| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' F Maingret, A J Patel, M Lazdunski, E Honor\\xc3\\xa. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. The EMBO journal. vol 20. issue 1-2. 2001-04-12. PMID:11226154.' |
we demonstrate that task-1, unlike the other two pore (2p) domain k(+) channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the cb1 and cb2 receptors. |
2001-04-12 |
2023-08-12 |
Not clear |
| H Iwamura, H Suzuki, Y Ueda, T Kaya, T Inab. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. The Journal of pharmacology and experimental therapeutics. vol 296. issue 2. 2001-04-05. PMID:11160626. |
in vitro and in vivo pharmacological characterization of jte-907, a novel selective ligand for cannabinoid cb2 receptor. |
2001-04-05 |
2023-08-12 |
mouse |
| J S Moody, K R Kozak, C Ji, L J Marnet. Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. Biochemistry. vol 40. issue 4. 2001-03-22. PMID:11170406. |
the identification of 2-arachidonylglycerol (2-ag) as an endogenous ligand for the central (cb1) and peripheral (cb2) cannabinoid receptors has prompted interest in enzymes capable of modifying or inactivating this endocannabinoid. |
2001-03-22 |
2023-08-12 |
cat |
| T Yamamoto, K Takad. Role of cannabinoid receptor in the brain as it relates to drug reward. Japanese journal of pharmacology. vol 84. issue 3. 2001-03-01. PMID:11138722. |
understanding of cannabinoid (cb) actions has been remarkably advanced during the last decade, due mainly to the identification of the g-protein-coupled cannabinoid receptors, namely, cb1 receptors that are predominantly found in the brain and cb2 receptors that are exclusively found in peripheral tissues. |
2001-03-01 |
2023-08-12 |
Not clear |
| G B Stefano, T V Bilfinger, C M Rialas, D G Deutsc. 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. Pharmacological research. vol 42. issue 4. 2001-01-25. PMID:10987990. |
2-ag occurs in vertebrate and invertebrate tissues and binds to both cannabinoid receptors (cb1 and cb2). |
2001-01-25 |
2023-08-12 |
human |
| A D Khanolkar, S L Palmer, A Makriyanni. Molecular probes for the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106781. |
cannabinoids produce most of their biochemical and pharmacological effects by interacting with cb1 and cb2 cannabinoid receptors, both of which are g-protein coupled membrane-bound functional proteins. |
2001-01-11 |
2023-08-12 |
Not clear |
| T Sugiura, K Wak. 2-Arachidonoylglycerol and the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106784. |
2-ag binds to the cannabinoid receptors (cb1 and cb2) and exhibits a variety of cannabimimetic activities in vitro and in vivo. |
2001-01-11 |
2023-08-12 |
rat |
| T Sugiura, K Wak. 2-Arachidonoylglycerol and the cannabinoid receptors. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106784. |
recently, we found that 2-ag induces ca(2+) transients in ng108-15 cells, which express the cb1 receptor, and in hl-60 cells, which express the cb2 receptor, through a cannabinoid receptor- and gi/go-dependent mechanism. |
2001-01-11 |
2023-08-12 |
rat |
| G Kunos, Z Járai, S Bátkai, S K Goparaju, E J Ishac, J Liu, L Wang, J A Wagne. Endocannabinoids as cardiovascular modulators. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106789. |
although multiple lines of evidence indicate that the hypotensive and bradycardic effects of anandamide and other cannabinoids are mediated by peripherally located cb1 cannabinoid receptors, anandamide can also elicit vasodilation in certain vascular beds, which is independent of cb1 or cb2 receptors. |
2001-01-11 |
2023-08-12 |
Not clear |
| K R Kozak, S W Rowlinson, L J Marnet. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. The Journal of biological chemistry. vol 275. issue 43. 2000-11-24. PMID:10931854. |
the neutral arachidonate derivative, 2-arachidonylglycerol (2-ag), is one of two described endocannabinoids and appears to be a ligand for both the central (cb1) and peripheral (cb2) cannabinoid receptors. |
