| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang He, Zhuan-Hong Qiao, Jian Cai, William Pierce, Da-Cheng He, Zhao-Hui Son. Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17698952. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) enhances cell migration through the cb2 cannabinoid receptor. |
2007-12-13 |
2023-08-12 |
human |
| Alexander Greenhough, Helena A Patsos, Ann C Williams, Christos Paraskev. The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. International journal of cancer. vol 121. issue 10. 2007-11-30. PMID:17583570. |
here, we report that cb1 and cb2 cannabinoid receptors are expressed in human colorectal adenoma and carcinoma cells, and show for the first time that thc induces apoptosis in colorectal cancer cells. |
2007-11-30 |
2023-08-12 |
human |
| Paul Cavuoto, Andrew J McAinch, George Hatzinikolas, Alena Janovská, Philip Game, Gary A Witter. The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and biophysical research communications. vol 364. issue 1. 2007-11-26. PMID:17935697. |
the most abundant endogenous endocannabinoid, anandamide, has been shown to activate the cannabinoid receptor type 1 (cb1) and type 2 (cb2) as well as the 'non-cannabinoid' transient receptor potential channel-vanilloid sub-family member 1 (trpv1), before being rapidly metabolised by fatty acid amide hydrolase (faah). |
2007-11-26 |
2023-08-12 |
human |
| Ying-Ching Liang, Chiung-Chun Huang, Kuei-Sen Hs. The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. Neuropharmacology. vol 53. issue 1. 2007-11-09. PMID:17572451. |
the effect of win 55,212-2 was mimicked by cannabinoid cb1 receptor agonist hu 210 and was antagonized by cb1 receptor antagonist am 251, but not by cb2 receptor antagonist am 630 or vanilloid receptor 1 antagonist capsazepine, suggesting the involvement of cb1 receptors. |
2007-11-09 |
2023-08-12 |
rat |
| Edward K Dziadulewicz, Stuart J Bevan, Christopher T Brain, Paul R Coote, Andrew J Culshaw, Andrew J Davis, Lee J Edwards, Adrian J Fisher, Alyson J Fox, Clive Gentry, Alex Groarke, Terance W Hart, Werner Huber, Iain F James, Adam Kesingland, Luigi La Vecchia, Yvonne Loong, Isabelle Lyothier, Kara McNair, Cathal O'Farrell, Marcus Peacock, Robert Portmann, Ulrich Schopfer, Mohammed Yaqoob, Jiri Zadrobile. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. Journal of medicinal chemistry. vol 50. issue 16. 2007-11-09. PMID:17630726. |
a new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human cb1 and cb2 receptors. |
2007-11-09 |
2023-08-12 |
human |
| Nella Pulvirenti, Maria Rita Nasca, Giuseppe Mical. Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. Acta dermatovenerologica Croatica : ADC. vol 15. issue 2. 2007-11-08. PMID:17631786. |
endogenous aliamides are capable of down-regulating mastocyte reactivity by their action through the vanilloid (vr1) receptors, and keratinocytes, and through the cb1 and cb2 cannabinoid receptors linked to g-protein, also expressed by sensitive nerve endings, macrophages, and epithelial cells. |
2007-11-08 |
2023-08-12 |
human |
| K Hillsley, C McCaul, J Aerssens, P J Peeters, H Gijsen, D Moechars, B Coulie, D Grundy, R H Stea. Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19. issue 9. 2007-11-07. PMID:17539892. |
activation of the cannabinoid 2 (cb2) receptor inhibits murine mesenteric afferent nerve activity. |
2007-11-07 |
2023-08-12 |
mouse |
| K Hillsley, C McCaul, J Aerssens, P J Peeters, H Gijsen, D Moechars, B Coulie, D Grundy, R H Stea. Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19. issue 9. 2007-11-07. PMID:17539892. |
abstract cannabinoid 2 (cb2) receptors have both antinociceptive and antihypersensitivity effects, although the precise mechanisms of action are still unclear. |
2007-11-07 |
2023-08-12 |
mouse |
| L Bricaire, T Bru. [Endocannabinoid system: from metabolic to neuroendocrine effects]. Annales d'endocrinologie. vol 68 Suppl 1. 2007-10-30. PMID:17961655. |
the endocannabinoid system associates the cannabinoid receptors (cb1 and cb2), largely expressed in the central nervous system as well as in the peripheric one, the endocannabinoids (the two main ones being anandamine and the 2 arachidonoyl glycerol), the endocannabinoid-degrading enzymes, and the synthetic antagonists of the cb1 receptor, such as sr141716 (rimonabant). |
2007-10-30 |
2023-08-12 |
Not clear |
| Mikko J Myllymäki, Susanna M Saario, Antti O Kataja, Joel A Castillo-Melendez, Tapio Nevalainen, Risto O Juvonen, Tomi Järvinen, Ari M P Koskine. Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 50. issue 17. 2007-10-29. PMID:17665899. |
