| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Darryl T Hamamoto, Subhalakshmi Giridharagopalan, Donald A Simon. Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia. European journal of pharmacology. vol 558. issue 1-3. 2007-04-04. PMID:17250825. |
the antihyperalgesic effect of cp 55,940 was mediated via the cannabinoid cb1 but not cb2 receptor. |
2007-04-04 |
2023-08-12 |
mouse |
| John C Ashton, Rosanna M A Rahman, Shiva M Nair, Brad A Sutherland, Michelle Glass, Ian Appleto. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123706. |
cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid cb2 receptor in the brain. |
2007-04-03 |
2023-08-12 |
rat |
| John C Ashton, Rosanna M A Rahman, Shiva M Nair, Brad A Sutherland, Michelle Glass, Ian Appleto. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123706. |
until recently the cannabinoid cb2 receptor was believed to be absent from the central nervous system. |
2007-04-03 |
2023-08-12 |
rat |
| T Gutierrez, J N Farthing, A M Zvonok, A Makriyannis, A G Hohman. Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis. British journal of pharmacology. vol 150. issue 2. 2007-04-02. PMID:17160008. |
activation of peripheral cannabinoid cb1 and cb2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis. |
2007-04-02 |
2023-08-12 |
Not clear |
| Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. |
anandamide (n-arachidonoylethanolamine) and 2-ag (2-arachidonoylglycerol) are two major endocannabinoids that bind to and activate g-protein coupled cannabinoid receptors cb1 and cb2. |
2007-03-29 |
2023-08-12 |
mouse |
| Ariane Mallat, Fatima Teixeira-Clerc, Vanessa Deveaux, Sophie Lotersztaj. Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases. Expert opinion on therapeutic targets. vol 11. issue 3. 2007-03-28. PMID:17298297. |
indeed, cannabinoid receptors cb1 and cb2 promote dual pro- and antifibrogenic effects, respectively. |
2007-03-28 |
2023-08-12 |
Not clear |
| b' Jan Komorowski, Henryk Stepie\\xc5\\x8. [The role of the endocannabinoid system in the regulation of endocrine function and in the control of energy balance in humans]. Postepy higieny i medycyny doswiadczalnej (Online). vol 61. 2007-03-28. PMID:17369778.' |
the important elements of this system are: endocannabinoid receptors (types cb1 and cb2), their endogenous ligands (n-arachidonoylethanolamide, 2-arachidonoyl glycerol), enzymes involved in their synthesis and degradation, as well as cannabinoid antagonists. |
2007-03-28 |
2023-08-12 |
Not clear |
| Javier Fernández-Ruiz, Julián Romero, Guillermo Velasco, Rosa M Tolón, José A Ramos, Manuel Guzmá. Cannabinoid CB2 receptor: a new target for controlling neural cell survival? Trends in pharmacological sciences. vol 28. issue 1. 2007-03-22. PMID:17141334. |
cannabinoid cb2 receptor: a new target for controlling neural cell survival? |
2007-03-22 |
2023-08-12 |
Not clear |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. |
2007-03-19 |
2023-08-12 |
human |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
however, most experimental data come from animal models of ms. we investigated the status of cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase (faah) enzyme in brain tissue samples obtained from ms patients. |
2007-03-19 |
2023-08-12 |
human |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
as seen for other neuroinflammatory conditions, selective glial expression of cannabinoid cb1 and cb2 receptors and faah enzyme is induced in ms, thus supporting a role for the endocannabinoid system in the pathogenesis and/or evolution of this disease. |
2007-03-19 |
2023-08-12 |
human |
| Yoshitomo Suhara, Saori Oka, Atsushi Kittaka, Hiroaki Takayama, Keizo Waku, Takayuki Sugiur. Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Bioorganic & medicinal chemistry. vol 15. issue 2. 2007-03-13. PMID:17110113. |
2-arachidonoylglycerol (2-ag (1)) is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2007-03-13 |
2023-08-12 |
Not clear |
| Yoshitomo Suhara, Saori Oka, Atsushi Kittaka, Hiroaki Takayama, Keizo Waku, Takayuki Sugiur. Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Bioorganic & medicinal chemistry. vol 15. issue 2. 2007-03-13. PMID:17110113. |
notably, these structural analogs of 2-arachidonoylglycerol exhibited only weak agonistic activities toward either the cb1 receptor or the cb2 receptor, which is in good contrast to 2-arachidonoylglycerol which acted as a full agonist at these cannabinoid receptors. |
2007-03-13 |
2023-08-12 |
Not clear |
| Yoshitomo Suhara, Saori Oka, Atsushi Kittaka, Hiroaki Takayama, Keizo Waku, Takayuki Sugiur. Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Bioorganic & medicinal chemistry. vol 15. issue 2. 2007-03-13. PMID:17110113. |
these results clearly indicate that the structure of 2-arachidonoylglycerol is strictly recognized by the cannabinoid receptors (cb1 and cb2) and provide further evidence that the cannabinoid receptors are primarily the intrinsic receptors for 2-arachidonoylglycerol. |
2007-03-13 |
2023-08-12 |
Not clear |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
new natural noncannabinoid ligands for cannabinoid type-2 (cb2) receptors. |
2007-03-06 |
2023-08-12 |
human |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
constitute a new class of cannabinomimetics, which specifically engage and activate the cannabinoid type-2 (cb2) receptors. |
2007-03-06 |
2023-08-12 |
human |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
cannabinoid type-1 (cb1) and cb2 receptors belong to the family of g protein-coupled receptors and are the primary targets of the endogenous cannabinoids n-arachidonoyl ethanolamine and 2-arachidonoyl glyerol. |
2007-03-06 |
2023-08-12 |
human |
| Christine Börner, Volker Höllt, Walter Sebald, Jürgen Krau. Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids. Journal of leukocyte biology. vol 81. issue 1. 2007-03-05. PMID:17041005. |
effects of cannabinoids (cbs) are mediated by two types of receptors, cb1 and cb2. |
2007-03-05 |
2023-08-12 |
Not clear |
| Gabriele Murineddu, Paolo Lazzari, Stefania Ruiu, Angela Sanna, Giovanni Loriga, Ilaria Manca, Matteo Falzoi, Christian Dessì, Maria M Curzu, Giorgio Chelucci, Luca Pani, Gérard A Pinn. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. Journal of medicinal chemistry. vol 49. issue 25. 2007-02-23. PMID:17149879. |
synthesis and biological evaluation of analogues of the robust and selective cb2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-n-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. |
2007-02-23 |
2023-08-12 |
human |
| Yoshifumi Ueda, Naoki Miyagawa, Korekiyo Wakitan. Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice. Life sciences. vol 80. issue 5. 2007-02-20. PMID:17055000. |
involvement of cannabinoid cb2 receptors in the ige-mediated triphasic cutaneous reaction in mice. |
2007-02-20 |
2023-08-12 |
mouse |