| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K R Kozak, S W Rowlinson, L J Marnet. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. The Journal of biological chemistry. vol 275. issue 43. 2000-11-24. PMID:10931854. |
the neutral arachidonate derivative, 2-arachidonylglycerol (2-ag), is one of two described endocannabinoids and appears to be a ligand for both the central (cb1) and peripheral (cb2) cannabinoid receptors. |
2000-11-24 |
2023-08-12 |
Not clear |
| A Mahadevan, C Siegel, B R Martin, M E Abood, I Beletskaya, R K Razda. Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. Journal of medicinal chemistry. vol 43. issue 20. 2000-11-08. PMID:11020293. |
novel cannabinol probes for cb1 and cb2 cannabinoid receptors. |
2000-11-08 |
2023-08-12 |
Not clear |
| A Mahadevan, C Siegel, B R Martin, M E Abood, I Beletskaya, R K Razda. Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. Journal of medicinal chemistry. vol 43. issue 20. 2000-11-08. PMID:11020293. |
the various analogues were assayed for binding both to the brain and the peripheral cannabinoid receptors (cb1 and cb2). |
2000-11-08 |
2023-08-12 |
Not clear |
| O D Zhukov, M V Artamonov, V M Klimashevs'kyiĭ, N M Hoseieva, V M Marhitych, N M Hul. [N-acylethanolamine--a new class of natural adrenotropic modulators]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 72. issue 2. 2000-10-23. PMID:10979576. |
anandamide--a well known representative of naes--is an agonist of central (cb1) and peripheral (cb2) cannabinoid receptors. |
2000-10-23 |
2023-08-12 |
rat |
| P Sacerdote, P Massi, A E Panerai, D Parolar. In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996217. |
in vivo and in vitro treatment with the synthetic cannabinoid cp55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both cb1 and cb2 receptors. |
2000-10-12 |
2023-08-12 |
rat |
| P Sacerdote, P Massi, A E Panerai, D Parolar. In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996217. |
our data confirm that cannabinoids can affect some macrophage functions, mainly throughout cb2 receptors, and suggest that the development of specific cb2 ligands may lead to an interesting new class of anti-inflammatory drugs. |
2000-10-12 |
2023-08-12 |
rat |
| R Mechoula. Looking back at Cannabis research. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903394. |
investigations on two non-psychotropic, synthetic cannabinoids, hu-211, a neuroprotective agent and hu-308, a specific cb2 agonist are presented. |
2000-09-25 |
2023-08-12 |
Not clear |
| S L Palmer, A D Khanolkar, A Makriyanni. Natural and synthetic endocannabinoids and their structure-activity relationships. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903399. |
the biological targets for endocannabinoids include the cannabinoid receptors (cb1 and cb2), the enzyme anandamide amidohydrolase (aah), and the carrier protein referred to as the anandamide transporter (ant). |
2000-09-25 |
2023-08-12 |
Not clear |
| S L Palmer, A D Khanolkar, A Makriyanni. Natural and synthetic endocannabinoids and their structure-activity relationships. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903399. |
the identification of arachidonylethanolamide (anandamide, aea) as an endogenous cannabinoid has been an important development in cannabinoid research which has led to the identification of two proteins associated with cannabinoid physiology in addition to the cb1 and cb2 receptors. |
2000-09-25 |
2023-08-12 |
Not clear |
| B A Berglund, P R Fleming, K C Rice, J Y Shim, W J Welsh, A C Howlet. Development of a novel class of monocyclic and bicyclic alkyl amides that exhibit CB1 and CB2 cannabinoid receptor affinity and receptor activation. Drug design and discovery. vol 16. issue 4. 2000-07-11. PMID:10807034. |
