| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Calignano, G La Rana, D Piomell. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. European journal of pharmacology. vol 419. issue 2-3. 2001-11-01. PMID:11426841. |
these effects were prevented by the cannabinoid cb1 receptor antagonist sr141716a, not the cannabinoid cb2 receptor antagonist sr141716a. |
2001-11-01 |
2023-08-12 |
mouse |
| Y Kobayashi, S Arai, K Waku, T Sugiur. Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. Journal of biochemistry. vol 129. issue 5. 2001-10-04. PMID:11328586. |
the addition of sr144528, a cannabinoid cb2 receptor-specific antagonist, to the cells prior to the addition of 2-ag abolished the response induced by 2-ag, indicating that the cb2 receptor is involved in the response. |
2001-10-04 |
2023-08-12 |
Not clear |
| A C Porter, C C Felde. The endocannabinoid nervous system: unique opportunities for therapeutic intervention. Pharmacology & therapeutics. vol 90. issue 1. 2001-10-04. PMID:11448725. |
delta(9)-thc binds to and activates two known cannabinoid receptors found in mammalian tissue, cb1 and cb2. |
2001-10-04 |
2023-08-12 |
Not clear |
| A Goutopoulos, P Fan, A D Khanolkar, X Q Xie, S Lin, A Makriyanni. Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425567. |
stereochemical selectivity of methanandamides for the cb1 and cb2 cannabinoid receptors and their metabolic stability. |
2001-09-20 |
2023-08-12 |
Not clear |
| A Goutopoulos, P Fan, A D Khanolkar, X Q Xie, S Lin, A Makriyanni. Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425567. |
several chiral, analogues of the endogenous cannabinoid receptor ligand, arachidonylethanolamide (anandamide), methylated at the 2,1' and 2' positions using asymmetric synthesis were evaluated in order to study (a) stereoselectivity of binding to cb1 and cb2 cannabinoid receptors; and (b) metabolic stability with regard to anandamide amidase. |
2001-09-20 |
2023-08-12 |
Not clear |
| G Esposito, A A Izzo, M Di Rosa, T Iuvon. Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells. Journal of neurochemistry. vol 78. issue 4. 2001-09-20. PMID:11520904. |
the cannabinoid cb1 receptor antagonist, sr141716a (0.1-100 nm), but not the cannabinoid cb2 receptor antagonist, sr144528 (0.1-100 nm), reduced in a dose-related manner win 55,212-2-and cannabinol-induced inhibition of nitrite production. |
2001-09-20 |
2023-08-12 |
rat |
| D Zhou, Z H Son. CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells. Journal of neuroscience research. vol 65. issue 4. 2001-09-13. PMID:11494371. |
using reverse transcription-polymerase chain reaction and immunofluorescence microscopy, the endogenously expressed cb1, but not cb2, cannabinoid receptors were detected in morphologically differentiated n1e-115 cells. |
2001-09-13 |
2023-08-12 |
mouse |
| K R Kozak, J J Prusakiewicz, S W Rowlinson, C Schneider, L J Marnet. Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11402053. |
the endocannabinoid, 2-arachidonylglycerol (2-ag), is an endogenous ligand for the central (cb1) and peripheral (cb2) cannabinoid receptors and has been shown to be efficiently and selectively oxygenated by cyclooxygenase (cox)-2. |
2001-09-06 |
2023-08-12 |
Not clear |
| Y H Chang, S T Lee, W W Li. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. Journal of cellular biochemistry. vol 81. issue 4. 2001-06-28. PMID:11329626. |
the endogenous cannabinoid, 2-ag, also serves as a substrate for cox-catalyzing pge(2) production, which in turn modulates the action of cb2. |
2001-06-28 |
2023-08-12 |
Not clear |
| M P Germanò, V D'Angelo, M R Mondello, S Pergolizzi, F Capasso, R Capasso, A A Izzo, N Mascolo, R De Pasqual. Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218077. |
the protective effect of win 55,212-2 (1 mg/kg) was counteracted by the cannabinoid cb1 receptor antagonist sr141716a, but not by the cannabinoid cb2 receptor antagonist sr144528. |
2001-05-03 |
2023-08-12 |
rat |
