| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
regression of fibrosis after chronic stimulation of cannabinoid cb2 receptor in cirrhotic rats. |
2008-02-19 |
2023-08-12 |
human |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
two cannabinoid (cb) receptor subtypes, cb1 and cb2, have been cloned and characterized. |
2008-02-19 |
2023-08-12 |
human |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
among other activities, receptor activation by cannabinoid ligands may result in pro- or antifibrogenic effects depending on their interaction with cb1 or cb2, respectively. |
2008-02-19 |
2023-08-12 |
human |
| Y Shi, M Zou, E Y Baitei, A S Alzahrani, R S Parhar, Z Al-Makhalafi, F A Al-Mohann. Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer gene therapy. vol 15. issue 2. 2008-02-19. PMID:18197164. |
given that cannabinoids have shown antitumor effects in many types of cancer models, cb2 may be a viable therapeutic target for the treatment of anaplastic thyroid carcinoma. |
2008-02-19 |
2023-08-12 |
mouse |
| Subramanian K Vadivel, Sundararaman Vardarajan, Richard I Duclos, JodiAnne T Wood, Jianxin Guo, Alexandros Makriyanni. Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorganic & medicinal chemistry letters. vol 17. issue 21. 2008-02-05. PMID:17826996. |
these head group constrained and conformationally restricted analogues of 2-ag as well as the 1-keto precursors were evaluated as substrates for the endocannabinoid deactivating hydrolytic enzymes monoacylglycerol lipase (mgl) and fatty acid amide hydrolase (faah), and also were tested for their affinities for cb1 and cb2 cannabinoid receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| R G Pertwe. GPR55: a new member of the cannabinoid receptor clan? British journal of pharmacology. vol 152. issue 7. 2008-02-05. PMID:17876300. |
their experiments have revealed several differences between the pharmacology of gpr55 and the established cannabinoid cb1 and cb2 receptors. |
2008-02-05 |
2023-08-12 |
mouse |
| E Ryberg, N Larsson, S Sjögren, S Hjorth, N-O Hermansson, J Leonova, T Elebring, K Nilsson, T Drmota, P J Greasle. The orphan receptor GPR55 is a novel cannabinoid receptor. British journal of pharmacology. vol 152. issue 7. 2008-02-05. PMID:17876302. |
the endocannabinoid system functions through two well characterized receptor systems, the cb1 and cb2 receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| David Fernández-López, M Ruth Pazos, Rosa M Tolón, M Angeles Moro, Julián Romero, Ignacio Lizasoain, José Martínez-Orgad. The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic-ischemic encephalopathy in newborn rats. Pediatric research. vol 62. issue 3. 2008-01-25. PMID:17622949. |
thus, 7-d-old wistar rats (p7) were exposed to 8% o2 for 120 min after left carotid artery ligature, then received s.c. vehicle (veh) (hi+veh), the cannabinoid agonist win55212 (win) (0.1 mg/kg), or win with the cb1 or cb2 receptor antagonist sr141617 (sr1) (3 mg/kg) or sr141588 (sr2) (2 mg/kg). |
2008-01-25 |
2023-08-12 |
rat |
| Christoph W Michalski, Florian E Oti, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Michael W Müller, Nathalia A Giese, Helmut Friess, Jörg Kleef. Cannabinoids in pancreatic cancer: correlation with survival and pain. International journal of cancer. vol 122. issue 4. 2008-01-17. PMID:17943729. |
in our study, we quantitatively evaluated the immunoreactivity for cannabinoid-1 (cb1) and cannabinoid-2 (cb2) receptors as well as for the endocannabinoid metabolizing enzymes fatty acid amide hydrolase (faah) and monoacyl glycerol lipase (mgll). |
2008-01-17 |
2023-08-12 |
Not clear |
| H Ishiguro, S Iwasaki, L Teasenfitz, S Higuchi, Y Horiuchi, T Saito, T Arinami, E S Onaiv. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. The pharmacogenomics journal. vol 7. issue 6. 2008-01-08. PMID:17189959. |
involvement of cannabinoid cb2 receptor in alcohol preference in mice and alcoholism in humans. |
2008-01-08 |
2023-08-12 |
mouse |
| H Ishiguro, S Iwasaki, L Teasenfitz, S Higuchi, Y Horiuchi, T Saito, T Arinami, E S Onaiv. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. The pharmacogenomics journal. vol 7. issue 6. 2008-01-08. PMID:17189959. |
we tested if cannabinoid type 2 receptor (cb2) in the central nervous system plays a role in alcohol abuse/dependence in animal model and then examined an association between the cb2 gene polymorphism and alcoholism in human. |
