| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maiko Gokoh, Seishi Kishimoto, Saori Oka, Masahiro Mori, Keizo Waku, Yoshio Ishima, Takayuki Sugiur. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. The Biochemical journal. vol 386. issue Pt 3. 2005-08-25. PMID:15456404. |
to date, two types of cannabinoid receptors have been identified: the cb1 receptor, which is abundantly expressed in the nervous system, and the cb2 receptor, which is predominantly expressed in the immune system. |
2005-08-25 |
2023-08-12 |
Not clear |
| Mikhail Bobrov, Natalia Gretskaya, Olivier Payet, Vladimir Bezuglov, Thierry Durand, Laurence Maurin, Frank Tourrel, Oumeya Adjali, Murielle Rinaldi-Carmona, Agnès Mulle. Different pharmacological profile of two closely related endocannabinoid ester analogs. Life sciences. vol 77. issue 13. 2005-08-18. PMID:15894337. |
we examined the interaction of both compounds with cannabinoid receptors (cb1 and cb2) and their efficacy in functional assays. |
2005-08-18 |
2023-08-12 |
human |
| Seishi Kishimoto, Mayumi Muramatsu, Maiko Gokoh, Saori Oka, Keizo Waku, Takayuki Sugiur. Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells. Journal of biochemistry. vol 137. issue 2. 2005-08-16. PMID:15749836. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2005-08-16 |
2023-08-12 |
human |
| Dai Lu, Zhaoxing Meng, Ganesh A Thakur, Pusheng Fan, John Steed, Cindy L Tartal, Dow P Hurst, Patricia H Reggio, Jeffrey R Deschamps, Damon A Parrish, Clifford George, Torbjörn U C Järbe, Richard J Lamb, Alexandros Makriyanni. Adamantyl cannabinoids: a novel class of cannabinergic ligands. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999995. |
exploration of the side chain conformational space using molecular modeling approaches has allowed us to develop cannabinoid side chain pharmacophore models for the cb1 and cb2 receptors. |
2005-08-16 |
2023-08-12 |
Not clear |
| Dai Lu, Zhaoxing Meng, Ganesh A Thakur, Pusheng Fan, John Steed, Cindy L Tartal, Dow P Hurst, Patricia H Reggio, Jeffrey R Deschamps, Damon A Parrish, Clifford George, Torbjörn U C Järbe, Richard J Lamb, Alexandros Makriyanni. Adamantyl cannabinoids: a novel class of cannabinergic ligands. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999995. |
our results suggest that although a bulky group at the c3 position of classical cannabinoids could be tolerated by both cb1 and cb2 binding sites, the relative orientation of that group with respect to the tricyclic component can lead to receptor subtype selectivity. |
2005-08-16 |
2023-08-12 |
Not clear |
| H Zheng, J Zhao, S Wang, C-M Lin, T Chen, D H Jones, C Ma, S Opella, X-Q Xi. Biosynthesis and purification of a hydrophobic peptide from transmembrane domains of G-protein-coupled CB2 receptor. The journal of peptide research : official journal of the American Peptide Society. vol 65. issue 4. 2005-08-02. PMID:15813893. |
in order to develop a high-yield and cost-effective method, and also to obtain preliminary structural information for the computer modeling of the three-dimensional receptor structural model, a highly hydrophobic peptide from human cannabinoid subtype 2 receptor cb2(65-101), was chosen to develop high-yield membrane protein expression and purification methods. |
2005-08-02 |
2023-08-12 |
human |
| Christophe Hézode, Françoise Roudot-Thoraval, Son Nguyen, Pascale Grenard, Boris Julien, Elie-Serge Zafrani, Jean-Michel Pawlotsky, Jean-Michel Pawlostky, Daniel Dhumeaux, Sophie Lotersztajn, Ariane Malla. Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. Hepatology (Baltimore, Md.). vol 42. issue 1. 2005-08-02. PMID:15892090. |
daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis c. cannabinoids present in cannabis sativa (marijuana) exert biological effects via cannabinoid receptors cb1 and cb2. |
2005-08-02 |
2023-08-12 |
Not clear |
| Rundong Zhang, Dow P Hurst, Judy Barnett-Norris, Patricia H Reggio, Zhao-Hui Son. Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15840841. |
pretreatment of the cb2 receptor with cannabinoid ligands prevented this inhibition, suggesting that mtsea modification occurred within the binding crevice. |
2005-08-01 |
2023-08-12 |
human |
| Angelo Vaccani, Paola Massi, Arianna Colombo, Tiziana Rubino, Daniela Parolar. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British journal of pharmacology. vol 144. issue 8. 2005-07-29. PMID:15700028. |
since these cells express both cannabinoid cb1 and cb2 receptors in the membrane, we also evaluated their engagement in the antimigratory effect of cbd. |
2005-07-29 |
2023-08-12 |
human |
| Angelo Vaccani, Paola Massi, Arianna Colombo, Tiziana Rubino, Daniela Parolar. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British journal of pharmacology. vol 144. issue 8. 2005-07-29. PMID:15700028. |
