| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Chaperon, M H Thiébo. Behavioral effects of cannabinoid agents in animals. Critical reviews in neurobiology. vol 13. issue 3. 2000-06-02. PMID:10803637. |
two subtypes of cannabinoid receptors have been identified to date, the cb1 receptor, essentially located in the cns, but also in peripheral tissues, and the cb2 receptor, found only at the periphery. |
2000-06-02 |
2023-08-12 |
Not clear |
| W Gonsiorek, C Lunn, X Fan, S Narula, D Lundell, R W Hipki. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779390. |
the endocannabinoids anandamide and 2-arachidonyl glycerol (2-ag) bind to g protein-coupled central and peripheral cannabinoid receptors cb1 and cb2, respectively. |
2000-05-25 |
2023-08-12 |
human |
| W Gonsiorek, C Lunn, X Fan, S Narula, D Lundell, R W Hipki. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779390. |
due to the relatively high expression of the cb2 isotype on peripheral immune cells, it has been hypothesized that this receptor mediates the immunosuppressive effects of cannabinoids. |
2000-05-25 |
2023-08-12 |
human |
| A Porcella, C Maxia, G L Gessa, L Pan. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. The European journal of neuroscience. vol 12. issue 3. 2000-05-22. PMID:10762343. |
we used reverse transcriptase polymerase chain reaction to detect the expression of the central and peripheral cannabinoid receptors (cb1 and cb2, respectively) mrna, and western blotting to show the presence of the cb1 protein in subregions of the human eye. |
2000-05-22 |
2023-08-12 |
human |
| Q Lu, A Straiker, Q Lu, G Maguir. Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Visual neuroscience. vol 17. issue 1. 2000-05-15. PMID:10750830. |
to date, two cannabinoid receptors, cb1 and cb2, have been cloned. |
2000-05-15 |
2023-08-12 |
mouse |
| A Gross, A Terraza, J Marchant, M Bouaboula, S Ouahrani-Bettache, J P Liautard, P Casellas, J Dornan. A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis. Journal of leukocyte biology. vol 67. issue 3. 2000-04-05. PMID:10733093. |
the triggering of cannabinoid receptors of cb1 and cb2 subtypes present on leukocytes may account for these effects. |
2000-04-05 |
2023-08-12 |
Not clear |
| B A Berglund, D L Boring, A C Howlet. Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils. Advances in experimental medicine and biology. vol 469. 2000-03-23. PMID:10667378. |
investigation of structural analogs of prostaglandin amides for binding to and activation of cb1 and cb2 cannabinoid receptors in rat brain and human tonsils. |
2000-03-23 |
2023-08-12 |
human |
| T Sugiura, S Kondo, S Kishimoto, T Miyashita, S Nakane, T Kodaka, Y Suhara, H Takayama, K Wak. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. The Journal of biological chemistry. vol 275. issue 1. 2000-01-31. PMID:10617657. |
evidence that 2-arachidonoylglycerol but not n-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid cb2 receptor. |
2000-01-31 |
2023-08-12 |
Not clear |
| T Sugiura, S Kondo, S Kishimoto, T Miyashita, S Nakane, T Kodaka, Y Suhara, H Takayama, K Wak. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. The Journal of biological chemistry. vol 275. issue 1. 2000-01-31. PMID:10617657. |
we examined the effect of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, on the intracellular free ca(2+) concentrations in hl-60 cells that express the cannabinoid cb2 receptor. |
2000-01-31 |
2023-08-12 |
Not clear |
| D Melck, L De Petrocellis, P Orlando, T Bisogno, C Laezza, M Bifulco, V Di Marz. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614630. |
beta-ngf-induced hbcc proliferation was potently inhibited (ic50 = 50-600 nm) by the synthetic cannabinoid hu-210, 2-ag, anandamide, and its metabolically stable analogs, but not by the anandamide congener, palmitoylethanolamide, or the selective agonist of cb2 cannabinoid receptors, bml-190. |
2000-01-13 |
2023-08-12 |
human |
| D Melck, L De Petrocellis, P Orlando, T Bisogno, C Laezza, M Bifulco, V Di Marz. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614630. |
