| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Barth, M Rinaldi-Carmon. The development of cannabinoid antagonists. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469889. |
the selective cb2 antagonist sr 144528 is expected to play the same role for the cb2 receptors, while the recent development of cannabinoid antagonists belonging to other chemical series illustrates the interest of these compounds which are now considered as interesting therapeutic targets by many pharmaceutical companies. |
1999-10-07 |
2023-08-12 |
Not clear |
| D Melck, T Bisogno, L De Petrocellis, H Chuang, D Julius, M Bifulco, V Di Marz. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochemical and biophysical research communications. vol 262. issue 1. 1999-09-23. PMID:10448105. |
we investigated the effect of changing the length and degree of unsaturation of the fatty acyl chain of n-(3-methoxy-4-hydroxy)-benzyl-cis-9-octadecenoamide (olvanil), a ligand of vanilloid receptors, on its capability to: (i) inhibit anandamide-facilitated transport into cells and enzymatic hydrolysis, (ii) bind to cb1 and cb2 cannabinoid receptors, and (iii) activate the vr1 vanilloid receptor. |
1999-09-23 |
2023-08-12 |
human |
| B Szabo, T Müller, H Koc. Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461898. |
the lack of a presynaptic effect on terminals of nigrostriatal and mesolimbic dopaminergic neurons is in accord with the anatomical distribution of cannabinoid receptors: the perikarya of these neurons in the substantia nigra and the ventral tegmental area do not synthesize mrna, and hence protein, for cb1 and cb2 cannabinoid receptors. |
1999-09-14 |
2023-08-12 |
rat |
| B Calandra, M Portier, A Kernéis, M Delpech, C Carillon, G Le Fur, P Ferrara, D Shir. Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor. European journal of pharmacology. vol 374. issue 3. 1999-09-13. PMID:10422789. |
under the same conditions the peripheral cannabinoid cb2 receptor proved to be incapable of inducing camp accumulation or luciferase activity. |
1999-09-13 |
2023-08-12 |
human |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
evaluation of the cannabinoid cb2 receptor-selective antagonist, sr144528: further evidence for cannabinoid cb2 receptor absence in the rat central nervous system. |
1999-09-08 |
2023-08-12 |
rat |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
the aim of this study was to characterize the activity of the cannabinoid cb2 receptor selective antagonist, n-[(1s)-endo-1,3,3-trimethyl bicyclo[2.2.1] heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazo le-3-carboxamide] (sr144528) in a number of biochemical assays and to look for evidence of cannabinoid cb2 receptors in the rat central nervous system. |
1999-09-08 |
2023-08-12 |
rat |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
in summary, this report characterizes the cannabinoid cb2 receptor-selective cannabinoid antagonist, sr144528, and additionally suggests an absence of cannabinoid cb2 receptors in the rat central nervous system, an observation confirmed by northern blot. |
1999-09-08 |
2023-08-12 |
rat |
| R G Pertwe. Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors. Life sciences. vol 65. issue 6-7. 1999-09-08. PMID:10462060. |
the discovery of cb1 and cb2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. |
1999-09-08 |
2023-08-12 |
Not clear |
| D Parolar. Presence and functional regulation of cannabinoid receptors in immune cells. Life sciences. vol 65. issue 6-7. 1999-09-08. PMID:10462064. |
both types of cannabinoid receptors, cb1 and cb2, have been found in immune cells, suggesting they are important in mediating the effects of cannabinoids on the immune system. |
1999-09-08 |
2023-08-12 |
Not clear |
| M Bouaboula, D Dussossoy, P Casella. Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400664. |
by blocking autoactivated receptors, inverse agonist sr 144528 treatment completely inhibited this phosphorylation state, leading to an up-regulated cb2 receptor level at the cell surface, and enhanced cannabinoid agonist sensitivity for mitogen-activated protein kinase activation of chinese hamster ovary-cb2 cells. |
1999-08-19 |
2023-08-12 |
human |
| P J Valk, R Delwe. The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis. Leukemia & lymphoma. vol 32. issue 1-2. 1999-06-29. PMID:10036999. |
although in the past many studies described growth inhibitory effects of cannabinoid agonists on the in vitro proliferation of hematopoietic cells, recent studies demonstrated that activation of cb2 may have growth stimulatory effects on blood precursor cells. |
1999-06-29 |
2023-08-12 |
mouse |
| C J Hillard, S Manna, M J Greenberg, R DiCamelli, R A Ross, L A Stevenson, V Murphy, R G Pertwee, W B Campbel. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336536. |
although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both cb1 and cb2 with similar affinities. |
1999-06-15 |
2023-08-12 |
mouse |
| K L McCoy, M Matveyeva, S J Carlisle, G A Cabra. Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation. The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336560. |
cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for cb2 receptor participation. |
1999-06-15 |
2023-08-12 |
Not clear |
| S I Jaggar, S Sellaturay, A S Ric. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. Neuroscience letters. vol 253. issue 2. 1999-06-04. PMID:9774165. |
the endogenous cannabinoid anandamide, but not the cb2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. |
1999-06-04 |
2023-08-12 |
rat |
| R A Ross, H C Brockie, L A Stevenson, V L Murphy, F Templeton, A Makriyannis, R G Pertwe. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188977. |
agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656, and am630. |
1999-05-27 |
2023-08-12 |
human |
| J P Meschler, A C Howlet. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacology, biochemistry, and behavior. vol 62. issue 3. 1999-05-17. PMID:10080239. |
radioligand receptor binding assays employing membrane preparations from rat brains containing cb1 cannabinoid receptors, and human tonsils containing cb2 receptors, demonstrated that thujone displaced [3h]cp55940, a cannabinoid agonist, only at concentrations above 10 microm. |
1999-05-17 |
2023-08-12 |
human |
| O Jbilo, J M Derocq, M Segui, G Le Fur, P Casella. Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS letters. vol 448. issue 2-3. 1999-05-13. PMID:10218491. |
using the recently developed methodology of nucleic acid microarrays spotted with specific cdnas probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand cp-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (il-8) and the beta-chemokine monocyte chemotactic protein-1 (mcp-1), in the promyelocytic cell line hl60 transfected with peripheral cannabinoid receptors (cb2). |
1999-05-13 |
2023-08-12 |
human |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |
| P Consro. Brain cannabinoid systems as targets for the therapy of neurological disorders. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974182. |
unprecedented developments in cannabinoid research within the past decade include discovery of a brain (cb1) and peripheral (cb2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at cb1 receptors, antagonism of nmda receptors and glutamate, and antioxidant activity; and preferential cb1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. |
1999-05-06 |
2023-08-12 |
Not clear |
| T Croci, L Manara, G Aureggi, F Guagnini, M Rinaldi-Carmona, J P Maffrand, G Le Fur, S Mukenge, G Ferl. In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum. British journal of pharmacology. vol 125. issue 7. 1999-04-01. PMID:9884065. |
the cannabinoid cb1 receptor antagonist sr 141716 (pa2 8.2), but not the cb2 receptor antagonist, sr 144528, competitively antagonized twitch inhibition by (+)win-55212-2. |
1999-04-01 |
2023-08-12 |
human |