| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco Molina-Holgado, Ana Rubio-Araiz, Daniel García-Ovejero, Robert J Williams, Jonathan D Moore, Angel Arévalo-Martín, Oscar Gómez-Torres, Eduardo Molina-Holgad. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. The European journal of neuroscience. vol 25. issue 3. 2007-05-02. PMID:17328768. |
in addition, cb1 or cb2 antagonists (1 microm sr-141716a and sr-144528, respectively) blocked basal proliferation, suggesting that endogenous cannabinoids are implicated in neurosphere proliferation. |
2007-05-02 |
2023-08-12 |
mouse |
| Francisco Molina-Holgado, Ana Rubio-Araiz, Daniel García-Ovejero, Robert J Williams, Jonathan D Moore, Angel Arévalo-Martín, Oscar Gómez-Torres, Eduardo Molina-Holgad. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. The European journal of neuroscience. vol 25. issue 3. 2007-05-02. PMID:17328768. |
together, our results suggest that cannabinoids stimulate proliferation of neural stem/precursor cells acting on both cb1 and cb2 cannabinoid receptors through a phosphoinositide-3 kinase/akt pathway. |
2007-05-02 |
2023-08-12 |
mouse |
| G T Whiteside, G P Lee, K J Valenzan. The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Current medicinal chemistry. vol 14. issue 8. 2007-05-02. PMID:17430144. |
the role of the cannabinoid cb2 receptor in pain transmission and therapeutic potential of small molecule cb2 receptor agonists. |
2007-05-02 |
2023-08-12 |
mouse |
| G T Whiteside, G P Lee, K J Valenzan. The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Current medicinal chemistry. vol 14. issue 8. 2007-05-02. PMID:17430144. |
this review gives a brief overview of the expression patterns, molecular pharmacology and physiological role of the cannabinoid 2 receptor (cb2) in pain. |
2007-05-02 |
2023-08-12 |
mouse |
| G T Whiteside, G P Lee, K J Valenzan. The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Current medicinal chemistry. vol 14. issue 8. 2007-05-02. PMID:17430144. |
through studies utilizing selective cb2 receptor agonists, non-selective cannabinoid agonists in conjunction with selective cb1 and cb2 receptor antagonists, or cb2 receptor knockout mice, it is now clear that this receptor plays a critical role in nociception. |
2007-05-02 |
2023-08-12 |
mouse |
| Aleksandra Ellert-Miklaszewska, Wieslawa Grajkowska, Konrad Gabrusiewicz, Bozena Kaminska, Liliana Konarsk. Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain research. vol 1137. issue 1. 2007-05-01. PMID:17239827. |
the efficacy of cannabinoids against high-grade glioma in animal models, mediated by two specific receptors, cb1 and cb2, raised promises for targeted treatment of the most frequent and malignant primary brain tumors. |
2007-05-01 |
2023-08-12 |
Not clear |
| Aleksandra Ellert-Miklaszewska, Wieslawa Grajkowska, Konrad Gabrusiewicz, Bozena Kaminska, Liliana Konarsk. Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain research. vol 1137. issue 1. 2007-05-01. PMID:17239827. |
the high levels of cb2 expression would predestine those tumors to be vulnerable to cannabinoid treatment. |
2007-05-01 |
2023-08-12 |
Not clear |
| N Mendez-Sanchez, D Zamora-Valdes, R Pichardo-Bahena, B Barredo-Prieto, G Ponciano-Rodriguez, L Bermejo-Martínez, N C Chavez-Tapia, H A Baptista-González, M Urib. Endocannabinoid receptor CB2 in nonalcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver. vol 27. issue 2. 2007-04-25. PMID:17311616. |
endocannabinoid receptor cb2 in nonalcoholic fatty liver disease. |
2007-04-25 |
2023-08-12 |
Not clear |
| G Pryce, D Bake. Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. British journal of pharmacology. vol 150. issue 4. 2007-04-17. PMID:17220914. |
control of spasticity in a multiple sclerosis model is mediated by cb1, not cb2, cannabinoid receptors. |
2007-04-17 |
2023-08-12 |
Not clear |