hbccs and du-145 cells were shown to contain 1) transcripts for cb1 and, to a lesser extent, cb2 cannabinoid receptors, 2) specific binding sites for [3h]sr141716a that could be displaced by anandamide, and 3) a cb1 receptor-immunoreactive protein. |
2000-01-13 |
2023-08-12 |
human |
| Z Járai, J A Wagner, K Varga, K D Lake, D R Compton, B R Martin, A M Zimmer, T I Bonner, N E Buckley, E Mezey, R K Razdan, A Zimmer, G Kuno. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 24. 2000-01-06. PMID:10570211. |
two cannabinoid receptors, cb1 and cb2, have been cloned, and studies with the selective cb1 receptor antagonist sr141716a have implicated peripherally located cb1 receptors in the hypotensive action of cannabinoids. |
2000-01-06 |
2023-08-12 |
mouse |
| Z Járai, J A Wagner, K Varga, K D Lake, D R Compton, B R Martin, A M Zimmer, T I Bonner, N E Buckley, E Mezey, R K Razdan, A Zimmer, G Kuno. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 24. 2000-01-06. PMID:10570211. |
here we show that "abnormal cannabidiol" (abn-cbd) is a neurobehaviorally inactive cannabinoid that does not bind to cb1 receptors, yet causes sr141716a-sensitive hypotension and mesenteric vasodilation in wild-type mice and in mice lacking cb1 receptors or both cb1 and cb2 receptors. |
2000-01-06 |
2023-08-12 |
mouse |
| R G Pertwe. Cannabis and cannabinoids: pharmacology and rationale for clinical use. Forschende Komplementarmedizin. vol 6 Suppl 3. 2000-01-05. PMID:10575283. |
the discovery of this 'endogenous cannabinoid system' has led to the development of selective cb1 and cb2 receptor ligands and fueled renewed interest in the clinical potential of cannabinoids. |
2000-01-05 |
2023-08-12 |
Not clear |
| R G Pertwe. Cannabis and cannabinoids: pharmacology and rationale for clinical use. Forschende Komplementarmedizin. vol 6 Suppl 3. 2000-01-05. PMID:10575283. |
so too may cb2 receptor ligands and drugs that activate cannabinoid receptors indirectly by augmenting endocannabinoid levels at cannabinoid receptors. |
2000-01-05 |
2023-08-12 |
Not clear |
| R Mechoula. Recent advantages in cannabinoid research. Forschende Komplementarmedizin. vol 6 Suppl 3. 2000-01-05. PMID:10575284. |
in the last decade it was established that delta9-thc acts through specific receptors - cb1 and cb2 - and mimics the physiological activity of endogenous cannabinoids of two types, the best known representatives being arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-ag). |
2000-01-05 |
2023-08-12 |
Not clear |
| R A Ross, T M Gibson, L A Stevenson, B Saha, P Crocker, R K Razdan, R G Pertwe. Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors. British journal of pharmacology. vol 128. issue 3. 1999-12-22. PMID:10516656. |
o-1184, o-1238 and o-584 displaced [3h]-cp55940 from specific binding sites on chinese hamster ovary (cho) cell membranes expressing cb1 or cb2 cannabinoid receptors, with pki values of 8.28 to 8.45 (cb1) and 8.03 to 8.13 (cb2). |
1999-12-22 |
2023-08-12 |
mouse |
| A C Herring, N E Kaminsk. Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565837. |
cannabinol (cbn), an immunosuppressive cannabinoid and ligand for the peripheral cannabinoid receptor cb2, inhibits the camp signaling cascade in forskolin-stimulated thymocytes. |
1999-12-20 |
2023-08-12 |
Not clear |
| B Y Ho, Y Uezono, S Takada, I Takase, F Izum. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors & channels. vol 6. issue 5. 1999-12-13. PMID:10551268. |
coupling of the expressed cannabinoid cb1 and cb2 receptors to phospholipase c and g protein-coupled inwardly rectifying k+ channels. |
1999-12-13 |
2023-08-12 |
xenopus_laevis |
| B Y Ho, Y Uezono, S Takada, I Takase, F Izum. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors & channels. vol 6. issue 5. 1999-12-13. PMID:10551268. |
signaling of the cannabinoid cb1 and cb2 receptors through phospholipase c (plc) and g protein-coupled inwardly rectifying k+ channels (girk) was studied after their expression in cos7 cells and xenopus oocytes. |
1999-12-13 |
2023-08-12 |
xenopus_laevis |