cb1 and cb2 cannabinoid receptors can be activated by several different classes of agonists, including cannabinoids such as delta9-tetrahydrocannabinol and 9-nor-9beta-hydroxyhexahydrocannabinol, and eicosanoids such as arachidonylethanolamide. |
2000-07-11 |
2023-08-12 |
Not clear |
| M Shapira, Z Vogel, Y Sarn. Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789829. |
opioid (mu, delta, kappa) and cannabinoid (cb1, cb2) receptors are coupled mainly to gi/go gtp-binding proteins. |
2000-07-03 |
2023-08-12 |
Not clear |
| J M Derocq, O Jbilo, M Bouaboula, M Ségui, C Clère, P Casella. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation. The Journal of biological chemistry. vol 275. issue 21. 2000-06-30. PMID:10821843. |
in an attempt to decipher its role, we used affymetrix dna chips to investigate the gene expression profile of the promyelocytic cells hl-60 transfected with the cb2 receptor and activated with the cannabinoid agonist cp 55,940. |
2000-06-30 |
2023-08-12 |
Not clear |
| F Chaperon, M H Thiébo. Behavioral effects of cannabinoid agents in animals. Critical reviews in neurobiology. vol 13. issue 3. 2000-06-02. PMID:10803637. |
two subtypes of cannabinoid receptors have been identified to date, the cb1 receptor, essentially located in the cns, but also in peripheral tissues, and the cb2 receptor, found only at the periphery. |
2000-06-02 |
2023-08-12 |
Not clear |
| W Gonsiorek, C Lunn, X Fan, S Narula, D Lundell, R W Hipki. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779390. |
the endocannabinoids anandamide and 2-arachidonyl glycerol (2-ag) bind to g protein-coupled central and peripheral cannabinoid receptors cb1 and cb2, respectively. |
2000-05-25 |
2023-08-12 |
human |
| W Gonsiorek, C Lunn, X Fan, S Narula, D Lundell, R W Hipki. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779390. |
due to the relatively high expression of the cb2 isotype on peripheral immune cells, it has been hypothesized that this receptor mediates the immunosuppressive effects of cannabinoids. |
2000-05-25 |
2023-08-12 |
human |
| A Porcella, C Maxia, G L Gessa, L Pan. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. The European journal of neuroscience. vol 12. issue 3. 2000-05-22. PMID:10762343. |
we used reverse transcriptase polymerase chain reaction to detect the expression of the central and peripheral cannabinoid receptors (cb1 and cb2, respectively) mrna, and western blotting to show the presence of the cb1 protein in subregions of the human eye. |
2000-05-22 |
2023-08-12 |
human |
| Q Lu, A Straiker, Q Lu, G Maguir. Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Visual neuroscience. vol 17. issue 1. 2000-05-15. PMID:10750830. |
to date, two cannabinoid receptors, cb1 and cb2, have been cloned. |
2000-05-15 |
2023-08-12 |
mouse |
| A Gross, A Terraza, J Marchant, M Bouaboula, S Ouahrani-Bettache, J P Liautard, P Casellas, J Dornan. A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis. Journal of leukocyte biology. vol 67. issue 3. 2000-04-05. PMID:10733093. |
the triggering of cannabinoid receptors of cb1 and cb2 subtypes present on leukocytes may account for these effects. |
2000-04-05 |
2023-08-12 |
Not clear |
| B A Berglund, D L Boring, A C Howlet. Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils. Advances in experimental medicine and biology. vol 469. 2000-03-23. PMID:10667378. |
investigation of structural analogs of prostaglandin amides for binding to and activation of cb1 and cb2 cannabinoid receptors in rat brain and human tonsils. |
2000-03-23 |
2023-08-12 |
human |
| T Sugiura, S Kondo, S Kishimoto, T Miyashita, S Nakane, T Kodaka, Y Suhara, H Takayama, K Wak. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. The Journal of biological chemistry. vol 275. issue 1. 2000-01-31. PMID:10617657. |
evidence that 2-arachidonoylglycerol but not n-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid cb2 receptor. |
2000-01-31 |
2023-08-12 |
Not clear |