| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M H Rhee, Z Vogel, J Barg, M Bayewitch, R Levy, L Hanus, A Breuer, R Mechoula. Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379442. |
several derivatives of cannabinol and the 1,1-dimethylheptyl homolog (dmh) of cannabinol were prepared and assayed for binding to the brain and the peripheral cannabinoid receptors (cb1 and cb2), as well as for activation of cb1- and cb2-mediated inhibition of adenylylcyclase. |
1997-11-10 |
2023-08-12 |
Not clear |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
importance of the c-1 substituent in classical cannabinoids to cb2 receptor selectivity: synthesis and characterization of a series of o,2-propano-delta 8-tetrahydrocannabinol analogs. |
1997-11-10 |
2023-08-12 |
mouse |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
results reported here for a series of c-9 analogs of the cyclic ether o,2-propano-delta 8-tetrahydrocannabinol (o,2-propano-delta 8-thc) point to the c-1 position in classical cannabinoids as a position for which cb2 subtype selectivity occurs within the cannabinoid receptors. |
1997-11-10 |
2023-08-12 |
mouse |
| P H Reggio, T Wang, A E Brown, D N Fleming, H H Seltzman, G Griffin, R G Pertwee, D R Compton, M E Abood, B R Marti. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of medicinal chemistry. vol 40. issue 20. 1997-11-10. PMID:9379452. |
o,2-propano-11-delta 8-thc, o,2-propano delta 9,11-thc, o,2-propano-9-oxo-11-nor-hexahydrocannabinol (o,2-propano-9-oxo-11-nor-hhc), and o,2-propano-9 alpha- and o,2-propano-9 beta-oh-11-nor-hhc were synthesized and evaluated in radioligand displacement assays for affinity at the cb1 and cb2 receptors and in the mouse vas deferens in vitro assay and the mouse tetrad in vivo assay for cannabinoid activity. |
1997-11-10 |
2023-08-12 |
mouse |
| M Glass, C C Felde. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204917. |
stimulation of camp accumulation was not observed after pertussis toxin treatment of cho cells expressing the human cb2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid cb1 receptor. |
1997-07-21 |
2023-08-12 |
human |
| A R Schatz, M Lee, R B Condie, J T Pulaski, N E Kaminsk. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicology and applied pharmacology. vol 142. issue 2. 1997-04-09. PMID:9070350. |
cannabinoid receptors cb1 and cb2: a characterization of expression and adenylate cyclase modulation within the immune system. |
1997-04-09 |
2023-08-12 |
mouse |
| A R Schatz, M Lee, R B Condie, J T Pulaski, N E Kaminsk. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicology and applied pharmacology. vol 142. issue 2. 1997-04-09. PMID:9070350. |
competition binding in intact mouse splenocytes demonstrated that nonradiolabeled cannabinoids cp-55940, win-55212-2, cp-56667, delta 9-thc, and cannabinol all competed for receptor binding with 3h-cp-55940, a high-affinity nondiscriminating cb1 and cb2 receptor ligand. |
1997-04-09 |
2023-08-12 |
mouse |
| D G Deutsch, S Lin, W A Hill, K L Morse, D Salehani, G Arreaza, R L Omeir, A Makriyanni. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochemical and biophysical research communications. vol 231. issue 1. 1997-04-07. PMID:9070252. |
arachidonoyl ethanolamide (anandamide) is an endogenous ligand for cannabinoid receptors (cb1, cb2) and a putative neurotransmitter. |
1997-04-07 |
2023-08-12 |
Not clear |
| M E Abood, B R Marti. Molecular neurobiology of the cannabinoid receptor. International review of neurobiology. vol 39. 1997-03-11. PMID:8894848. |
two cannabinoid receptors have been identified to date: one is located predominantly in the central nervous system (cbi), whereas the other is expressed in peripheral tissues (cb2). |
1997-03-11 |
2023-08-12 |
Not clear |
| S Mazzari, R Canella, L Petrelli, G Marcolongo, A Leo. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. European journal of pharmacology. vol 300. issue 3. 1997-02-06. PMID:8739213. |
recently, n-(2-hydroxyethyl)hexadecanamide (lg 2110/1) has been reported to down-modulate mast cell activation in vitro by behaving as an agonist at the peripheral cannabinoid cb2 receptor. |