inhibition of faah or magl activity might lead to beneficial effects in many physiological disorders such as pain, inflammation, and anxiety due to increased endocannabinoid-induced activation of cannabinoid receptors cb1 and cb2. |
2007-10-29 |
2023-08-12 |
Not clear |
| Demetris P Papahatjis, Victoria R Nahmias, Spyros P Nikas, Thanos Andreou, Shakiru O Alapafuja, Andrew Tsotinis, Jianxin Guo, Pusheng Fan, Alexandros Makriyanni. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of medicinal chemistry. vol 50. issue 17. 2007-10-29. PMID:17672444. |
in earlier work we have provided evidence for the presence of a subsite within the cb1 and cb2 cannabinoid receptor binding domains of classical cannabinoids. |
2007-10-29 |
2023-08-12 |
Not clear |
| Andrea Cippitelli, Ainhoa Bilbao, Miguel Angel Gorriti, Miguel Navarro, Maurizio Massi, Daniele Piomelli, Roberto Ciccocioppo, Fernando Rodríguez de Fonsec. The anandamide transport inhibitor AM404 reduces ethanol self-administration. The European journal of neuroscience. vol 26. issue 2. 2007-10-25. PMID:17650118. |
the effects of am404 are not mediated by either vanilloid vr1 receptors or cannabinoid cb2 receptors because it is not antagonized by either the vr1 receptor antagonist capsazepine or the cb2 antagonist am630. |
2007-10-25 |
2023-08-12 |
rat |
| Onintza Sagredo, José A Ramos, Alessandra Decio, Raphael Mechoulam, Javier Fernández-Rui. Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. The European journal of neuroscience. vol 26. issue 4. 2007-10-25. PMID:17672854. |
we used the cb1 agonist arachidonyl-2-chloroethylamide (acea), the cb2 agonist hu-308, and cannabidiol (cbd), an antioxidant phytocannabinoid with negligible affinity for cannabinoid receptors. |
2007-10-25 |
2023-08-12 |
rat |
| Giuseppe Esposito, Teresa Iuvone, Claudia Savani, Caterina Scuderi, Daniele De Filippis, Michele Papa, Vincenzo Di Marzo, Luca Steard. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17545311. |
c6 rat astroglioma cells were challenged with 1 microg/ml a beta 1-42 in the presence or absence of selective agonists and antagonists of cannabinoid (cb)1 and cb2 receptors. |
2007-10-19 |
2023-08-12 |
rat |
| Barbara Cost. On the pharmacological properties of Delta9-tetrahydrocannabinol (THC). Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712813. |
the isolation of its main constituent, delta9-tetrahydrocannabinol (thc), and the discovery of the endocannabinoid system (cannabinoid receptors cb1 and cb2 and their endogenous ligands) made possible studies concerning the pharmacological activity of cannabinoids. |
2007-09-28 |
2023-08-12 |
human |
| Giulio G Mucciol. Blocking the cannabinoid receptors: drug candidates and therapeutic promises. Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712820. |
the cb1 and cb2 cannabinoid receptors have been described as two prime sites of action for endocannabinoids. |
2007-09-28 |
2023-08-12 |
Not clear |
| Jean-Pierre Despré. The endocannabinoid system: a new target for the regulation of energy balance and metabolism. Critical pathways in cardiology. vol 6. issue 2. 2007-09-19. PMID:17667864. |
endocannabinoids are endogenous phospholipid derivatives which bind and activate cannabinoid receptors type 1 and type 2 (cb1 and cb2 receptors). |
2007-09-19 |
2023-08-12 |
Not clear |
| Fang He, Zhao-Hui Son. Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells. Molecular vision. vol 13. 2007-09-18. PMID:17679938. |
molecular and cellular changes induced by the activation of cb2 cannabinoid receptors in trabecular meshwork cells. |
2007-09-18 |
2023-08-12 |
Not clear |
| Fang He, Zhao-Hui Son. Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells. Molecular vision. vol 13. 2007-09-18. PMID:17679938. |
to study the role of cb2 cannabinoid receptors in cellular functions of trabecular meshwork (tm) cells including cytoskeleton changes and migration and to investigate the possible signaling pathways utilized by cb2 receptor for these cellular functions. |
2007-09-18 |
2023-08-12 |
Not clear |
| Serdar Durdagi, Agnes Kapou, Therapia Kourouli, Thanos Andreou, Spyros P Nikas, Victoria R Nahmias, Demetris P Papahatjis, Manthos G Papadopoulos, Thomas Mavromoustako. The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2. Journal of medicinal chemistry. vol 50. issue 12. 2007-08-15. PMID:17521177. |
the application of 3d-qsar studies for novel cannabinoid ligands substituted at the c1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors cb1 and cb2. |
2007-08-15 |
2023-08-12 |
Not clear |