2000-11-24 |
2023-08-12 |
Not clear |
| A Mahadevan, C Siegel, B R Martin, M E Abood, I Beletskaya, R K Razda. Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. Journal of medicinal chemistry. vol 43. issue 20. 2000-11-08. PMID:11020293. |
novel cannabinol probes for cb1 and cb2 cannabinoid receptors. |
2000-11-08 |
2023-08-12 |
Not clear |
| A Mahadevan, C Siegel, B R Martin, M E Abood, I Beletskaya, R K Razda. Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. Journal of medicinal chemistry. vol 43. issue 20. 2000-11-08. PMID:11020293. |
the various analogues were assayed for binding both to the brain and the peripheral cannabinoid receptors (cb1 and cb2). |
2000-11-08 |
2023-08-12 |
Not clear |
| O D Zhukov, M V Artamonov, V M Klimashevs'kyiĭ, N M Hoseieva, V M Marhitych, N M Hul. [N-acylethanolamine--a new class of natural adrenotropic modulators]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 72. issue 2. 2000-10-23. PMID:10979576. |
anandamide--a well known representative of naes--is an agonist of central (cb1) and peripheral (cb2) cannabinoid receptors. |
2000-10-23 |
2023-08-12 |
rat |
| P Sacerdote, P Massi, A E Panerai, D Parolar. In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996217. |
in vivo and in vitro treatment with the synthetic cannabinoid cp55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both cb1 and cb2 receptors. |
2000-10-12 |
2023-08-12 |
rat |
| P Sacerdote, P Massi, A E Panerai, D Parolar. In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996217. |
our data confirm that cannabinoids can affect some macrophage functions, mainly throughout cb2 receptors, and suggest that the development of specific cb2 ligands may lead to an interesting new class of anti-inflammatory drugs. |
2000-10-12 |
2023-08-12 |
rat |
| R Mechoula. Looking back at Cannabis research. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903394. |
investigations on two non-psychotropic, synthetic cannabinoids, hu-211, a neuroprotective agent and hu-308, a specific cb2 agonist are presented. |
2000-09-25 |
2023-08-12 |
Not clear |
| S L Palmer, A D Khanolkar, A Makriyanni. Natural and synthetic endocannabinoids and their structure-activity relationships. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903399. |
the biological targets for endocannabinoids include the cannabinoid receptors (cb1 and cb2), the enzyme anandamide amidohydrolase (aah), and the carrier protein referred to as the anandamide transporter (ant). |
2000-09-25 |
2023-08-12 |
Not clear |
| S L Palmer, A D Khanolkar, A Makriyanni. Natural and synthetic endocannabinoids and their structure-activity relationships. Current pharmaceutical design. vol 6. issue 13. 2000-09-25. PMID:10903399. |
the identification of arachidonylethanolamide (anandamide, aea) as an endogenous cannabinoid has been an important development in cannabinoid research which has led to the identification of two proteins associated with cannabinoid physiology in addition to the cb1 and cb2 receptors. |
2000-09-25 |
2023-08-12 |
Not clear |
| B A Berglund, P R Fleming, K C Rice, J Y Shim, W J Welsh, A C Howlet. Development of a novel class of monocyclic and bicyclic alkyl amides that exhibit CB1 and CB2 cannabinoid receptor affinity and receptor activation. Drug design and discovery. vol 16. issue 4. 2000-07-11. PMID:10807034. |
cb1 and cb2 cannabinoid receptors can be activated by several different classes of agonists, including cannabinoids such as delta9-tetrahydrocannabinol and 9-nor-9beta-hydroxyhexahydrocannabinol, and eicosanoids such as arachidonylethanolamide. |
2000-07-11 |
2023-08-12 |
Not clear |
| M Shapira, Z Vogel, Y Sarn. Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789829. |
opioid (mu, delta, kappa) and cannabinoid (cb1, cb2) receptors are coupled mainly to gi/go gtp-binding proteins. |
2000-07-03 |
2023-08-12 |
Not clear |