| C Lagneux, D Lamontagn. Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide. British journal of pharmacology. vol 132. issue 4. 2001-04-26. PMID:11181418. |
some hearts were perfused with either sr 141716a (a cannabinoid cb(1), receptor antagonist 1 microm), sr 144528 (a cb2 receptor anagonist microm), nnla (3 microm) or sodium nitroprusside (1 microm) 5 min before ischaemia and during the ischaemic period. |
2001-04-26 |
2023-08-12 |
rat |
| b' F Maingret, A J Patel, M Lazdunski, E Honor\\xc3\\xa. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. The EMBO journal. vol 20. issue 1-2. 2001-04-12. PMID:11226154.' |
we demonstrate that task-1, unlike the other two pore (2p) domain k(+) channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the cb1 and cb2 receptors. |
2001-04-12 |
2023-08-12 |
Not clear |
| H Iwamura, H Suzuki, Y Ueda, T Kaya, T Inab. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. The Journal of pharmacology and experimental therapeutics. vol 296. issue 2. 2001-04-05. PMID:11160626. |
in vitro and in vivo pharmacological characterization of jte-907, a novel selective ligand for cannabinoid cb2 receptor. |
2001-04-05 |
2023-08-12 |
mouse |
| J S Moody, K R Kozak, C Ji, L J Marnet. Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. Biochemistry. vol 40. issue 4. 2001-03-22. PMID:11170406. |
the identification of 2-arachidonylglycerol (2-ag) as an endogenous ligand for the central (cb1) and peripheral (cb2) cannabinoid receptors has prompted interest in enzymes capable of modifying or inactivating this endocannabinoid. |
2001-03-22 |
2023-08-12 |
cat |
| T Yamamoto, K Takad. Role of cannabinoid receptor in the brain as it relates to drug reward. Japanese journal of pharmacology. vol 84. issue 3. 2001-03-01. PMID:11138722. |
understanding of cannabinoid (cb) actions has been remarkably advanced during the last decade, due mainly to the identification of the g-protein-coupled cannabinoid receptors, namely, cb1 receptors that are predominantly found in the brain and cb2 receptors that are exclusively found in peripheral tissues. |
2001-03-01 |
2023-08-12 |
Not clear |
| G B Stefano, T V Bilfinger, C M Rialas, D G Deutsc. 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. Pharmacological research. vol 42. issue 4. 2001-01-25. PMID:10987990. |
2-ag occurs in vertebrate and invertebrate tissues and binds to both cannabinoid receptors (cb1 and cb2). |
2001-01-25 |
2023-08-12 |
human |
| A D Khanolkar, S L Palmer, A Makriyanni. Molecular probes for the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106781. |
cannabinoids produce most of their biochemical and pharmacological effects by interacting with cb1 and cb2 cannabinoid receptors, both of which are g-protein coupled membrane-bound functional proteins. |
2001-01-11 |
2023-08-12 |
Not clear |
| T Sugiura, K Wak. 2-Arachidonoylglycerol and the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106784. |
2-ag binds to the cannabinoid receptors (cb1 and cb2) and exhibits a variety of cannabimimetic activities in vitro and in vivo. |
2001-01-11 |
2023-08-12 |
rat |
| T Sugiura, K Wak. 2-Arachidonoylglycerol and the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106784. |
recently, we found that 2-ag induces ca(2+) transients in ng108-15 cells, which express the cb1 receptor, and in hl-60 cells, which express the cb2 receptor, through a cannabinoid receptor- and gi/go-dependent mechanism. |
2001-01-11 |
2023-08-12 |
rat |
| G Kunos, Z Járai, S Bátkai, S K Goparaju, E J Ishac, J Liu, L Wang, J A Wagne. Endocannabinoids as cardiovascular modulators. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106789. |
although multiple lines of evidence indicate that the hypotensive and bradycardic effects of anandamide and other cannabinoids are mediated by peripherally located cb1 cannabinoid receptors, anandamide can also elicit vasodilation in certain vascular beds, which is independent of cb1 or cb2 receptors. |
2001-01-11 |
2023-08-12 |
Not clear |