| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Malysz, Anthony V Daza, Karen Kage, George K Grayson, Betty B Yao, Michael D Meyer, Murali Gopalakrishna. Characterization of human cannabinoid CB2 receptor coupled to chimeric Galpha(qi5) and Galpha(qo5) proteins. European journal of pharmacology. vol 603. issue 1-3. 2009-03-18. PMID:19071106. |
characterization of human cannabinoid cb2 receptor coupled to chimeric galpha(qi5) and galpha(qo5) proteins. |
2009-03-18 |
2023-08-12 |
human |
| b' Krystyna Nadolska, Roman Go\\xc5\\x9. [The role of endocannabinoid system in physiological and pathological processes in the eye]. Klinika oczna. vol 110. issue 10-12. 2009-03-17. PMID:19195174.' |
besides cannabinoid receptors cb1 and cb2, the system includes it's endogenic ligands (endocannabinoids) and compounds that participate in their biosynthesis and inactivation. |
2009-03-17 |
2023-08-12 |
Not clear |
| M Widmer, C O Hanemann, J Zajice. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. Journal of neuroscience research. vol 86. issue 14. 2009-02-06. PMID:18615640. |
cannabinoids bind to two g-protein-coupled receptors, cb1 and cb2, expressed by neurons and cells of the immune system, respectively. |
2009-02-06 |
2023-08-12 |
human |
| Lucía Márquez, Sergio Abanades, Montserrat Andre. [Endocannabinoid system and bowel inflammation]. Medicina clinica. vol 131. issue 13. 2009-02-05. PMID:19007582. |
there are 2 specific receptors, cb1 and cb2, through which the cannabinoids exert their effect. |
2009-02-05 |
2023-08-12 |
Not clear |
| Fabio Cianchi, Laura Papucci, Nicola Schiavone, Matteo Lulli, Lucia Magnelli, Maria Cristina Vinci, Luca Messerini, Clementina Manera, Elisa Ronconi, Paola Romagnani, Martino Donnini, Giuliano Perigli, Giacomo Trallori, Elisabetta Tanganelli, Sergio Capaccioli, Emanuela Masin. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 14. issue 23. 2009-02-05. PMID:19047095. |
the present study was undertaken to investigate the expression of the two cannabinoid receptors, cb1 and cb2, in colorectal cancer and to provide new insight into the molecular pathways underlying the apoptotic activity induced by their activation. |
2009-02-05 |
2023-08-12 |
Not clear |
| Betty B Yao, Gin Hsieh, Anthony V Daza, Yihong Fan, George K Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A Hooker, Madhavi Pai, Erica J Wensink, Anita K Salyers, Prasant Chandran, Chang Z Zhu, Chengmin Zhong, Keith Ryther, Megan E Gallagher, Chih-Liang Chin, Ann E Tovcimak, Vincent P Hradil, Gerard B Fox, Michael J Dart, Prisca Honore, Michael D Meye. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging. The Journal of pharmacology and experimental therapeutics. vol 328. issue 1. 2009-02-03. PMID:18931146. |
characterization of a cannabinoid cb2 receptor-selective agonist, a-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3h-thiazol-(2z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging. |
2009-02-03 |
2023-08-12 |
human |
| George Kunos, Douglas Osei-Hyiaman, Jie Liu, Gregorz Godlewski, Sándor Bátka. Endocannabinoids and the control of energy homeostasis. The Journal of biological chemistry. vol 283. issue 48. 2009-01-29. PMID:18694938. |
endocannabinoids (ecbs) are ubiquitous lipid mediators that act through the same g protein-coupled receptors (cb1 and cb2) that recognize plant-derived cannabinoids. |
2009-01-29 |
2023-08-12 |
Not clear |
| Jean-Ha Baek, Yiwen Zheng, Cynthia L Darlington, Paul F Smit. Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei. Acta oto-laryngologica. vol 128. issue 9. 2009-01-27. PMID:19086305. |
cannabinoid cb2 receptor expression in the rat brainstem cochlear and vestibular nuclei. |
2009-01-27 |
2023-08-12 |
rat |
| Ekaterina A Placzek, Yasuo Okamoto, Natsuo Ueda, Eric L Barke. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. Neuropharmacology. vol 55. issue 7. 2009-01-26. PMID:18760289. |
anandamide (aea) and 2-arachidonyl glycerol (2-ag), endogenous ligands for the cb1 and cb2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the actions of delta9-tetrahydrocannabinol (delta9-thc), a plant-derived cannabinoid. |
2009-01-26 |
2023-08-12 |
Not clear |
| Alison E B Springs, Peer W F Karmaus, Robert B Crawford, Barbara L F Kaplan, Norbert E Kaminsk. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. Journal of leukocyte biology. vol 84. issue 6. 2009-01-22. PMID:18791168. |
