| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M McPartland, M Glass, R G Pertwe. Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17641667. |
pooled data from 211 studies measured ligand binding affinities at human (hs) or rat (rn) cannabinoid receptors cb1 and cb2. |
2008-02-25 |
2023-08-12 |
human |
| M D Jhaveri, D Richardson, V Chapma. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17704819. |
cannabinoid cb1 and cb2 receptors are located at key sites involved in the relaying and processing of noxious inputs. |
2008-02-25 |
2023-08-12 |
Not clear |
| S E O'Sulliva. Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17704824. |
cannabinoids act at two classical cannabinoid receptors (cb1 and cb2), a 7tm orphan receptor and the transmitter-gated channel transient receptor potential vanilloid type-1 receptor. |
2008-02-25 |
2023-08-12 |
Not clear |
| C R Hiley, S S Kau. GPR55 and the vascular receptors for cannabinoids. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17704825. |
cb1 and cb2 receptors mediate most responses to cannabinoids but not some of the cardiovascular actions of endocannabinoids such as anandamide and virodhamine, or those of some synthetic agents, like abnormal cannabidiol (abn-cbd). |
2008-02-25 |
2023-08-12 |
mouse |
| D Baker, S J Jackson, G Pryc. Cannabinoid control of neuroinflammation related to multiple sclerosis. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17891167. |
in experimental studies it has been recently shown that synthetic cannabinoids can affect the immune response both indirectly via cb1 receptor-mediated signalling nerve centres controlling the systemic release of immunosuppressive molecules and directly by cb2 receptor-mediated inhibition of lymphocyte and macrophage/microglial cell function. |
2008-02-25 |
2023-08-12 |
Not clear |
| A Mallat, S Lotersztaj. Endocannabinoids and liver disease. I. Endocannabinoids and their receptors in the liver. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 1. 2008-02-21. PMID:17975129. |
cannabinoid receptors (cb1 and cb2) and their endogenous ligands (endocannabinoids) have recently emerged as novel mediators of liver diseases. |
2008-02-21 |
2023-08-12 |
Not clear |
| Douglas McHugh, Carolyn Tanner, Raphael Mechoulam, Roger G Pertwee, Ruth A Ros. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Molecular pharmacology. vol 73. issue 2. 2008-02-19. PMID:17965195. |
inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from cb1 and cb2. |
2008-02-19 |
2023-08-12 |
human |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
regression of fibrosis after chronic stimulation of cannabinoid cb2 receptor in cirrhotic rats. |
2008-02-19 |
2023-08-12 |
human |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
two cannabinoid (cb) receptor subtypes, cb1 and cb2, have been cloned and characterized. |
2008-02-19 |
2023-08-12 |
human |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
among other activities, receptor activation by cannabinoid ligands may result in pro- or antifibrogenic effects depending on their interaction with cb1 or cb2, respectively. |
2008-02-19 |
2023-08-12 |
human |
| Y Shi, M Zou, E Y Baitei, A S Alzahrani, R S Parhar, Z Al-Makhalafi, F A Al-Mohann. Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer gene therapy. vol 15. issue 2. 2008-02-19. PMID:18197164. |
given that cannabinoids have shown antitumor effects in many types of cancer models, cb2 may be a viable therapeutic target for the treatment of anaplastic thyroid carcinoma. |
2008-02-19 |
2023-08-12 |
mouse |
| Subramanian K Vadivel, Sundararaman Vardarajan, Richard I Duclos, JodiAnne T Wood, Jianxin Guo, Alexandros Makriyanni. Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorganic & medicinal chemistry letters. vol 17. issue 21. 2008-02-05. PMID:17826996. |
