| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Esposito, Teresa Iuvone, Claudia Savani, Caterina Scuderi, Daniele De Filippis, Michele Papa, Vincenzo Di Marzo, Luca Steard. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17545311. |
c6 rat astroglioma cells were challenged with 1 microg/ml a beta 1-42 in the presence or absence of selective agonists and antagonists of cannabinoid (cb)1 and cb2 receptors. |
2007-10-19 |
2023-08-12 |
rat |
| Barbara Cost. On the pharmacological properties of Delta9-tetrahydrocannabinol (THC). Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712813. |
the isolation of its main constituent, delta9-tetrahydrocannabinol (thc), and the discovery of the endocannabinoid system (cannabinoid receptors cb1 and cb2 and their endogenous ligands) made possible studies concerning the pharmacological activity of cannabinoids. |
2007-09-28 |
2023-08-12 |
human |
| Giulio G Mucciol. Blocking the cannabinoid receptors: drug candidates and therapeutic promises. Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712820. |
the cb1 and cb2 cannabinoid receptors have been described as two prime sites of action for endocannabinoids. |
2007-09-28 |
2023-08-12 |
Not clear |
| Jean-Pierre Despré. The endocannabinoid system: a new target for the regulation of energy balance and metabolism. Critical pathways in cardiology. vol 6. issue 2. 2007-09-19. PMID:17667864. |
endocannabinoids are endogenous phospholipid derivatives which bind and activate cannabinoid receptors type 1 and type 2 (cb1 and cb2 receptors). |
2007-09-19 |
2023-08-12 |
Not clear |
| Fang He, Zhao-Hui Son. Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells. Molecular vision. vol 13. 2007-09-18. PMID:17679938. |
molecular and cellular changes induced by the activation of cb2 cannabinoid receptors in trabecular meshwork cells. |
2007-09-18 |
2023-08-12 |
Not clear |
| Fang He, Zhao-Hui Son. Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells. Molecular vision. vol 13. 2007-09-18. PMID:17679938. |
to study the role of cb2 cannabinoid receptors in cellular functions of trabecular meshwork (tm) cells including cytoskeleton changes and migration and to investigate the possible signaling pathways utilized by cb2 receptor for these cellular functions. |
2007-09-18 |
2023-08-12 |
Not clear |
| Serdar Durdagi, Agnes Kapou, Therapia Kourouli, Thanos Andreou, Spyros P Nikas, Victoria R Nahmias, Demetris P Papahatjis, Manthos G Papadopoulos, Thomas Mavromoustako. The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2. Journal of medicinal chemistry. vol 50. issue 12. 2007-08-15. PMID:17521177. |
the application of 3d-qsar studies for novel cannabinoid ligands substituted at the c1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors cb1 and cb2. |
2007-08-15 |
2023-08-12 |
Not clear |
| Maiko Gokoh, Seishi Kishimoto, Saori Oka, Takayuki Sugiur. 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. Biological & pharmaceutical bulletin. vol 30. issue 7. 2007-08-13. PMID:17603153. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2007-08-13 |
2023-08-12 |
Not clear |
| Stefan Raduner, William Bisson, Ruben Abagyan, Karl-Heinz Altmann, Jürg Gertsc. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17497806. |
certain fatty acid n-alkyl amides from the medicinal plant echinacea activate cannabinoid type-2 (cb2) receptors. |
2007-08-06 |
2023-08-12 |
Not clear |
| Stefan Raduner, William Bisson, Ruben Abagyan, Karl-Heinz Altmann, Jürg Gertsc. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17497806. |
in contrast, micelle formation is not observed for undeca-2e-ene-8,10-diynoic acid isobutylamide (3), which does not bind to cb2, or structurally related endogenous cannabinoids, such as arachidonoyl ethanolamine (anandamide). |
2007-08-06 |
2023-08-12 |
Not clear |
| Nissar A Darmani, Jano J Janoyan, Jennifer Crim, Juan Ramire. Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew. European journal of pharmacology. vol 563. issue 1-3. 2007-08-03. PMID:17362921. |
cannabinoids prevented the induced emesis via the stimulation of cannabinoid cb1-receptors because the cb1 (sr141716a)--and not the cb2 (sr144528)--receptor antagonist reversed both the observed reduction in emesis frequency and shrew emesis protection afforded by either delta9-thc or cp55,940 against radiation-induced emesis. |
2007-08-03 |
2023-08-12 |
Not clear |
| John C Ashton, Paul F Smit. Cannabinoids and cardiovascular disease: the outlook for clinical treatments. Current vascular pharmacology. vol 5. issue 3. 2007-08-02. PMID:17627561. |
cannabinoid drugs exert their effects primarily through activation of cannabinoid cb1 and cb2 receptors. |
2007-08-02 |
2023-08-12 |
Not clear |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
ibu-am5 inhibited the binding of [3h]-cp55,940 to rat brain cb1 and human cb2 cannabinoid receptors more potently than ibuprofen, but the increase in potency was less than the corresponding increase in potency seen for inhibition of faah activity. |
2007-07-26 |
2023-08-12 |
human |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
role of cannabinoid cb2 receptors in glucose homeostasis in rats. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
here we show that the activation of cannabinoid cb2 receptors improved glucose tolerance after a glucose load. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
blockade of cannabinoid cb2 receptors counteracted this effect, leading to glucose intolerance. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
since blockade of cannabinoid cb1 receptors mimics the actions of cannabinoid cb2 receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid cb1 and cb2 receptors. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
we also describe the presence of both cannabinoid cb1 and cb2 receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis. |
2007-07-26 |
2023-08-12 |
rat |
| David Le Goanvic, Marcus A Tiu. Oxaza adamantyl cannabinoids. A new class of cannabinoid receptor probes. The Journal of organic chemistry. vol 71. issue 20. 2007-07-25. PMID:16995689. |
the oxaza adamantyl cannabinoids that have been prepared represent a new class of ligands for the cb1 and cb2 receptors. |
2007-07-25 |
2023-08-12 |
Not clear |
| Jared Ehrhart, Demian Obregon, Takashi Mori, Huayan Hou, Nan Sun, Yun Bai, Thomas Klein, Francisco Fernandez, Jun Tan, R Douglas Shytl. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. Journal of neuroinflammation. vol 2. 2007-07-20. PMID:16343349. |
many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (cb2). |
2007-07-20 |
2023-08-12 |
Not clear |