba Ur Rehman, Filzah Fahee. The Potential of Cannabis in Managing Inflammatory Bowel Disease and Its Future Perspective. Cureus. vol 16. issue 10. 2024-12-03. PMID:39624503. |
cannabinoids act on two g-protein coupled receptors, cb1 and cb2 located in the brain, enteric nervous system, gastrointestinal cells (epithelial cells), and immune cells. |
2024-12-03 |
2024-12-06 |
Not clear |
| Han-Ting Chen, Ken Macki. CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605459. |
cb1 and cb2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure maternal immune activation (mia) commonly arises in response to an infection during pregnancy. |
2024-11-28 |
2024-11-30 |
mouse |
| Han-Ting Chen, Ken Macki. CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605459. |
taken together, these results suggest a complex interplay between pce, mia and cb1 and cb2 cannabinoid receptors. |
2024-11-28 |
2024-11-30 |
mouse |
| Shijia Li, Weini Li, Naseeb Kaur Malhi, Junwei Huang, Quanqi Li, Ziwei Zhou, Ruiheng Wang, Jiangling Peng, Tong Yin, Honggen Wan. Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential. Molecules (Basel, Switzerland). vol 29. issue 22. 2024-11-27. PMID:39598860. |
we discuss how cbg interacts with the endocannabinoid system and other key signaling pathways, such as cb1, cb2, tpr channels, and α2-adrenoceptor, potentially influencing inflammation, pain, neurodegeneration, and other ailments. |
2024-11-27 |
2024-11-29 |
human |
| Shereif H Rezkalla, Robert A Klone. A Review of Cardiovascular Effects of Marijuana Use. Journal of cardiopulmonary rehabilitation and prevention. 2024-11-20. PMID:39565147. |
cannabinoids exert their effects on body tissues via cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptors. |
2024-11-20 |
2024-11-23 |
Not clear |
| Júlia Dalfovo Marquez, Talissa Dezanetti, Roger Walz, Cristiane Ribeiro de Carvalh. Cannabinoid for alcohol use disorder. International review of neurobiology. vol 178. 2024-11-10. PMID:39523058. |
several pieces of evidence have implicated the endocannabinoid system on dopaminergic mesolimbic brain reward, as well as the potential role of cannabinoid receptors cb1 and cb2 on modulation of reinforced properties of drug abuse and consequently to the treatment of substance use disorder, including alcoholism. |
2024-11-10 |
2024-11-17 |
Not clear |
| Ari Misael Martínez-Torres, Julio Morá. CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate-Induced Excitotoxicity Through a Reduction of NOX-2 Activity and Oxidative Stress. CNS neuroscience & therapeutics. vol 30. issue 11. 2024-11-04. PMID:39496572. |
the endocannabinoid system is widely distributed in the brain, particularly through the cannabinoid receptor type 1 (cb1) and type 2 (cb2), which have been shown to have a neuroprotective function in brain injury. |
2024-11-04 |
2024-11-07 |
Not clear |
| Matheus Perez, Aline Barroso Spejo, Gabriela Bortolança Chiarotto, Francisco Silveira Guimarães, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozz. Selective blockade of cannabinoid receptors influence motoneuron survival and glial reaction after neonatal axotomy. Neuroscience. 2024-10-31. PMID:39481830. |
the present work investigated the role of the cannabinoid receptors cb1 and cb2 in the neuroprotective response after neonatal axotomy. |
2024-10-31 |
2024-11-03 |
rat |
| Dominik Duczmal, Aleksandra Bazan-Wozniak, Krystyna Niedzielska, Robert Pietrza. Cannabinoids-Multifunctional Compounds, Applications and Challenges-Mini Review. Molecules (Basel, Switzerland). vol 29. issue 20. 2024-10-26. PMID:39459291. |
all of these compounds interact biologically with type 1 (cb1) and/or type 2 (cb2) cannabinoid receptors. |
2024-10-26 |
2024-10-29 |
Not clear |
| Lujain Bader Eddin, M F Nagoor Meeran, Sandeep B Subramanya, Niraj Kumar Jha, Shreesh Ojh. Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis. Pharmacology research & perspectives. vol 12. issue 6. 2024-10-19. PMID:39425446. |
cannabinoid receptors type 2 (cb2) are a class of g protein-coupled receptors responsible for transmitting intracellular signals triggered by both endogenous and exogenous cannabinoids, including those derived from plants (phytocannabinoids) or manufactured synthetically (synthetic cannabinoids). |
2024-10-19 |
2024-10-21 |
Not clear |
| Rachel Luba, Gabriela Madera, Rebecca Schusterman, Andrew Kolodziej, Ian Hodgson, Sandra D Come. Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist. The Journal of pharmacology and experimental therapeutics. vol 391. issue 2. 2024-10-18. PMID:38936978. |
endocannabinoids, which are present throughout the central nervous system (cns), can activate cannabinoid receptors 1 and 2 (cb1 and cb2). |
2024-10-18 |
2024-10-21 |
human |