| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A A Izzo, N Mascolo, R Capasso, M P Germanò, R De Pasquale, F Capass. Inhibitory effect of cannabinoid agonists on gastric emptying in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494894. |
we have studied the effect of win 55,212-2 (a psychoactive cannabinoid agonist), cannabinol (a nonpsychoactive cannabinoid agonist), sr141716a, a cannabinoid cb1 antagonist, and sr144528, a cannabinoid cb2 antagonist, on gastric emptying in the rat. |
1999-11-08 |
2023-08-12 |
rat |
| V Chapma. The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat. British journal of pharmacology. vol 127. issue 8. 1999-10-21. PMID:10482905. |
the effect of spinal administration of the selective cannabinoid cb1 receptor antagonist, sr141716a, and the selective cb2 receptor antagonist, sr144528, on innocuous versus noxious evoked responses of dorsal horn neurones in the spinal cord of the anaesthetized rat was investigated. |
1999-10-21 |
2023-08-12 |
rat |
| V Chapma. The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat. British journal of pharmacology. vol 127. issue 8. 1999-10-21. PMID:10482905. |
the results of this study provide evidence that tonic cannabinoid cb1 receptor activation, but not cb2 receptor activation, attenuates acute nociceptive transmission, at the level of the spinal cord. |
1999-10-21 |
2023-08-12 |
rat |
| A G Hohmann, M Herkenha. Cannabinoid receptors undergo axonal flow in sensory nerves. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426476. |
the present study was conducted to evaluate axonal flow of cannabinoid receptors from the dorsal root ganglion to the periphery and to identify the putative involvement of cb1 and/or cb2 receptor subtypes. |
1999-10-08 |
2023-08-12 |
rat |
| P H Reggi. Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: achievements and challenges. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469885. |
ligand-ligand and ligand-receptor approaches to modeling the cannabinoid cb1 and cb2 receptors: achievements and challenges. |
1999-10-07 |
2023-08-12 |
Not clear |
| P H Reggi. Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: achievements and challenges. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469885. |
the cannabinoid cb1 and cb2 receptors belong to the super family of g protein-coupled receptors. |
1999-10-07 |
2023-08-12 |
Not clear |
| J W Huffma. Cannabimimetic indoles, pyrroles and indenes. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469887. |
this led to the discovery that 1-propyl-3-(1-naphthoyl)indole is a selective ligand for the peripheral cannabinoid (cb2) receptor, and to the development of a series of cannabimimetic pyrroles. |
1999-10-07 |
2023-08-12 |
Not clear |
| F Barth, M Rinaldi-Carmon. The development of cannabinoid antagonists. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469889. |
the discovery of two distinct cannabinoid receptors (cb1 and cb2) in the early 1990's has revived the research on cannabinoid antagonists. |
1999-10-07 |
2023-08-12 |
Not clear |
| F Barth, M Rinaldi-Carmon. The development of cannabinoid antagonists. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469889. |
the selective cb2 antagonist sr 144528 is expected to play the same role for the cb2 receptors, while the recent development of cannabinoid antagonists belonging to other chemical series illustrates the interest of these compounds which are now considered as interesting therapeutic targets by many pharmaceutical companies. |
1999-10-07 |
2023-08-12 |
Not clear |
| D Melck, T Bisogno, L De Petrocellis, H Chuang, D Julius, M Bifulco, V Di Marz. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochemical and biophysical research communications. vol 262. issue 1. 1999-09-23. PMID:10448105. |
we investigated the effect of changing the length and degree of unsaturation of the fatty acyl chain of n-(3-methoxy-4-hydroxy)-benzyl-cis-9-octadecenoamide (olvanil), a ligand of vanilloid receptors, on its capability to: (i) inhibit anandamide-facilitated transport into cells and enzymatic hydrolysis, (ii) bind to cb1 and cb2 cannabinoid receptors, and (iii) activate the vr1 vanilloid receptor. |
1999-09-23 |
2023-08-12 |
human |
| B Szabo, T Müller, H Koc. Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461898. |
the lack of a presynaptic effect on terminals of nigrostriatal and mesolimbic dopaminergic neurons is in accord with the anatomical distribution of cannabinoid receptors: the perikarya of these neurons in the substantia nigra and the ventral tegmental area do not synthesize mrna, and hence protein, for cb1 and cb2 cannabinoid receptors. |
1999-09-14 |
2023-08-12 |
rat |
| B Calandra, M Portier, A Kernéis, M Delpech, C Carillon, G Le Fur, P Ferrara, D Shir. Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor. European journal of pharmacology. vol 374. issue 3. 1999-09-13. PMID:10422789. |
under the same conditions the peripheral cannabinoid cb2 receptor proved to be incapable of inducing camp accumulation or luciferase activity. |
1999-09-13 |
2023-08-12 |
human |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
evaluation of the cannabinoid cb2 receptor-selective antagonist, sr144528: further evidence for cannabinoid cb2 receptor absence in the rat central nervous system. |
1999-09-08 |
2023-08-12 |
rat |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
the aim of this study was to characterize the activity of the cannabinoid cb2 receptor selective antagonist, n-[(1s)-endo-1,3,3-trimethyl bicyclo[2.2.1] heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazo le-3-carboxamide] (sr144528) in a number of biochemical assays and to look for evidence of cannabinoid cb2 receptors in the rat central nervous system. |
1999-09-08 |
2023-08-12 |
rat |
| G Griffin, E J Wray, Q Tao, S D McAllister, W K Rorrer, M M Aung, B R Martin, M E Aboo. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448934. |
in summary, this report characterizes the cannabinoid cb2 receptor-selective cannabinoid antagonist, sr144528, and additionally suggests an absence of cannabinoid cb2 receptors in the rat central nervous system, an observation confirmed by northern blot. |
1999-09-08 |
2023-08-12 |
rat |
| R G Pertwe. Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors. Life sciences. vol 65. issue 6-7. 1999-09-08. PMID:10462060. |
the discovery of cb1 and cb2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. |
1999-09-08 |
2023-08-12 |
Not clear |
| D Parolar. Presence and functional regulation of cannabinoid receptors in immune cells. Life sciences. vol 65. issue 6-7. 1999-09-08. PMID:10462064. |
both types of cannabinoid receptors, cb1 and cb2, have been found in immune cells, suggesting they are important in mediating the effects of cannabinoids on the immune system. |
1999-09-08 |
2023-08-12 |
Not clear |
| M Bouaboula, D Dussossoy, P Casella. Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400664. |
by blocking autoactivated receptors, inverse agonist sr 144528 treatment completely inhibited this phosphorylation state, leading to an up-regulated cb2 receptor level at the cell surface, and enhanced cannabinoid agonist sensitivity for mitogen-activated protein kinase activation of chinese hamster ovary-cb2 cells. |
1999-08-19 |
2023-08-12 |
human |
| P J Valk, R Delwe. The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis. Leukemia & lymphoma. vol 32. issue 1-2. 1999-06-29. PMID:10036999. |
although in the past many studies described growth inhibitory effects of cannabinoid agonists on the in vitro proliferation of hematopoietic cells, recent studies demonstrated that activation of cb2 may have growth stimulatory effects on blood precursor cells. |
1999-06-29 |
2023-08-12 |
mouse |
| C J Hillard, S Manna, M J Greenberg, R DiCamelli, R A Ross, L A Stevenson, V Murphy, R G Pertwee, W B Campbel. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336536. |
although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both cb1 and cb2 with similar affinities. |
1999-06-15 |
2023-08-12 |
mouse |