| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haruka Hosoki, Toru Asahi, Chihiro Nozak. Cannabinoid CB2 receptors enhance high-fat diet evoked peripheral neuroinflammation. Life sciences. 2024-08-22. PMID:39173999. |
cannabinoid cb2 receptors enhance high-fat diet evoked peripheral neuroinflammation. |
2024-08-22 |
2024-08-25 |
mouse |
| Haruka Hosoki, Toru Asahi, Chihiro Nozak. Cannabinoid CB2 receptors enhance high-fat diet evoked peripheral neuroinflammation. Life sciences. 2024-08-22. PMID:39173999. |
it is known that the cannabinoid type 2 (cb2) receptor has an anti-inflammatory role. |
2024-08-22 |
2024-08-25 |
mouse |
| Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Sabine Grüner, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Jürg Gertsc. A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for ACS pharmacology & translational science. vol 7. issue 8. 2024-08-15. PMID:39144568. |
a highly potent, orally bioavailable pyrazole-derived cannabinoid cb2 receptor- selective full agonist for the cannabinoid cb2 receptor (cb2r) is a potential therapeutic target for distinct forms of tissue injury and inflammatory diseases. |
2024-08-15 |
2024-08-17 |
Not clear |
| Fabienne Briand-Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean-Pierre Salles, Hugues Cha. From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125098. |
2-arachidonoylglycerol (2-ag) is the most abundant endocannabinoid (ec), acting as a full agonist at both cb1 and cb2 cannabinoid receptors. |
2024-08-10 |
2024-08-13 |
Not clear |
| Basak Isildar, Alisa Bahar Beydogan, Ece Koyuturk, Zeynep Mine Coskun Yazici, Meral Koyuturk, Sema Bolken. Effects of ∆-9 tetrahydrocannabinol on the small intestine altered by high fructose diet: A Histopathological study. Histochemistry and cell biology. 2024-08-07. PMID:39110194. |
∆9-tetrahydrocannabinol (thc), a key cannabinoid, interacts with cb1 and cb2 receptors in the gastrointestinal tract, potentially mitigating inflammation. |
2024-08-07 |
2024-08-09 |
rat |
| Bruna R Kouba, Glorister A Altê, Ana Lúcia S Rodrigue. Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking. Pharmaceuticals (Basel, Switzerland). vol 17. issue 7. 2024-07-27. PMID:39065743. |
the main targets found are the vitamin d receptor (vdr), histamine h3 receptor (h3r), endocannabinoid receptors 1 and 2 (cb1 and cb2), nuclear receptor nr1h3, patched-1 (ptch1) protein, opioid receptor nop, and phosphodiesterase enzymes pde3a and pde5a. |
2024-07-27 |
2024-07-29 |
Not clear |
| Willias Masocha, Esraa Aly, Aisha Albaloushi, Altaf Al-Romaiya. Licofelone, a Dual COX/LOX Inhibitor, Ameliorates Paclitaxel-Induced Mechanical Allodynia in Rats in a Cannabinoid Receptor-Dependent Manner. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062118. |
molecular docking showed that licofelone binds to both cb1 and cb2 receptors with a high affinity similar to the phytocannabinoid 1-trans-delta-9-tetrahydrocannabinol and the synthetic cannabinoid win 55,212-2. |
2024-07-27 |
2024-07-29 |
mouse |
| Man Liu, Dong Pan, MengYa Wang, Han Deng, ZeGang M. JWH133 attenuates behavior deficits and iron accumulation in the 6-OHDA-induced Parkinson's disease model rats. Journal of neurophysiology. 2024-07-17. PMID:39015077. |
growing evidence indicated that activation of cannabinoid type 2 (cb2) receptors protect dopamine neurons in the pathogenesis of parkinson's disease (pd). |
2024-07-17 |
2024-07-19 |
rat |
| Hikari Tachibana, Moeka Nomura, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemur. Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940. Neurotoxicology. 2024-06-28. PMID:38942151. |
cp-55,940, a synthetic cannabinoid having the ability to activate both cb1 and cb2 receptors, has been shown to induce cell death in neurons as well as other cells. |
2024-06-28 |
2024-07-01 |
mouse |
| Robert C Barnes, Henry Blanton, Canice Lei Dancel, Isabel Castro-Piedras, Boyd R Rorabaugh, Daniel J Morgan, Josée Guindo. Chronic administration of cannabinoid agonists ACEA (CB1), AM1241 (CB2), and CP55,940 (mixed CB1/CB2) induce sex-specific differences in tolerance and sex hormone changes in a chemotherapy-induced peripheral neuropathy. The Journal of pharmacology and experimental therapeutics. 2024-06-27. PMID:38936979. |
chronic administration of cannabinoid agonists acea (cb1), am1241 (cb2), and cp55,940 (mixed cb1/cb2) induce sex-specific differences in tolerance and sex hormone changes in a chemotherapy-induced peripheral neuropathy. |
2024-06-27 |
2024-06-30 |
Not clear |
