| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J Fowler, Sandra Holt, Olov Nilsson, Kent-Olov Jonsson, Gunnar Tiger, Stig O P Jacobsso. The endocannabinoid signaling system: pharmacological and therapeutic aspects. Pharmacology, biochemistry, and behavior. vol 81. issue 2. 2005-09-08. PMID:15935456. |
with respect to the treatment of pain, topical cb1 agonists and cb2 agonists may prove therapeutically useful, and there is evidence that the non-steroidal inflammatory agent indomethacin produces effects secondary to activation of the endocannabinoid system. |
2005-09-08 |
2023-08-12 |
Not clear |
| María Ruth Pazos, Estefanía Núñez, Cristina Benito, Rosa María Tolón, Julián Romer. Functional neuroanatomy of the endocannabinoid system. Pharmacology, biochemistry, and behavior. vol 81. issue 2. 2005-09-08. PMID:15936805. |
among them are two types of cannabinoid receptors (termed cb1 and cb2), endogenous ligands for those receptors (referred to as "endocannabinoids"), and specific enzymes responsible for their degradation and inactivation. |
2005-09-08 |
2023-08-12 |
Not clear |
| Karen Wright, Nicholas Rooney, Mark Feeney, Jeremy Tate, Duncan Robertson, Melanie Welham, Stephen War. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology. vol 129. issue 2. 2005-09-07. PMID:16083701. |
two g-protein-coupled cannabinoid receptors, termed cb1 and cb2, have been identified and several mammalian enteric nervous systems express cb1 receptors and produce endocannabinoids. |
2005-09-07 |
2023-08-12 |
human |
| Saori Oka, Shin Yanagimoto, Shinobu Ikeda, Maiko Gokoh, Seishi Kishimoto, Keizo Waku, Yoshio Ishima, Takayuki Sugiur. Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15749716. |
evidence for the involvement of the cannabinoid cb2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-o-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. |
2005-09-02 |
2023-08-12 |
mouse |
| Malcolm Begg, Pál Pacher, Sándor Bátkai, Douglas Osei-Hyiaman, László Offertáler, Fong Ming Mo, Jie Liu, George Kuno. Evidence for novel cannabinoid receptors. Pharmacology & therapeutics. vol 106. issue 2. 2005-08-30. PMID:15866316. |
to date, two g protein-coupled cannabinoid receptors have been identified by molecular cloning, cb1 receptors mainly expressed in the brain and mediating most of the neurobehavioral effects of cannabinoids and cb2 receptors expressed by immune and hematopoietic tissues. |
2005-08-30 |
2023-08-12 |
Not clear |
| Malcolm Begg, Pál Pacher, Sándor Bátkai, Douglas Osei-Hyiaman, László Offertáler, Fong Ming Mo, Jie Liu, George Kuno. Evidence for novel cannabinoid receptors. Pharmacology & therapeutics. vol 106. issue 2. 2005-08-30. PMID:15866316. |
recent findings indicate that some cannabinoid effects are not mediated by either cb1 or cb2 receptors, and in some cases there is compelling evidence to implicate additional receptors in these actions. |
2005-08-30 |
2023-08-12 |
Not clear |
| Fernando Correa, Leyre Mestre, Fabian Docagne, Carmen Guaz. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. British journal of pharmacology. vol 145. issue 4. 2005-08-29. PMID:15821753. |
activation of cannabinoid cb2 receptor negatively regulates il-12p40 production in murine macrophages: role of il-10 and erk1/2 kinase signaling. |
2005-08-29 |
2023-08-12 |
Not clear |
| Maiko Gokoh, Seishi Kishimoto, Saori Oka, Masahiro Mori, Keizo Waku, Yoshio Ishima, Takayuki Sugiur. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. The Biochemical journal. vol 386. issue Pt 3. 2005-08-25. PMID:15456404. |
to date, two types of cannabinoid receptors have been identified: the cb1 receptor, which is abundantly expressed in the nervous system, and the cb2 receptor, which is predominantly expressed in the immune system. |
2005-08-25 |
2023-08-12 |
Not clear |
| Mikhail Bobrov, Natalia Gretskaya, Olivier Payet, Vladimir Bezuglov, Thierry Durand, Laurence Maurin, Frank Tourrel, Oumeya Adjali, Murielle Rinaldi-Carmona, Agnès Mulle. Different pharmacological profile of two closely related endocannabinoid ester analogs. Life sciences. vol 77. issue 13. 2005-08-18. PMID:15894337. |
we examined the interaction of both compounds with cannabinoid receptors (cb1 and cb2) and their efficacy in functional assays. |
2005-08-18 |
2023-08-12 |
human |
| Seishi Kishimoto, Mayumi Muramatsu, Maiko Gokoh, Saori Oka, Keizo Waku, Takayuki Sugiur. Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells. Journal of biochemistry. vol 137. issue 2. 2005-08-16. PMID:15749836. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2005-08-16 |
2023-08-12 |
human |
