| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Nieri, Enrica Martinotti, Lara Testai, Cinzia Martinelli, Maria Cristina Bresch. Effects of cannabinoids on non-adrenergic non-cholinergic-mediated relaxation in guinea-pig trachea. European journal of pharmacology. vol 475. issue 1-3. 2004-05-03. PMID:12954367. |
the effect of win 55,212-2 was not modified by the cannabinoid cb1 and cb2 receptor-selective antagonists, n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide hydrochloride (sr141716a; 10(-5) m) and n-(1s)-endo-1,3,3-trimethyl bicyclo [2.2.1] heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr 144528; 10(-5) m), respectively. |
2004-05-03 |
2023-08-12 |
Not clear |
| Paola Nieri, Enrica Martinotti, Lara Testai, Cinzia Martinelli, Maria Cristina Bresch. Effects of cannabinoids on non-adrenergic non-cholinergic-mediated relaxation in guinea-pig trachea. European journal of pharmacology. vol 475. issue 1-3. 2004-05-03. PMID:12954367. |
in conclusion, our results suggest that (a) cannabinoid cb1 and cb2 receptor stimulation does not alter the inhibitory nanc transmission in guinea-pig trachea, and (b) win 55,212-2 potentiates the no-mediated component of the nanc relaxant response to electrical stimulation through a cannabinoid receptor-independent mechanism. |
2004-05-03 |
2023-08-12 |
Not clear |
| Allyn Franklin, Nephi Stell. Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. European journal of pharmacology. vol 474. issue 2-3. 2004-04-23. PMID:12921861. |
arachidonylcyclopropylamide increases microglial cell migration through cannabinoid cb2 and abnormal-cannabidiol-sensitive receptors. |
2004-04-23 |
2023-08-12 |
mouse |
| Clara Di Filippo, Francesco Rossi, Settimio Rossi, Michele D'Amic. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. Journal of leukocyte biology. vol 75. issue 3. 2004-04-23. PMID:14657208. |
cannabinoid cb2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and pmn. |
2004-04-23 |
2023-08-12 |
mouse |
| Clara Di Filippo, Francesco Rossi, Settimio Rossi, Michele D'Amic. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. Journal of leukocyte biology. vol 75. issue 3. 2004-04-23. PMID:14657208. |
in this study, we have assessed the activation of the cannabinoid cb2 receptor (cb2-r) in a model of mouse myocardial ischemia/reperfusion (i/r). |
2004-04-23 |
2023-08-12 |
mouse |
| Erica J Carrier, Christopher S Kearn, Andrew J Barkmeier, Nicole M Breese, Wenqi Yang, Kasem Nithipatikom, Sandra L Pfister, William B Campbell, Cecilia J Hillar. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Molecular pharmacology. vol 65. issue 4. 2004-04-21. PMID:15044630. |
cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a cb2 receptor-dependent mechanism. |
2004-04-21 |
2023-08-12 |
rat |
| Susanna M Saario, Juha R Savinainen, Jarmo T Laitinen, Tomi Järvinen, Riku Niem. Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. Biochemical pharmacology. vol 67. issue 7. 2004-04-13. PMID:15013854. |
2-arachidonoylglycerol (2-ag) is an endogenous cannabinoid that binds to cb1 and cb2 cannabinoid receptors, inducing cannabimimetic effects. |
2004-04-13 |
2023-08-12 |
rat |
| Celine Gongora, Stacey Hose, Terrence P O'Brien, Debasish Sinh. Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940. Immunology letters. vol 91. issue 1. 2004-03-30. PMID:14757364. |
many effects of cannabinoids are mediated by two g-protein coupled receptors, designated cb1 and cb2. |
2004-03-30 |
2023-08-12 |
Not clear |
| Andis Klegeris, Christopher J Bissonnette, Patrick L McGee. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British journal of pharmacology. vol 139. issue 4. 2004-03-24. PMID:12813001. |
1 two cannabinoid receptors, cb1 and cb2, have been identified. |
2004-03-24 |
2023-08-12 |
human |
| Andrew J Irving, Mark G Rae, Angela A Coutt. Cannabinoids on the brain. TheScientificWorldJournal. vol 2. 2004-03-23. PMID:12805989. |
