| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina Montero, Nuria Eugenia Campillo, Pilar Goya, Juan Antonio Páe. Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study. European journal of medicinal chemistry. vol 40. issue 1. 2005-06-02. PMID:15642412. |
homology models of the cannabinoid cb1 and cb2 receptors. |
2005-06-02 |
2023-08-12 |
human |
| Sören V Siegmund, Hiroshi Uchinami, Yosuke Osawa, David A Brenner, Robert F Schwab. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology (Baltimore, Md.). vol 41. issue 5. 2005-06-01. PMID:15841466. |
although the putative endocannabinoid receptors cb1, cb2, and vr1 were expressed in hscs, specific receptor blockade failed to block cell death. |
2005-06-01 |
2023-08-12 |
Not clear |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
species comparison and pharmacological characterization of rat and human cb2 cannabinoid receptors. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
pharmacological effects of cannabinoid ligands are thought to be mediated through cannabinoid cb1 and cb2 receptor subtypes. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
sequence analysis revealed that rat and human cannabinoid cb2 receptors are divergent and share 81% amino acid homology. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
pharmacological analysis of the possible species differences between rat and human cannabinoid cb2 receptors was performed using radioligand binding and functional assays. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
pronounced species selectivity at the rat cannabinoid cb2 receptor (50- to 140-fold) was observed with am-1710 (3-(1,1-dimethyl-heptyl)-1-hydroxy-9-methoxy-benzo[c]chromen-6-one) and am-1714 (3-(1,1-dimethyl-heptyl)-1-9-dihydroxy-benzo[c]chromen-6-one). |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
in contrast, jwh-015 ((2-methyl-1-propyl-1h-indol-3-yl)-napthalen-1-yl-methanone) was 3- to 10-fold selective at the human cannabinoid cb2 receptor. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
cannabinoid cb2 receptor antagonist, am-630 ((6-iodo-2-methyl-1-(2-morpholin-4-yl-ethyl)-1h-indol-3-yl)-(4-methoxy-phenyl)-methanone) was more potent at the rat receptor in radioligand binding and functional assays than that of the human receptor. |
2005-05-16 |
2023-08-12 |
human |
| Sutapa Mukherjee, Monique Adams, Kristi Whiteaker, Anthony Daza, Karen Kage, Steven Cassar, Michael Meyer, Betty Bei Ya. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556131. |
the findings of the pharmacological differences between the human and rat cannabinoid cb2 receptors in this study provide critical information for characterizing cannabinoid ligands in in vivo rodent models for drug discovery purpose. |
2005-05-16 |
2023-08-12 |
human |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
delta9-tetrahydrocannabinol (delta9-thc) and (-)-cannabidiol are major constituents of the cannabis sativa plant with different pharmacological profiles: (-)-delta9-tetrahydrocannabinol, but not (-)-cannabidiol, activates cannabinoid cb1 and cb2 receptors and induces psychoactive and peripheral effects. |
2005-05-06 |
2023-08-12 |
mouse |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
although all (+)-cannabidiols bind to cannabinoid cb1 and cb2 receptors, only (+)-7-oh-cannabidiol-dmh was centrally active, while all (+)-cannabidiol analogues completely arrested defecation. |
2005-05-06 |
2023-08-12 |
mouse |
| Ester Fride, Cfir Feigin, Datta E Ponde, Aviva Breuer, Lumír Hanus, Nina Arshavsky, Raphael Mechoula. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. European journal of pharmacology. vol 506. issue 2. 2005-05-06. PMID:15588739. |
the effects of (+)-cannabidiol-dmh and (+)-7-oh-cannabidiol-dmh were partially antagonized by the cannabinoid cb1 receptor antagonist n-(piperidiny-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide (sr141716), but not by the cannabinoid cb2 receptor antagonist n-[-(1s)-endo-1,3,3-trimethil bicyclo [2.2.1] heptan-2-yl-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528), and had no effect on cb1(-/-) receptor knockout mice. |
2005-05-06 |
2023-08-12 |
mouse |
| Takayuki Sugiura, Saori Oka, Maiko Gokoh, Seishi Kishimoto, Keizo Wak. New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation. Journal of pharmacological sciences. vol 96. issue 4. 2005-04-28. PMID:15599096. |
to date, two types of cannabinoid receptors (cb1 and cb2) have been identified. |
2005-04-28 |
2023-08-12 |
mouse |
| Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 6. 2005-04-28. PMID:15749859. |
we demonstrated that the human breast cancer cell lines mcf-7 and mda-mb-231 and the mouse mammary carcinoma 4t1 express low to undetectable levels of cannabinoid receptors, cb1 and cb2, and that these cells are resistant to delta9-thc-induced cytotoxicity. |
2005-04-28 |
2023-08-12 |
mouse |
| S Filppula, S Yaddanapudi, R Mercier, W Xu, S Pavlopoulos, A Makriyanni. Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system. The journal of peptide research : official journal of the American Peptide Society. vol 64. issue 6. 2005-04-22. PMID:15613086. |
expressed protein encoded by a carboxy (c)-terminal his-tagged cb2 construct displayed a b(max) value of 9.3 pmol/mg with a k(d) of 7.30 nm using [3(h)]cp-55(940), a standard cannabinoid radioligand, and was selected for subsequent purification experiments. |
2005-04-22 |
2023-08-12 |
human |
| Sabine Steffens, Niels R Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Meliha Karsak, Andreas Zimmer, Jean-Louis Frossard, François Mac. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. vol 434. issue 7034. 2005-04-21. PMID:15815632. |
thus, thc or cannabinoids with activity at the cb2 receptor may be valuable targets for treating atherosclerosis. |
2005-04-21 |
2023-08-12 |
mouse |
| Sami Sarfaraz, Farrukh Afaq, Vaqar M Adhami, Hasan Mukhta. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer research. vol 65. issue 5. 2005-04-19. PMID:15753356. |
here we show that expression levels of both cannabinoid receptors, cb1 and cb2, are significantly higher in ca-human papillomavirus-10 (virally transformed cells derived from adenocarcinoma of human prostate tissue), and other human prostate cells lncap, dui45, pc3, and cwr22rnu1 than in human prostate epithelial and pz-hpv-7 (virally transformed cells derived from normal human prostate tissue) cells. |
2005-04-19 |
2023-08-12 |
human |
| Boris Julien, Pascale Grenard, Fatima Teixeira-Clerc, Jeanne Tran Van Nhieu, Liying Li, Meliha Karsak, Andreas Zimmer, Ariane Mallat, Sophie Lotersztaj. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. vol 128. issue 3. 2005-04-06. PMID:15765409. |
cannabinoids are the active components of marijuana and act via 2 g-protein-coupled receptors, cb1 and cb2. |
2005-04-06 |
2023-08-12 |
Not clear |
| Heidi M B Lesscher, Emily Hoogveld, J Peter H Burbach, Jan M van Ree, Mirjam A F M Gerrit. Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 1. 2005-03-29. PMID:15572271. |
the endogenous cannabinoid system is a relatively novel discovered system consisting of cannabinoid cb1 receptors, which are expressed both in the periphery and in the central nervous system, peripheral cannabinoid cb2 receptors and endogenous cannabinoids, which are anandamide and 2-arachidonyl glycerol. |
2005-03-29 |
2023-08-12 |
Not clear |