| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Ross, H C Brockie, S R Fernando, B Saha, R K Razdan, R G Pertwe. Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863666. |
the cannabinoids used were the cb1-selective antagonist sr141716a, the cb2-selective antagonist sr144528, the novel cannabinoid receptor ligand, 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol (o-1184), and the agonists cp55940, which binds equally well to cb1 and cb2 receptors, and win55212-2, which shows marginal cb2 selectivity. |
1999-03-25 |
2023-08-12 |
Not clear |
| Q Tao, S D McAllister, J Andreassi, K W Nowell, G A Cabral, D P Hurst, K Bachtel, M C Ekman, P H Reggio, M E Aboo. Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. Molecular pharmacology. vol 55. issue 3. 1999-03-25. PMID:10051546. |
the human cannabinoid receptors, central cannabinoid receptor (cb1) and peripheral cannabinoid receptor (cb2), share only 44% amino acid identity overall, yet most ligands do not discriminate between receptor subtypes. |
1999-03-25 |
2023-08-12 |
human |
| Q Tao, S D McAllister, J Andreassi, K W Nowell, G A Cabral, D P Hurst, K Bachtel, M C Ekman, P H Reggio, M E Aboo. Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. Molecular pharmacology. vol 55. issue 3. 1999-03-25. PMID:10051546. |
in contrast, in human embryonic kidney (hek)-293 cells expressing the mutant or wild-type cb2 receptors, we found no significant differences in either the binding profile of several cannabinoid ligands nor in inhibition of camp accumulation. |
1999-03-25 |
2023-08-12 |
human |
| J A Wagner, K Varga, G Kuno. Cardiovascular actions of cannabinoids and their generation during shock. Journal of molecular medicine (Berlin, Germany). vol 76. issue 12. 1999-02-11. PMID:9846953. |
a second receptor subtype, the cb2 receptor, is expressed on cells of the immune system and is thought to be responsible for the immunosuppressant effects of cannabinoids. |
1999-02-11 |
2023-08-12 |
human |
| S Lin, A D Khanolkar, P Fan, A Goutopoulos, C Qin, D Papahadjis, A Makriyanni. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of medicinal chemistry. vol 41. issue 27. 1999-02-01. PMID:9876105. |
novel analogues of arachidonylethanolamide (anandamide): affinities for the cb1 and cb2 cannabinoid receptors and metabolic stability. |
1999-02-01 |
2023-08-12 |
Not clear |
| S Lin, A D Khanolkar, P Fan, A Goutopoulos, C Qin, D Papahadjis, A Makriyanni. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of medicinal chemistry. vol 41. issue 27. 1999-02-01. PMID:9876105. |
several analogues of the endogenous cannabinoid receptor ligand arachidonylethanolamide (anandamide) were synthesized and evaluated in order to study (a) the structural requirements for high-affinity binding to the cb1 and cb2 cannabinoid receptors and (b) their hydrolytic stability toward anandamide amidase. |
1999-02-01 |
2023-08-12 |
Not clear |
| P H Reggio, S Basu-Dutt, J Barnett-Norris, M T Castro, D P Hurst, H H Seltzman, M J Roche, A F Gilliam, B F Thomas, L A Stevenson, R G Pertwee, M E Aboo. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes. Journal of medicinal chemistry. vol 41. issue 26. 1999-01-21. PMID:9857088. |
the bioactive conformation of aminoalkylindoles at the cannabinoid cb1 and cb2 receptors: insights gained from (e)- and (z)-naphthylidene indenes. |
1999-01-21 |
2023-08-12 |
rat |
| P H Reggio, S Basu-Dutt, J Barnett-Norris, M T Castro, D P Hurst, H H Seltzman, M J Roche, A F Gilliam, B F Thomas, L A Stevenson, R G Pertwee, M E Aboo. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes. Journal of medicinal chemistry. vol 41. issue 26. 1999-01-21. PMID:9857088. |
the aminoalkylindoles (aais) are agonists at both the cannabinoid cb1 and cb2 receptors. |
1999-01-21 |
2023-08-12 |
rat |
| P Carayon, J Marchand, D Dussossoy, J M Derocq, O Jbilo, A Bord, M Bouaboula, S Galiègue, P Mondière, G Pénarier, G L Fur, T Defrance, P Casella. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood. vol 92. issue 10. 1998-12-21. PMID:9808554. |
modulation and functional involvement of cb2 peripheral cannabinoid receptors during b-cell differentiation. |
1998-12-21 |
2023-08-12 |
Not clear |
| P Carayon, J Marchand, D Dussossoy, J M Derocq, O Jbilo, A Bord, M Bouaboula, S Galiègue, P Mondière, G Pénarier, G L Fur, T Defrance, P Casella. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood. vol 92. issue 10. 1998-12-21. PMID:9808554. |