| Andrea Chicca, Daniel Batora, Christoph Ullmer, Antonello Caruso, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Jürg Gertsc. A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for bioRxiv : the preprint server for biology. 2024-06-21. PMID:38903103. |
a highly potent, orally bioavailable pyrazole-derived cannabinoid cb2 receptor-selective full agonist for the cannabinoid cb2 receptor (cb2r) is a potential therapeutic target for distinct forms of tissue injury and inflammatory diseases. |
2024-06-21 |
2024-06-23 |
Not clear |
| Spyros P Nikas, Lipin Ji, Yingpeng Liu, Markos-Orestis Georgiadis, Amey Dopeshwarkar, Alex Straiker, Shalley Kudalkar, Anastasiia V Sadybekov, Michaela Dvorakova, Vsevolod Katritch, Ken Mackie, Lawrence Marnett, Alexandros Makriyanni. Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2. ACS medicinal chemistry letters. vol 15. issue 6. 2024-06-19. PMID:38894922. |
2-arachidonoyl glycerol (2-ag) is the principal endogenously produced ligand for the cannabinoid cb1 and cb2 receptors (cbrs). |
2024-06-19 |
2024-06-21 |
Not clear |
| Magdalena Smereczańska, Natalia Domian, Alicja Lewandowska, Irena Kasack. Comparative assessment of CacyBP/SIP, β-catenin and cannabinoid receptors in the adrenals of hypertensive rats. Journal of cellular and molecular medicine. vol 28. issue 10. 2024-05-23. PMID:38780511. |
the results of this study show, for the first time, marked differences in the expression of cacybp/sip, β-catenin and cb1 and cb2 cannabinoid receptors in the adrenal glands of rats with primary (shr) and secondary hypertension (2k1c). |
2024-05-23 |
2024-05-27 |
rat |
| Fatima Doganc, Tulin Ozkan, Nazila Farhangzad, Acelya Mavideniz, Ismail Celik, Asuman Sunguroglu, Hakan Göke. Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorganic chemistry. vol 148. 2024-05-10. PMID:38728910. |
cannabinoids bind to cannabinoid receptors cb1 and cb2 and their antitumoral activity has been reported against some various cancer cell lines. |
2024-05-10 |
2024-05-27 |
Not clear |
| Fatima Doganc, Tulin Ozkan, Nazila Farhangzad, Acelya Mavideniz, Ismail Celik, Asuman Sunguroglu, Hakan Göke. Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorganic chemistry. vol 148. 2024-05-10. PMID:38728910. |
some synthetic cannabinoids possessing indole rings such as jwh-015 and jwh-133 particularly bind to the cannabinoid cb2 receptor and it was reported that they inhibit the proliferation and growth of various cancer cells without their psychoactive effects. |
2024-05-10 |
2024-05-27 |
Not clear |
| Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P Manfredsson, Bob M Moore, Malú Gámez Tanse. Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562842. |
cannabinoid receptor-2 (cb2) is highly expressed on activated microglia and peripheral immune cells, is upregulated in the substantia nigra of individuals with pd and in mouse models of nigral degeneration. |
2024-04-02 |
2024-04-04 |
mouse |
| Lindsey Russell, Kayla Condo, Tiffany DeFlorvill. Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2024-03-31. PMID:38555505. |
exogenous cannabinoid (cb) use, either organic or synthetic, stimulates the ecs through cb1 and cb2 receptors. |
2024-03-31 |
2024-04-02 |
Not clear |
| Ruohan Shan, Yuxiang Zhang, Yiping Shi, Xiaowen Wang, Xueke Wang, Guanying Ma, Qian L. Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension. Biomolecules. vol 14. issue 3. 2024-03-28. PMID:38540753. |
our previous studies prove that activating the cannabinoid type 2 (cb2) receptor in the brain can effectively reduce blood pressure in spontaneously hypertensive rats; however, the exact mechanism has not been clarified. |
2024-03-28 |
2024-03-30 |
rat |
| Mathias C Eymery, Ahcène Boumendjel, Andrew A McCarthy, Jens Hausman. Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542186. |
this finding opens new areas of research regarding cannabinoids and endocannabinoids, as it could establish the effect of these compounds at the molecular level, particularly in relation to inflammation, which cannot be explained by the interaction with cb1 and cb2 receptors alone. |
2024-03-28 |
2024-03-30 |
Not clear |
| Natalia Mansur Haddad, Leonardo Peroni De Jesus, Mauricio Serpa, Martinus Van De Bilt, Leda Talib, Alana Costa, Wagner Gattaz, Alexandre Andrade Loc. Endocannabinoid system alterations in schizophrenia: association with cannabis use and antipsychotic medication. European archives of psychiatry and clinical neuroscience. 2024-03-19. PMID:38502208. |
we found for the first time that cannabis use and non-clozapine antipsychotic medication are potentially involved in the modulation of the ecs, specifically influencing 2-ag endocannabinoid and cb2 receptor levels. |
2024-03-19 |
2024-03-23 |
Not clear |