| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seishi Kishimoto, Maiko Gokoh, Saori Oka, Mayumi Muramatsu, Takashi Kajiwara, Keizo Waku, Takayuki Sugiur. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12711605. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2) and has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. |
2003-08-18 |
2023-08-12 |
human |
| Seishi Kishimoto, Maiko Gokoh, Saori Oka, Mayumi Muramatsu, Takashi Kajiwara, Keizo Waku, Takayuki Sugiur. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12711605. |
recently, we proposed that 2-arachidonoylglycerol is the true endogenous ligand for the cannabinoid receptors, and both receptors (cb1 and cb2) are primarily 2-arachidonoylglycerol receptors. |
2003-08-18 |
2023-08-12 |
human |
| Demetris P Papahatjis, Spyros P Nikas, Therapia Kourouli, Ravi Chari, Wei Xu, Roger G Pertwee, Alexandros Makriyanni. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of medicinal chemistry. vol 46. issue 15. 2003-08-18. PMID:12852753. |
earlier work from our laboratories has provided evidence for the existence of a subsite within the cb1 and cb2 cannabinoid receptor binding domain corresponding to substituents at the benzylic side chain position of classical cannabinoids. |
2003-08-18 |
2023-08-12 |
Not clear |
| Tamas F Freund, Istvan Katona, Daniele Piomell. Role of endogenous cannabinoids in synaptic signaling. Physiological reviews. vol 83. issue 3. 2003-08-01. PMID:12843414. |
research of cannabinoid actions was boosted in the 1990s by remarkable discoveries including identification of endogenous compounds with cannabimimetic activity (endocannabinoids) and the cloning of their molecular targets, the cb1 and cb2 receptors. |
2003-08-01 |
2023-08-12 |
Not clear |
| Stefania Ruiu, Gèrard A Pinna, Giorgio Marchese, Jean-Mario Mussinu, Pierluigi Saba, Simone Tambaro, Paola Casti, Romina Vargiu, Luca Pan. Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12663689. |
the compound n-piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo [6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide] (ness 0327) was synthesized and evaluated for binding affinity toward cannabinoid cb1 and cb2 receptor. |
2003-07-24 |
2023-08-12 |
mouse |
| Demetris P Papahatjis, Spyros P Nikas, Thanos Andreou, Alexandros Makriyanni. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443781. |
1',1'-cyclopropyl side chain substituents enhance the affinities of delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the cb1 and cb2 cannabinoid receptors. |
2003-07-16 |
2023-08-12 |
Not clear |
| Allyn C Howlet. The cannabinoid receptors. Prostaglandins & other lipid mediators. vol 68-69. 2003-07-10. PMID:12432948. |
the two types of cannabinoid receptors, cb1 and cb2. |
2003-07-10 |
2023-08-12 |
Not clear |
| Jean Mario Mussinu, Stefania Ruiu, Antonio C Mulè, Amedeo Pau, Mauro A M Carai, Giovanni Loriga, Gabriele Murineddu, Gérard A Pinn. Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors. Bioorganic & medicinal chemistry. vol 11. issue 2. 2003-07-10. PMID:12470719. |
part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for cb1and cb2 cannabinoid receptors. |
2003-07-10 |
2023-08-12 |
Not clear |
| Stephen T Wrobleski, Ping Chen, John Hynes, Shuqun Lin, Derek J Norris, Chennagiri R Pandit, Steven Spergel, Hong Wu, John S Tokarski, Xiaorong Chen, Kathleen M Gillooly, Peter A Kiener, Kim W McIntyre, Vina Patil-Koota, David J Shuster, Lori A Turk, Guchen Yang, Katerina Leftheri. Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747783. |
this has led to the discovery of the novel indolopyridone 3a as a conformationally constrained cannabinoid ligand that displays high affinity for the cb2 receptor (k(i)(cb2) = 1.0 nm) and possesses antiinflammatory properties when administered orally in an in vivo murine inflammation model. |
2003-06-23 |
2023-08-12 |
Not clear |
| Declan Walsh, Kristine A Nelson, Fade Aziz Mahmou. Established and potential therapeutic applications of cannabinoids in oncology. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 11. issue 3. 2003-06-12. PMID:12618922. |
two types of cannabinoid receptors, cb1 and cb2, have been detected. |
