| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia R Clarke, Janine I Rossato, Siomara Monteiro, Lia R M Bevilaqua, Iván Izquierdo, Martín Cammarot. Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiology of learning and memory. vol 90. issue 2. 2008-11-18. PMID:18524639. |
however, the participation of cb1 and cb2 cannabinoid receptors in recognition memory has not been yet conclusively determined. |
2008-11-18 |
2023-08-12 |
rat |
| V Di Marz. The endocannabinoid system in obesity and type 2 diabetes. Diabetologia. vol 51. issue 8. 2008-11-18. PMID:18563385. |
endocannabinoids (ecs) are defined as endogenous agonists of cannabinoid receptors type 1 and 2 (cb1 and cb2). |
2008-11-18 |
2023-08-12 |
Not clear |
| A J Scheen, V Seutin, L F Van Gaa. [Endocannabinoid system in the brain...and elsewhere]. Revue medicale de Liege. vol 63. issue 5-6. 2008-11-14. PMID:18669206. |
the endocannabinoid system is a complex system with endogenous ligands, synthesis and transport processes, specific receptors (cb1 and cb2) and intracellular degrading enzymes. |
2008-11-14 |
2023-08-12 |
Not clear |
| G Aviello, B Romano, A A Izz. Cannabinoids and gastrointestinal motility: animal and human studies. European review for medical and pharmacological sciences. vol 12 Suppl 1. 2008-11-14. PMID:18924447. |
delta9-tetrahydrocannabinol, the main psychotropic component of cannabis, acts via at least two types of cannabinoid receptors, named cb1 and cb2 receptors. |
2008-11-14 |
2023-08-12 |
human |
| G Aviello, B Romano, A A Izz. Cannabinoids and gastrointestinal motility: animal and human studies. European review for medical and pharmacological sciences. vol 12 Suppl 1. 2008-11-14. PMID:18924447. |
consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of cb1, but not cb2, receptors. |
2008-11-14 |
2023-08-12 |
human |
| Maria Notarnicola, Caterina Messa, Antonella Orlando, Maurizio Bifulco, Chiara Laezza, Patrizia Gazzerro, Maria Gabriella Carus. Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. Scandinavian journal of gastroenterology. vol 43. issue 1. 2008-11-14. PMID:18938775. |
cannabinoids are a class of compounds that have the ability to activate two specific receptor subtypes, the cannabinoid cb1 and cb2 receptors. |
2008-11-14 |
2023-08-12 |
human |
| M Cella, G F Leguizamón, M S Sordelli, M Cervini, T Guadagnoli, M L Ribeiro, A M Franchi, M G Farin. Dual effect of anandamide on rat placenta nitric oxide synthesis. Placenta. vol 29. issue 8. 2008-11-13. PMID:18561998. |
we found that cannabinoids receptors (cb1 and cb2), faah and trpv1 were expressed in chorio-allantoic placenta. |
2008-11-13 |
2023-08-12 |
rat |
| Elizabeth J Rahn, Alexander M Zvonok, Ganesh A Thakur, Atmaram D Khanolkar, Alexandros Makriyannis, Andrea G Hohman. Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. The Journal of pharmacology and experimental therapeutics. vol 327. issue 2. 2008-11-13. PMID:18664590. |
selective activation of cannabinoid cb2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. |
2008-11-13 |
2023-08-12 |
rat |
| Dai Lu, Jianxin Guo, Richard I Duclos, Anna L Bowman, Alexandros Makriyanni. Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands. Journal of medicinal chemistry. vol 51. issue 20. 2008-11-13. PMID:18826296. |
in earlier work, we provided evidence for the presence of subsites within the cb1 and cb2 cannabinoid receptor binding domains that can accommodate bulky conformationally defined substituents at the c3 alkyl side chain pharmacophore of classical cannabinoids. |
2008-11-13 |
2023-08-12 |
Not clear |
| Martin A Storr, Catherine M Keenan, Dominik Emmerdinger, Hong Zhang, Birol Yüce, Andrei Sibaev, Federico Massa, Nancy E Buckley, Beat Lutz, Burkhard Göke, Stephan Brand, Kamala D Patel, Keith A Sharke. Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. Journal of molecular medicine (Berlin, Germany). vol 86. issue 8. 2008-11-12. PMID:18493729. |
targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of cb1 and cb2 receptors. |
2008-11-12 |
2023-08-12 |
mouse |
| Serdar Durdagi, Heribert Reis, Manthos G Papadopoulos, Thomas Mavromoustako. Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors. Bioorganic & medicinal chemistry. vol 16. issue 15. 2008-11-07. PMID:18595717. |
comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand amg3 in solution and at binding site of the cb1 and cb2 receptors. |
