| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J MacLennan, P H Reynen, J Kwan, D W Bonhau. Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. British journal of pharmacology. vol 124. issue 4. 1998-10-02. PMID:9690851. |
evidence for inverse agonism of sr141716a at human recombinant cannabinoid cb1 and cb2 receptors. |
1998-10-02 |
2023-08-12 |
human |
| E Berdyshev, E Boichot, M Corbel, N Germain, V Lagent. Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. Life sciences. vol 63. issue 8. 1998-09-03. PMID:9718090. |
these results demonstrate that the cannabinoid receptor ligands inhibited lps-induced pulmonary inflammation and suggest that this effect could be at least in part mediated by the cannabinoid cb2 receptor. |
1998-09-03 |
2023-08-12 |
mouse |
| N A Patel, R L Moldow, J A Patel, G Wu, S L Chan. Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. Brain research. vol 797. issue 2. 1998-08-06. PMID:9666136. |
it is thought that the physiological actions of endogenous cannabinoid arachidonylethanolamide (aea), as well as exogenous cannabinoids such as delta9-tetrahydrocannabinol (thc), are mediated by two subtypes of cannabinoid receptors, cb1 and cb2, which have recently been characterized. |
1998-08-06 |
2023-08-12 |
rat |
| G van Zadelhoff, G A Veldink, J F Vliegenthar. With anandamide as substrate plant 5-lipoxygenases behave like 11-lipoxygenases. Biochemical and biophysical research communications. vol 248. issue 1. 1998-08-06. PMID:9675081. |
anandamide, an endogenous ligand for cannabinoid receptors cb1 and cb2, was incubated with purified 5-lipoxygenases from barley and tomato. |
1998-08-06 |
2023-08-12 |
Not clear |
| Q Tao, M E Aboo. Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580609. |
mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, cb1 and cb2, disrupts g-protein coupling. |
1998-06-08 |
2023-08-12 |
Not clear |
| Q Tao, M E Aboo. Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580609. |
the cannabinoid receptors, cb1 and cb2, are members of the g-protein coupled receptor family and share many of this family's structural features. |
1998-06-08 |
2023-08-12 |
Not clear |
| A C Herring, W S Koh, N E Kaminsk. Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Biochemical pharmacology. vol 55. issue 7. 1998-06-08. PMID:9605425. |
the identification of two major types of g-protein-coupled cannabinoid receptors expressed on leukocytes, cb1 and cb2, has provided a putative mechanism of action for immune modulation by cannabinoid compounds. |
1998-06-08 |
2023-08-12 |
mouse |
| A C Herring, W S Koh, N E Kaminsk. Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Biochemical pharmacology. vol 55. issue 7. 1998-06-08. PMID:9605425. |
collectively, these results demonstrate that cbn, a cannabinoid with minimal cns activity, inhibited both camp signal transduction and immune function, further supporting the involvement of cb2 receptors in immune modulation by cannabimimetic agents. |
1998-06-08 |
2023-08-12 |
mouse |
| J M Derocq, M Bouaboula, J Marchand, M Rinaldi-Carmona, M Ségui, P Casella. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. FEBS letters. vol 425. issue 3. 1998-05-13. PMID:9563506. |
the effect of anandamide, an endogenous ligand for central (cb1) and peripheral (cb2) cannabinoid receptors, was investigated on the growth of the murine il-6-dependent lymphoid cell line b9 and the murine il-3-dependent myeloblastic cell line fdc-p1. |
1998-05-13 |
2023-08-12 |
Not clear |
| J M Derocq, M Bouaboula, J Marchand, M Rinaldi-Carmona, M Ségui, P Casella. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. FEBS letters. vol 425. issue 3. 1998-05-13. PMID:9563506. |
comparison with other fatty acid cannabinoid ligands such as (r)-methanandamide, a ligand with improved selectivity for the cb1 receptor, or palmitylethanolamide, an endogenous ligand for the cb2 receptor, showed a very similar effect, suggesting that cell growth enhancement by anandamide or its analogs could be mediated through either receptor subtype. |
1998-05-13 |
