| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen S Sheng, Shuxian Hu, Xinan Min, Guy A Cabral, James R Lokensgard, Phillip K Peterso. Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia. vol 49. issue 2. 2005-03-02. PMID:15390091. |
expression of the cannabinoid receptors cb1 and cb2 was detected on human astrocytes. |
2005-03-02 |
2023-08-12 |
human |
| Susanne Andrea Golech, Richard M McCarron, Ye Chen, Joliet Bembry, Frederick Lenz, Raphael Mechoulam, Esther Shohami, Maria Spat. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain research. Molecular brain research. vol 132. issue 1. 2005-03-02. PMID:15548432. |
many of the 2-ag-induced cellular responses (i.e., neuromodulation, cytoprotection and vasodilation) are mediated by cannabinoid receptors cb1 and cb2. |
2005-03-02 |
2023-08-12 |
human |
| Basalingappa L Hungund, Balapal S Basavarajapp. Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542757. |
the cdna and genomic sequences encoding g-protein-coupled cannabinoid receptors (cb1 and cb2) from several species have now been cloned. |
2005-02-18 |
2023-08-12 |
mouse |
| T U C Järbe, N V DiPatrizio, D Lu, A Makriyanni. (-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats. Behavioural pharmacology. vol 15. issue 7. 2005-02-17. PMID:15472574. |
the compound is cannabinoid cb1 receptor subtype selective (cb1 ki=6.86 nmol/l, cb2 ki=52.0 nmol/l). |
2005-02-17 |
2023-08-12 |
rat |
| Matthew J McFarland, Eric L Barke. Anandamide transport. Pharmacology & therapeutics. vol 104. issue 2. 2005-02-17. PMID:15518883. |
n-arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid cb1 and cb2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-thc), the active component of marijuana. |
2005-02-17 |
2023-08-12 |
Not clear |
| Angelo A Izz. Cannabinoids and intestinal motility: welcome to CB2 receptors. British journal of pharmacology. vol 142. issue 8. 2005-01-26. PMID:15277313. |
cannabinoids and intestinal motility: welcome to cb2 receptors. |
2005-01-26 |
2023-08-12 |
rat |
| Eric Jüttler, Ioana Potrovita, Victoria Tarabin, Simone Prinz, Tuan Dong-Si, George Fink, Markus Schwaninge. The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B). Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380375. |
this suggests that neither the antioxidant properties of cannabinoids nor binding to cb1 or cb2 receptors are responsible for the inhibition of nf-kappab activity and apoptosis. |
2005-01-18 |
2023-08-12 |
Not clear |
| A G Nackley, A M Zvonok, A Makriyannis, A G Hohman. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15317842. |
activation of cannabinoid cb2 receptors suppresses c-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. |
2004-12-30 |
2023-08-12 |
rat |
| A G Nackley, A M Zvonok, A Makriyannis, A G Hohman. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15317842. |
these data demonstrate that activation of cannabinoid cb2 receptors is sufficient to suppress neuronal activity at central levels of processing in the spinal dorsal horn. |
2004-12-30 |
2023-08-12 |
rat |
| Saori Oka, Shinobu Ikeda, Seishi Kishimoto, Maiko Gokoh, Shin Yanagimoto, Keizo Waku, Takayuki Sugiur. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. Journal of leukocyte biology. vol 76. issue 5. 2004-12-14. PMID:15316028. |
to date, two types of cannabinoid receptors have been identified: the cb1 receptor, abundantly expressed in the brain, and the cb2 receptor, expressed in various lymphoid tissues such as the spleen. |
2004-12-14 |
2023-08-12 |
human |
| Benjamin F Cravatt, Aron H Lichtma. The endogenous cannabinoid system and its role in nociceptive behavior. Journal of neurobiology. vol 61. issue 1. 2004-12-13. PMID:15362158. |