2008-01-08 |
2023-08-12 |
mouse |
| Takashi Tanikawa, Kohta Kurohane, Yasuyuki Ima. Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. Microbiology and immunology. vol 51. issue 10. 2008-01-08. PMID:17951991. |
there are two types of cannabinoid receptors, cb1 and cb2. |
2008-01-08 |
2023-08-12 |
mouse |
| Rundong Zhang, Tae-Kang Kim, Zhaun-Hong Qiao, Jian Cai, William M Pierce, Zhao-Hui Son. Biochemical and mass spectrometric characterization of the human CB2 cannabinoid receptor expressed in Pichia pastoris--importance of correct processing of the N-terminus. Protein expression and purification. vol 55. issue 2. 2008-01-07. PMID:17500008. |
this study was conducted to optimize the expression of human cb2 cannabinoid receptors in methylotrophic yeast pichia pastoris (p. pastoris). |
2008-01-07 |
2023-08-12 |
human |
| Somnath Mukhopadhyay, David A Tuli. Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. Cardiovascular & hematological agents in medicinal chemistry. vol 5. issue 4. 2008-01-03. PMID:17979695. |
recent findings from several laboratories have identified the endocannabinoid signaling pathway, comprised of the endocannabinoid agonist anandamide and its pharmacological targets, cb1 and cb2 cannabinoid receptors and associated anandamide receptors, as a physiological system with capacity to mitigate cardiovascular and cerebrovascular disorders through neuronal and endothelial actions. |
2008-01-03 |
2023-08-12 |
Not clear |
| J A Piszcz, D Lemancewicz, J Kloczko, J Dzieciol, M Rusak, M Dabrowsk. Cannabinoid receptors expression in bone marrow trephine biopsy of chronic lymphocytic leukaemia patients treated with purine analogues. Experimental oncology. vol 29. issue 3. 2007-12-31. PMID:18004250. |
cannabinoid receptors cb1 and cb2 are part the endocannabinoid system that plays an important role in the process of proliferation and apoptosis of different neoplastic cells. |
2007-12-31 |
2023-08-12 |
Not clear |
| Bill H McCarberg, Robert L Barki. The future of cannabinoids as analgesic agents: a pharmacologic, pharmacokinetic, and pharmacodynamic overview. American journal of therapeutics. vol 14. issue 5. 2007-12-28. PMID:17890938. |
however, since the discovery and cloning of cannabinoid receptors (cb1 and cb2) in the 1990s, scientific interest in the area has burgeoned, and the complexities of this fascinating receptor system, and its endogenous ligands, have been actively explored. |
2007-12-28 |
2023-08-12 |
Not clear |
| Allyn C Howlett, Somnath Mukhopadhyay, Derek C Norfor. Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 1. issue 3. 2007-12-27. PMID:18040807. |
the endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the cb1 and cb2 cannabinoid receptors, has been implicated in the pathophysiology of these disease states, and can be a target for therapeutic interventions. |
2007-12-27 |
2023-08-12 |
Not clear |
| Maulik D Jhaveri, Devi R Sagar, Steven J R Elmes, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor-mediated anti-nociception in models of acute and chronic pain. Molecular neurobiology. vol 36. issue 1. 2007-12-18. PMID:17952647. |
cannabinoid cb2 receptor-mediated anti-nociception in models of acute and chronic pain. |
2007-12-18 |
2023-08-12 |
human |
| Onintza Sagredo, Moisés García-Arencibia, Eva de Lago, Simone Finetti, Alessandra Decio, Javier Fernández-Rui. Cannabinoids and neuroprotection in basal ganglia disorders. Molecular neurobiology. vol 36. issue 1. 2007-12-18. PMID:17952653. |
there are two key mechanisms involved in the neuroprotection by cannabinoids in experimental models of these two disorders: first, a cannabinoid receptor-independent mechanism aimed at producing a decrease in the oxidative injury and second, an induction/upregulation of cannabinoid cb2 receptors, mainly in reactive microglia, that is capable to regulate the influence of these glial cells on neuronal homeostasis. |
2007-12-18 |
2023-08-12 |
Not clear |
| Fang He, Zhuan-Hong Qiao, Jian Cai, William Pierce, Da-Cheng He, Zhao-Hui Son. Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17698952. |
involvement of the 90-kda heat shock protein (hsp-90) in cb2 cannabinoid receptor-mediated cell migration: a new role of hsp-90 in migration signaling of a g protein-coupled receptor. |
2007-12-13 |
2023-08-12 |
human |