| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alyson Fox, Stuart Beva. Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert opinion on investigational drugs. vol 14. issue 6. 2006-04-14. PMID:16004597. |
animal studies show that although these side effects are mediated via central cannabinoid type 1 (cb(1)) receptors, the analgesic activity in chronic pain states may be mediated via spinal cb(1) and potentially cb(2) receptors, as well as peripheral cb(1) and cb2 receptors on sensory nerves or immune cells. |
2006-04-14 |
2023-08-12 |
Not clear |
| Ken Macki. Cannabinoid receptors as therapeutic targets. Annual review of pharmacology and toxicology. vol 46. 2006-04-12. PMID:16402900. |
cb1 and cb2 cannabinoid receptors are the primary targets of endogenous cannabinoids (endocannabinoids). |
2006-04-12 |
2023-08-12 |
Not clear |
| Garry Milman, Yehoshua Maor, Saleh Abu-Lafi, Michal Horowitz, Ruth Gallily, Sandor Batkai, Fong-Ming Mo, Laszlo Offertaler, Pal Pacher, George Kunos, Raphael Mechoula. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 7. 2006-04-07. PMID:16467152. |
contrary to anandamide, ara-s binds very weakly to cannabinoid cb1 and cb2 or vanilloid trpv1 (transient receptor potential vanilloid 1) receptors. |
2006-04-07 |
2023-08-12 |
mouse |
| Tiziano Tuccinardi, Pier Luigi Ferrarini, Clementina Manera, Gabriella Ortore, Giuseppe Saccomanni, Adriano Martinell. Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451064. |
three-dimensional models of the cb1 and cb2 cannabinoid receptors were constructed by means of a molecular modeling procedure, using the x-ray structure of bovine rhodopsin as the initial template, and taking into account the available site-directed mutagenesis data. |
2006-03-29 |
2023-08-12 |
cattle |
| Yumiko Nakajima, Yasushi Furuichi, Kamal Krishna Biswas, Teruto Hashiguchi, Ko-ichi Kawahara, Kazuyo Yamaji, Tomonori Uchimura, Yuichi Izumi, Ikuro Maruyam. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. FEBS letters. vol 580. issue 2. 2006-03-21. PMID:16406050. |
the cannabinoid receptors cb1 and cb2 were expressed by human gingival fibroblasts (hgfs), and markedly upregulated under pathological conditions. |
2006-03-21 |
2023-08-12 |
human |
| Giovanni Appendino, Maria Grazia Cascio, Sara Bacchiega, Aniello Schiano Moriello, Alberto Minassi, Adèle Thomas, Ruth Ross, Roger Pertwee, Luciano De Petrocellis, Vincenzo Di Marz. First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. FEBS letters. vol 580. issue 2. 2006-03-21. PMID:16406364. |
first "hybrid" ligands of vanilloid trpv1 and cannabinoid cb2 receptors and non-polyunsaturated fatty acid-derived cb2-selective ligands. |
2006-03-21 |
2023-08-12 |
human |
| Jian-Zhong Chen, Xiu-Wen Han, Qian Liu, Alexandros Makriyannis, Junmei Wang, Xiang-Qun Xi. 3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach. Journal of medicinal chemistry. vol 49. issue 2. 2006-03-21. PMID:16420048. |
the present work focuses on the study of the three-dimensional (3d) structural requirements for selective antagonist activity of arylpyrazole compounds at the cannabinoid cb1 and cb2 receptors. |
2006-03-21 |
2023-08-12 |
Not clear |
| Pablo Juan-Picó, Esther Fuentes, F Javier Bermúdez-Silva, F Javier Díaz-Molina, Cristina Ripoll, Fernando Rodríguez de Fonseca, Angel Nada. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. Cell calcium. vol 39. issue 2. 2006-03-20. PMID:16321437. |
the endocannabinoid 2-arachidonylglycerol (2-ag) through cb2 receptors regulates [ca(2+)](i) signals in beta-cells and as a consequence, it decreases insulin secretion. |
2006-03-20 |
2023-08-12 |
Not clear |
| Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasqual. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine reviews. vol 27. issue 1. 2006-03-16. PMID:16306385. |
cannabinoid receptors, named cb1 receptor and cb2 receptor, first discovered as the molecular targets of the psychotropic component of the plant cannabis sativa, participate in the physiological modulation of many central and peripheral functions. |
