| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malcolm Begg, Fong-Ming Mo, László Offertaler, Sándor Bátkai, Pál Pacher, Raj K Razdan, David M Lovinger, George Kuno. G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952947. |
the cannabinoid analog "abnormal cannabidiol" (abn-cbd) causes endothelium-dependent vasodilation in rat isolated mesenteric arteries through a g protein-coupled receptor distinct from cb1 or cb2. |
2003-12-24 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
cannabinoid cb2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in alzheimer's disease brains. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
we have studied the status of some of the components of the endocannabinoid system, fatty acid amide hydrolase and cannabinoid cb1 and cb2 receptors, in postmortem brains from patients with alzheimer's disease. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
our results show that both fatty acid amide hydrolase and cannabinoid cb2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of cb1 receptors remains unchanged. |
2003-12-23 |
2023-08-12 |
human |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2003-12-10 |
2023-08-12 |
human |
| Aline Quartilho, Heriberto P Mata, Mohab M Ibrahim, Todd W Vanderah, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. vol 99. issue 4. 2003-10-29. PMID:14508331. |
inhibition of inflammatory hyperalgesia by activation of peripheral cb2 cannabinoid receptors. |
2003-10-29 |
2023-08-12 |
Not clear |
| Aline Quartilho, Heriberto P Mata, Mohab M Ibrahim, Todd W Vanderah, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. vol 99. issue 4. 2003-10-29. PMID:14508331. |
agonists selective for cb2 cannabinoid receptors, which are not found in the cns, do not produce the cns effects typical of nonselective cannabinoid receptor agonists but do inhibit acute nociception. |
2003-10-29 |
2023-08-12 |
Not clear |
| Mohab M Ibrahim, Hongfeng Deng, Alexander Zvonok, Debra A Cockayne, Joyce Kwan, Heriberto P Mata, Todd W Vanderah, Josephine Lai, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 18. 2003-10-23. PMID:12917492. |
activation of cb2 cannabinoid receptors by am1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the cns. |
2003-10-23 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
traditionally, the effects of these compounds have been attributed to cannabinoid receptors cb1 and cb2, both of which are expressed in mouse splenocytes. |
2003-10-03 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
therefore, n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorphenyl)-4-methyl-h-pyrazole-3 carboxyamidehydrochloride (sr141716a), a cb1 antagonist, and n-[(1s)-endo-1,3,3,-trimethyl-bicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528), a cb2 antagonist, were used to investigate the role of cannabinoid receptors in the cannabinoid-induced inhibition of phorbol ester plus calcium ionophore (pma/io)-stimulated interleukin-2 production by mouse splenocytes. |
2003-10-03 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
with the demonstration that cannabinoid-induced inhibition of pma/io-stimulated interleukin-2 was not mediated via cb1 or cb2, alternative targets of cannabinoids in t cells were examined. |
2003-10-03 |
2023-08-12 |
mouse |
| T J Price, G Helesic, D Parghi, K M Hargreaves, C M Flore. The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat. Neuroscience. vol 120. issue 1. 2003-09-30. PMID:12849749. |
taken together with the absence of an above background in situ signal for cb2 mrna in tg neurons, these findings suggest that the peripherally mediated antinociceptive effects of cannabinoids may involve either as yet unidentified receptors or interaction with afferent neuron populations that normally subserve non-nociceptive functions. |
2003-09-30 |
2023-08-12 |
rat |
| b' Mauro Maccarrone, Monica Bari, Domenico Del Principe, Alessandro Finazzi-Agr\\xc3\\xb. Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin. Thrombosis and haemostasis. vol 89. issue 2. 2003-09-26. PMID:12574815.' |
selective antagonists of both cb1 and cb2 cannabinoid receptors inhibited this binding, which was enhanced up to approximately 230% over the controls by 1 micro m serotonin (5-hydroxytryptamine, 5-ht). |
2003-09-26 |
2023-08-12 |
human |
| Marja D Van Sickle, Lorraine D Oland, Ken Mackie, Joseph S Davison, Keith A Sharke. Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 3. 2003-09-26. PMID:12791597. |
a specific cannabinoid (cb)1 receptor antagonist sr-141716a (5 mg/kg ip) reversed the effect of thc, whereas the cb2 receptor antagonist sr-144528 (5 mg/kg ip) was ineffective. |
2003-09-26 |
2023-08-12 |
Not clear |
| Ji Zhang, Cyrla Hoffert, Huy Khang Vu, Thierry Groblewski, Sultan Ahmad, Dajan O'Donnel. Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. The European journal of neuroscience. vol 17. issue 12. 2003-09-24. PMID:12823482. |
although much of the existing data suggest that the analgesic effects of cannabinoids are mediated via neuronal cb1 receptors, there is increasing evidence to support a role for peripheral cb2 receptors, which are expressed preferentially on immune cells. |
2003-09-24 |
2023-08-12 |
rat |
| Allyn Franklin, Sophie Parmentier-Batteur, Lisa Walter, David A Greenberg, Nephi Stell. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944505. |
interestingly, these receptors engaged by pea are pharmacologically distinct from cb1 and cb2 cannabinoid receptors, as well as from the win and abn-cbd (abnormal-cannabidiol) receptors, two recently identified cannabinoid receptors. |
2003-09-16 |
2023-08-12 |
mouse |
| Maria-Teresa Samson, Andrea Small-Howard, Lori M N Shimoda, Murielle Koblan-Huberson, Alexander J Stokes, Helen Turne. Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 10. 2003-08-26. PMID:12734338. |
differential roles of cb1 and cb2 cannabinoid receptors in mast cells. |
2003-08-26 |
2023-08-12 |
Not clear |
| Maria-Teresa Samson, Andrea Small-Howard, Lori M N Shimoda, Murielle Koblan-Huberson, Alexander J Stokes, Helen Turne. Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 10. 2003-08-26. PMID:12734338. |
analysis of signaling pathways downstream of cannabinoid application reveals that activation of extracellular signal-regulated kinase, akt, and a selected subset of akt targets is accomplished by cb2 ligands and nonselective cb1/cb2 agonists in mast cells. |
2003-08-26 |
2023-08-12 |
Not clear |
| Maria-Teresa Samson, Andrea Small-Howard, Lori M N Shimoda, Murielle Koblan-Huberson, Alexander J Stokes, Helen Turne. Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 10. 2003-08-26. PMID:12734338. |
cb1 inhibition does not affect akt or extracellular signal-regulated kinase activation by cannabinoids, indicating that cb2 is the predominant regulatory receptor for these kinases in this cell context. |
2003-08-26 |
2023-08-12 |
Not clear |
| Andrea G Hohman. Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505699. |
these studies provide insight into the functional roles of cannabinoid receptor subtypes, cb1 and cb2, in cannabinoid antinociceptive mechanisms as revealed in animal models of acute and persistent (somatic inflammatory, visceral inflammatory, neuropathic) pain. |
2003-08-22 |
2023-08-12 |
Not clear |