| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takayuki Sugiura, Seishi Kishimoto, Saori Oka, Maiko Goko. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Progress in lipid research. vol 45. issue 5. 2007-07-02. PMID:16678907. |
2-ag binds to the cannabinoid receptors (cb1 and cb2) and exhibits a variety of cannabimimetic activities in vitro and in vivo. |
2007-07-02 |
2023-08-12 |
rat |
| Peter J Barne. The problem of cough and development of novel antitussives. Pulmonary pharmacology & therapeutics. vol 20. issue 4. 2007-06-26. PMID:17189707. |
perhaps the most promising drugs are transient receptor potential vanilloid-1 (trpv(1)) antagonists, selective cannabinoid agonists (cb2 agonists), maxi-k channel openers and p2x3 antagonists. |
2007-06-26 |
2023-08-12 |
human |
| Christian C Felder, Amy K Dickason-Chesterfield, Steven A Moor. Cannabinoids biology: the search for new therapeutic targets. Molecular interventions. vol 6. issue 3. 2007-06-22. PMID:16809476. |
the discovery of tetrahydrocannabinol, the active principal in marijuana, and the identification and cloning of two cannabinoid receptors (i.e., cb1 and cb2) has subsequently led to biomedical appreciation for a family of endocannabinoid lipid transmitters. |
2007-06-22 |
2023-08-12 |
Not clear |
| Fabian Docagne, Vilma Muñetón, Diego Clemente, Carine Ali, Frida Loría, Fernando Correa, Míriam Hernangómez, Leyre Mestre, Denis Vivien, Carmen Guaz. Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Molecular and cellular neurosciences. vol 34. issue 4. 2007-06-22. PMID:17229577. |
excitotoxicity in a chronic model of multiple sclerosis: neuroprotective effects of cannabinoids through cb1 and cb2 receptor activation. |
2007-06-22 |
2023-08-12 |
mouse |
| Fabian Docagne, Vilma Muñetón, Diego Clemente, Carine Ali, Frida Loría, Fernando Correa, Míriam Hernangómez, Leyre Mestre, Denis Vivien, Carmen Guaz. Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Molecular and cellular neurosciences. vol 34. issue 4. 2007-06-22. PMID:17229577. |
moreover, hu210 reduced ampa-induced excitotoxicity both in vivo and in vitro through the obligatory activation of both cb1 and cb2 cannabinoid receptors. |
2007-06-22 |
2023-08-12 |
mouse |
| John C Ashto. Cannabinoids for the treatment of inflammation. Current opinion in investigational drugs (London, England : 2000). vol 8. issue 5. 2007-06-22. PMID:17520866. |
the non-psychoactive cannabinoid receptor cb2 is emerging as a critical target for cannabinoid regulation of inflammation, and thus cb2-selective agonists are undergoing intense investigation and research. |
2007-06-22 |
2023-08-12 |
mouse |
| Josée Guindon, Jesse LoVerme, Daniele Piomelli, Pierre Beaulie. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and analgesia. vol 104. issue 6. 2007-06-14. PMID:17513659. |
the antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid cb1 and cb2 receptors. |
2007-06-14 |
2023-08-12 |
rat |
| Josée Guindon, Jesse LoVerme, Daniele Piomelli, Pierre Beaulie. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and analgesia. vol 104. issue 6. 2007-06-14. PMID:17513659. |
to further investigate the mechanisms by which propofol produced its antinociceptive effect, we used specific antagonists for the cannabinoid cb1 (am251) and cb2 (am630) receptors and measured fatty-acid amide/endocannabinoid (anandamide, 2-arachidonylglycerol, and palmitoylethanolamide) concentrations in skin paw tissues. |
2007-06-14 |
2023-08-12 |
rat |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
neuropsychobiological evidence for the functional presence and expression of cannabinoid cb2 receptors in the brain. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
for over a decade, until recently, it was thought that marijuana acts by activating brain-type cannabinoid receptors called cb1, and that a second type called cb2 cannabinoid receptor was found only in peripheral tissues. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
we reported the discovery and functional presence of cb2 cannabinoid receptors in the mammalian brain that may be involved in depression and drug abuse and this was supported by reports of identification of neuronal cb2 receptors that are involved in emesis. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
rt-pcr, immunoblotting, hippocampal cultures, immunohistochemistry, transmission electron microscopy, and stereotaxic techniques with behavioral assays were used to determine the functional expression of cb2 cannabinoid receptors in the rat brain and mouse brain exposed to chronic mild stress or treated with abused drugs. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
the effect of direct cb2 antisense oligonucleotide injection into the brain and treatment with jwh015 in motor function and plus-maze tests also demonstrated the functional presence of cb2 cannabinoid receptors in the central nervous system. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
contrary to the prevailing view that cb2 cannabinoid receptors are restricted to peripheral tissues and predominantly in immune cells, we demonstrated that cb2 cannabinoid receptors and their gene transcripts are widely distributed in the brain. |
2007-06-13 |
2023-08-12 |
mouse |
| Jennifer L Shoemaker, Kathryn A Seely, Ronald L Reed, John P Crow, Paul L Prathe. The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. Journal of neurochemistry. vol 101. issue 1. 2007-05-29. PMID:17241118. |
the cb2 cannabinoid agonist am-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. |
2007-05-29 |
2023-08-12 |
mouse |
| Jennifer L Shoemaker, Kathryn A Seely, Ronald L Reed, John P Crow, Paul L Prathe. The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. Journal of neurochemistry. vol 101. issue 1. 2007-05-29. PMID:17241118. |
cannabinoids produce anti-inflammatory actions via cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2), and delay the progression of neuroinflammatory diseases. |
2007-05-29 |
2023-08-12 |
mouse |
| A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwe. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British journal of pharmacology. vol 150. issue 5. 2007-05-10. PMID:17245363. |
a nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid cb1 and cb2 receptors. |
2007-05-10 |
2023-08-12 |
mouse |
| J Guindon, J Desroches, P Beaulie. The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. British journal of pharmacology. vol 150. issue 6. 2007-05-03. PMID:17179944. |
the antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid cb2 receptors. |
2007-05-03 |
2023-08-12 |
Not clear |
| Francisco Molina-Holgado, Ana Rubio-Araiz, Daniel García-Ovejero, Robert J Williams, Jonathan D Moore, Angel Arévalo-Martín, Oscar Gómez-Torres, Eduardo Molina-Holgad. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. The European journal of neuroscience. vol 25. issue 3. 2007-05-02. PMID:17328768. |
cb2 cannabinoid receptors promote mouse neural stem cell proliferation. |
2007-05-02 |
2023-08-12 |
mouse |
| Francisco Molina-Holgado, Ana Rubio-Araiz, Daniel García-Ovejero, Robert J Williams, Jonathan D Moore, Angel Arévalo-Martín, Oscar Gómez-Torres, Eduardo Molina-Holgad. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. The European journal of neuroscience. vol 25. issue 3. 2007-05-02. PMID:17328768. |
in the present study we investigated the expression of cb2 cannabinoid receptors and the effect of exogenous cannabinoids on neural stem/precursor cell proliferation. |
2007-05-02 |
2023-08-12 |
mouse |