2003-06-12 |
2023-08-12 |
Not clear |
| M Barann, G Molderings, M Brüss, H Bönisch, B W Urban, M Göther. Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site. British journal of pharmacology. vol 137. issue 5. 2003-04-16. PMID:12381672. |
in addition, binding studies with radioligands for 5-ht3 as well as for cannabinoid cb1 and cb2 receptors were carried out. |
2003-04-16 |
2023-08-12 |
human |
| Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M McCann, Valeria Rettor. The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 4. 2003-04-01. PMID:12578974. |
recent research has revealed that endogenous cannabinoid receptors (cb1 and cb2) react with the active ingredient of marijuana, delta(9)-tetrahydrocannabinol. |
2003-04-01 |
2023-08-12 |
rat |
| Brad L Upham, Alisa M Rummel, Joseph M Carbone, James E Trosko, Yanli Ouyang, Robert B Crawford, Norbert E Kaminsk. Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. International journal of cancer. vol 104. issue 1. 2003-03-25. PMID:12532414. |
based on rt-pcr analysis and employment of an antagonist of cb1 and cb2, the effects on gjic and mapk were independent of both cannabinoid receptors. |
2003-03-25 |
2023-08-12 |
rat |
| Manabu Kagaya, Jasmine Lamb, Jon Robbins, Clive P Page, Domenico Spin. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. British journal of pharmacology. vol 137. issue 1. 2003-03-19. PMID:12183329. |
both capsaicin and anandamide depolarized de-sheathed whole vagal nerve preparations that was antagonized by the vr1 antagonist, capsazepine (p<0.05) whilst this response was unaltered by the cannabinoid (cb1) selective antagonist sr141716a or the cb2 selective antagonist, sr144528, thereby ruling out a role for cannabinoid receptors in this response. |
2003-03-19 |
2023-08-12 |
Not clear |
| David C New, Yung H Won. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS letters. vol 536. issue 1-3. 2003-03-10. PMID:12586356. |
bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. |
2003-03-10 |
2023-08-12 |
human |
| G Choi, J Landin, X-Q Xi. The cytoplasmic helix of cannabinoid receptor CB2, a conformational study by circular dichroism and (1)H NMR spectroscopy in aqueous and membrane-like environments. The journal of peptide research : official journal of the American Peptide Society. vol 60. issue 3. 2003-02-25. PMID:12213126. |
computer models also predict this structure for the cannabinoid cb2 receptor, another member of the gpcr superfamily. |
2003-02-25 |
2023-08-12 |
Not clear |
| Michael Yuan, Sylvia M Kiertscher, Qingwen Cheng, Richard Zoumalan, Donald P Tashkin, Michael D Rot. Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. Journal of neuroimmunology. vol 133. issue 1-2. 2003-01-14. PMID:12446015. |
we conclude that cannabinoids have the potential to regulate the activation and balance of human th1/th2 cells by a cb2 receptor-dependent pathway. |
2003-01-14 |
2023-08-12 |
human |
| Mario van der Stelt, Wouter B Veldhuis, Mauro Maccarrone, Peter R Bär, Klaas Nicolay, Gerrit A Veldink, Vincenzo Di Marzo, Johannes F G Vliegenthar. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Molecular neurobiology. vol 26. issue 2-3. 2002-12-24. PMID:12428763. |
the endocannabinoid system constitutes the endogenous lipids anandamide, 2-arachidonoylglycerol and noladin ether, and the cannabinoid cb1 and cb2 receptors as well as the proteins for their inactivation. |
2002-12-24 |
2023-08-12 |
Not clear |
| T Sugiura, Y Kobayashi, S Oka, K Wak. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052034. |
2-ag acts as a full agonist at the cannabinoid receptors (cb1 and cb2). |
2002-12-06 |
2023-08-12 |
Not clear |
| Noëlla Germain, Elisabeth Boichot, Charles Advenier, Evgueni V Berdyshev, Vincent Lagent. Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells. International immunopharmacology. vol 2. issue 4. 2002-11-25. PMID:11962732. |
to address this question, the interference of cb1 and cb2 receptor antagonists with the inhibition of tnf-alpha production by synthetic cannabinoid win 55,212-2 was studied using human peripheral blood mononuclear cells (pbmc) in vitro. |
2002-11-25 |
2023-08-12 |
human |