All Relations between cb2 and cannabinoids

Publication Sentence Publish Date Extraction Date Species
A C Howlet. Pharmacology of cannabinoid receptors. Annual review of pharmacology and toxicology. vol 35. 1995-08-01. PMID:7598509. two subtypes of cannabinoid receptors, cb1 and cb2, have been described to date, although future investigations may elucidate other receptors. 1995-08-01 2023-08-12 Not clear
L Facci, R Dal Toso, S Romanello, A Buriani, S D Skaper, A Leo. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 8. 1995-05-25. PMID:7724569. the results suggest that (i) peripheral cannabinoid cb2 receptors control, upon agonist binding, mast cell activation and therefore inflammation; (ii) palmitoylethanolamide, unlike anandamide, behaves as an endogenous agonist for the cb2 receptor on mast cells; (iii) modulatory activities on mast cells exerted by the naturally occurring molecule strengthen a proposed autacoid local inflammation antagonism (alia) mechanism; and (iv) palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells ("aliamides"). 1995-05-25 2023-08-12 Not clear