| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
selective cb2 activation may provide some of the therapeutic effects of cannabinoids, such as their immuno-modulatory properties, without the psychoactive effects of cb1 activation. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
therefore, cannabinoid cb2 receptors represent an attractive target for drug development. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
mutational and ligand binding studies, functional mapping, and computer modelling have revealed key residues and domains in cannabinoid receptors that are involved in agonist and antagonist binding to cb1 and cb2. |
2008-08-14 |
2023-08-12 |
mouse |
| Christine Börner, Volker Höllt, Jürgen Krau. Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription. Neuroimmunomodulation. vol 14. issue 6. 2008-07-22. PMID:18287809. |
effects of cannabinoids are mediated by cb1 and cb2 receptors. |
2008-07-22 |
2023-08-12 |
human |
| Daniela Accorsi-Mendonça, Carlos E L Almado, André L A Dagostin, Benedito H Machado, Ricardo M Leã. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain research. vol 1200. 2008-07-18. PMID:18308297. |
inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist win 55212-2 is not via cb1 or cb2 receptors. |
2008-07-18 |
2023-08-12 |
rat |
| Daniela Accorsi-Mendonça, Carlos E L Almado, André L A Dagostin, Benedito H Machado, Ricardo M Leã. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain research. vol 1200. 2008-07-18. PMID:18308297. |
both cb1 and cb2 cannabinoid receptors have been described in the nucleus tractus solitarius (nts), which receives direct afferent projections of cardiovascular reflexes. |
2008-07-18 |
2023-08-12 |
rat |
| Kristin Gustafsson, Xiao Wang, Denise Severa, Maeve Eriksson, Eva Kimby, Mats Merup, Birger Christensson, Jenny Flygare, Birgitta Sande. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation. International journal of cancer. vol 123. issue 5. 2008-07-18. PMID:18546271. |
in this study, we evaluated the expression of cannabinoid receptors type 1 and type 2 (cb1 and cb2) in non-hodgkin lymphomas of b cell type (n = 62). |
2008-07-18 |
2023-08-12 |
mouse |
| Kristin Gustafsson, Xiao Wang, Denise Severa, Maeve Eriksson, Eva Kimby, Mats Merup, Birger Christensson, Jenny Flygare, Birgitta Sande. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation. International journal of cancer. vol 123. issue 5. 2008-07-18. PMID:18546271. |
with the exception of mcl, which uniformly overexpresses both cb1 and cb2, the levels of cannabinoid receptors within other lymphoma entities were highly variable, ranging from 0.1 to 224 times the expression in reactive lymph nodes. |
2008-07-18 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A Tagliaferro, Eileen Gardner, Alicia Brusco, B Emmanuel Akinshola, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami, George R Uh. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286196. |
brain neuronal cb2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. |
2008-07-15 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A Tagliaferro, Eileen Gardner, Alicia Brusco, B Emmanuel Akinshola, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami, George R Uh. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286196. |
many laboratories were not able to detect the presence of cannabinoid cb2 receptors (cb2-rs) in healthy brains, but there has been demonstration of cb2-r expression in rat microglial cells and other brain associated cells during inflammation. |
2008-07-15 |
2023-08-12 |
mouse |
| Javier Fernández-Ruiz, María Ruth Pazos, Moisés García-Arencibia, Onintza Sagredo, José A Ramo. Role of CB2 receptors in neuroprotective effects of cannabinoids. Molecular and cellular endocrinology. vol 286. issue 1-2 Suppl 1. 2008-07-11. PMID:18291574. |
role of cb2 receptors in neuroprotective effects of cannabinoids. |
2008-07-11 |
2023-08-12 |
Not clear |
| Xiaofei Sun, Sudhansu K De. Aspects of endocannabinoid signaling in periimplantation biology. Molecular and cellular endocrinology. vol 286. issue 1-2 Suppl 1. 2008-07-11. PMID:18294762. |
the discovery of cannabinoid receptors (cb1 and cb2), endocannabinoid ligands (anandamide and 2-acylglycerol) as well as their key synthetic and hydrolytic pathways has helped to better understand the roles of cannabinoid/endocannabinoid signaling in preimplantation embryo development, oviductal embryo transport, embryo implantation and postimplantation embryonic growth. |
2008-07-11 |
2023-08-12 |
mouse |
| Rosanna Chianese, Gilda Cobellis, Riccardo Pierantoni, Silvia Fasano, Rosaria Meccariell. Non-mammalian vertebrate models and the endocannabinoid system: relationships with gonadotropin-releasing hormone. Molecular and cellular endocrinology. vol 286. issue 1-2 Suppl 1. 2008-07-11. PMID:18325658. |
endocannabinoids, via cannabinoid receptors (cb1 and cb2), affect reproductive functions at both local and central level. |
2008-07-11 |
2023-08-12 |
Not clear |
| C Calatozzolo, A Salmaggi, B Pollo, F L Sciacca, M Lorenzetti, A Franzini, A Boiardi, G Broggi, C Marra. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 28. issue 6. 2008-06-12. PMID:18175076. |
recent studies have shown an anti-tumour activity of cannabinoid receptors cb1 and cb2 in gliomas. |
2008-06-12 |
2023-08-12 |
human |
| C Calatozzolo, A Salmaggi, B Pollo, F L Sciacca, M Lorenzetti, A Franzini, A Boiardi, G Broggi, C Marra. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 28. issue 6. 2008-06-12. PMID:18175076. |
the aim of this study was to investigate the expression of cannabinoid receptors cb1 and cb2, neurotrophin ngf and nt-3 and their receptors trka and trkc in glioma and endothelial cells. |
2008-06-12 |
2023-08-12 |
human |
| C Calatozzolo, A Salmaggi, B Pollo, F L Sciacca, M Lorenzetti, A Franzini, A Boiardi, G Broggi, C Marra. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 28. issue 6. 2008-06-12. PMID:18175076. |
a potential role of cannabinoids, particularly of cb2 agonists devoid of psychotropic side effects, in glioma therapy could have a basis in glioblastomas, because they were all positive, though weakly, to cb2. |
2008-06-12 |
2023-08-12 |
human |
| Christopher Butt, Alp Alptekin, Toni Shippenberg, Murat O. Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18194436. |
pre-treatment with the cannabinoid (cb1) receptor antagonist sr141716a (1 microm), the cb2 receptor antagonist sr144528 (1 microm), or pertussis toxin (0.2 mg/ml) did not alter the inhibitory effects of aea, suggesting that known cb receptors are not involved in aea inhibition of nachrs. |
2008-06-06 |
2023-08-12 |
mouse |
| Wataru Yamamoto, Tadayoshi Mikami, Hiroyuki Iwamur. Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18279850. |
involvement of central cannabinoid cb2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. |
2008-05-27 |
2023-08-12 |
mouse |
| Wataru Yamamoto, Tadayoshi Mikami, Hiroyuki Iwamur. Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18279850. |
we sought to examine the involvement of central cannabinoid cb2 receptor activation in modulating mechanical allodynia in a mouse model of neuropathic pain. |
2008-05-27 |
2023-08-12 |
mouse |
| Wataru Yamamoto, Tadayoshi Mikami, Hiroyuki Iwamur. Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18279850. |
jwh133 was demonstrated to be a selective cannabinoid cb2 receptor agonist in mice, reducing forskolin-stimulated camp production in cho cells expressing mouse cannabinoid cb2 and cannabinoid cb1 receptors with ec50 values of 63 nm and 2500 nm, respectively. |
2008-05-27 |
2023-08-12 |
mouse |