| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M McCann, Valeria Rettor. The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 4. 2003-04-01. PMID:12578974. |
recent research has revealed that endogenous cannabinoid receptors (cb1 and cb2) react with the active ingredient of marijuana, delta(9)-tetrahydrocannabinol. |
2003-04-01 |
2023-08-12 |
rat |
| Brad L Upham, Alisa M Rummel, Joseph M Carbone, James E Trosko, Yanli Ouyang, Robert B Crawford, Norbert E Kaminsk. Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. International journal of cancer. vol 104. issue 1. 2003-03-25. PMID:12532414. |
based on rt-pcr analysis and employment of an antagonist of cb1 and cb2, the effects on gjic and mapk were independent of both cannabinoid receptors. |
2003-03-25 |
2023-08-12 |
rat |
| Manabu Kagaya, Jasmine Lamb, Jon Robbins, Clive P Page, Domenico Spin. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. British journal of pharmacology. vol 137. issue 1. 2003-03-19. PMID:12183329. |
both capsaicin and anandamide depolarized de-sheathed whole vagal nerve preparations that was antagonized by the vr1 antagonist, capsazepine (p<0.05) whilst this response was unaltered by the cannabinoid (cb1) selective antagonist sr141716a or the cb2 selective antagonist, sr144528, thereby ruling out a role for cannabinoid receptors in this response. |
2003-03-19 |
2023-08-12 |
Not clear |
| David C New, Yung H Won. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS letters. vol 536. issue 1-3. 2003-03-10. PMID:12586356. |
bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. |
2003-03-10 |
2023-08-12 |
human |
| G Choi, J Landin, X-Q Xi. The cytoplasmic helix of cannabinoid receptor CB2, a conformational study by circular dichroism and (1)H NMR spectroscopy in aqueous and membrane-like environments. The journal of peptide research : official journal of the American Peptide Society. vol 60. issue 3. 2003-02-25. PMID:12213126. |
computer models also predict this structure for the cannabinoid cb2 receptor, another member of the gpcr superfamily. |
2003-02-25 |
2023-08-12 |
Not clear |
| Michael Yuan, Sylvia M Kiertscher, Qingwen Cheng, Richard Zoumalan, Donald P Tashkin, Michael D Rot. Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. Journal of neuroimmunology. vol 133. issue 1-2. 2003-01-14. PMID:12446015. |
we conclude that cannabinoids have the potential to regulate the activation and balance of human th1/th2 cells by a cb2 receptor-dependent pathway. |
2003-01-14 |
2023-08-12 |
human |
| Mario van der Stelt, Wouter B Veldhuis, Mauro Maccarrone, Peter R Bär, Klaas Nicolay, Gerrit A Veldink, Vincenzo Di Marzo, Johannes F G Vliegenthar. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Molecular neurobiology. vol 26. issue 2-3. 2002-12-24. PMID:12428763. |
the endocannabinoid system constitutes the endogenous lipids anandamide, 2-arachidonoylglycerol and noladin ether, and the cannabinoid cb1 and cb2 receptors as well as the proteins for their inactivation. |
2002-12-24 |
2023-08-12 |
Not clear |
| T Sugiura, Y Kobayashi, S Oka, K Wak. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052034. |
2-ag acts as a full agonist at the cannabinoid receptors (cb1 and cb2). |
2002-12-06 |
2023-08-12 |
Not clear |
| Noëlla Germain, Elisabeth Boichot, Charles Advenier, Evgueni V Berdyshev, Vincent Lagent. Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells. International immunopharmacology. vol 2. issue 4. 2002-11-25. PMID:11962732. |
to address this question, the interference of cb1 and cb2 receptor antagonists with the inhibition of tnf-alpha production by synthetic cannabinoid win 55,212-2 was studied using human peripheral blood mononuclear cells (pbmc) in vitro. |
2002-11-25 |
2023-08-12 |
human |
| Rene Anikwue, John W Huffman, Zachary L Martin, Sandra P Welc. Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. The Journal of pharmacology and experimental therapeutics. vol 303. issue 1. 2002-10-21. PMID:12235269. |
our studies with a cannabinoid receptor (cb1) antagonist [n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboximide hydrochloride (sr141716a)], a cb2 antagonist [n-((1s)-endo-1,3,3-trimethyl-bicyclo-heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide) (sr144528)], and an another cb2 agonist [1,1-dimethylbutyl-1-deoxy-delta(9)-thc (jwh-133)] were performed to better characterize ppq interactions with cannabinoid receptors. |