| G Pryce, D Bake. Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. British journal of pharmacology. vol 150. issue 4. 2007-04-17. PMID:17220914. |
the purpose of this study was to investigate further the involvement of cb1 and cb2)cannabinoid receptors in the control of experimental spasticity. |
2007-04-17 |
2023-08-12 |
Not clear |
| Catherine Lombard, Mitzi Nagarkatti, Prakash Nagarkatt. CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents. Clinical immunology (Orlando, Fla.). vol 122. issue 3. 2007-04-11. PMID:17185040. |
cannabinoids are known to interact with cb1 and cb2 receptors expressed in the nervous and immune system, respectively, and mediate a wide range of effects, including anti-inflammatory properties. |
2007-04-11 |
2023-08-12 |
Not clear |
| Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Rui. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196181. |
we used the cb1 receptor agonist arachidonyl-2-chloroethylamide (acea), the cb2 receptor agonist hu-308, the non-selective agonist win55,212-2, and the inhibitors of the endocannabinoid inactivation am404 and ucm707, all of them administered i.p. |
2007-04-05 |
2023-08-12 |
rat |
| Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Rui. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196181. |
in addition, the activation of cb2 (but not cb1) receptors, or other additional mechanisms, might also contribute to some extent to the potential of cannabinoids in this disease. |
2007-04-05 |
2023-08-12 |
rat |
| Darryl T Hamamoto, Subhalakshmi Giridharagopalan, Donald A Simon. Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia. European journal of pharmacology. vol 558. issue 1-3. 2007-04-04. PMID:17250825. |
the antihyperalgesic effect of cp 55,940 was mediated via the cannabinoid cb1 but not cb2 receptor. |
2007-04-04 |
2023-08-12 |
mouse |
| John C Ashton, Rosanna M A Rahman, Shiva M Nair, Brad A Sutherland, Michelle Glass, Ian Appleto. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123706. |
cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid cb2 receptor in the brain. |
2007-04-03 |
2023-08-12 |
rat |
| John C Ashton, Rosanna M A Rahman, Shiva M Nair, Brad A Sutherland, Michelle Glass, Ian Appleto. Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123706. |
until recently the cannabinoid cb2 receptor was believed to be absent from the central nervous system. |
2007-04-03 |
2023-08-12 |
rat |
| T Gutierrez, J N Farthing, A M Zvonok, A Makriyannis, A G Hohman. Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis. British journal of pharmacology. vol 150. issue 2. 2007-04-02. PMID:17160008. |
activation of peripheral cannabinoid cb1 and cb2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis. |
2007-04-02 |
2023-08-12 |
Not clear |
| Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. |
anandamide (n-arachidonoylethanolamine) and 2-ag (2-arachidonoylglycerol) are two major endocannabinoids that bind to and activate g-protein coupled cannabinoid receptors cb1 and cb2. |
2007-03-29 |
2023-08-12 |
mouse |
| Ariane Mallat, Fatima Teixeira-Clerc, Vanessa Deveaux, Sophie Lotersztaj. Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases. Expert opinion on therapeutic targets. vol 11. issue 3. 2007-03-28. PMID:17298297. |
indeed, cannabinoid receptors cb1 and cb2 promote dual pro- and antifibrogenic effects, respectively. |
2007-03-28 |
2023-08-12 |
Not clear |
| b' Jan Komorowski, Henryk Stepie\\xc5\\x8. [The role of the endocannabinoid system in the regulation of endocrine function and in the control of energy balance in humans]. Postepy higieny i medycyny doswiadczalnej (Online). vol 61. 2007-03-28. PMID:17369778.' |
the important elements of this system are: endocannabinoid receptors (types cb1 and cb2), their endogenous ligands (n-arachidonoylethanolamide, 2-arachidonoyl glycerol), enzymes involved in their synthesis and degradation, as well as cannabinoid antagonists. |
2007-03-28 |
2023-08-12 |
Not clear |