these head group constrained and conformationally restricted analogues of 2-ag as well as the 1-keto precursors were evaluated as substrates for the endocannabinoid deactivating hydrolytic enzymes monoacylglycerol lipase (mgl) and fatty acid amide hydrolase (faah), and also were tested for their affinities for cb1 and cb2 cannabinoid receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| R G Pertwe. GPR55: a new member of the cannabinoid receptor clan? British journal of pharmacology. vol 152. issue 7. 2008-02-05. PMID:17876300. |
their experiments have revealed several differences between the pharmacology of gpr55 and the established cannabinoid cb1 and cb2 receptors. |
2008-02-05 |
2023-08-12 |
mouse |
| E Ryberg, N Larsson, S Sjögren, S Hjorth, N-O Hermansson, J Leonova, T Elebring, K Nilsson, T Drmota, P J Greasle. The orphan receptor GPR55 is a novel cannabinoid receptor. British journal of pharmacology. vol 152. issue 7. 2008-02-05. PMID:17876302. |
the endocannabinoid system functions through two well characterized receptor systems, the cb1 and cb2 receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| David Fernández-López, M Ruth Pazos, Rosa M Tolón, M Angeles Moro, Julián Romero, Ignacio Lizasoain, José Martínez-Orgad. The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic-ischemic encephalopathy in newborn rats. Pediatric research. vol 62. issue 3. 2008-01-25. PMID:17622949. |
thus, 7-d-old wistar rats (p7) were exposed to 8% o2 for 120 min after left carotid artery ligature, then received s.c. vehicle (veh) (hi+veh), the cannabinoid agonist win55212 (win) (0.1 mg/kg), or win with the cb1 or cb2 receptor antagonist sr141617 (sr1) (3 mg/kg) or sr141588 (sr2) (2 mg/kg). |
2008-01-25 |
2023-08-12 |
rat |
| Christoph W Michalski, Florian E Oti, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Michael W Müller, Nathalia A Giese, Helmut Friess, Jörg Kleef. Cannabinoids in pancreatic cancer: correlation with survival and pain. International journal of cancer. vol 122. issue 4. 2008-01-17. PMID:17943729. |
in our study, we quantitatively evaluated the immunoreactivity for cannabinoid-1 (cb1) and cannabinoid-2 (cb2) receptors as well as for the endocannabinoid metabolizing enzymes fatty acid amide hydrolase (faah) and monoacyl glycerol lipase (mgll). |
2008-01-17 |
2023-08-12 |
Not clear |
| H Ishiguro, S Iwasaki, L Teasenfitz, S Higuchi, Y Horiuchi, T Saito, T Arinami, E S Onaiv. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. The pharmacogenomics journal. vol 7. issue 6. 2008-01-08. PMID:17189959. |
involvement of cannabinoid cb2 receptor in alcohol preference in mice and alcoholism in humans. |
2008-01-08 |
2023-08-12 |
mouse |
| H Ishiguro, S Iwasaki, L Teasenfitz, S Higuchi, Y Horiuchi, T Saito, T Arinami, E S Onaiv. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. The pharmacogenomics journal. vol 7. issue 6. 2008-01-08. PMID:17189959. |
we tested if cannabinoid type 2 receptor (cb2) in the central nervous system plays a role in alcohol abuse/dependence in animal model and then examined an association between the cb2 gene polymorphism and alcoholism in human. |
2008-01-08 |
2023-08-12 |
mouse |
| Takashi Tanikawa, Kohta Kurohane, Yasuyuki Ima. Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. Microbiology and immunology. vol 51. issue 10. 2008-01-08. PMID:17951991. |
there are two types of cannabinoid receptors, cb1 and cb2. |
2008-01-08 |
2023-08-12 |
mouse |
| Rundong Zhang, Tae-Kang Kim, Zhaun-Hong Qiao, Jian Cai, William M Pierce, Zhao-Hui Son. Biochemical and mass spectrometric characterization of the human CB2 cannabinoid receptor expressed in Pichia pastoris--importance of correct processing of the N-terminus. Protein expression and purification. vol 55. issue 2. 2008-01-07. PMID:17500008. |
this study was conducted to optimize the expression of human cb2 cannabinoid receptors in methylotrophic yeast pichia pastoris (p. pastoris). |
2008-01-07 |
2023-08-12 |
human |