All Relations between cb2 and cannabinoids
Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
A C Howlet. Pharmacology of cannabinoid receptors. Annual review of pharmacology and toxicology. vol 35. 1995-08-01. PMID:7598509. |
two subtypes of cannabinoid receptors, cb1 and cb2, have been described to date, although future investigations may elucidate other receptors. |
1995-08-01 |
2023-08-12 |
Not clear |
L Facci, R Dal Toso, S Romanello, A Buriani, S D Skaper, A Leo. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 8. 1995-05-25. PMID:7724569. |
the results suggest that (i) peripheral cannabinoid cb2 receptors control, upon agonist binding, mast cell activation and therefore inflammation; (ii) palmitoylethanolamide, unlike anandamide, behaves as an endogenous agonist for the cb2 receptor on mast cells; (iii) modulatory activities on mast cells exerted by the naturally occurring molecule strengthen a proposed autacoid local inflammation antagonism (alia) mechanism; and (iv) palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells ("aliamides"). |
1995-05-25 |
2023-08-12 |
Not clear |