| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
a cannabinoid cb2 agonist, jwh 133, also inhibited electrical field stimulation-induced guinea pig bronchial smooth muscle contraction and its inhibitory effect was blocked by sr 144528. |
2004-12-02 |
2023-08-12 |
Not clear |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
these findings suggest that win 55212-2 inhibit the activation of c-fibers via cannabinoid cb2 receptors and maxi-k+ channels in guinea pig airways. |
2004-12-02 |
2023-08-12 |
Not clear |
| Victoria E Mendizábal, Edda Adler-Graschinsk. Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Current vascular pharmacology. vol 1. issue 3. 2004-12-01. PMID:15320476. |
hence, the endocannabinoid system, including the cb1 and cb2 receptors, the metabolizing enzyme fatty acid amide hydrolase and the anandamide transporter, is a potential target for the development of novel therapeutic drugs in the treatment of various conditions, such as pain, feeding disorders and vascular disease among others. |
2004-12-01 |
2023-08-12 |
Not clear |
| Rachel J A Helliwell, Lawrence W Chamley, Katherine Blake-Palmer, Murray D Mitchell, Janice Wu, Christopher S Kearn, Michelle Glas. Characterization of the endocannabinoid system in early human pregnancy. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472222. |
in this study, we examined the distribution of the cannabinoid receptors, cb1 and cb2, and the endocannabinoid-metabolizing enzyme faah in first trimester human placenta. |
2004-11-19 |
2023-08-12 |
human |
| Rachel J A Helliwell, Lawrence W Chamley, Katherine Blake-Palmer, Murray D Mitchell, Janice Wu, Christopher S Kearn, Michelle Glas. Characterization of the endocannabinoid system in early human pregnancy. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472222. |
the immune system-associated cannabinoid cb2 receptors were localized only to placental macrophages. |
2004-11-19 |
2023-08-12 |
human |
| Estefanía Núñez, Cristina Benito, M Ruth Pazos, Antonio Barbachano, Otto Fajardo, Sara González, Rosa M Tolón, Julián Romer. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266552. |
cannabinoid cb2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. |
2004-11-10 |
2023-08-12 |
human |
| Estefanía Núñez, Cristina Benito, M Ruth Pazos, Antonio Barbachano, Otto Fajardo, Sara González, Rosa M Tolón, Julián Romer. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266552. |
two types of cannabinoid receptors have been characterized so far, cb1 and cb2. |
2004-11-10 |
2023-08-12 |
human |
| Cristina Zoratti, Dijle Kipmen-Korgun, Karin Osibow, Roland Malli, Wolfgang F Graie. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. British journal of pharmacology. vol 140. issue 8. 2004-10-21. PMID:14645143. |
the endocannabinoid anandamide has been reported to affect neuronal cells, immune cells and smooth muscle cells via either cb1 or cb2 receptors. |
2004-10-21 |
2023-08-12 |
cattle |
| Emmanuel Contassot, Rick Wilmotte, Mirna Tenan, Marie-Claude Belkouch, Valérie Schnüriger, Nicolas de Tribolet, Karim Burkhardt, Pierre-Yves Dietrich, Karim Bourkhard. Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. Journal of neuropathology and experimental neurology. vol 63. issue 9. 2004-10-21. PMID:15453094. |
however, the clinical application of this drug is limited by possible undesirable side effects due to a broad expression of cannabinoid receptors (cb1 and cb2). |
2004-10-21 |
2023-08-12 |
human |
| Yoonkyung Do, Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294950. |
the precise role of cannabinoid receptors (cb)1 and cb2, as well as endogenous ligands for these receptors, on immune cells remains unclear. |
2004-09-28 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
cannabinoid antagonist sr-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving cb1 or cb2 receptors. |
2004-09-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
recent evidence indicates the existence of cannabinoid receptors distinct from cb1 or cb2 that are inhibited by sr-141716 but not by other cb1 antagonists such as am251. |
2004-09-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A Wagner, George Kuno. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. American journal of physiology. Heart and circulatory physiology. vol 287. issue 2. 2004-09-03. PMID:15059774. |
we conclude that sr-141716 inhibits the acute hemodynamic effects of lps by interacting with a cardiac receptor distinct from cb1 or cb2 that mediates negative inotropy and may be activated by anandamide or a related endocannabinoid released during endotoxemia. |
2004-09-03 |
2023-08-12 |
mouse |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
dronabinol (delta 9-tetrahydocannabinol, thc), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the cb1 and the cb2 subtype of cannabinoid receptors. |
2004-08-03 |
2023-08-12 |
Not clear |
| Ester Frid. The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159678. |
endogenous cannabinoids (endocannabinoids) and their cannabinoid cb1 and cb2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. |
2004-08-03 |
2023-08-12 |
human |
| Marc Steffens, Thomas J Feuerstei. Receptor-independent depression of DA and 5-HT uptake by cannabinoids in rat neocortex--involvement of Na(+)/K(+)-ATPase. Neurochemistry international. vol 44. issue 7. 2004-07-28. PMID:15209421. |
the effect of win55212-2 was not mediated by cannabinoid receptors, since the cb1 receptor antagonist am251 failed to diminish uptake inhibition by win55212-2 and since the ki estimates of win55212-2 were outside the range of the dissociation constants of win55212-2 at both cb1 and cb2 receptors. |
2004-07-28 |
2023-08-12 |
rat |
| B Park, H M Gibbons, M D Mitchell, M Glas. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 10. 2004-07-15. PMID:14580383. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) plant and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2004-07-15 |
2023-08-12 |
human |
| Nazik Rayman, King H Lam, Jon D Laman, Peter J Simons, Bob Löwenberg, Pieter Sonneveld, Ruud Delwe. Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 4. 2004-06-15. PMID:14764676. |
using the human raji b cell line as a model, we demonstrate in a transwell assay that moderate migration occurs upon stimulation of the cb2 receptor with the endocannabinoid 2-arachidonoylglycerol, which is enhanced by cd40 costimulation. |
2004-06-15 |
2023-08-12 |
human |
| Sultan Ahmad, Andy Dra. Novel G protein-coupled receptors as pain targets. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 1. 2004-06-03. PMID:14983976. |
indeed, opioid and cannabinoid ligands are of established therapeutic value for pain management, and further exploitation of the specific gpcr subtypes (delta-opioid, cb1 and cb2) for these ligands may yield more selective, potent analgesics with favorable side effects. |
2004-06-03 |
2023-08-12 |
Not clear |
| Xiang Ni, Ellen B Geller, Michael J Eppihimer, Toby K Eisenstein, Martin W Adler, Ronald F Tum. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Multiple sclerosis (Houndmills, Basingstoke, England). vol 10. issue 2. 2004-06-03. PMID:15124761. |
furthermore, use of the selective antagonists for the cb1 receptor (sr 141716a) and the cb2 receptor (sr144528) in this study demonstrated that the cannabinoid's inhibitory effects on leukocyte/endothelial interactions can be mediated by activating cb2 receptor. |
2004-06-03 |
2023-08-12 |
mouse |