| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Blanca Herrera, Arkaitz Carracedo, María Diez-Zaera, Teresa Gómez del Pulgar, Manuel Guzmán, Guillermo Velasc. The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Experimental cell research. vol 312. issue 11. 2006-08-04. PMID:16624285. |
cannabinoid treatment led to a cb2 receptor-dependent stimulation of ceramide biosynthesis and inhibition of this pathway prevented delta9-tetrahydrocannabinol-induced mitochondrial hypopolarization and cytochrome c release, indicating that ceramide acts at a pre-mitochondrial level. |
2006-08-04 |
2023-08-12 |
human |
| K A Takahashi, P E Castill. The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16527424. |
of the two cloned cannabinoid receptors, cannabinoid receptor 1 (cb1) is widely distributed in the cns and accounts for most of the neurological effects of cannabinoids, while cannabinoid receptor 2 (cb2) expression in the cns is very limited. |
2006-08-03 |
2023-08-12 |
mouse |
| K A Takahashi, P E Castill. The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16527424. |
cannabinoid receptor 3 (cb3)] is suggested by growing evidence of cannabinoid effects that are not mediated by cb1 or cb2. |
2006-08-03 |
2023-08-12 |
mouse |
| Seishi Kishimoto, Saori Oka, Maiko Gokoh, Takayuki Sugiur. Chemotaxis of human peripheral blood eosinophils to 2-arachidonoylglycerol: comparison with other eosinophil chemoattractants. International archives of allergy and immunology. vol 140 Suppl 1. 2006-08-03. PMID:16772720. |
2-arachidonoylglycerol (2-ag), an endogenous ligand for the cannabinoid receptors (cb1 and cb2), has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. |
2006-08-03 |
2023-08-12 |
human |
| Spiro Pavlopoulos, Ganesh A Thakur, Spyros P Nikas, Alexandros Makriyanni. Cannabinoid receptors as therapeutic targets. Current pharmaceutical design. vol 12. issue 14. 2006-08-01. PMID:16712486. |
the cannabinoid receptors cb1 and cb2 are family a, g-protein coupled receptors that mediate the effects of cannabinoids, a class of compounds that are so named because the first members were isolates of the cannabis plant. |
2006-08-01 |
2023-08-12 |
Not clear |
| Erica J Carrier, John A Auchampach, Cecilia J Hillar. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 20. 2006-07-28. PMID:16672367. |
the plant-derived cannabinoids delta9-tetrahydrocannabinol (thc) and cannabidiol (cbd) both have immunosuppressive effects; although some effects of thc are mediated by the cb2 receptor, cb2 binds cbd weakly. |
2006-07-28 |
2023-08-12 |
mouse |
| Jean-Sébastien Walczak, Vincent Pichette, François Leblond, Karine Desbiens, Pierre Beaulie. Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes. Journal of neuroscience research. vol 83. issue 7. 2006-07-25. PMID:16511871. |
these behavioral changes were accompanied after surgery by an increase of c-fos expression and by an overexpression of mu-opioid and cannabinoid cb1 and cb2 receptors in the spinal cord and the dorsal hind paw skin. |
2006-07-25 |
2023-08-12 |
mouse |
| Stefan Raduner, Adriana Majewska, Jian-Zhong Chen, Xiang-Qun Xie, Jacques Hamon, Bernard Faller, Karl-Heinz Altmann, Jürg Gertsc. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. The Journal of biological chemistry. vol 281. issue 20. 2006-07-21. PMID:16547349. |
alkylamides (alkamides) from echinacea modulate tumor necrosis factor alpha mrna expression in human monocytes/macrophages via the cannabinoid type 2 (cb2) receptor (gertsch, j., schoop, r., kuenzle, u., and suter, a. |
2006-07-21 |
2023-08-12 |
human |
| Stefan Raduner, Adriana Majewska, Jian-Zhong Chen, Xiang-Qun Xie, Jacques Hamon, Bernard Faller, Karl-Heinz Altmann, Jürg Gertsc. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. The Journal of biological chemistry. vol 281. issue 20. 2006-07-21. PMID:16547349. |
here we show that the alkylamides dodeca-2e,4e,8z,10z-tetraenoic acid isobutylamide (a1) and dodeca-2e,4e-dienoic acid isobutylamide (a2) bind to the cb2 receptor more strongly than the endogenous cannabinoids. |
2006-07-21 |
2023-08-12 |
human |
| Stefan Raduner, Adriana Majewska, Jian-Zhong Chen, Xiang-Qun Xie, Jacques Hamon, Bernard Faller, Karl-Heinz Altmann, Jürg Gertsc. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. The Journal of biological chemistry. vol 281. issue 20. 2006-07-21. PMID:16547349. |