2006-03-16 |
2023-08-12 |
Not clear |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
several recent reports have demonstrated a role for selective cannabinoid cb2 receptor agonists in pain modulation, showing both analgesic and antihyperalgesic activities. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
we have previously reported that administration of the selective cannabinoid cb2 receptor agonist gw405833 (2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone) to rats elicits potent and efficacious antihyperalgesic effects against neuropathic and inflammatory pain and, at high dose (100 mg/kg), is analgesic and ataxic [valenzano, k.j., tafesse, l., lee, g., harrison, j.e., boulet, j., gottshall, s.l., mark, l., pearson, m.s., miller, w., shan, s., rabadi, l., rotstheyn, y., chaffer, s.m., turchin, p.i., elsemore, d.a., toth, m., koetzner, l., whiteside, g.t., 2005. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
in the current study, we confirm these properties using mouse models and investigate the role of cannabinoid cb2 receptors using knockout animals. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
in contrast, gw405833 showed no antihyperalgesic activity against freund's complete adjuvant-mediated inflammatory pain in cannabinoid cb2 receptor knockout mice. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
as in rats, high-dose gw405833 (100 mg/kg) showed both analgesic and sedative activities in wild-type mice, activities that were also apparent in cannabinoid cb2 receptor knockout mice. |
2006-03-09 |
2023-08-12 |
mouse |
| Garth T Whiteside, Susan L Gottshall, Jamie M Boulet, Suzanne M Chaffer, James E Harrison, Michelle S Pearson, Paul I Turchin, Lilly Mark, Augusta E Garrison, Kenneth J Valenzan. A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. European journal of pharmacology. vol 528. issue 1-3. 2006-03-09. PMID:16316650. |
these data demonstrate that the antihyperalgesic effects of gw405833 are mediated via the cannabinoid cb2 receptor, whereas the analgesic and sedative effects are not. |
2006-03-09 |
2023-08-12 |
mouse |
| Cristina Benito, Woong-Ki Kim, Wong-Ki Kim, Iván Chavarría, Ceceila J Hillard, Ken Mackie, Rosa M Tolón, Kenneth Williams, Ken Williams, Julián Romer. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758162. |
specifically, expression of cannabinoid receptors of the cb2 subtype was induced in the brains of infected animals, mainly in perivascular macrophages, microglial nodules, and t-lymphocytes, most likely of the cd8 subtype. |
2006-03-02 |
2023-08-12 |
human |
| Cristina Benito, Woong-Ki Kim, Wong-Ki Kim, Iván Chavarría, Ceceila J Hillard, Ken Mackie, Rosa M Tolón, Kenneth Williams, Ken Williams, Julián Romer. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758162. |
these results resemble previous data obtained in alzheimer's disease human tissue samples and suggest that the endocannabinoid system may participate in the development of human immunodeficiency virus-induced encephalitis, because activation of cb2 receptors expressed by immune cells is likely to reduce their antiviral response and thus could favor the cns entry of infected monocytes. |
2006-03-02 |
2023-08-12 |
human |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
the endogenous cannabinoids bind to and activate two g protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (cb1) and peripheral cannabinoid receptor type 2 (cb2). |
2006-02-28 |
2023-08-12 |
mouse |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
whereas cb1 mediates the cannabinoid psychotropic, analgesic, and orectic effects, cb2 has been implicated recently in the regulation of liver fibrosis and atherosclerosis. |
2006-02-28 |
2023-08-12 |
mouse |
| Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, Itai Ba. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407142. |
these results demonstrate that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic cb2 signaling. |
2006-02-28 |
2023-08-12 |
mouse |