cannabinoids act primarily via two types of receptor, cb1 and cb2, with cb1 receptors mediating most of the central actions of cannabinoids. |
2004-03-23 |
2023-08-12 |
Not clear |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Joe Chou, Izabella Perkins, Lily Lu, Liang Nong, Herman Friedma. Cannabinoid receptors and T helper cells. Journal of neuroimmunology. vol 147. issue 1-2. 2004-03-15. PMID:14741435. |
receptor antagonists for cb1 (sr141716a, sr1) and cb2 (sr144528, sr2) were also injected to analyze the involvement of cannabinoid receptors. |
2004-03-15 |
2023-08-12 |
mouse |
| Andrea G Hohmann, Jesse N Farthing, Alexander M Zvonok, Alexandros Makriyanni. Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. The Journal of pharmacology and experimental therapeutics. vol 308. issue 2. 2004-03-11. PMID:14610224. |
selective activation of cannabinoid cb2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. |
2004-03-11 |
2023-08-12 |
Not clear |
| Giovanna Zolese, Michal Wozniak, Paolo Mariani, Letizia Saturni, Enrico Bertoli, Annarina Ambrosin. Different modulation of phospholipase A2 activity by saturated and monounsaturated N-acylethanolamines. Journal of lipid research. vol 44. issue 4. 2004-03-02. PMID:12562826. |
the binding with cannabinoid receptors cb1 and cb2 was demonstrated for some naes, such as anandamide. |
2004-03-02 |
2023-08-12 |
Not clear |
| Asha K Nadipuram, Mathangi Krishnamurthy, Antonio M Ferreira, Wei Li, Bob M Moor. Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors. Bioorganic & medicinal chemistry. vol 11. issue 14. 2004-02-27. PMID:12818675. |
synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the cb1 and cb2 receptors. |
2004-02-27 |
2023-08-12 |
Not clear |
| Asha K Nadipuram, Mathangi Krishnamurthy, Antonio M Ferreira, Wei Li, Bob M Moor. Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors. Bioorganic & medicinal chemistry. vol 11. issue 14. 2004-02-27. PMID:12818675. |
a series of c3 cyclic side-chain analogues of classical cannabinoids were synthesized to probe the ligand binding pocket of the cb1 and cb2 receptors. |
2004-02-27 |
2023-08-12 |
Not clear |
| Xiang-Qun Xie, Jian-Zhong Chen, Eric M Billing. 3D structural model of the G-protein-coupled cannabinoid CB2 receptor. Proteins. vol 53. issue 2. 2004-02-26. PMID:14517981. |
3d structural model of the g-protein-coupled cannabinoid cb2 receptor. |
2004-02-26 |
2023-08-12 |
cattle |
| Xiang-Qun Xie, Jian-Zhong Chen, Eric M Billing. 3D structural model of the G-protein-coupled cannabinoid CB2 receptor. Proteins. vol 53. issue 2. 2004-02-26. PMID:14517981. |
the cannabinoid (cb) receptor subtype cb2 is of particular interest due to its involvement in signal transduction in the immune system and its increased characterization by mutational and other studies. |
2004-02-26 |
2023-08-12 |
cattle |
| Alison J Drysdale, Bettina Plat. Cannabinoids: mechanisms and therapeutic applications in the CNS. Current medicinal chemistry. vol 10. issue 24. 2004-02-02. PMID:14529462. |
to date, two distinct cannabinoid receptors (cb1 and cb2) have been discovered, but evidence for further receptor types has been brought forward. |
2004-02-02 |
2023-08-12 |
Not clear |
| Claudio Castellano, Clelia Rossi-Arnaud, Vincenzo Cestari, Marco Costanz. Cannabinoids and memory: animal studies. Current drug targets. CNS and neurological disorders. vol 2. issue 6. 2004-01-30. PMID:14683467. |
two subtypes of cannabinoid receptors have been identified to date: the central cb1 subtype and the peripheral cb2 subtype. |
2004-01-30 |
2023-08-12 |
mouse |
| Mathangi Krishnamurthy, Antonio M Ferreira, Bob M Moor. Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids. Bioorganic & medicinal chemistry letters. vol 13. issue 20. 2004-01-12. PMID:14505654. |
a series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their cb1 and cb2 binding affinities were evaluated relative to delta(8)-thc and compound 2. |
2004-01-12 |
2023-08-12 |
Not clear |