| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Brizzi, Vittorio Brizzi, Maria Grazia Cascio, Tiziana Bisogno, Rossella Sirianni, Vincenzo Di Marz. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. Journal of medicinal chemistry. vol 48. issue 23. 2006-01-17. PMID:16279794. |
binding studies on cb1 and cb2 receptors, anandamide membrane transporter (amt), and fatty acid amide hydrolase (faah) showed that some of the newly developed compounds have high affinity and specificity for cannabinoid cb1 and cb2 receptors. |
2006-01-17 |
2023-08-12 |
Not clear |
| Birgit Kraft, Hans G Kres. Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16055676. |
indirect cb2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. |
2006-01-12 |
2023-08-12 |
human |
| Jennifer L Shoemaker, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16081674. |
this study examined the ability of the endocannabinoids 2-arachidonoyl glycerol (2-ag) and noladin ether as well as the synthetic cannabinoid cp-55,940 [(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol] to regulate three intracellular effectors via cb2 receptors in transfected chinese hamster ovary cells. |
2006-01-12 |
2023-08-12 |
Not clear |
| Jennifer L Shoemaker, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16081674. |
this suggests that 2-ag stimulates ca(2+)-transients by binding to sites on cb2 receptors distinct from those occupied by am630 and the other cannabinoids examined. |
2006-01-12 |
2023-08-12 |
Not clear |
| Jennifer L Shoemaker, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16081674. |
in summary, cannabinoid agonists distinctly bind to cb2 receptors and display different rank order of potencies and fractional receptor occupancies for regulation of intracellular effectors. |
2006-01-12 |
2023-08-12 |
Not clear |
| P M Beardsley, B F Thoma. Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders. Behavioural pharmacology. vol 16. issue 5-6. 2006-01-09. PMID:16148435. |
since the discovery of the cannabinoid cb1 receptor (cb1r) in 1988, and subsequently of the cb2 receptor (cb2r) in 1993, there has been an exponential growth of research investigating the functions of the endocannabinoid system. |
2006-01-09 |
2023-08-12 |
Not clear |
| Billy R Marti. Role of lipids and lipid signaling in the development of cannabinoid tolerance. Life sciences. vol 77. issue 14. 2006-01-05. PMID:15949820. |
the discovery of the endocannabinoid system that contains two receptor subtypes, cb1 and cb2, associated signaling pathways, endocannabinoids (anandamide and 2-arachidonoylglycerol) and their synthetic and degradative pathways has provided a means of systematically evaluating the mechanism of cannabinoid tolerance. |
2006-01-05 |
2023-08-12 |
Not clear |
| Sumner Burstei. PPAR-gamma: a nuclear receptor with affinity for cannabinoids. Life sciences. vol 77. issue 14. 2006-01-05. PMID:16005906. |
an increasing number of cannabinoid actions are being reported that do not appear to be mediated by either cb1 or cb2, the known cannabinoid receptors. |
2006-01-05 |
2023-08-12 |
human |
| Niamh M Curran, Bryan D Griffin, Daniel O'Toole, Kevin J Brady, Stephen N Fitzgerald, Paul N Moynag. The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner. The Journal of biological chemistry. vol 280. issue 43. 2006-01-04. PMID:16105834. |
this inhibition is not mediated via the cb1 or cb2 cannabinoid receptors, because their selective antagonists and pertussis toxin failed to affect the inhibitory effects of r(+)win 55,212-2. |
2006-01-04 |
2023-08-12 |
human |
| Mario van der Stelt, Vincenzo Di Marz. Cannabinoid receptors and their role in neuroprotection. Neuromolecular medicine. vol 7. issue 1-2. 2005-12-08. PMID:16052037. |
two g protein-coupled receptors for marijuana's psychoactive component, delta9-tetrahydrocannabinol, have been cloned to date, the cannabinoid cb1 and cb2 receptors. |
2005-12-08 |
2023-08-12 |
Not clear |