2008-11-07 |
2023-08-12 |
Not clear |
| Visitación Lípez-Miranda, Esperanza Herradón, Ma Isabel Martí. Vasorelaxation caused by cannabinoids: mechanisms in different vascular beds. Current vascular pharmacology. vol 6. issue 4. 2008-11-06. PMID:18855721. |
with regard to the former, the stimulation of cannabinoid cb1, cb2 or noncb1/noncb2 cannabinoid receptors and the stimulation of vanilloid receptors, transient potential vanilloid receptors, on perivascular nerve endings with the subsequent release of the vasodilator neurotransmitter calcitonin gene-related peptide have been described. |
2008-11-06 |
2023-08-12 |
Not clear |
| Osama M H Habayeb, Anthony H Taylor, Stephen C Bell, David J Taylor, Justin C Konj. Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. Endocrinology. vol 149. issue 10. 2008-11-04. PMID:18599552. |
the endocannabinoid, anandamide, which binds to two major receptor proteins, the cannabinoid receptors (cbs) 1 and 2 (cb1 and cb2), has been shown to play a role in first trimester miscarriage possibly through impairment of the developing trophoblast. |
2008-11-04 |
2023-08-12 |
human |
| John Ashto. Pro-drugs for indirect cannabinoids as therapeutic agents. Current drug delivery. vol 5. issue 4. 2008-11-04. PMID:18855592. |
these include the psychoactivity of cannabinoid cb1 receptor agonists and the lack of availability of highly selective cannabinoid receptor full agonists (for the cb1 or cb2 receptor), as well as problems of pharmacokinetics. |
2008-11-04 |
2023-08-12 |
Not clear |
| b' N\\xc3\\xb3ra Dobrosi, Bal\\xc3\\xa1zs I T\\xc3\\xb3th, Georgina Nagy, Anik\\xc3\\xb3 D\\xc3\\xb3zsa, Tam\\xc3\\xa1s G\\xc3\\xa9czy, L\\xc3\\xa1szl\\xc3\\xb3 Nagy, Christos C Zouboulis, Ralf Paus, L\\xc3\\xa1szl\\xc3\\xb3 Kov\\xc3\\xa1cs, Tam\\xc3\\xa1s B\\xc3\\xadr\\xc3\\xb. Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18596221.' |
because cells with "silenced" cb2 exhibited significantly suppressed basal lipid production, our results collectively suggest that human sebocytes utilize a paracrine-autocrine, endogenously active, cb2-mediated endocannabinoid signaling system for positively regulating lipid production and cell death. |
2008-10-21 |
2023-08-12 |
human |
| Jian-Kang Chen, Jianchun Chen, John D Imig, Shouzuo Wei, David L Hachey, Jagadeesh Setti Guthi, John R Falck, Jorge H Capdevila, Raymond C Harri. Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. The Journal of biological chemistry. vol 283. issue 36. 2008-10-20. PMID:18606824. |
both 2-11,12-eg and 2-14,15-eg activated the two cannabinoid (cb) receptor subtypes, cb1 and cb2, with high affinity and elicited biological responses in cultured cells expressing cb receptors and in intact animals. |
2008-10-20 |
2023-08-12 |
Not clear |
| María Iribarne, Vanesa Torbidoni, Karina Julián, Juan P Prestifilippo, Debasish Sinha, Valeria Rettori, Alejandro Berra, Angela M Subur. Cannabinoid receptors in conjunctival epithelium: identification and functional properties. Investigative ophthalmology & visual science. vol 49. issue 10. 2008-10-10. PMID:18566465. |
therefore, the authors explored the presence and properties of cannabinoid receptors (cb1 and cb2) in conjunctival epithelial cells. |
2008-10-10 |
2023-08-12 |
Not clear |
| Erinn S Raborn, Francine Marciano-Cabral, Nancy E Buckley, Billy R Martin, Guy A Cabra. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 3. issue 2. 2008-10-08. PMID:18247131. |
the cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to rantes/ccl5: linkage to the cb2 receptor. |
2008-10-08 |
2023-08-12 |
mouse |
| Erinn S Raborn, Francine Marciano-Cabral, Nancy E Buckley, Billy R Martin, Guy A Cabra. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 3. issue 2. 2008-10-08. PMID:18247131. |
collectively, these results suggest that cannabinoids act through the cb2 receptor to transdeactivate migratory responsiveness to rantes/ccl5. |
2008-10-08 |
2023-08-12 |
mouse |
| Jian Zhang, Chu Che. Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. The Journal of biological chemistry. vol 283. issue 33. 2008-10-03. PMID:18534982. |
2-arachidonoylglycerol (2-ag), the most abundant endogenous cannabinoid and a full agonist for cannabinoid receptors (cb1 and cb2), is a substrate for cyclooxygenase-2 (cox-2) and can be metabolized by cox-2. |
2008-10-03 |
2023-08-12 |
Not clear |