| Dai Lu, Zhaoxing Meng, Ganesh A Thakur, Pusheng Fan, John Steed, Cindy L Tartal, Dow P Hurst, Patricia H Reggio, Jeffrey R Deschamps, Damon A Parrish, Clifford George, Torbjörn U C Järbe, Richard J Lamb, Alexandros Makriyanni. Adamantyl cannabinoids: a novel class of cannabinergic ligands. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999995. |
exploration of the side chain conformational space using molecular modeling approaches has allowed us to develop cannabinoid side chain pharmacophore models for the cb1 and cb2 receptors. |
2005-08-16 |
2023-08-12 |
Not clear |
| Dai Lu, Zhaoxing Meng, Ganesh A Thakur, Pusheng Fan, John Steed, Cindy L Tartal, Dow P Hurst, Patricia H Reggio, Jeffrey R Deschamps, Damon A Parrish, Clifford George, Torbjörn U C Järbe, Richard J Lamb, Alexandros Makriyanni. Adamantyl cannabinoids: a novel class of cannabinergic ligands. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999995. |
our results suggest that although a bulky group at the c3 position of classical cannabinoids could be tolerated by both cb1 and cb2 binding sites, the relative orientation of that group with respect to the tricyclic component can lead to receptor subtype selectivity. |
2005-08-16 |
2023-08-12 |
Not clear |
| H Zheng, J Zhao, S Wang, C-M Lin, T Chen, D H Jones, C Ma, S Opella, X-Q Xi. Biosynthesis and purification of a hydrophobic peptide from transmembrane domains of G-protein-coupled CB2 receptor. The journal of peptide research : official journal of the American Peptide Society. vol 65. issue 4. 2005-08-02. PMID:15813893. |
in order to develop a high-yield and cost-effective method, and also to obtain preliminary structural information for the computer modeling of the three-dimensional receptor structural model, a highly hydrophobic peptide from human cannabinoid subtype 2 receptor cb2(65-101), was chosen to develop high-yield membrane protein expression and purification methods. |
2005-08-02 |
2023-08-12 |
human |
| Christophe Hézode, Françoise Roudot-Thoraval, Son Nguyen, Pascale Grenard, Boris Julien, Elie-Serge Zafrani, Jean-Michel Pawlotsky, Jean-Michel Pawlostky, Daniel Dhumeaux, Sophie Lotersztajn, Ariane Malla. Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. Hepatology (Baltimore, Md.). vol 42. issue 1. 2005-08-02. PMID:15892090. |
daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis c. cannabinoids present in cannabis sativa (marijuana) exert biological effects via cannabinoid receptors cb1 and cb2. |
2005-08-02 |
2023-08-12 |
Not clear |
| Rundong Zhang, Dow P Hurst, Judy Barnett-Norris, Patricia H Reggio, Zhao-Hui Son. Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15840841. |
pretreatment of the cb2 receptor with cannabinoid ligands prevented this inhibition, suggesting that mtsea modification occurred within the binding crevice. |
2005-08-01 |
2023-08-12 |
human |
| Angelo Vaccani, Paola Massi, Arianna Colombo, Tiziana Rubino, Daniela Parolar. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British journal of pharmacology. vol 144. issue 8. 2005-07-29. PMID:15700028. |
since these cells express both cannabinoid cb1 and cb2 receptors in the membrane, we also evaluated their engagement in the antimigratory effect of cbd. |
2005-07-29 |
2023-08-12 |
human |
| Angelo Vaccani, Paola Massi, Arianna Colombo, Tiziana Rubino, Daniela Parolar. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British journal of pharmacology. vol 144. issue 8. 2005-07-29. PMID:15700028. |
the inhibition of cell was not antagonized either by the selective cannabinoid receptor antagonists sr141716 (cb1) and sr144528 (cb2) or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or receptors coupled to gi/o proteins. |
2005-07-29 |
2023-08-12 |
human |
| K H Raitio, O M H Salo, T Nevalainen, A Poso, T Järvine. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Current medicinal chemistry. vol 12. issue 10. 2005-07-28. PMID:15892633. |
targeting the cannabinoid cb2 receptor: mutations, modeling and development of cb2 selective ligands. |
2005-07-28 |
2023-08-12 |
human |
| K H Raitio, O M H Salo, T Nevalainen, A Poso, T Järvine. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Current medicinal chemistry. vol 12. issue 10. 2005-07-28. PMID:15892633. |
since the discovery of the cannabinoid cb2 receptor in 1993, there has been a growing interest to clarify the importance of this g-protein coupled receptor (gpcr) for human physiology, and to investigate it as a possible target for current and future drug development. |
2005-07-28 |
2023-08-12 |
human |
| Sophie J Govaerts, Giulio G Muccioli, Emmanuel Hermans, Didier M Lamber. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors. European journal of pharmacology. vol 495. issue 1. 2005-07-26. PMID:15219819. |
characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid cb1 and cb2 receptors. |
2005-07-26 |
2023-08-12 |
human |