2023-08-12 |
Not clear |
| D P Papahatjis, T Kourouli, V Abadji, A Goutopoulos, A Makriyanni. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of medicinal chemistry. vol 41. issue 7. 1998-05-04. PMID:9544219. |
all the analogues tested showed nanomolar or subnanomolar affinities for the receptors; 2-(6a,7,10,10a-tetrahydro-6,6,9-trimethyl-1-hydroxy-6h- dibenzo[b,d]pyranyl)-2-hexyl-1,3-dithiolane was found to possess very high affinity for both cannabinoid receptors (cb1, ki = 0.32 nm; cb2, ki = 0.52 nm). |
1998-05-04 |
2023-08-12 |
Not clear |
| V V Bezuglov, Bobrov MYu, A V Archako. Bioactive amides of fatty acids. Biochemistry. Biokhimiia. vol 63. issue 1. 1998-04-28. PMID:9526091. |
ethanolamides of fatty acids are the most well-studied species of this group; an alternative pathway for their biosynthesis includes hydrolysis of n-acylated phosphatidylethanolamines by phospholipase d. ethanolamides of fatty acids bind to the cannabinoid receptors of the central nervous system (cb1) or peripheral tissues (cb2) and can be considered as endogenous ligands of these receptors. |
1998-04-28 |
2023-08-12 |
Not clear |
| N E Buckley, S Hansson, G Harta, E Meze. Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat. Neuroscience. vol 82. issue 4. 1998-03-26. PMID:9466436. |
we mapped the distribution of cb1 and cb2 receptor messenger rnas in the developing rat to gain insight into how cannabinoids may affect embryogenesis. |
1998-03-26 |
2023-08-12 |
rat |
| G Griffin, S R Fernando, R A Ross, N G McKay, M L Ashford, D Shire, J W Huffman, S Yu, J A Lainton, R G Pertwe. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. European journal of pharmacology. vol 339. issue 1. 1998-02-25. PMID:9450616. |
we have investigated whether there are cannabinoid cb2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. |
1998-02-25 |
2023-08-12 |
mouse |
| G Griffin, S R Fernando, R A Ross, N G McKay, M L Ashford, D Shire, J W Huffman, S Yu, J A Lainton, R G Pertwe. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. European journal of pharmacology. vol 339. issue 1. 1998-02-25. PMID:9450616. |
jwh-015 (1-propyl-2-methyl-3-( -naphthoyl)indole) and jwh-051 (1-deoxy-11-hydroxy-delta8-tetrahydrocannabinol-dimethylheptyl+ ++), which have higher affinities for cb2 than cb1 cannabinoid binding sites, inhibited electrically evoked contractions of both tissues in a concentration related manner. |
1998-02-25 |
2023-08-12 |
mouse |
| G Patrini, P Sacerdote, D Fuzio, B Manfredi, D Parolar. Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound. Journal of neuroimmunology. vol 80. issue 1-2. 1998-01-08. PMID:9413270. |
the data provided indicate that cb1 cannabinoid receptors are not involved in mediating the acute and chronic effects of cannabinoids on the immune system and suggest a possible implication of cb2 receptor although other modalities of cp-55,940 action can not be ruled out. |
1998-01-08 |
2023-08-12 |
rat |
| D G Deutsch, M S Goligorsky, P C Schmid, R J Krebsbach, H H Schmid, S K Das, S K Dey, G Arreaza, C Thorup, G Stefano, L C Moor. Production and physiological actions of anandamide in the vasculature of the rat kidney. The Journal of clinical investigation. vol 100. issue 6. 1997-12-08. PMID:9294122. |
reverse-transcriptase pcr shows that ec contain transcripts for cannabinoid type 1 (cb1) receptors, while mesangial cells have mrna for both cb1 and cb2 receptors. |
1997-12-08 |
2023-08-12 |
rat |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
pharmacology of cannabinoid cb1 and cb2 receptors. |
1997-11-19 |
2023-08-12 |
Not clear |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
there are at least two types of cannabinoid receptors, cb1 and cb2, both coupled to g-proteins. |
1997-11-19 |
2023-08-12 |
Not clear |
| R G Pertwe. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & therapeutics. vol 74. issue 2. 1997-11-19. PMID:9336020. |
these discoveries have led to the development of selective cannabinoid cb1 and cb2 receptor ligands. |
1997-11-19 |
2023-08-12 |
Not clear |