| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Revue medicale de Bruxelles. vol 26. issue 3. 2006-02-21. PMID:16038140. |
the endocannabinoid system modulates many physiological functions by acting on receptors cb1 and cb2. |
2006-02-21 |
2023-08-12 |
Not clear |
| Eric Stern, Giulio G Muccioli, Régis Millet, Jean-François Goossens, Amaury Farce, Philippe Chavatte, Jacques H Poupaert, Didier M Lambert, Patrick Depreux, Jean-Pierre Hénichar. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. Journal of medicinal chemistry. vol 49. issue 1. 2006-02-16. PMID:16392793. |
novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new cb2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. |
2006-02-16 |
2023-08-12 |
human |
| Zhe Ding, Alan Cowan, Scott M Rawl. Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors. Brain research. vol 1065. issue 1-2. 2006-02-15. PMID:16309633. |
capsaicin evokes hypothermia independent of cannabinoid cb1 and cb2 receptors. |
2006-02-15 |
2023-08-12 |
rat |
| Kent-Olov Jonsson, Emma Persson, Christopher J Fowle. The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. Life sciences. vol 78. issue 6. 2006-02-14. PMID:16111718. |
the cannabinoid cb2 receptor selective agonist jwh133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. |
2006-02-14 |
2023-08-12 |
mouse |
| Steven J R Elmes, Lisa A Winyard, Stephen J Medhurst, Nick M Clayton, Alex W Wilson, David A Kendall, Victoria Chapma. Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain. vol 118. issue 3. 2006-02-14. PMID:16289798. |
we have compared the effects of pre-administration versus post-administration of a potent non-selective cannabinoid agonist hu210 and a selective cb2 receptor agonist jwh-133 on hindpaw weight bearing and paw oedema in the carrageenan model of inflammatory hyperalgesia. |
2006-02-14 |
2023-08-12 |
rat |
| G A Cabral, F Marciano-Cabra. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204639. |
microglia, in addition to exhibiting phenotypic markers for macrophages, express cb1 and cb2 cannabinoid receptors. |
2006-02-09 |
2023-08-12 |
Not clear |
| Hong Im Kim, Tae Hoon Kim, Yong Kyoo Shin, Chung Soo Lee, Mijung Park, Jin-Ho Son. Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. Brain research. vol 1062. issue 1-2. 2006-02-09. PMID:16256960. |
it is an agonist at cb1 and cb2 cannabinoid receptors as well as the vanilloid receptor, vr1. |
2006-02-09 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
cannabinoid cb2 receptor agonist activity in the hindpaw incision model of postoperative pain. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
the identification of peripherally expressed cb2 receptors and reports that the selective activation of cannabinoid cb2 receptors produces antinociception without traditional cannabinergic side effects suggests that selective cannabinoid cb2 receptor agonists might be useful in the management of pain. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
in a rat hindpaw incision model, we examined the antiallodynic activity of the selective cannabinoid cb2 receptor agonists am1241 (3-30 mg/kg i.p. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
was am1241 > gw405833 = hu-308, and the selective cannabinoid cb2 receptor antagonist, sr144528, reversed the antiallodynic effect of hu-308. |
2006-02-08 |
2023-08-12 |
rat |
| Christopher J LaBuda, Michael Koblish, Patrick J Littl. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16316653. |
together, these data suggest that selective cannabinoid cb2 receptor agonists might represent a new class of postoperative analgesics. |
2006-02-08 |
2023-08-12 |
rat |
| Robyn A Puffenbarge. Molecular biology of the enzymes that degrade endocannabinoids. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375680. |
the endocannabinoid circuit involves two cloned receptors: cb1 in the cns and cb2 in the periphery; endogenously produced ligands including anandamide, 2-arachidonylglycerol and palmitoylethanolamide; and enzymes that degrade endocannabinoid ligands to terminate signaling. |
2006-02-07 |
2023-08-12 |
Not clear |
| Yosef Sarne, Raphael Mechoula. Cannabinoids: between neuroprotection and neurotoxicity. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375685. |
some of these mechanisms involve the activation of cb1 and cb2 cannabinoid receptors, while others are not dependent on them. |
2006-02-07 |
2023-08-12 |
Not clear |
| Nichola J Underdown, C Robin Hiley, William R For. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. British journal of pharmacology. vol 146. issue 6. 2006-02-03. PMID:16158067. |
despite sensitivity to cb1 and cb2 receptor antagonists, the infarct-limiting action of anandamide was not mimicked by agonists selective for cb1 or cb2 receptors suggesting the involvement of a novel cannabinoid site of action. |
2006-02-03 |
2023-08-12 |
rat |
| Jenny Flygare, Kristin Gustafsson, Eva Kimby, Birger Christensson, Birgitta Sande. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS letters. vol 579. issue 30. 2006-01-23. PMID:16337199. |
we have earlier reported overexpression of the central and peripheral cannabinoid receptors cb1 and cb2 in mantle cell lymphoma (mcl), a b cell non-hodgkin lymphoma. |
2006-01-23 |
2023-08-12 |
Not clear |
| Adèle Thomas, Lesley A Stevenson, Kerrie N Wease, Martin R Price, Gemma Baillie, Ruth A Ross, Roger G Pertwe. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. British journal of pharmacology. vol 146. issue 7. 2006-01-20. PMID:16205722. |
evidence that the plant cannabinoid delta9-tetrahydrocannabivarin is a cannabinoid cb1 and cb2 receptor antagonist. |
2006-01-20 |
2023-08-12 |
mouse |
| U Schneider, J Seifert, M Karst, J Schlimme, K Cimander, K R Müller-Vah. [The endogenous cannabinoid system. Therapeutic implications for neurologic and psychiatric disorders]. Der Nervenarzt. vol 76. issue 9. 2006-01-19. PMID:15776259. |
this is based on the discovery that cannabinoids act with specific receptors (cb1 and cb2). |
2006-01-19 |
2023-08-12 |
Not clear |
| S A Moore, G G Nomikos, A K Dickason-Chesterfield, D A Schober, J M Schaus, B-P Ying, Y-C Xu, L Phebus, R M A Simmons, D Li, S Iyengar, C C Felde. Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 49. 2006-01-18. PMID:16314570. |
delta9-tetrahydrocannabinol and endogenous cannabinoids (e.g., anandamide) initiate their agonist properties by stimulating the cannabinoid family of g protein-coupled receptors (cb1 and cb2). |
2006-01-18 |
2023-08-12 |
Not clear |
| Outi M H Salo, Katri H Raitio, Juha R Savinainen, Tapio Nevalainen, Maija Lahtela-Kakkonen, Jarmo T Laitinen, Tomi Järvinen, Antti Pos. Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor. Journal of medicinal chemistry. vol 48. issue 23. 2006-01-17. PMID:16279774. |
virtual screening of novel cb2 ligands using a comparative model of the human cannabinoid cb2 receptor. |
2006-01-17 |
2023-08-12 |
human |