| Andrew S Yates, Stephen W Doughty, David A Kendall, Barrie Kella. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry letters. vol 15. issue 16. 2005-12-05. PMID:15993070. |
chemical modification of the naphthoyl 3-position of jwh-015: in search of a fluorescent probe to the cannabinoid cb2 receptor. |
2005-12-05 |
2023-08-12 |
Not clear |
| Andrew S Yates, Stephen W Doughty, David A Kendall, Barrie Kella. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry letters. vol 15. issue 16. 2005-12-05. PMID:15993070. |
in silico modelling was used to guide the positioning of the fluorescent dye nbd-f on the cannabinoid cb2 receptor agonist jwh-015. |
2005-12-05 |
2023-08-12 |
Not clear |
| Andrew S Yates, Stephen W Doughty, David A Kendall, Barrie Kella. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry letters. vol 15. issue 16. 2005-12-05. PMID:15993070. |
while the ultimate fluorescent conjugate lost extensive binding affinity to the cannabinoid cb2 receptor, affinity and efficacy studies on the naphthoyl 3-position modified precursor molecules have provided new insight into structure-activity relationships associated with this position. |
2005-12-05 |
2023-08-12 |
Not clear |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Journal de pharmacie de Belgique. vol 60. issue 3. 2005-12-01. PMID:16252509. |
the endocannabinoid system modulates many physiological functions by acting on receptors cb1 and cb2. |
2005-12-01 |
2023-08-12 |
Not clear |
| John W Huffman, Paul V Szklennik, Amanda Almond, Kristen Bushell, Dana E Selley, Hengjun He, Michael P Cassidy, Jenny L Wiley, Billy R Marti. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & medicinal chemistry letters. vol 15. issue 18. 2005-11-21. PMID:16005223. |
a new class of cannabimimetic indoles, with 3-phenylacetyl or substituted 3-phenylacetyl substituents, has been prepared and their affinities for the cannabinoid cb1 and cb2 receptors have been determined. |
2005-11-21 |
2023-08-12 |
Not clear |
| Marja D Van Sickle, Marnie Duncan, Philip J Kingsley, Abdeslam Mouihate, Paolo Urbani, Ken Mackie, Nephi Stella, Alexandros Makriyannis, Daniele Piomelli, Joseph S Davison, Lawrence J Marnett, Vincenzo Di Marzo, Quentin J Pittman, Kamala D Patel, Keith A Sharke. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). vol 310. issue 5746. 2005-11-04. PMID:16224028. |
identification and functional characterization of brainstem cannabinoid cb2 receptors. |
2005-11-04 |
2023-08-12 |
Not clear |
| Marja D Van Sickle, Marnie Duncan, Philip J Kingsley, Abdeslam Mouihate, Paolo Urbani, Ken Mackie, Nephi Stella, Alexandros Makriyannis, Daniele Piomelli, Joseph S Davison, Lawrence J Marnett, Vincenzo Di Marzo, Quentin J Pittman, Kamala D Patel, Keith A Sharke. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). vol 310. issue 5746. 2005-11-04. PMID:16224028. |
cb2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas. |
2005-11-04 |
2023-08-12 |
Not clear |
| Katarzyna Maresz, Erica J Carrier, Eugene D Ponomarev, Cecilia J Hillard, Bonnie N Ditte. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086683. |
modulation of the cannabinoid cb2 receptor in microglial cells in response to inflammatory stimuli. |
2005-11-02 |
2023-08-12 |
mouse |
| Juha R Savinainen, Tarja Kokkola, Outi M H Salo, Antti Poso, Tomi Järvinen, Jarmo T Laitine. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. British journal of pharmacology. vol 145. issue 5. 2005-10-31. PMID:15852035. |
identification of win55212-3 as a competitive neutral antagonist of the human cannabinoid cb2 receptor. |
2005-10-31 |
2023-08-12 |
human |
| Belén G Ramírez, Cristina Blázquez, Teresa Gómez del Pulgar, Manuel Guzmán, María L de Ceballo. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728830. |
here, we show that senile plaques in ad patients express cannabinoid receptors cb1 and cb2, together with markers of microglial activation, and that cb1-positive neurons, present in high numbers in control cases, are greatly reduced in areas of microglial activation. |
2005-10-26 |
2023-08-12 |
rat |