| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asha K Nadipuram, Mathangi Krishnamurthy, Antonio M Ferreira, Wei Li, Bob M Moor. Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors. Bioorganic & medicinal chemistry. vol 11. issue 14. 2004-02-27. PMID:12818675. |
synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the cb1 and cb2 receptors. |
2004-02-27 |
2023-08-12 |
Not clear |
| Asha K Nadipuram, Mathangi Krishnamurthy, Antonio M Ferreira, Wei Li, Bob M Moor. Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors. Bioorganic & medicinal chemistry. vol 11. issue 14. 2004-02-27. PMID:12818675. |
a series of c3 cyclic side-chain analogues of classical cannabinoids were synthesized to probe the ligand binding pocket of the cb1 and cb2 receptors. |
2004-02-27 |
2023-08-12 |
Not clear |
| Xiang-Qun Xie, Jian-Zhong Chen, Eric M Billing. 3D structural model of the G-protein-coupled cannabinoid CB2 receptor. Proteins. vol 53. issue 2. 2004-02-26. PMID:14517981. |
3d structural model of the g-protein-coupled cannabinoid cb2 receptor. |
2004-02-26 |
2023-08-12 |
cattle |
| Xiang-Qun Xie, Jian-Zhong Chen, Eric M Billing. 3D structural model of the G-protein-coupled cannabinoid CB2 receptor. Proteins. vol 53. issue 2. 2004-02-26. PMID:14517981. |
the cannabinoid (cb) receptor subtype cb2 is of particular interest due to its involvement in signal transduction in the immune system and its increased characterization by mutational and other studies. |
2004-02-26 |
2023-08-12 |
cattle |
| Alison J Drysdale, Bettina Plat. Cannabinoids: mechanisms and therapeutic applications in the CNS. Current medicinal chemistry. vol 10. issue 24. 2004-02-02. PMID:14529462. |
to date, two distinct cannabinoid receptors (cb1 and cb2) have been discovered, but evidence for further receptor types has been brought forward. |
2004-02-02 |
2023-08-12 |
Not clear |
| Claudio Castellano, Clelia Rossi-Arnaud, Vincenzo Cestari, Marco Costanz. Cannabinoids and memory: animal studies. Current drug targets. CNS and neurological disorders. vol 2. issue 6. 2004-01-30. PMID:14683467. |
two subtypes of cannabinoid receptors have been identified to date: the central cb1 subtype and the peripheral cb2 subtype. |
2004-01-30 |
2023-08-12 |
mouse |
| Mathangi Krishnamurthy, Antonio M Ferreira, Bob M Moor. Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids. Bioorganic & medicinal chemistry letters. vol 13. issue 20. 2004-01-12. PMID:14505654. |
a series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their cb1 and cb2 binding affinities were evaluated relative to delta(8)-thc and compound 2. |
2004-01-12 |
2023-08-12 |
Not clear |
| Malcolm Begg, Fong-Ming Mo, László Offertaler, Sándor Bátkai, Pál Pacher, Raj K Razdan, David M Lovinger, George Kuno. G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952947. |
the cannabinoid analog "abnormal cannabidiol" (abn-cbd) causes endothelium-dependent vasodilation in rat isolated mesenteric arteries through a g protein-coupled receptor distinct from cb1 or cb2. |
2003-12-24 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
cannabinoid cb2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in alzheimer's disease brains. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
we have studied the status of some of the components of the endocannabinoid system, fatty acid amide hydrolase and cannabinoid cb1 and cb2 receptors, in postmortem brains from patients with alzheimer's disease. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
our results show that both fatty acid amide hydrolase and cannabinoid cb2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of cb1 receptors remains unchanged. |
2003-12-23 |
2023-08-12 |
human |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2003-12-10 |
2023-08-12 |
human |
| Aline Quartilho, Heriberto P Mata, Mohab M Ibrahim, Todd W Vanderah, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. vol 99. issue 4. 2003-10-29. PMID:14508331. |
inhibition of inflammatory hyperalgesia by activation of peripheral cb2 cannabinoid receptors. |
2003-10-29 |
2023-08-12 |
Not clear |
| Aline Quartilho, Heriberto P Mata, Mohab M Ibrahim, Todd W Vanderah, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. vol 99. issue 4. 2003-10-29. PMID:14508331. |
agonists selective for cb2 cannabinoid receptors, which are not found in the cns, do not produce the cns effects typical of nonselective cannabinoid receptor agonists but do inhibit acute nociception. |
2003-10-29 |
2023-08-12 |
Not clear |
| Mohab M Ibrahim, Hongfeng Deng, Alexander Zvonok, Debra A Cockayne, Joyce Kwan, Heriberto P Mata, Todd W Vanderah, Josephine Lai, Frank Porreca, Alexandros Makriyannis, T Philip Mala. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 18. 2003-10-23. PMID:12917492. |
activation of cb2 cannabinoid receptors by am1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the cns. |
2003-10-23 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
traditionally, the effects of these compounds have been attributed to cannabinoid receptors cb1 and cb2, both of which are expressed in mouse splenocytes. |
2003-10-03 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
therefore, n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorphenyl)-4-methyl-h-pyrazole-3 carboxyamidehydrochloride (sr141716a), a cb1 antagonist, and n-[(1s)-endo-1,3,3,-trimethyl-bicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528), a cb2 antagonist, were used to investigate the role of cannabinoid receptors in the cannabinoid-induced inhibition of phorbol ester plus calcium ionophore (pma/io)-stimulated interleukin-2 production by mouse splenocytes. |
2003-10-03 |
2023-08-12 |
mouse |
| Barbara L Faubert Kaplan, Cheryl E Rockwell, Norbert E Kaminsk. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805480. |
with the demonstration that cannabinoid-induced inhibition of pma/io-stimulated interleukin-2 was not mediated via cb1 or cb2, alternative targets of cannabinoids in t cells were examined. |
2003-10-03 |
2023-08-12 |
mouse |
| T J Price, G Helesic, D Parghi, K M Hargreaves, C M Flore. The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat. Neuroscience. vol 120. issue 1. 2003-09-30. PMID:12849749. |
taken together with the absence of an above background in situ signal for cb2 mrna in tg neurons, these findings suggest that the peripherally mediated antinociceptive effects of cannabinoids may involve either as yet unidentified receptors or interaction with afferent neuron populations that normally subserve non-nociceptive functions. |
2003-09-30 |
2023-08-12 |
rat |
| b' Mauro Maccarrone, Monica Bari, Domenico Del Principe, Alessandro Finazzi-Agr\\xc3\\xb. Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin. Thrombosis and haemostasis. vol 89. issue 2. 2003-09-26. PMID:12574815.' |
selective antagonists of both cb1 and cb2 cannabinoid receptors inhibited this binding, which was enhanced up to approximately 230% over the controls by 1 micro m serotonin (5-hydroxytryptamine, 5-ht). |
2003-09-26 |
2023-08-12 |
human |