| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N E Buckley, S Hansson, G Harta, E Meze. Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat. Neuroscience. vol 82. issue 4. 1998-03-26. PMID:9466436. |
we mapped the distribution of cb1 and cb2 receptor messenger rnas in the developing rat to gain insight into how cannabinoids may affect embryogenesis. |
1998-03-26 |
2023-08-12 |
rat |
| G Griffin, S R Fernando, R A Ross, N G McKay, M L Ashford, D Shire, J W Huffman, S Yu, J A Lainton, R G Pertwe. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. European journal of pharmacology. vol 339. issue 1. 1998-02-25. PMID:9450616. |
we have investigated whether there are cannabinoid cb2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. |
1998-02-25 |
2023-08-12 |
mouse |
| G Griffin, S R Fernando, R A Ross, N G McKay, M L Ashford, D Shire, J W Huffman, S Yu, J A Lainton, R G Pertwe. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. European journal of pharmacology. vol 339. issue 1. 1998-02-25. PMID:9450616. |
jwh-015 (1-propyl-2-methyl-3-( -naphthoyl)indole) and jwh-051 (1-deoxy-11-hydroxy-delta8-tetrahydrocannabinol-dimethylheptyl+ ++), which have higher affinities for cb2 than cb1 cannabinoid binding sites, inhibited electrically evoked contractions of both tissues in a concentration related manner. |
1998-02-25 |
2023-08-12 |
mouse |
| G Patrini, P Sacerdote, D Fuzio, B Manfredi, D Parolar. Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound. Journal of neuroimmunology. vol 80. issue 1-2. 1998-01-08. PMID:9413270. |
the data provided indicate that cb1 cannabinoid receptors are not involved in mediating the acute and chronic effects of cannabinoids on the immune system and suggest a possible implication of cb2 receptor although other modalities of cp-55,940 action can not be ruled out. |
1998-01-08 |
2023-08-12 |
rat |
| D G Deutsch, M S Goligorsky, P C Schmid, R J Krebsbach, H H Schmid, S K Das, S K Dey, G Arreaza, C Thorup, G Stefano, L C Moor. Production and physiological actions of anandamide in the vasculature of the rat kidney. The Journal of clinical investigation. vol 100. issue 6. 1997-12-08. PMID:9294122. |
reverse-transcriptase pcr shows that ec contain transcripts for cannabinoid type 1 (cb1) receptors, while mesangial cells have mrna for both cb1 and cb2 receptors. |
1997-12-08 |
2023-08-12 |
rat |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
pharmacology of cannabinoid cb1 and cb2 receptors. |
1997-11-19 |
2023-08-12 |
Not clear |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
there are at least two types of cannabinoid receptors, cb1 and cb2, both coupled to g-proteins. |
1997-11-19 |
2023-08-12 |
Not clear |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
these discoveries have led to the development of selective cannabinoid cb1 and cb2 receptor ligands. |
1997-11-19 |
2023-08-12 |
Not clear |
| M H Rhee, Z Vogel, J Barg, M Bayewitch, R Levy, L Hanus, A Breuer, R Mechoula. Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379442. |
several derivatives of cannabinol and the 1,1-dimethylheptyl homolog (dmh) of cannabinol were prepared and assayed for binding to the brain and the peripheral cannabinoid receptors (cb1 and cb2), as well as for activation of cb1- and cb2-mediated inhibition of adenylylcyclase. |
1997-11-10 |
2023-08-12 |
Not clear |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
importance of the c-1 substituent in classical cannabinoids to cb2 receptor selectivity: synthesis and characterization of a series of o,2-propano-delta 8-tetrahydrocannabinol analogs. |
1997-11-10 |
2023-08-12 |
mouse |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
