| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maiko Gokoh, Seishi Kishimoto, Saori Oka, Takayuki Sugiur. 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. Biological & pharmaceutical bulletin. vol 30. issue 7. 2007-08-13. PMID:17603153. |
2-arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2007-08-13 |
2023-08-12 |
Not clear |
| Stefan Raduner, William Bisson, Ruben Abagyan, Karl-Heinz Altmann, Jürg Gertsc. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17497806. |
certain fatty acid n-alkyl amides from the medicinal plant echinacea activate cannabinoid type-2 (cb2) receptors. |
2007-08-06 |
2023-08-12 |
Not clear |
| Stefan Raduner, William Bisson, Ruben Abagyan, Karl-Heinz Altmann, Jürg Gertsc. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17497806. |
in contrast, micelle formation is not observed for undeca-2e-ene-8,10-diynoic acid isobutylamide (3), which does not bind to cb2, or structurally related endogenous cannabinoids, such as arachidonoyl ethanolamine (anandamide). |
2007-08-06 |
2023-08-12 |
Not clear |
| Nissar A Darmani, Jano J Janoyan, Jennifer Crim, Juan Ramire. Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew. European journal of pharmacology. vol 563. issue 1-3. 2007-08-03. PMID:17362921. |
cannabinoids prevented the induced emesis via the stimulation of cannabinoid cb1-receptors because the cb1 (sr141716a)--and not the cb2 (sr144528)--receptor antagonist reversed both the observed reduction in emesis frequency and shrew emesis protection afforded by either delta9-thc or cp55,940 against radiation-induced emesis. |
2007-08-03 |
2023-08-12 |
Not clear |
| John C Ashton, Paul F Smit. Cannabinoids and cardiovascular disease: the outlook for clinical treatments. Current vascular pharmacology. vol 5. issue 3. 2007-08-02. PMID:17627561. |
cannabinoid drugs exert their effects primarily through activation of cannabinoid cb1 and cb2 receptors. |
2007-08-02 |
2023-08-12 |
Not clear |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
ibu-am5 inhibited the binding of [3h]-cp55,940 to rat brain cb1 and human cb2 cannabinoid receptors more potently than ibuprofen, but the increase in potency was less than the corresponding increase in potency seen for inhibition of faah activity. |
2007-07-26 |
2023-08-12 |
human |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
role of cannabinoid cb2 receptors in glucose homeostasis in rats. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
here we show that the activation of cannabinoid cb2 receptors improved glucose tolerance after a glucose load. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
blockade of cannabinoid cb2 receptors counteracted this effect, leading to glucose intolerance. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
since blockade of cannabinoid cb1 receptors mimics the actions of cannabinoid cb2 receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid cb1 and cb2 receptors. |
2007-07-26 |
2023-08-12 |
rat |
| Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonsec. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17499236. |
we also describe the presence of both cannabinoid cb1 and cb2 receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis. |
2007-07-26 |
2023-08-12 |
rat |
| David Le Goanvic, Marcus A Tiu. Oxaza adamantyl cannabinoids. A new class of cannabinoid receptor probes. The Journal of organic chemistry. vol 71. issue 20. 2007-07-25. PMID:16995689. |
the oxaza adamantyl cannabinoids that have been prepared represent a new class of ligands for the cb1 and cb2 receptors. |
2007-07-25 |
2023-08-12 |
Not clear |
| Jared Ehrhart, Demian Obregon, Takashi Mori, Huayan Hou, Nan Sun, Yun Bai, Thomas Klein, Francisco Fernandez, Jun Tan, R Douglas Shytl. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. Journal of neuroinflammation. vol 2. 2007-07-20. PMID:16343349. |
many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (cb2). |
2007-07-20 |
2023-08-12 |
Not clear |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
comprehensive proteomic mass spectrometric characterization of human cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
the cb1 and cb2 cannabinoid receptors belong to the gpcr superfamily and are associated with a variety of physiological and pathophysiological processes. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
as a first step toward obtaining information on the structural features of the drug-receptor complex, we describe the full mass spectrometric (ms) analysis of the recombinant human cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
both instruments gave very similar patterns of identified peptides, with full coverage of all transmembrane helices, resulting in the complete characterization of the cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
mass spectrometric identification of all amino acid residues in the cannabinoid cb2 receptor is a key step toward the "ligand based structural biology" approach developed in our laboratory for characterizing ligand binding sites in gpcrs using a variety of covalent cannabinergic ligands. |
2007-07-18 |
2023-08-12 |
human |
| Sándor Bátkai, Douglas Osei-Hyiaman, Hao Pan, Osama El-Assal, Mohanraj Rajesh, Partha Mukhopadhyay, Feng Hong, Judith Harvey-White, Anjum Jafri, György Haskó, John W Huffman, Bin Gao, George Kunos, Pál Pache. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17327359. |
activation of cb2 cannabinoid receptors by jwh133 protects against i/r damage by decreasing inflammatory cell infiltration, tissue and serum tnf-alpha, mip-1alpha and mip-2 levels, tissue lipid peroxidation, and expression of adhesion molecule icam-1 in vivo. |
2007-07-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Douglas Osei-Hyiaman, Hao Pan, Osama El-Assal, Mohanraj Rajesh, Partha Mukhopadhyay, Feng Hong, Judith Harvey-White, Anjum Jafri, György Haskó, John W Huffman, Bin Gao, George Kunos, Pál Pache. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17327359. |
these findings suggest that oxidative/nitrosative stress and inflammatory stimuli may trigger endocannabinoid production, and indicate that targeting cb2 cannabinoid receptors may represent a novel protective strategy against i/r injury. |
2007-07-03 |
2023-08-12 |
mouse |