the inhibition of cell was not antagonized either by the selective cannabinoid receptor antagonists sr141716 (cb1) and sr144528 (cb2) or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or receptors coupled to gi/o proteins. |
2005-07-29 |
2023-08-12 |
human |
| K H Raitio, O M H Salo, T Nevalainen, A Poso, T Järvine. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Current medicinal chemistry. vol 12. issue 10. 2005-07-28. PMID:15892633. |
targeting the cannabinoid cb2 receptor: mutations, modeling and development of cb2 selective ligands. |
2005-07-28 |
2023-08-12 |
human |
| K H Raitio, O M H Salo, T Nevalainen, A Poso, T Järvine. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Current medicinal chemistry. vol 12. issue 10. 2005-07-28. PMID:15892633. |
since the discovery of the cannabinoid cb2 receptor in 1993, there has been a growing interest to clarify the importance of this g-protein coupled receptor (gpcr) for human physiology, and to investigate it as a possible target for current and future drug development. |
2005-07-28 |
2023-08-12 |
human |
| Sophie J Govaerts, Giulio G Muccioli, Emmanuel Hermans, Didier M Lamber. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors. European journal of pharmacology. vol 495. issue 1. 2005-07-26. PMID:15219819. |
characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid cb1 and cb2 receptors. |
2005-07-26 |
2023-08-12 |
human |
| Sophie J Govaerts, Giulio G Muccioli, Emmanuel Hermans, Didier M Lamber. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors. European journal of pharmacology. vol 495. issue 1. 2005-07-26. PMID:15219819. |
the pharmacology of 3-(2-ethylmorpholino)-5,5'-di(p-bromophenyl)-imidazolidinedione (dml20), 3-(1-hydroxypropyl)-5,5'-di(p-bromophenyl)-imidazolidinedione (dml21) and 3-heptyl-5,5'-di(p-bromophenyl)-imidazolidinedione (dml23) was extended by studying affinity and gtp binding modulation on cannabinoid receptor subtypes (cb1 and cb2) from rat tissues and human cannabinoid receptors expressed in chinese hamster ovary cells. |
2005-07-26 |
2023-08-12 |
human |
| Sophie J Govaerts, Giulio G Muccioli, Emmanuel Hermans, Didier M Lamber. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors. European journal of pharmacology. vol 495. issue 1. 2005-07-26. PMID:15219819. |
however, in cho cells homogenates expressing selectively either human cannabinoid cb1 or cb2 receptors, they behaved as inverse agonists decreasing the [35s]gtpgammas binding, with similar efficacy. |
2005-07-26 |
2023-08-12 |
human |
| Xiang-Qun Xie, Ju Zhao, Haian Zhen. Expression, purification, and isotope labeling of cannabinoid CB2 receptor fragment, CB2(180-233). Protein expression and purification. vol 38. issue 1. 2005-07-26. PMID:15477083. |
expression, purification, and isotope labeling of cannabinoid cb2 receptor fragment, cb2(180-233). |
2005-07-26 |
2023-08-12 |
Not clear |
| Xiang-Qun Xie, Ju Zhao, Haian Zhen. Expression, purification, and isotope labeling of cannabinoid CB2 receptor fragment, CB2(180-233). Protein expression and purification. vol 38. issue 1. 2005-07-26. PMID:15477083. |
to develop an approach to obtain milligram quantities of purified isotope-labeled seven transmembrane g-protein coupled cannabinoid (cb) receptor for nmr structural analysis, we chose a truncated cb receptor fragment, cb2(180-233), spanning from the fifth transmembrane domain (tm5) to the associated loop regions of cannabinoid cb2 receptor. |
2005-07-26 |
2023-08-12 |
Not clear |
| Saoirse E O'Sullivan, David A Kendall, Michael D Randal. Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. European journal of pharmacology. vol 507. issue 1-3. 2005-07-25. PMID:15659311. |
the vasorelaxant effects of the cannabinoids were not inhibited by cannabinoid cb1 receptor antagonism; however, vasorelaxation to both cp55,940 and thc was inhibited by cannabinoid cb2 receptor antagonism. |
2005-07-25 |
2023-08-12 |
rat |
| Lichun Zhong, Lijun Geng, Yafatou Njie, Wenke Feng, Zhao-Hui Son. CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility. Investigative ophthalmology & visual science. vol 46. issue 6. 2005-07-21. PMID:15914613. |
cb2 cannabinoid receptors in trabecular meshwork cells mediate jwh015-induced enhancement of aqueous humor outflow facility. |
2005-07-21 |
2023-08-12 |
Not clear |
| Lichun Zhong, Lijun Geng, Yafatou Njie, Wenke Feng, Zhao-Hui Son. CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility. Investigative ophthalmology & visual science. vol 46. issue 6. 2005-07-21. PMID:15914613. |
to study the effects of jwh015, a cb2-selective agonist, on aqueous humor outflow facility, to investigate whether functional cb2 cannabinoid receptors are expressed in trabecular meshwork cells, and to study whether these receptors are involved in the enhancement of outflow facility induced by jwh015. |
2005-07-21 |
2023-08-12 |
Not clear |