results reported here for a series of c-9 analogs of the cyclic ether o,2-propano-delta 8-tetrahydrocannabinol (o,2-propano-delta 8-thc) point to the c-1 position in classical cannabinoids as a position for which cb2 subtype selectivity occurs within the cannabinoid receptors. |
1997-11-10 |
2023-08-12 |
mouse |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
o,2-propano-11-delta 8-thc, o,2-propano delta 9,11-thc, o,2-propano-9-oxo-11-nor-hexahydrocannabinol (o,2-propano-9-oxo-11-nor-hhc), and o,2-propano-9 alpha- and o,2-propano-9 beta-oh-11-nor-hhc were synthesized and evaluated in radioligand displacement assays for affinity at the cb1 and cb2 receptors and in the mouse vas deferens in vitro assay and the mouse tetrad in vivo assay for cannabinoid activity. |
1997-11-10 |
2023-08-12 |
mouse |
| M Glass, C C Felde. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204917. |
stimulation of camp accumulation was not observed after pertussis toxin treatment of cho cells expressing the human cb2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid cb1 receptor. |
1997-07-21 |
2023-08-12 |
human |
| A R Schatz, M Lee, R B Condie, J T Pulaski, N E Kaminsk. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicology and applied pharmacology. vol 142. issue 2. 1997-04-09. PMID:9070350. |
cannabinoid receptors cb1 and cb2: a characterization of expression and adenylate cyclase modulation within the immune system. |
1997-04-09 |
2023-08-12 |
mouse |
| A R Schatz, M Lee, R B Condie, J T Pulaski, N E Kaminsk. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicology and applied pharmacology. vol 142. issue 2. 1997-04-09. PMID:9070350. |
competition binding in intact mouse splenocytes demonstrated that nonradiolabeled cannabinoids cp-55940, win-55212-2, cp-56667, delta 9-thc, and cannabinol all competed for receptor binding with 3h-cp-55940, a high-affinity nondiscriminating cb1 and cb2 receptor ligand. |
1997-04-09 |
2023-08-12 |
mouse |
| D G Deutsch, S Lin, W A Hill, K L Morse, D Salehani, G Arreaza, R L Omeir, A Makriyanni. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochemical and biophysical research communications. vol 231. issue 1. 1997-04-07. PMID:9070252. |
arachidonoyl ethanolamide (anandamide) is an endogenous ligand for cannabinoid receptors (cb1, cb2) and a putative neurotransmitter. |
1997-04-07 |
2023-08-12 |
Not clear |
| M E Abood, B R Marti. Molecular neurobiology of the cannabinoid receptor. International review of neurobiology. vol 39. 1997-03-11. PMID:8894848. |
two cannabinoid receptors have been identified to date: one is located predominantly in the central nervous system (cbi), whereas the other is expressed in peripheral tissues (cb2). |
1997-03-11 |
2023-08-12 |
Not clear |
| S Mazzari, R Canella, L Petrelli, G Marcolongo, A Leo. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. European journal of pharmacology. vol 300. issue 3. 1997-02-06. PMID:8739213. |
recently, n-(2-hydroxyethyl)hexadecanamide (lg 2110/1) has been reported to down-modulate mast cell activation in vitro by behaving as an agonist at the peripheral cannabinoid cb2 receptor. |
1997-02-06 |
2023-08-12 |
mouse |
| S A Edsall, R J Knapp, T W Vanderah, W R Roeske, P Consroe, H I Yamamur. Antisense oligodeoxynucleotide treatment to the brain cannabinoid receptor inhibits antinociception. Neuroreport. vol 7. issue 2. 1996-11-25. PMID:8730837. |
however, other studies suggest the presence of multiple cannabinoid receptors and at least one other receptor (cb2) has been cloned. |
1996-11-25 |
2023-08-12 |
mouse |
| J W Huffman, S Yu, V Showalter, M E Abood, J L Wiley, D R Compton, B R Martin, R D Bramblett, P H Reggi. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Journal of medicinal chemistry. vol 39. issue 20. 1996-11-14. PMID:8831752. |
synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the cb2 receptor. |
1996-11-14 |
2023-08-12 |
Not clear |