the endocannabinoid system includes: (1) at least two families of lipid signaling molecules, the n-acyl ethanolamines (e.g., anandamide) and the monoacylglycerols (e.g., 2-arachidonoyl glycerol); (2) multiple enzymes involved in the biosynthesis and degradation of these lipids, including the integral membrane enzyme fatty acid amide hydrolase; and (3) two g-protein coupled receptors, cb1 and cb2, which are primarily localized to the nervous system and immune system, respectively. |
2004-12-13 |
2023-08-12 |
Not clear |
| Siriporn Chuchawankul, Mika Shima, Nancy E Buckley, Constance B Hartmann, Kathleen L McCo. Role of cannabinoid receptors in inhibiting macrophage costimulatory activity. International immunopharmacology. vol 4. issue 2. 2004-12-02. PMID:14996418. |
hence, cb2 and possibly another receptor subtype may be involved in mediating cannabinoid suppression of macrophage costimulation. |
2004-12-02 |
2023-08-12 |
mouse |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
a cannabinoid cb2 receptor antagonist, [n-[(1s)-endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide] (sr 144528), reduced the inhibitory effect of win 55212-2, but not a cannabinoid cb1 antagonist, [n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamidehydrochloride] (sr 141716a). |
2004-12-02 |
2023-08-12 |
Not clear |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
a cannabinoid cb2 agonist, jwh 133, also inhibited electrical field stimulation-induced guinea pig bronchial smooth muscle contraction and its inhibitory effect was blocked by sr 144528. |
2004-12-02 |
2023-08-12 |
Not clear |
| Shigemi Yoshihara, Hiroshi Morimoto, Yumi Yamada, Toshio Abe, Osamu Arisak. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine. vol 170. issue 9. 2004-12-02. PMID:15306537. |
these findings suggest that win 55212-2 inhibit the activation of c-fibers via cannabinoid cb2 receptors and maxi-k+ channels in guinea pig airways. |
2004-12-02 |
2023-08-12 |
Not clear |
| Victoria E Mendizábal, Edda Adler-Graschinsk. Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Current vascular pharmacology. vol 1. issue 3. 2004-12-01. PMID:15320476. |
hence, the endocannabinoid system, including the cb1 and cb2 receptors, the metabolizing enzyme fatty acid amide hydrolase and the anandamide transporter, is a potential target for the development of novel therapeutic drugs in the treatment of various conditions, such as pain, feeding disorders and vascular disease among others. |
2004-12-01 |
2023-08-12 |
Not clear |
| Rachel J A Helliwell, Lawrence W Chamley, Katherine Blake-Palmer, Murray D Mitchell, Janice Wu, Christopher S Kearn, Michelle Glas. Characterization of the endocannabinoid system in early human pregnancy. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472222. |
in this study, we examined the distribution of the cannabinoid receptors, cb1 and cb2, and the endocannabinoid-metabolizing enzyme faah in first trimester human placenta. |
2004-11-19 |
2023-08-12 |
human |
| Rachel J A Helliwell, Lawrence W Chamley, Katherine Blake-Palmer, Murray D Mitchell, Janice Wu, Christopher S Kearn, Michelle Glas. Characterization of the endocannabinoid system in early human pregnancy. The Journal of clinical endocrinology and metabolism. vol 89. issue 10. 2004-11-19. PMID:15472222. |
the immune system-associated cannabinoid cb2 receptors were localized only to placental macrophages. |
2004-11-19 |
2023-08-12 |
human |
| Estefanía Núñez, Cristina Benito, M Ruth Pazos, Antonio Barbachano, Otto Fajardo, Sara González, Rosa M Tolón, Julián Romer. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266552. |
cannabinoid cb2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. |
2004-11-10 |
2023-08-12 |
human |
| Estefanía Núñez, Cristina Benito, M Ruth Pazos, Antonio Barbachano, Otto Fajardo, Sara González, Rosa M Tolón, Julián Romer. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266552. |
two types of cannabinoid receptors have been characterized so far, cb1 and cb2. |
2004-11-10 |
2023-08-12 |
human |