the ki values of a1 and a2 (cb2 approximately 60 nm; cb1 >1500 nm) were determined by displacement of the synthetic high affinity cannabinoid ligand [3h]cp-55,940. |
2006-07-21 |
2023-08-12 |
human |
| Stefan Raduner, Adriana Majewska, Jian-Zhong Chen, Xiang-Qun Xie, Jacques Hamon, Bernard Faller, Karl-Heinz Altmann, Jürg Gertsc. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. The Journal of biological chemistry. vol 281. issue 20. 2006-07-21. PMID:16547349. |
at 50 nm, a1, a2, and the endogenous cannabinoid anandamide (cb2 ki >200 nm) up-regulated constitutive interleukin (il)-6 expression in human whole blood in a seemingly cb2-dependent manner. |
2006-07-21 |
2023-08-12 |
human |
| Anna C Svensson, Mattias Johansson, Emma Persson, Marta San Celestino Carchenilla, Stig O P Jacobsso. Expression of functional CB1 cannabinoid receptors in retinoic acid-differentiated P19 embryonal carcinoma cells. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16477621. |
this study was undertaken to investigate the expression of cb1 and cb2 cannabinoid receptors in neurons that develop from retinoic acid (ra)-primed mouse p19 embryonal carcinoma cells. |
2006-07-13 |
2023-08-12 |
mouse |
| Estery C Mbvundula, Rowena A D Bunning, K D Rainsfor. Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. The Journal of pharmacy and pharmacology. vol 58. issue 3. 2006-07-07. PMID:16536902. |
expression of cannabinoid receptors, cb1 and cb2; cyclooxygenase-1 and -2 (cox-1 and cox-2); inducible nitric oxide synthase (inos); as well as activation of nuclear factor-kappa b (nf-kappab) in chondrocytes were studied using immunoblotting techniques and immunofluorescence. |
2006-07-07 |
2023-08-12 |
cattle |
| Estery C Mbvundula, Rowena A D Bunning, K D Rainsfor. Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. The Journal of pharmacy and pharmacology. vol 58. issue 3. 2006-07-07. PMID:16536902. |
chondrocytes appeared to constitutively express cannabinoid receptors cb1 and cb2. |
2006-07-07 |
2023-08-12 |
cattle |
| I Matias, V Di Marz. Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance. Journal of endocrinological investigation. vol 29. issue 3 Suppl. 2006-06-29. PMID:16751706. |
endocannabinoids are endogenous substances capable of binding to and functionally activating the two types of cannabinoid receptors identified to date, the cannabinoid receptors type 1 and 2 (cb1 and cb2 receptors). |
2006-06-29 |
2023-08-12 |
Not clear |
| F Massa, K Monor. Endocannabinoids and the gastrointestinal tract. Journal of endocrinological investigation. vol 29. issue 3 Suppl. 2006-06-29. PMID:16751708. |
delta9-tetrahydrocannabinol (thc; the active component of marijuana), as well as endogenous and synthetic cannabinoids, exert their biological functions on the gastrointestinal tract by activating two types of cannabinoid receptors, cannabinoid type 1 receptor (cb1 receptor) and cannabinoid type 2 receptor (cb2 receptor). |
2006-06-29 |
2023-08-12 |
Not clear |
| J M McPartland, J Agraval, D Gleeson, K Heasman, M Glas. Cannabinoid receptors in invertebrates. Journal of evolutionary biology. vol 19. issue 2. 2006-06-23. PMID:16599912. |
two cannabinoid receptors, cb1 and cb2, are expressed in mammals, birds, reptiles, and fish. |
2006-06-23 |
2023-08-12 |
rat |
| Karla-Sue C Marriott, John W Huffman, Jenny L Wiley, Billy R Marti. Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry. vol 14. issue 7. 2006-06-22. PMID:16321538. |
synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid cb2 receptor. |
2006-06-22 |
2023-08-12 |
Not clear |
| Karla-Sue C Marriott, John W Huffman, Jenny L Wiley, Billy R Marti. Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry. vol 14. issue 7. 2006-06-22. PMID:16321538. |
fourteen novel cb2 receptor selective cannabinoids were synthesized via initial lewis acid catalyzed rearrangement of resorcinol precursors to obtain the cannabinoid moiety. |
2006-06-22 |
2023-08-12 |
Not clear |
| Christopher P Canno. The endocannabinoid system: a new approach to control cardiovascular disease. Clinical cornerstone. vol 7. issue 2-3. 2006-06-20. PMID:16473257. |
the endocannabinoid (ec) system consists of 2 types of g-protein-coupled cannabinoid receptors--cannabinoid type 1 (cb1) and cannabinoid type 2 (cb2)--and their natural ligands. |
2006-06-20 |
2023-08-12 |
Not clear |