| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Woelkart, Wei Xu, Ying Pei, Alexandros Makriyannis, Robert P Picone, Rudolf Baue. The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. Planta medica. vol 71. issue 8. 2005-10-25. PMID:16142631. |
due to their structural similarity with anandamide, we have evaluated their ability to bind to rodent cannabinoid receptors cb1 and cb2 by a standard receptor binding assay using [(3)h]cp-55,940 as a radioligand. |
2005-10-25 |
2023-08-12 |
Not clear |
| Süreyya Barun, Ismail Mert Vural, Ergin Dileköz, Zeynep Sevim Ercan, Yusuf Sariogl. Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. Clinical and experimental pharmacology & physiology. vol 32. issue 9. 2005-10-19. PMID:16173925. |
the cannabinoid cb1 receptor antagonist am 251 (10(-6) mol/l) and the cannabinoid cb2 receptor antagonist am 630 (10(-6) mol/l) had no effect on the inhibitory action of anandamide on the biphasic twitch responses in the prostatic and epididymal portions of the rabbit vas deferens. |
2005-10-19 |
2023-08-12 |
rabbit |
| Uberto Pagotto, Valentina Vicennati, Renato Pasqual. The endocannabinoid system and the treatment of obesity. Annals of medicine. vol 37. issue 4. 2005-10-13. PMID:16019725. |
the endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (cb) cb1 and cb2. |
2005-10-13 |
2023-08-12 |
Not clear |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
the endocannabinoid noladin ether acts as a full agonist at human cb2 cannabinoid receptors. |
2005-09-30 |
2023-08-12 |
human |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
surprisingly, in transfected cho cells, ne exhibits a relatively high nanomolar affinity for cb2 receptors (k(i) = 480 nm), comparable to that observed for the endocannabinoid 2-arachidonoyl glycerol (2-ag) (k(i) = 1016 nm). |
2005-09-30 |
2023-08-12 |
human |
| Jennifer L Shoemaker, Biny K Joseph, Michael B Ruckle, Philip R Mayeux, Paul L Prathe. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15901805. |
together, these data indicate that ne acts as a full agonist at human cb2 receptors and thus might have important physiological functions at peripheral cannabinoid receptors. |
2005-09-30 |
2023-08-12 |
human |
| Devi Rani Sagar, Sara Kelly, Paul J Millns, Celestine T O'Shaughnessey, David A Kendall, Victoria Chapma. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045490. |
cannabinoid 2 (cb2) receptor mediated antinociception and increased levels of spinal cb2 receptor mrna are reported in neuropathic sprague-dawley rats. |
2005-09-23 |
2023-08-12 |
rat |
| Devi Rani Sagar, Sara Kelly, Paul J Millns, Celestine T O'Shaughnessey, David A Kendall, Victoria Chapma. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045490. |
the aim of this study was to provide functional evidence for a role of peripheral, vs. spinal, cb2 and cannabinoid 1 (cb1) receptors in neuropathic rats. |
2005-09-23 |
2023-08-12 |
rat |
| Xiaoyu Tian, Jianxin Guo, Fenmei Yao, De-Ping Yang, Alexandros Makriyanni. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. The Journal of biological chemistry. vol 280. issue 33. 2005-09-22. PMID:15964843. |
the endogenous cannabinoid ligand anandamide is biosynthesized from membrane phospholipid precursors and is believed to reach its sites of action on the cb1 and cb2 receptors through fast lateral diffusion within the cell membrane. |
2005-09-22 |
2023-08-12 |
Not clear |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
reduced endocannabinoid immune modulation by a common cannabinoid 2 (cb2) receptor gene polymorphism: possible risk for autoimmune disorders. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
to assess the immunomodulating role of the cannabinoid 2 (cb2) receptor, we sought polymorphisms in the human gene, identified a common dinucleotide polymorphism, and investigated its effect on endocannabinoid-induced inhibition of t lymphocyte proliferation. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