two subtypes of g-protein-coupled cannabinoid receptors have been identified to date: the cb1 central receptor subtype, which is mainly expressed in the brain, and the cb2 peripheral receptor subtype, which appears particularly abundant in the immune system. |
1998-12-21 |
2023-08-12 |
Not clear |
| J Barnett-Norris, F Guarnieri, D P Hurst, P H Reggi. Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories. Journal of medicinal chemistry. vol 41. issue 24. 1998-12-17. PMID:9822555. |
the endogenous cannabinoid anandamide (n-arachidonoylethanolamide) has been shown to possess higher affinity for the cannabinoid cb1 receptor than for the cb2 receptor. |
1998-12-17 |
2023-08-12 |
Not clear |
| B A Berglund, D L Boring, G H Wilken, A Makriyannis, A C Howlett, S Li. Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. Prostaglandins, leukotrienes, and essential fatty acids. vol 59. issue 2. 1998-12-09. PMID:9774174. |
structural requirements for arachidonylethanolamide interaction with cb1 and cb2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. |
1998-12-09 |
2023-08-12 |
Not clear |
| B A Berglund, D L Boring, G H Wilken, A Makriyannis, A C Howlett, S Li. Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. Prostaglandins, leukotrienes, and essential fatty acids. vol 59. issue 2. 1998-12-09. PMID:9774174. |
analogs of arachidonylethanolamide (anandamide) were prepared to investigate the structural requirements for ligand binding to and activation of the cb1 and cb2 cannabinoid receptors. |
1998-12-09 |
2023-08-12 |
Not clear |
| S Ben-Shabat, E Fride, T Sheskin, T Tamiri, M H Rhee, Z Vogel, T Bisogno, L De Petrocellis, V Di Marzo, R Mechoula. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European journal of pharmacology. vol 353. issue 1. 1998-10-29. PMID:9721036. |
2-arachidonoyl-glycerol (2-ara-gi) has been isolated from various tissues and identified as an endogenous ligand for both cannabinoid receptors, cb1 and cb2. |
1998-10-29 |
2023-08-12 |
mouse |
| S Ben-Shabat, E Fride, T Sheskin, T Tamiri, M H Rhee, Z Vogel, T Bisogno, L De Petrocellis, V Di Marzo, R Mechoula. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European journal of pharmacology. vol 353. issue 1. 1998-10-29. PMID:9721036. |
these two esters do not bind to the cannabinoid receptors, nor do they inhibit adenylyl cyclase via either cb1 or cb2; however, they significantly potentiate the apparent binding of 2-ara-gl and its apparent capacity to inhibit adenylyl cyclase. |
1998-10-29 |
2023-08-12 |
mouse |
| M H Rhee, M Bayewitch, T Avidor-Reiss, R Levy, Z Voge. Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751186. |
two cannabinoid receptors belonging to the superfamily of g protein-coupled membrane receptors have been identified and cloned: the neuronal cannabinoid receptor (cb1) and the peripheral cannabinoid receptor (cb2). |
1998-10-14 |
2023-08-12 |
Not clear |
| M H Rhee, M Bayewitch, T Avidor-Reiss, R Levy, Z Voge. Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751186. |
we found that independently of the method used to stimulate specific adenylyl cyclase isozymes (e.g., ionomycin, forskolin, constitutively active alpha(s), thyroid-stimulating hormone receptor activation), activation of the cannabinoid receptors cb1 and cb2 inhibited the activity of adenylyl cyclase types i, v, vi, and viii, whereas types ii, iv, and vii were stimulated by cannabinoid receptor activation. |
1998-10-14 |
2023-08-12 |
Not clear |
| S I Jaggar, F S Hasnie, S Sellaturay, A S Ric. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain. vol 76. issue 1-2. 1998-10-13. PMID:9696473. |
the anti-hyperalgesic actions of the cannabinoid anandamide and the putative cb2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. |
1998-10-13 |
2023-08-12 |
rat |
| S I Jaggar, F S Hasnie, S Sellaturay, A S Ric. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain. vol 76. issue 1-2. 1998-10-13. PMID:9696473. |
(1) the therapeutic effects of the cannabinoid anandamide and the putative cb2 agonist palmitoylethanolamide were tested in a model of persistent visceral pain (turpentine inflammation of the urinary bladder). |
1998-10-13 |
2023-08-12 |
rat |
| T W Klein, C Newton, H Friedma. Cannabinoid receptors and the cytokine network. Advances in experimental medicine and biology. vol 437. 1998-10-08. PMID:9666274. |
these results suggest that cannabinoids may increase th2 development and il-4 production in cultured immune cells through the activity of the cb2 receptor subtype. |
1998-10-08 |
2023-08-12 |
mouse |