| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
as in rats, high-dose gw405833 (100 mg/kg) showed both analgesic and sedative activities in wild-type mice, activities that were also apparent in cannabinoid cb2 receptor knockout mice. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
these data demonstrate that the antihyperalgesic effects of gw405833 are mediated via the cannabinoid cb2 receptor, whereas the analgesic and sedative effects are not. |
2006-03-09 |
2023-08-12 |
mouse |
| Cristina Benito, Woong-Ki Kim, Wong-Ki Kim, Iván Chavarría, Ceceila J Hillard, Ken Mackie, Rosa M Tolón, Kenneth Williams, Ken Williams, Julián Romer. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758162. |
specifically, expression of cannabinoid receptors of the cb2 subtype was induced in the brains of infected animals, mainly in perivascular macrophages, microglial nodules, and t-lymphocytes, most likely of the cd8 subtype. |
2006-03-02 |
2023-08-12 |
human |
| Cristina Benito, Woong-Ki Kim, Wong-Ki Kim, Iván Chavarría, Ceceila J Hillard, Ken Mackie, Rosa M Tolón, Kenneth Williams, Ken Williams, Julián Romer. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758162. |
these results resemble previous data obtained in alzheimer's disease human tissue samples and suggest that the endocannabinoid system may participate in the development of human immunodeficiency virus-induced encephalitis, because activation of cb2 receptors expressed by immune cells is likely to reduce their antiviral response and thus could favor the cns entry of infected monocytes. |
2006-03-02 |
2023-08-12 |
human |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
the endogenous cannabinoids bind to and activate two g protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (cb1) and peripheral cannabinoid receptor type 2 (cb2). |
2006-02-28 |
2023-08-12 |
mouse |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
whereas cb1 mediates the cannabinoid psychotropic, analgesic, and orectic effects, cb2 has been implicated recently in the regulation of liver fibrosis and atherosclerosis. |
2006-02-28 |
2023-08-12 |
mouse |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
these results demonstrate that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic cb2 signaling. |
2006-02-28 |
2023-08-12 |
mouse |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Revue medicale de Bruxelles. vol 26. issue 3. 2006-02-21. PMID:16038140. |
the endocannabinoid system modulates many physiological functions by acting on receptors cb1 and cb2. |
2006-02-21 |
2023-08-12 |
Not clear |
| Eric Stern, Giulio G Muccioli, Régis Millet, Jean-François Goossens, Amaury Farce, Philippe Chavatte, Jacques H Poupaert, Didier M Lambert, Patrick Depreux, Jean-Pierre Hénichar. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. Journal of medicinal chemistry. vol 49. issue 1. 2006-02-16. PMID:16392793. |
novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new cb2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. |
2006-02-16 |
2023-08-12 |
human |
| Zhe Ding, Alan Cowan, Scott M Rawl. Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors. Brain research. vol 1065. issue 1-2. 2006-02-15. PMID:16309633. |
capsaicin evokes hypothermia independent of cannabinoid cb1 and cb2 receptors. |
2006-02-15 |
2023-08-12 |
rat |
| Kent-Olov Jonsson, Emma Persson, Christopher J Fowle. The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. Life sciences. vol 78. issue 6. 2006-02-14. PMID:16111718. |
the cannabinoid cb2 receptor selective agonist jwh133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. |
2006-02-14 |
2023-08-12 |
mouse |
| Steven J R Elmes, Lisa A Winyard, Stephen J Medhurst, Nick M Clayton, Alex W Wilson, David A Kendall, Victoria Chapma. Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain. vol 118. issue 3. 2006-02-14. PMID:16289798. |
we have compared the effects of pre-administration versus post-administration of a potent non-selective cannabinoid agonist hu210 and a selective cb2 receptor agonist jwh-133 on hindpaw weight bearing and paw oedema in the carrageenan model of inflammatory hyperalgesia. |
2006-02-14 |
2023-08-12 |
rat |
| G A Cabral, F Marciano-Cabra. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204639. |
microglia, in addition to exhibiting phenotypic markers for macrophages, express cb1 and cb2 cannabinoid receptors. |
2006-02-09 |
2023-08-12 |
Not clear |
| Hong Im Kim, Tae Hoon Kim, Yong Kyoo Shin, Chung Soo Lee, Mijung Park, Jin-Ho Son. Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. Brain research. vol 1062. issue 1-2. 2006-02-09. PMID:16256960. |
it is an agonist at cb1 and cb2 cannabinoid receptors as well as the vanilloid receptor, vr1. |
2006-02-09 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
cannabinoid cb2 receptor agonist activity in the hindpaw incision model of postoperative pain. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
the identification of peripherally expressed cb2 receptors and reports that the selective activation of cannabinoid cb2 receptors produces antinociception without traditional cannabinergic side effects suggests that selective cannabinoid cb2 receptor agonists might be useful in the management of pain. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
in a rat hindpaw incision model, we examined the antiallodynic activity of the selective cannabinoid cb2 receptor agonists am1241 (3-30 mg/kg i.p. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
was am1241 > gw405833 = hu-308, and the selective cannabinoid cb2 receptor antagonist, sr144528, reversed the antiallodynic effect of hu-308. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
together, these data suggest that selective cannabinoid cb2 receptor agonists might represent a new class of postoperative analgesics. |
2006-02-08 |
2023-08-12 |
rat |
| Robyn A Puffenbarge. Molecular biology of the enzymes that degrade endocannabinoids. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375680. |
the endocannabinoid circuit involves two cloned receptors: cb1 in the cns and cb2 in the periphery; endogenously produced ligands including anandamide, 2-arachidonylglycerol and palmitoylethanolamide; and enzymes that degrade endocannabinoid ligands to terminate signaling. |
2006-02-07 |
2023-08-12 |
Not clear |