in gg/gg subjects, the reduced endocannabinoid inhibitory response was highly significant for n-arachidonylglycine and nearly significant for 2-arachidonylglycerol, and a specific cb2 receptor antagonist partially blocked these effects. |
2005-09-08 |
2023-08-12 |
human |
| Jack C Sipe, Nathalie Arbour, Alexandra Gerber, Ernest Beutle. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845647. |
the results also support the proposition that the cb2 receptor may represent a novel pharmacological target for selective agonists designed to suppress autoreactive immune responses while avoiding cb1 receptor-mediated cannabinoid adverse effects. |
2005-09-08 |
2023-08-12 |
human |
| Christopher J Fowler, Sandra Holt, Olov Nilsson, Kent-Olov Jonsson, Gunnar Tiger, Stig O P Jacobsso. The endocannabinoid signaling system: pharmacological and therapeutic aspects. Pharmacology, biochemistry, and behavior. vol 81. issue 2. 2005-09-08. PMID:15935456. |
with respect to the treatment of pain, topical cb1 agonists and cb2 agonists may prove therapeutically useful, and there is evidence that the non-steroidal inflammatory agent indomethacin produces effects secondary to activation of the endocannabinoid system. |
2005-09-08 |
2023-08-12 |
Not clear |
| María Ruth Pazos, Estefanía Núñez, Cristina Benito, Rosa María Tolón, Julián Romer. Functional neuroanatomy of the endocannabinoid system. Pharmacology, biochemistry, and behavior. vol 81. issue 2. 2005-09-08. PMID:15936805. |
among them are two types of cannabinoid receptors (termed cb1 and cb2), endogenous ligands for those receptors (referred to as "endocannabinoids"), and specific enzymes responsible for their degradation and inactivation. |
2005-09-08 |
2023-08-12 |
Not clear |
| Karen Wright, Nicholas Rooney, Mark Feeney, Jeremy Tate, Duncan Robertson, Melanie Welham, Stephen War. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology. vol 129. issue 2. 2005-09-07. PMID:16083701. |
two g-protein-coupled cannabinoid receptors, termed cb1 and cb2, have been identified and several mammalian enteric nervous systems express cb1 receptors and produce endocannabinoids. |
2005-09-07 |
2023-08-12 |
human |
| Saori Oka, Shin Yanagimoto, Shinobu Ikeda, Maiko Gokoh, Seishi Kishimoto, Keizo Waku, Yoshio Ishima, Takayuki Sugiur. Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15749716. |
evidence for the involvement of the cannabinoid cb2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-o-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. |
2005-09-02 |
2023-08-12 |
mouse |
| Malcolm Begg, Pál Pacher, Sándor Bátkai, Douglas Osei-Hyiaman, László Offertáler, Fong Ming Mo, Jie Liu, George Kuno. Evidence for novel cannabinoid receptors. Pharmacology & therapeutics. vol 106. issue 2. 2005-08-30. PMID:15866316. |
to date, two g protein-coupled cannabinoid receptors have been identified by molecular cloning, cb1 receptors mainly expressed in the brain and mediating most of the neurobehavioral effects of cannabinoids and cb2 receptors expressed by immune and hematopoietic tissues. |
2005-08-30 |
2023-08-12 |
Not clear |
| Malcolm Begg, Pál Pacher, Sándor Bátkai, Douglas Osei-Hyiaman, László Offertáler, Fong Ming Mo, Jie Liu, George Kuno. Evidence for novel cannabinoid receptors. Pharmacology & therapeutics. vol 106. issue 2. 2005-08-30. PMID:15866316. |
recent findings indicate that some cannabinoid effects are not mediated by either cb1 or cb2 receptors, and in some cases there is compelling evidence to implicate additional receptors in these actions. |
2005-08-30 |
2023-08-12 |
Not clear |
| Fernando Correa, Leyre Mestre, Fabian Docagne, Carmen Guaz. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. British journal of pharmacology. vol 145. issue 4. 2005-08-29. PMID:15821753. |
activation of cannabinoid cb2 receptor negatively regulates il-12p40 production in murine macrophages: role of il-10 and erk1/2 kinase signaling. |
2005-08-29 |
2023-08-12 |
Not clear |