| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Journal de pharmacie de Belgique. vol 60. issue 3. 2005-12-01. PMID:16252509. |
the endocannabinoid system modulates many physiological functions by acting on receptors cb1 and cb2. |
2005-12-01 |
2023-08-12 |
Not clear |
| John W Huffman, Paul V Szklennik, Amanda Almond, Kristen Bushell, Dana E Selley, Hengjun He, Michael P Cassidy, Jenny L Wiley, Billy R Marti. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & medicinal chemistry letters. vol 15. issue 18. 2005-11-21. PMID:16005223. |
a new class of cannabimimetic indoles, with 3-phenylacetyl or substituted 3-phenylacetyl substituents, has been prepared and their affinities for the cannabinoid cb1 and cb2 receptors have been determined. |
2005-11-21 |
2023-08-12 |
Not clear |
| Marja D Van Sickle, Marnie Duncan, Philip J Kingsley, Abdeslam Mouihate, Paolo Urbani, Ken Mackie, Nephi Stella, Alexandros Makriyannis, Daniele Piomelli, Joseph S Davison, Lawrence J Marnett, Vincenzo Di Marzo, Quentin J Pittman, Kamala D Patel, Keith A Sharke. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). vol 310. issue 5746. 2005-11-04. PMID:16224028. |
identification and functional characterization of brainstem cannabinoid cb2 receptors. |
2005-11-04 |
2023-08-12 |
Not clear |
| Marja D Van Sickle, Marnie Duncan, Philip J Kingsley, Abdeslam Mouihate, Paolo Urbani, Ken Mackie, Nephi Stella, Alexandros Makriyannis, Daniele Piomelli, Joseph S Davison, Lawrence J Marnett, Vincenzo Di Marzo, Quentin J Pittman, Kamala D Patel, Keith A Sharke. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). vol 310. issue 5746. 2005-11-04. PMID:16224028. |
cb2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas. |
2005-11-04 |
2023-08-12 |
Not clear |
| Katarzyna Maresz, Erica J Carrier, Eugene D Ponomarev, Cecilia J Hillard, Bonnie N Ditte. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086683. |
modulation of the cannabinoid cb2 receptor in microglial cells in response to inflammatory stimuli. |
2005-11-02 |
2023-08-12 |
mouse |
| Juha R Savinainen, Tarja Kokkola, Outi M H Salo, Antti Poso, Tomi Järvinen, Jarmo T Laitine. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. British journal of pharmacology. vol 145. issue 5. 2005-10-31. PMID:15852035. |
identification of win55212-3 as a competitive neutral antagonist of the human cannabinoid cb2 receptor. |
2005-10-31 |
2023-08-12 |
human |
| Belén G Ramírez, Cristina Blázquez, Teresa Gómez del Pulgar, Manuel Guzmán, María L de Ceballo. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728830. |
here, we show that senile plaques in ad patients express cannabinoid receptors cb1 and cb2, together with markers of microglial activation, and that cb1-positive neurons, present in high numbers in control cases, are greatly reduced in areas of microglial activation. |
2005-10-26 |
2023-08-12 |
rat |
| Karin Woelkart, Wei Xu, Ying Pei, Alexandros Makriyannis, Robert P Picone, Rudolf Baue. The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. Planta medica. vol 71. issue 8. 2005-10-25. PMID:16142631. |
due to their structural similarity with anandamide, we have evaluated their ability to bind to rodent cannabinoid receptors cb1 and cb2 by a standard receptor binding assay using [(3)h]cp-55,940 as a radioligand. |
2005-10-25 |
2023-08-12 |
Not clear |
| Süreyya Barun, Ismail Mert Vural, Ergin Dileköz, Zeynep Sevim Ercan, Yusuf Sariogl. Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. Clinical and experimental pharmacology & physiology. vol 32. issue 9. 2005-10-19. PMID:16173925. |
the cannabinoid cb1 receptor antagonist am 251 (10(-6) mol/l) and the cannabinoid cb2 receptor antagonist am 630 (10(-6) mol/l) had no effect on the inhibitory action of anandamide on the biphasic twitch responses in the prostatic and epididymal portions of the rabbit vas deferens. |
2005-10-19 |
2023-08-12 |
rabbit |
| Uberto Pagotto, Valentina Vicennati, Renato Pasqual. The endocannabinoid system and the treatment of obesity. Annals of medicine. vol 37. issue 4. 2005-10-13. PMID:16019725. |
the endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (cb) cb1 and cb2. |
2005-10-13 |
2023-08-12 |
Not clear |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
the endocannabinoid noladin ether acts as a full agonist at human cb2 cannabinoid receptors. |
2005-09-30 |
2023-08-12 |
human |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
surprisingly, in transfected cho cells, ne exhibits a relatively high nanomolar affinity for cb2 receptors (k(i) = 480 nm), comparable to that observed for the endocannabinoid 2-arachidonoyl glycerol (2-ag) (k(i) = 1016 nm). |
2005-09-30 |
2023-08-12 |
human |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
together, these data indicate that ne acts as a full agonist at human cb2 receptors and thus might have important physiological functions at peripheral cannabinoid receptors. |
2005-09-30 |
2023-08-12 |
human |
| Devi Rani Sagar, Sara Kelly, Paul J Millns, Celestine T O'Shaughnessey, David A Kendall, Victoria Chapma. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045490. |
cannabinoid 2 (cb2) receptor mediated antinociception and increased levels of spinal cb2 receptor mrna are reported in neuropathic sprague-dawley rats. |
2005-09-23 |
2023-08-12 |
rat |
| Devi Rani Sagar, Sara Kelly, Paul J Millns, Celestine T O'Shaughnessey, David A Kendall, Victoria Chapma. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045490. |
the aim of this study was to provide functional evidence for a role of peripheral, vs. spinal, cb2 and cannabinoid 1 (cb1) receptors in neuropathic rats. |
2005-09-23 |
2023-08-12 |
rat |
| Xiaoyu Tian, Jianxin Guo, Fenmei Yao, De-Ping Yang, Alexandros Makriyanni. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. The Journal of biological chemistry. vol 280. issue 33. 2005-09-22. PMID:15964843. |
the endogenous cannabinoid ligand anandamide is biosynthesized from membrane phospholipid precursors and is believed to reach its sites of action on the cb1 and cb2 receptors through fast lateral diffusion within the cell membrane. |
2005-09-22 |
2023-08-12 |
Not clear |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
reduced endocannabinoid immune modulation by a common cannabinoid 2 (cb2) receptor gene polymorphism: possible risk for autoimmune disorders. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
to assess the immunomodulating role of the cannabinoid 2 (cb2) receptor, we sought polymorphisms in the human gene, identified a common dinucleotide polymorphism, and investigated its effect on endocannabinoid-induced inhibition of t lymphocyte proliferation. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
in gg/gg subjects, the reduced endocannabinoid inhibitory response was highly significant for n-arachidonylglycine and nearly significant for 2-arachidonylglycerol, and a specific cb2 receptor antagonist partially blocked these effects. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
the results also support the proposition that the cb2 receptor may represent a novel pharmacological target for selective agonists designed to suppress autoreactive immune responses while avoiding cb1 receptor-mediated cannabinoid adverse effects. |
2005-09-08 |
2023-08-12 |
human |