effects of targeted deletion of cannabinoid receptors cb1 and cb2 on immune competence and sensitivity to immune modulation by delta9-tetrahydrocannabinol. |
2009-01-22 |
2023-08-12 |
mouse |
| Alison E B Springs, Peer W F Karmaus, Robert B Crawford, Barbara L F Kaplan, Norbert E Kaminsk. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. Journal of leukocyte biology. vol 84. issue 6. 2009-01-22. PMID:18791168. |
the role of cannabinoid receptors, cb1 and cb2, in immune competence and modulation by delta9-tetrahydrocannabinol (delta9-thc) was investigated in cb1(-/-)/cb2(-/-) mice. |
2009-01-22 |
2023-08-12 |
mouse |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
am404 inhibits endocannabinoid cellular uptake, binds weakly to cb1 and cb2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (faah) in vivo. |
2009-01-22 |
2023-08-12 |
mouse |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
we prepared three derivatives of this new (endo)cannabinoid using bioisosteric replacement (1), homology (2), and derivatization (3) of the 4-aminophenol moiety in am404 and tested them against cb1, cb2, and faah. |
2009-01-22 |
2023-08-12 |
mouse |
| Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman, Benjamin F Cravat. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature chemical biology. vol 5. issue 1. 2009-01-15. PMID:19029917. |
2-arachidonoylglycerol (2-ag) and anandamide are endocannabinoids that activate the cannabinoid receptors cb1 and cb2. |
2009-01-15 |
2023-08-12 |
mouse |
| Natalie E Freeman-Anderson, Theresa G Pickle, Courtney D Netherland, Alicia Bales, Nancy E Buckley, Douglas P Thewk. Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. Journal of lipid research. vol 49. issue 11. 2009-01-14. PMID:18614816. |
cannabinoid (cb2) receptor deficiency reduces the susceptibility of macrophages to oxidized ldl/oxysterol-induced apoptosis. |
2009-01-14 |
2023-08-12 |
Not clear |
| Fernando Correa, Fabian Docagne, Leyre Mestre, Diego Clemente, Miriam Hernangómez, Frida Loría, Carmen Guaz. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. Biochemical pharmacology. vol 77. issue 1. 2008-12-29. PMID:18848818. |
together, our results provide the first demonstration of a role of aea in inhibiting il-12p70/il-23 axis in human and murine microglial cells via the cb2 receptor and suggest that the pharmacological manipulation of the endocannabinoid system is a potential tool for treating brain inflammatory and autoimmune diseases, like ms. |
2008-12-29 |
2023-08-12 |
human |
| Marco Koch, Iris Habazettl, Faramarz Dehghani, Horst-Werner Kor. The rat pineal gland comprises an endocannabinoid system. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18554250. |
immunohistochemical and immunoblot analyses revealed the presence of cb1 and cb2 receptor proteins, of n-acyl phosphatidyl ethanolamine hydrolyzing phospholipase d (nape-pld), an enzyme catalyzing endocannabinoid biosynthesis and of fatty acid amide hydrolase (faah), an endocannabinoid catabolizing enzyme, in pinealocytes, and in pineal sympathetic nerve fibers identified by double immunofluorescence with an antibody against tyrosine hydroxylase. |
2008-12-24 |
2023-08-12 |
rat |
| E S Onaivi, O Carpio, H Ishiguro, N Schanz, G R Uhl, R Benn. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991890. |
although past research revealed that the cb1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal cb2 cannabinoid receptors in the brain has been controversial. |
2008-12-09 |
2023-08-12 |
mouse |
| E S Onaivi, O Carpio, H Ishiguro, N Schanz, G R Uhl, R Benn. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991890. |
this is because cb2 cannabinoid receptors were thought to be absent from the brain and expressed primarily in immune cells and in the periphery. |
2008-12-09 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A Tagliaferro, Eileen Gardner, Alicia Brusco, B Emmanuel Akinshola, Qing-Rong Liu, Sanika S Chirwa, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami, George R Uh. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991891. |
functional expression of brain neuronal cb2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. |
2008-12-09 |
2023-08-12 |
mouse |