| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
comprehensive proteomic mass spectrometric characterization of human cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
the cb1 and cb2 cannabinoid receptors belong to the gpcr superfamily and are associated with a variety of physiological and pathophysiological processes. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
as a first step toward obtaining information on the structural features of the drug-receptor complex, we describe the full mass spectrometric (ms) analysis of the recombinant human cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
both instruments gave very similar patterns of identified peptides, with full coverage of all transmembrane helices, resulting in the complete characterization of the cannabinoid cb2 receptor. |
2007-07-18 |
2023-08-12 |
human |
| Nikolai Zvonok, Suma Yaddanapudi, John Williams, Shujia Dai, Keling Dong, Tomas Rejtar, Barry L Karger, Alexandros Makriyanni. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of proteome research. vol 6. issue 6. 2007-07-18. PMID:17472360. |
mass spectrometric identification of all amino acid residues in the cannabinoid cb2 receptor is a key step toward the "ligand based structural biology" approach developed in our laboratory for characterizing ligand binding sites in gpcrs using a variety of covalent cannabinergic ligands. |
2007-07-18 |
2023-08-12 |
human |
| Sándor Bátkai, Douglas Osei-Hyiaman, Hao Pan, Osama El-Assal, Mohanraj Rajesh, Partha Mukhopadhyay, Feng Hong, Judith Harvey-White, Anjum Jafri, György Haskó, John W Huffman, Bin Gao, George Kunos, Pál Pache. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17327359. |
activation of cb2 cannabinoid receptors by jwh133 protects against i/r damage by decreasing inflammatory cell infiltration, tissue and serum tnf-alpha, mip-1alpha and mip-2 levels, tissue lipid peroxidation, and expression of adhesion molecule icam-1 in vivo. |
2007-07-03 |
2023-08-12 |
mouse |
| Sándor Bátkai, Douglas Osei-Hyiaman, Hao Pan, Osama El-Assal, Mohanraj Rajesh, Partha Mukhopadhyay, Feng Hong, Judith Harvey-White, Anjum Jafri, György Haskó, John W Huffman, Bin Gao, George Kunos, Pál Pache. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17327359. |
these findings suggest that oxidative/nitrosative stress and inflammatory stimuli may trigger endocannabinoid production, and indicate that targeting cb2 cannabinoid receptors may represent a novel protective strategy against i/r injury. |
2007-07-03 |
2023-08-12 |
mouse |
| Takayuki Sugiura, Seishi Kishimoto, Saori Oka, Maiko Goko. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Progress in lipid research. vol 45. issue 5. 2007-07-02. PMID:16678907. |
2-ag binds to the cannabinoid receptors (cb1 and cb2) and exhibits a variety of cannabimimetic activities in vitro and in vivo. |
2007-07-02 |
2023-08-12 |
rat |
| Peter J Barne. The problem of cough and development of novel antitussives. Pulmonary pharmacology & therapeutics. vol 20. issue 4. 2007-06-26. PMID:17189707. |
perhaps the most promising drugs are transient receptor potential vanilloid-1 (trpv(1)) antagonists, selective cannabinoid agonists (cb2 agonists), maxi-k channel openers and p2x3 antagonists. |
2007-06-26 |
2023-08-12 |
human |
| Christian C Felder, Amy K Dickason-Chesterfield, Steven A Moor. Cannabinoids biology: the search for new therapeutic targets. Molecular interventions. vol 6. issue 3. 2007-06-22. PMID:16809476. |
the discovery of tetrahydrocannabinol, the active principal in marijuana, and the identification and cloning of two cannabinoid receptors (i.e., cb1 and cb2) has subsequently led to biomedical appreciation for a family of endocannabinoid lipid transmitters. |
2007-06-22 |
2023-08-12 |
Not clear |
| Fabian Docagne, Vilma Muñetón, Diego Clemente, Carine Ali, Frida Loría, Fernando Correa, Míriam Hernangómez, Leyre Mestre, Denis Vivien, Carmen Guaz. Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Molecular and cellular neurosciences. vol 34. issue 4. 2007-06-22. PMID:17229577. |
excitotoxicity in a chronic model of multiple sclerosis: neuroprotective effects of cannabinoids through cb1 and cb2 receptor activation. |
2007-06-22 |
2023-08-12 |
mouse |
| Fabian Docagne, Vilma Muñetón, Diego Clemente, Carine Ali, Frida Loría, Fernando Correa, Míriam Hernangómez, Leyre Mestre, Denis Vivien, Carmen Guaz. Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Molecular and cellular neurosciences. vol 34. issue 4. 2007-06-22. PMID:17229577. |
moreover, hu210 reduced ampa-induced excitotoxicity both in vivo and in vitro through the obligatory activation of both cb1 and cb2 cannabinoid receptors. |
2007-06-22 |
2023-08-12 |
mouse |
| John C Ashto. Cannabinoids for the treatment of inflammation. Current opinion in investigational drugs (London, England : 2000). vol 8. issue 5. 2007-06-22. PMID:17520866. |
the non-psychoactive cannabinoid receptor cb2 is emerging as a critical target for cannabinoid regulation of inflammation, and thus cb2-selective agonists are undergoing intense investigation and research. |
2007-06-22 |
2023-08-12 |
mouse |
| Josée Guindon, Jesse LoVerme, Daniele Piomelli, Pierre Beaulie. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and analgesia. vol 104. issue 6. 2007-06-14. PMID:17513659. |
the antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid cb1 and cb2 receptors. |
2007-06-14 |
2023-08-12 |
rat |
| Josée Guindon, Jesse LoVerme, Daniele Piomelli, Pierre Beaulie. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and analgesia. vol 104. issue 6. 2007-06-14. PMID:17513659. |
to further investigate the mechanisms by which propofol produced its antinociceptive effect, we used specific antagonists for the cannabinoid cb1 (am251) and cb2 (am630) receptors and measured fatty-acid amide/endocannabinoid (anandamide, 2-arachidonylglycerol, and palmitoylethanolamide) concentrations in skin paw tissues. |
2007-06-14 |
2023-08-12 |
rat |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
neuropsychobiological evidence for the functional presence and expression of cannabinoid cb2 receptors in the brain. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
for over a decade, until recently, it was thought that marijuana acts by activating brain-type cannabinoid receptors called cb1, and that a second type called cb2 cannabinoid receptor was found only in peripheral tissues. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
we reported the discovery and functional presence of cb2 cannabinoid receptors in the mammalian brain that may be involved in depression and drug abuse and this was supported by reports of identification of neuronal cb2 receptors that are involved in emesis. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
rt-pcr, immunoblotting, hippocampal cultures, immunohistochemistry, transmission electron microscopy, and stereotaxic techniques with behavioral assays were used to determine the functional expression of cb2 cannabinoid receptors in the rat brain and mouse brain exposed to chronic mild stress or treated with abused drugs. |
2007-06-13 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
the effect of direct cb2 antisense oligonucleotide injection into the brain and treatment with jwh015 in motor function and plus-maze tests also demonstrated the functional presence of cb2 cannabinoid receptors in the central nervous system. |
2007-06-13 |
2023-08-12 |
mouse |