1997-02-06 |
2023-08-12 |
mouse |
| S A Edsall, R J Knapp, T W Vanderah, W R Roeske, P Consroe, H I Yamamur. Antisense oligodeoxynucleotide treatment to the brain cannabinoid receptor inhibits antinociception. Neuroreport. vol 7. issue 2. 1996-11-25. PMID:8730837. |
however, other studies suggest the presence of multiple cannabinoid receptors and at least one other receptor (cb2) has been cloned. |
1996-11-25 |
2023-08-12 |
mouse |
| J W Huffman, S Yu, V Showalter, M E Abood, J L Wiley, D R Compton, B R Martin, R D Bramblett, P H Reggi. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Journal of medicinal chemistry. vol 39. issue 20. 1996-11-14. PMID:8831752. |
synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the cb2 receptor. |
1996-11-14 |
2023-08-12 |
Not clear |
| C C Felder, A Nielsen, E M Briley, M Palkovits, J Priller, J Axelrod, D N Nguyen, J M Richardson, R M Riggin, G A Koppel, S M Paul, G W Becke. Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS letters. vol 393. issue 2-3. 1996-11-07. PMID:8814296. |
anandamide (arachidonylethanolamide) is a novel lipid neurotransmitter first isolated from porcine brain which has been shown to be a functional agonist for the cannabinoid cb1 and cb2 receptors. |
1996-11-07 |
2023-08-12 |
human |
| V M Showalter, D R Compton, B R Martin, M E Aboo. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. The Journal of pharmacology and experimental therapeutics. vol 278. issue 3. 1996-11-05. PMID:8819477. |
two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (cb1), whereas the other is located exclusively in the periphery (cb2). |
1996-11-05 |
2023-08-12 |
human |
| V M Showalter, D R Compton, B R Martin, M E Aboo. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. The Journal of pharmacology and experimental therapeutics. vol 278. issue 3. 1996-11-05. PMID:8819477. |
the binding affinities of a series of cannabinoids tested previously at the cb1 receptor were determined at cloned human cb1 and cb2 receptors using a filtration assay. |
1996-11-05 |
2023-08-12 |
human |
| J Busch-Petersen, W A Hill, P Fan, A Khanolkar, X Q Xie, M A Tius, A Makriyanni. Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs. Journal of medicinal chemistry. vol 39. issue 19. 1996-11-04. PMID:8809166. |
the cannabinoid side chain is a key pharmacophore in the interaction of cannabinoids with their receptors (cb1 and cb2). |
1996-11-04 |
2023-08-12 |
Not clear |
| Y J Jeon, K H Yang, J T Pulaski, N E Kaminsk. Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. Molecular pharmacology. vol 50. issue 2. 1996-09-03. PMID:8700141. |
the putative mechanism for cannabinoid biological action involves binding to cannabinoid receptor types 1 and 2 (cb1 and cb2) to negatively regulate adenylate cyclase and inhibit intracellular signaling via the camp cascade. |
1996-09-03 |
2023-08-12 |
Not clear |
| M Bouaboula, C Poinot-Chazel, J Marchand, X Canat, B Bourrié, M Rinaldi-Carmona, B Calandra, G Le Fur, P Casella. Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. European journal of biochemistry. vol 237. issue 3. 1996-07-25. PMID:8647116. |
the recent isolation and cloning of the g-protein-coupled peripheral cannabinoid receptor (cb2), mainly expressed in immune tissues, have provided molecular tools to determine how cannabinoid compounds may mediate immunomodulation. |
1996-07-25 |
2023-08-12 |
human |
| S D Skaper, A Buriani, R Dal Toso, L Petrelli, S Romanello, L Facci, A Leo. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633002. |
cannabinoids, which like palmitoylethanolamide are functionally active at the peripheral cannabinoid receptor cb2 on mast cells, also prevented neuron loss in this delayed postglutamate model. |
1996-07-01 |
2023-08-12 |
mouse |
| S D Skaper, A Buriani, R Dal Toso, L Petrelli, S Romanello, L Facci, A Leo. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633002. |
cerebellar granule cells expressed mrna for cb1 and cb2 by in situ hybridization, while two cannabinoid binding sites were detected in cerebellar membranes. |
1996-07-01 |
2023-08-12 |
mouse |