| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K L McCoy, M Matveyeva, S J Carlisle, G A Cabra. Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation. The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336560. |
cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for cb2 receptor participation. |
1999-06-15 |
2023-08-12 |
Not clear |
| S I Jaggar, S Sellaturay, A S Ric. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. Neuroscience letters. vol 253. issue 2. 1999-06-04. PMID:9774165. |
the endogenous cannabinoid anandamide, but not the cb2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. |
1999-06-04 |
2023-08-12 |
rat |
| R A Ross, H C Brockie, L A Stevenson, V L Murphy, F Templeton, A Makriyannis, R G Pertwe. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188977. |
agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656, and am630. |
1999-05-27 |
2023-08-12 |
human |
| J P Meschler, A C Howlet. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacology, biochemistry, and behavior. vol 62. issue 3. 1999-05-17. PMID:10080239. |
radioligand receptor binding assays employing membrane preparations from rat brains containing cb1 cannabinoid receptors, and human tonsils containing cb2 receptors, demonstrated that thujone displaced [3h]cp55940, a cannabinoid agonist, only at concentrations above 10 microm. |
1999-05-17 |
2023-08-12 |
human |
| O Jbilo, J M Derocq, M Segui, G Le Fur, P Casella. Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS letters. vol 448. issue 2-3. 1999-05-13. PMID:10218491. |
using the recently developed methodology of nucleic acid microarrays spotted with specific cdnas probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand cp-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (il-8) and the beta-chemokine monocyte chemotactic protein-1 (mcp-1), in the promyelocytic cell line hl60 transfected with peripheral cannabinoid receptors (cb2). |
1999-05-13 |
2023-08-12 |
human |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |
| P Consro. Brain cannabinoid systems as targets for the therapy of neurological disorders. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974182. |
unprecedented developments in cannabinoid research within the past decade include discovery of a brain (cb1) and peripheral (cb2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at cb1 receptors, antagonism of nmda receptors and glutamate, and antioxidant activity; and preferential cb1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. |
1999-05-06 |
2023-08-12 |
Not clear |
| T Croci, L Manara, G Aureggi, F Guagnini, M Rinaldi-Carmona, J P Maffrand, G Le Fur, S Mukenge, G Ferl. In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum. British journal of pharmacology. vol 125. issue 7. 1999-04-01. PMID:9884065. |
the cannabinoid cb1 receptor antagonist sr 141716 (pa2 8.2), but not the cb2 receptor antagonist, sr 144528, competitively antagonized twitch inhibition by (+)win-55212-2. |
1999-04-01 |
2023-08-12 |
human |
| R A Ross, H C Brockie, S R Fernando, B Saha, R K Razdan, R G Pertwe. Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863666. |
the cannabinoids used were the cb1-selective antagonist sr141716a, the cb2-selective antagonist sr144528, the novel cannabinoid receptor ligand, 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol (o-1184), and the agonists cp55940, which binds equally well to cb1 and cb2 receptors, and win55212-2, which shows marginal cb2 selectivity. |
1999-03-25 |
2023-08-12 |
Not clear |
| Q Tao, S D McAllister, J Andreassi, K W Nowell, G A Cabral, D P Hurst, K Bachtel, M C Ekman, P H Reggio, M E Aboo. Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. Molecular pharmacology. vol 55. issue 3. 1999-03-25. PMID:10051546. |
the human cannabinoid receptors, central cannabinoid receptor (cb1) and peripheral cannabinoid receptor (cb2), share only 44% amino acid identity overall, yet most ligands do not discriminate between receptor subtypes. |
1999-03-25 |
2023-08-12 |
human |
| Q Tao, S D McAllister, J Andreassi, K W Nowell, G A Cabral, D P Hurst, K Bachtel, M C Ekman, P H Reggio, M E Aboo. Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. Molecular pharmacology. vol 55. issue 3. 1999-03-25. PMID:10051546. |