2002-10-21 |
2023-08-12 |
mouse |
| Isabel Matias, Pierre Pochard, Pierangelo Orlando, Michel Salzet, Joel Pestel, Vincenzo Di Marz. Presence and regulation of the endocannabinoid system in human dendritic cells. European journal of biochemistry. vol 269. issue 15. 2002-09-09. PMID:12153574. |
here we have analyzed human dendritic cells for the presence of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-ag), the cannabinoid cb1 and cb2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (faah). |
2002-09-09 |
2023-08-12 |
human |
| Robert J McKallip, Catherine Lombard, Michael Fisher, Billy R Martin, Seongho Ryu, Steven Grant, Prakash S Nagarkatti, Mitzi Nagarkatt. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood. vol 100. issue 2. 2002-08-30. PMID:12091357. |
targeting cb2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. |
2002-08-30 |
2023-08-12 |
mouse |
| Robert J McKallip, Catherine Lombard, Michael Fisher, Billy R Martin, Seongho Ryu, Steven Grant, Prakash S Nagarkatti, Mitzi Nagarkatt. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood. vol 100. issue 2. 2002-08-30. PMID:12091357. |
together, the current data demonstrate that cb2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of apoptosis. |
2002-08-30 |
2023-08-12 |
mouse |
| N Clayton, F H Marshall, C Bountra, C T O'Shaughness. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain. vol 96. issue 3. 2002-08-16. PMID:11972997. |
cb1 and cb2 cannabinoid receptors are implicated in inflammatory pain. |
2002-08-16 |
2023-08-12 |
rat |
| Emmanuel S Onaivi, Claire M Leonard, Hiroki Ishiguro, Ping Wu Zhang, Zhicheng Lin, Babatunde E Akinshola, George R Uh. Endocannabinoids and cannabinoid receptor genetics. Progress in neurobiology. vol 66. issue 5. 2002-08-12. PMID:12015198. |
availability of increasingly-specific cb1 and cb2 cnr antagonists and of cb1 and cb2 cnr knockout mice have increased our understanding of these cannabinoid systems and provides tantalizing evidence for even more g protein-coupled cnrs. |
2002-08-12 |
2023-08-12 |
mouse |
| W Paul Farquhar-Smith, Sian I Jaggar, Andrew S C Ric. Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. Pain. vol 97. issue 1-2. 2002-08-12. PMID:12031775. |
the use of cannabinoid cb1 receptor (sr141617a) and cb2 receptor (sr144528) antagonists suggested that the effect of anandamide was mediated by both cb1 and cb2 cannabinoid receptors whilst the action of pea was via cb2 (or cb2-like) receptors only. |
2002-08-12 |
2023-08-12 |
Not clear |
| S J Carlisle, F Marciano-Cabral, A Staab, C Ludwick, G A Cabra. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. International immunopharmacology. vol 2. issue 1. 2002-07-16. PMID:11789671. |
furthermore, since inflammatory and primed macrophages express the highest levels of cb2, the functional activities of macrophages when in these respective states of activation may be the most sensitive to the action of cannabinoids. |
2002-07-16 |
2023-08-12 |
rat |
| Peter M Zygmunt, David A Andersson, Edward D Hogestat. Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 11. 2002-07-05. PMID:12040079. |
delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a cb1 and cb2 cannabinoid receptor-independent mechanism. |
2002-07-05 |
2023-08-12 |
mouse |
| Meritxell Alberich Jordà, Sandra E Verbakel, Peter J M Valk, Yolanda V Vankan-Berkhoudt, Mauro Maccarrone, Allessandro Finazzi-Agrò, Bob Löwenberg, Ruud Delwe. Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. Blood. vol 99. issue 8. 2002-06-17. PMID:11929767. |
exposure of cb2-expressing cells to different cannabinoids showed that the true ligand for cb2 is 2-arachidonoylglycerol (2-ag), which may act as chemoattractant and as a chemokinetic agent. |
2002-06-17 |
2023-08-12 |
mouse |
| P Valk, S Verbakel, M von Lindern, B Löwenberg, R Delwe. Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2. The hematology journal : the official journal of the European Haematology Association. vol 1. issue 4. 2002-06-10. PMID:11920199. |
anandamide (ana) is an endogenous ligand for the cannabinoid receptors cb1 and cb2 that is able to synergistically stimulate the proliferation of hematopoietic growth factor-dependent blood cells in serum-free culture. |
2002-06-10 |
2023-08-12 |
Not clear |