| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bayewitch, T Avidor-Reiss, R Levy, J Barg, R Mechoulam, Z Voge. The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS letters. vol 375. issue 1-2. 1996-01-17. PMID:7498464. |
two cannabinoid receptors, designated neuronal (or cb1) and peripheral (or cb2), have recently been cloned. |
1996-01-17 |
2023-08-12 |
Not clear |
| M Bayewitch, T Avidor-Reiss, R Levy, J Barg, R Mechoulam, Z Voge. The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS letters. vol 375. issue 1-2. 1996-01-17. PMID:7498464. |
here we show, using a cb2 transfected chinese hamster ovary cell line, that this receptor binds a variety of tricyclic cannabinoid ligands as well as the endogenous ligand anandamide. |
1996-01-17 |
2023-08-12 |
Not clear |
| M Bayewitch, T Avidor-Reiss, R Levy, J Barg, R Mechoulam, Z Voge. The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS letters. vol 375. issue 1-2. 1996-01-17. PMID:7498464. |
activation of the cb2 receptor by various tricyclic cannabinoids inhibits adenylate cyclase activity and this inhibition is pertussis toxin sensitive indicating that this receptor is coupled to the gi/g(o) gtp-binding proteins. |
1996-01-17 |
2023-08-12 |
Not clear |
| S Galiègue, S Mary, J Marchand, D Dussossoy, D Carrière, P Carayon, M Bouaboula, D Shire, G Le Fur, P Casella. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. European journal of biochemistry. vol 232. issue 1. 1995-11-14. PMID:7556170. |
two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, cb1, and the peripheral cannabinoid receptor, cb2, initially described in rat brain and spleen, respectively. |
1995-11-14 |
2023-08-12 |
human |
| S Galiègue, S Mary, J Marchand, D Dussossoy, D Carrière, P Carayon, M Bouaboula, D Shire, G Le Fur, P Casella. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. European journal of biochemistry. vol 232. issue 1. 1995-11-14. PMID:7556170. |
these results suggest that (a) cb1 and cb2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the cb2 receptor. |
1995-11-14 |
2023-08-12 |
human |
| C C Felder, K E Joyce, E M Briley, J Mansouri, K Mackie, O Blond, Y Lai, A L Ma, R L Mitchel. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Molecular pharmacology. vol 48. issue 3. 1995-10-30. PMID:7565624. |
comparison of the pharmacology and signal transduction of the human cannabinoid cb1 and cb2 receptors. |
1995-10-30 |
2023-08-12 |
human |
| J Priller, E M Briley, J Mansouri, W A Devane, K Mackie, C C Felde. Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors. Molecular pharmacology. vol 48. issue 2. 1995-09-26. PMID:7651362. |
mead ethanolamide, a novel eicosanoid, is an agonist for the central (cb1) and peripheral (cb2) cannabinoid receptors. |
1995-09-26 |
2023-08-12 |
human |
| D M Slipetz, G P O'Neill, L Favreau, C Dufresne, M Gallant, Y Gareau, D Guay, M Labelle, K M Metter. Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Molecular pharmacology. vol 48. issue 2. 1995-09-26. PMID:7651369. |
the human peripheral cannabinoid (cb2) receptor has been cloned by reverse transcription-polymerase chain reaction from human spleen rna and expressed, to study both ligand binding characteristics and signal transduction pathways. |
1995-09-26 |
2023-08-12 |
human |
| D M Slipetz, G P O'Neill, L Favreau, C Dufresne, M Gallant, Y Gareau, D Guay, M Labelle, K M Metter. Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Molecular pharmacology. vol 48. issue 2. 1995-09-26. PMID:7651369. |
cb2 receptor activation by cannabinoid agonists inhibited forskolin-induced camp production in a concentration-dependent and stereoselective manner but did not increase either camp production or ca2+ mobilization in fura-2/acetoxymethyl ester-loaded cb2-cho-k1 cells. |
1995-09-26 |
2023-08-12 |
human |
| J M Derocq, M Ségui, J Marchand, G Le Fur, P Casella. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS letters. vol 369. issue 2-3. 1995-09-22. PMID:7544292. |
in addition, the absence of antagonistic effect of sr141716a, a specific cb1 receptor antagonist, together with the demonstration that human b-cells displayed large amount of cb2 receptor mrnas, led us to assume that the growth enhancing activity observed on b-cells at very low concentrations of cannabinoids could be mediated through the cb2 receptor. |
1995-09-22 |
2023-08-12 |
human |
| R Mechoulam, S Ben-Shabat, L Hanus, M Ligumsky, N E Kaminski, A R Schatz, A Gopher, S Almog, B R Martin, D R Compto. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochemical pharmacology. vol 50. issue 1. 1995-08-10. PMID:7605349. |
2-ara-gl bound to membranes from cells transiently transfected with expression plasmids carrying dna of either cb1 or cb2--the two cannabinoid receptors identified thus far--with ki values of 472 +/- 55 and 1400 +/- 172 nm, respectively. |
1995-08-10 |
2023-08-12 |
mouse |
| A C Howlet. Pharmacology of cannabinoid receptors. Annual review of pharmacology and toxicology. vol 35. 1995-08-01. PMID:7598509. |
two subtypes of cannabinoid receptors, cb1 and cb2, have been described to date, although future investigations may elucidate other receptors. |
1995-08-01 |
2023-08-12 |
Not clear |
| L Facci, R Dal Toso, S Romanello, A Buriani, S D Skaper, A Leo. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 8. 1995-05-25. PMID:7724569. |
the results suggest that (i) peripheral cannabinoid cb2 receptors control, upon agonist binding, mast cell activation and therefore inflammation; (ii) palmitoylethanolamide, unlike anandamide, behaves as an endogenous agonist for the cb2 receptor on mast cells; (iii) modulatory activities on mast cells exerted by the naturally occurring molecule strengthen a proposed autacoid local inflammation antagonism (alia) mechanism; and (iv) palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells ("aliamides"). |
1995-05-25 |
2023-08-12 |
Not clear |