in contrast, in human embryonic kidney (hek)-293 cells expressing the mutant or wild-type cb2 receptors, we found no significant differences in either the binding profile of several cannabinoid ligands nor in inhibition of camp accumulation. |
1999-03-25 |
2023-08-12 |
human |
| J A Wagner, K Varga, G Kuno. Cardiovascular actions of cannabinoids and their generation during shock. Journal of molecular medicine (Berlin, Germany). vol 76. issue 12. 1999-02-11. PMID:9846953. |
a second receptor subtype, the cb2 receptor, is expressed on cells of the immune system and is thought to be responsible for the immunosuppressant effects of cannabinoids. |
1999-02-11 |
2023-08-12 |
human |
| S Lin, A D Khanolkar, P Fan, A Goutopoulos, C Qin, D Papahadjis, A Makriyanni. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of medicinal chemistry. vol 41. issue 27. 1999-02-01. PMID:9876105. |
novel analogues of arachidonylethanolamide (anandamide): affinities for the cb1 and cb2 cannabinoid receptors and metabolic stability. |
1999-02-01 |
2023-08-12 |
Not clear |
| S Lin, A D Khanolkar, P Fan, A Goutopoulos, C Qin, D Papahadjis, A Makriyanni. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of medicinal chemistry. vol 41. issue 27. 1999-02-01. PMID:9876105. |
several analogues of the endogenous cannabinoid receptor ligand arachidonylethanolamide (anandamide) were synthesized and evaluated in order to study (a) the structural requirements for high-affinity binding to the cb1 and cb2 cannabinoid receptors and (b) their hydrolytic stability toward anandamide amidase. |
1999-02-01 |
2023-08-12 |
Not clear |
| P H Reggio, S Basu-Dutt, J Barnett-Norris, M T Castro, D P Hurst, H H Seltzman, M J Roche, A F Gilliam, B F Thomas, L A Stevenson, R G Pertwee, M E Aboo. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes. Journal of medicinal chemistry. vol 41. issue 26. 1999-01-21. PMID:9857088. |
the bioactive conformation of aminoalkylindoles at the cannabinoid cb1 and cb2 receptors: insights gained from (e)- and (z)-naphthylidene indenes. |
1999-01-21 |
2023-08-12 |
rat |
| P H Reggio, S Basu-Dutt, J Barnett-Norris, M T Castro, D P Hurst, H H Seltzman, M J Roche, A F Gilliam, B F Thomas, L A Stevenson, R G Pertwee, M E Aboo. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes. Journal of medicinal chemistry. vol 41. issue 26. 1999-01-21. PMID:9857088. |
the aminoalkylindoles (aais) are agonists at both the cannabinoid cb1 and cb2 receptors. |
1999-01-21 |
2023-08-12 |
rat |
| P Carayon, J Marchand, D Dussossoy, J M Derocq, O Jbilo, A Bord, M Bouaboula, S Galiègue, P Mondière, G Pénarier, G L Fur, T Defrance, P Casella. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood. vol 92. issue 10. 1998-12-21. PMID:9808554. |
modulation and functional involvement of cb2 peripheral cannabinoid receptors during b-cell differentiation. |
1998-12-21 |
2023-08-12 |
Not clear |
| P Carayon, J Marchand, D Dussossoy, J M Derocq, O Jbilo, A Bord, M Bouaboula, S Galiègue, P Mondière, G Pénarier, G L Fur, T Defrance, P Casella. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood. vol 92. issue 10. 1998-12-21. PMID:9808554. |
two subtypes of g-protein-coupled cannabinoid receptors have been identified to date: the cb1 central receptor subtype, which is mainly expressed in the brain, and the cb2 peripheral receptor subtype, which appears particularly abundant in the immune system. |
1998-12-21 |
2023-08-12 |
Not clear |
| J Barnett-Norris, F Guarnieri, D P Hurst, P H Reggi. Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories. Journal of medicinal chemistry. vol 41. issue 24. 1998-12-17. PMID:9822555. |
the endogenous cannabinoid anandamide (n-arachidonoylethanolamide) has been shown to possess higher affinity for the cannabinoid cb1 receptor than for the cb2 receptor. |
1998-12-17 |
2023-08-12 |
Not clear |
| B A Berglund, D L Boring, G H Wilken, A Makriyannis, A C Howlett, S Li. Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. Prostaglandins, leukotrienes, and essential fatty acids. vol 59. issue 2. 1998-12-09. PMID:9774174. |
structural requirements for arachidonylethanolamide interaction with cb1 and cb2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. |
1998-12-09 |
2023-08-12 |
Not clear |